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| 1 | 多器官床旁即时超声在新型冠状病毒肺炎中的应用:国际专家共识显示文摘新型冠状病毒肺炎(简称新冠肺炎,COVID-19)自首次报道以来,已造成全球超一亿人感染,给各国的公共卫生体系造成了巨大威胁。新冠肺炎的临床表现以呼吸系统体征和症状为主,80%的患者症状轻微,约5%为危重症患者,常表现为急性呼吸窘迫综合征(ARDS)。前期,由于缺乏相关研究,面对日益紧迫的临床困境,医务人员不得不借鉴采取一些经验性措施以应对疫情。 | 王臻(译) Arif Hussain Gabriele Via Lawrence Melniker Alberto Goffi Guido Tavazzi Luca Neri Tomas Villen Richard Hoppmann Francesco Mojoli Vicki Noble Laurent Zieleskiewicz Pablo Blanco Irene W.Y.Ma Mahathar Abd.Wahab Abdulmohsen Alsaawi Majid AI Salamah Martin Balik Diego Barca Karim Bendjelid Belaid Bouhemad Pablo Bravo-Figueroa Raoul Breitkreutz Juan Calderon Jim Connolly Roberto Copetti Francesco Corradi Anthony J.Dean AndréDenault Deepak Govil Carmela Graci Young-Rock Ha Laura Hurtado Toru Kameda Michael Lanspa Christian B Laursen Francis Lee Rachel Liu Massimiliano Meineri Miguel Montorfano Peiman Nazerian Bret P.Nelson Aleksandar N.Neskovic Ramon Nogue Adi Osman JoséPazeli Elmo Pereira-Junior Tomislav Petrovic Emanuele Pivetta Jan Poelaert Susanna Price Gregor Prosen Shalim Rodriguez Philippe Rola Colin Royse Yale Tung Chen Mike Wells Adrian Wong Wang Xiaoting Wang Zhen Yaseen Arabi | 2021 | 中国呼吸与危重监护杂志2021，20，2： | 5 |
| 2 | Femtojoule electro-optic modulation using a silicon– organic hybrid device显示文摘Energy-efficient electro-optic modulators are at the heart of short-reach optical interconnects,and silicon photonics is considered the leading technology for realizing such devices.However,the performance of all-silicon devices is limited by intrinsic material properties.In particular,the absence of linear electro-optic effects in silicon renders the integration of energy-efficient photonic–electronic interfaces challenging.Silicon–organic hybrid(SOH)integration can overcome these limitations by combining nanophotonic silicon waveguides with organic cladding materials,thereby offering the prospect of designing optical properties by molecular engineering.In this paper,we demonstrate an SOH Mach–Zehnder modulator with unprecedented efficiency:the 1-mm-long device consumes only 0.7 fJ bit^(-1) to generate a 12.5 Gbit s^(-1) data stream with a bit-error ratio below the threshold for hard-decision forward-error correction.This power consumption represents the lowest value demonstrated for a non-resonant Mach–Zehnder modulator in any material system.It is enabled by a novel class of organic electro-optic materials that are designed for high chromophore density and enhanced molecular orientation.The device features an electro-optic coefficient of r33<180 pm V^(-1) and can be operated at data rates of up to 40 Gbit s^(-1). | Sebastian Koeber Robert Palmer Matthias Lauermann Wolfgang Heni Delwin L Elder Dietmar Korn Markus Woessner Luca Alloatti Swen Koenig Philipp C Schindler Hui Yu Wim Bogaerts Larry R Dalton Wolfgang Freude Juerg Leuthold Christian Koos | 2015 | Light(Science & Applications)2015，4，1： | 4 |
| 3 | 100 GHz silicon–organic hybrid modulator显示文摘Electro-optic modulation at frequencies of 100 GHz and beyond is important for photonic-electronic signal processing at the highest speeds.To date,however,only a small number of devices exist that can operate up to this frequency.In this study,we demonstrate that this frequency range can be addressed by nanophotonic,silicon-based modulators.We exploit the ultrafast Pockels effect by using the silicon–organic hybrid(SOH)platform,which combines highly nonlinear organic molecules with silicon waveguides.Until now,the bandwidth of these devices was limited by the losses of the radiofrequency(RF)signal and the RC(resistor-capacitor)time constant of the silicon structure.The RF losses are overcome by using a device as short as 500 μm,and the RC time constant is decreased by using a highly conductive electron accumulation layer and an improved gate insulator.Using this method,we demonstrate for the first time an integrated silicon modulator with a 3dB bandwidth at an operating frequency beyond 100 GHz.Our results clearly indicate that the RC time constant is not a fundamental speed limitation of SOH devices at these frequencies.Our device has a voltage–length product of only V_(π)L=11 V mm,which compares favorably with the best silicon-photonic modulators available today.Using cladding materials with stronger nonlinearities,the voltage–length product is expected to improve by more than an order of magnitude. | Luca Alloatti Robert Palmer Sebastian Diebold Kai Philipp Pahl Baoquan Chen Raluca Dinu Maryse Fournier Jean-Marc Fedeli Thomas Zwick Wolfgang Freude Christian Koos Juerg Leuthold | 2014 | Light(Science & Applications)2014，3，1： | 3 |
| 4 | CGIS Compiler-A Tool Demonstration 显示文摘 | PHILIPP LUCAS NICOLAS FRITZ REINHARD WILHELM | 2006 | Lecture Notes in Computer Science2006，39，23： | 1 |
| 5 | Treatment of Peritoneal Carcinomatosis From Colorectal Cancer: Impact of Complete Cytoreductive Surgery and Difficulties in Conducting Randomized Trials显示文摘 | Dominique Elias Jean-Robert Delperro Lucas Sideris Ellen Benhamou Marc Pocard Olivier Baton Marc Giovannini Philippe Lasser | 2004 | Annals of Surgical Oncology2004，，5： | 1 |
| 6 | Local Recurrences After Intraoperative Radiofrequency Ablation of Liver Metastases: A Comparative Study with Anatomic and Wedge Resections显示文摘 | Dominique Elias MD PhD Olivier Baton MD Lucas Sideris MD FRCSC Tadashi Matsuhisa MD Marc Pocard MD PhD Philippe Lasser MD | 2004 | Annals of Surgical Oncology2004，，5： | 1 |
| 7 | Functional Characterization of a New Class of Odorant-Binding Proteins in the Moth Mamestra brassicae显示文摘 | Jonathan Bohbot Franck Sobrio Philippe Lucas Patricia Nagnan-Le Meillour | 1998 | Biochemical and Biophysical Research Communications1998，，2： | 1 |
| 8 | Liver transplantation using fatty livers: Always feasible?显示文摘 | Lucas McCormack Philipp Dutkowski Ashraf Mohammad El-Badry Pierre-Alain Clavien | 2010 | Journal of Hepatology2010，，5： | 1 |
| 9 | Patents, trademarks, and their complementarity in venture capital funding显示文摘 | Haibo Zhou Philipp G. Sandner Simon Luca Martinelli Joern H. Block | 2015 | Technovation2015，，： | 1 |
| 10 | Voltage and calcium activated currents in cultured olfactory receptor neurons of male mamestra brassicae 显示文摘 | Lucas Philippe Shimahara Takeshi I | 2002 | Chemical Senses2002，27，7： | 1 |
| 11 | Metallurgical Aspects of Ultra Fast Cooling in Front of the Down-Coiler显示文摘 | Aurelie LUCAS Philippe RICHE etc | 2004 | Steel Research International2004，，2： | 1 |
| 12 | Results of R0 Resection for Colorectal Liver Metastases Associated With Extrahepatic Disease显示文摘 | Dominique Elias MD PhD Lucas Sideris MD FRCSC Marc Pocard MD PhD Jean-Francois Ouellet MD FRCSC Valérie Boige MD Philippe Lasser MD Jean-Pierre Pignon MD PhD Michel Ducreux MD | 2004 | Annals of Surgical Oncology2004，，3： | 1 |
| 13 | Survival, liver failure, and hepatocellular carcinoma in obesity-related cryptogenic cirrhosis显示文摘 | Vlad Ratziu Luminita Bonyhay Vincent Di Martino Frederic Charlotte Lucas Cavallaro Marie-Hélène Sayegh-Tainturier Philippe Giral André Grimaldi Pierre Opolon Thierry Poynard | 2002 | Hepatology2002，，6： | 1 |
| 14 | QTL analysis for ascorbic acid content in strawberry fruit reveals a complex genetic architecture and association with GDP-L-galactose phosphorylase显示文摘Strawberry(Fragaria×ananassa)fruits are an excellent source of L-ascorbic acid(AsA),a powerful antioxidant for plants and humans.Identifying the genetic components underlying AsA accumulation is crucial for enhancing strawberry nutritional quality.Here,we unravel the genetic architecture of AsA accumulation using an F1 population derived from parental lines‘Candonga’and‘Senga Sengana’,adapted to distinct Southern and Northern European areas.To account for environmental effects,the F1 and parental lines were grown and phenotyped in five locations across Europe(France,Germany,Italy,Poland and Spain).Fruit AsA content displayed normal distribution typical of quantitative traits and ranged five-fold,with significant differences among genotypes and environments.AsA content in each country and the average in all of them was used in combination with 6,974 markers for quantitative trait locus(QTL)analysis.Environmentally stable QTLs for AsA content were detected in linkage group(LG)3A,LG 5A,LG 5B,LG 6B and LG 7C.Candidate genes were identified within stable QTL intervals and expression analysis in lines with contrasting AsA content suggested that GDP-L-Galactose Phosphorylase FaGGP(3A),and the chloroplast-located AsA transporter gene FaPHT4;4(7C)might be the underlying genetic factors for QTLs on LG 3A and 7C,respectively.We show that recessive alleles of FaGGP(3A)inherited from both parental lines increase fruit AsA content.Furthermore,expression of FaGGP(3A)was two-fold higher in lines with high AsA.Markers here identified represent a useful resource for efficient selection of new strawberry cultivars with increased AsA content. | Pilar Muñoz Cristina Castillejo JoséAntonio Gómez Luis Miranda Silke Lesemann Klaus Olbricht Aurélie Petit Philippe Chartier Annika Haugeneder Johanna Trinkl Luca Mazzoni Agnieszka Masny Edward Zurawicz Freya Maria Rosemarie Ziegler Björn Usadel Wilfried Schwab Béatrice Denoyes Bruno Mezzetti Sonia Osorio JoséFSánchez-Sevilla Iraida Amaya | 2023 | Horticulture Research2023，10，3： | 1 |
| 15 | Characterization of a new keratinolytic bacterium that completely degrades native feather keratin显示文摘 | Alessandro Riffel Fran?oise Lucas Philipp Heeb Adriano Brandelli | 2003 | Archives of Microbiology2003，，4： | 1 |
| 16 | Evaluation and Reduction of Asymptomatic Cerebral Embolism in Ablation of Atrial Fibrillation, But High Prevalence of Chronic Silent Infarction: Results of the Evaluation of Reduction of Asymptomatic Cerebral Embolism Trial显示文摘 | Atul Verma Philippe Debruyne Stefano Nardi Thomas Deneke Yves DeGreef Stefan Spitzer J?rn O. Balzer Lucas Boersma | 2013 | Circulation: Arrhythmia and Electrophysiology2013，，5： | 1 |
| 17 | Gene expression analysis by cDNA-AFLP highlights a set of new signaling networks and translational control during seed dormancy breaking in Nicotiana plumbaginifolia显示文摘 | Jér?me Bove Philippe Lucas Béatrice Godin Laurent Ogé Marc Jullien Philippe Grappin | 2005 | Plant Molecular Biology2005，，4： | 1 |
| 18 | Large G3BP-induced granules trigger eIF2α phosphorylation显示文摘 | Lucas C. Reineke Jon D. Dougherty Philippe Pierre Richard E. Lloyd | 2012 | Molecular Biology of the Cell2012，，18： | 1 |
| 19 | A multifunctional network of basic residues confers unique properties to protein kinase CK2显示文摘 | Stefania S Philippe V Luca C | 1999 | Mol Cell Biochem1999，191，12： | 1 |
| 20 | Characterization of multi-scale microstructural features in Opalinus Clay显示文摘 | Lukas M. Keller Philipp Schuetz Rolf Erni Marta D. Rossell Falk Lucas Philippe Gasser Lorenz Holzer | 2013 | Microporous and Mesoporous Materials2013，，： | 1 |
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