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| 1 | 直流电阻率三维正演的代数多重网格方法(英文)显示文摘多重网格方法在求解由偏微分方程的边值问题离散所得线性系统时,具有非常高的计算效率.但常用的几何多重网格法在处理带跃变系数的偏微分方程时存在一定缺陷,限制了其应用.本文应用代数多重网格(AMG)方法求解三维直流电阻率法正演模拟形成的有限差分线性方程组,通过求解二次场的方法消除了总场中由点电源导致的奇异性,从而获得快速、精确的三维电阻率数值模拟.对两个存在大的电性差异的模型进行了模拟计算,以验证代数多重网格法的收敛效率.计算结果表明,与不完全Cholesky共轭梯度(ICCG)方法相比,代数多重网格方法具有更高的计算效率及稳定性.而且,随着三维网格节点数的增加,代数多重网格方法计算的高效性更加明显. | 鲁晶津 吴小平 Klaus Spitzer | 2010 | 地球物理学报2010，53，3： | 25 |
| 2 | 全髋关节置换术后血栓预防 使用便携式加压器或低分子量肝素的前瞻性随机对照研究显示文摘背景:血栓栓塞性疾病是全髋关节置换术后常见的并发症。本研究的目的在于比较新型便携式加压器与低分子量肝素在静脉血栓预防中的安全性和有效性。方法:全髋置换患者随机接受为期10d便携式加压器或者低分子量肝素预防治疗。术中开始使用加压器,并且这组患者在术后日服81mg的阿司匹林。使用肝素者,术后12-24h开始注射低分子量肝素。在10-12d后,所有患者行多普勒超声筛查双下肢小腿、大腿部深静脉血栓;有肺栓塞临床症状的患者均接受肺部螺旋CT扫描评价。记录两组出血和于预性治疗情况(即:依从性)。术后12周进行深静脉血栓和肺栓塞证据的临床评估。结果:410例患者(414髋)进行随机化分组;392例患者(395髋)进行手术安全性评估,386例(389髋)治疗结果有效。两组间的一般临床情况无差异。加压组严重出血发生率O%,低分子量肝素组6%。加压组远端和近端深静脉血栓发生率分别为3%、2%,肝素组3%、1%。肺栓塞发生率加压组1%,肝素组1%,无致命性肺栓塞。随访12周,1例加压组患者出现两项事件(深静脉血栓和肺栓塞),该患者术后第12天多普勒超声检查阴性。在静脉血栓栓塞预防上两组比较无明显差异。结论:全髋置换术后静脉血栓栓塞预防,便携式加压器与低分子量肝素比较,可明显减少严重出血。 | CliffordW. Colwell Jr. Mark I. Froimson Michael A.Mont Merrill A. Ritter Robert T. Trousdale Knute C. Buehler Andrew Spitzer Thomas K. Donaldson Douglas E. Padgett 勘武生(译) | 2010 | 中华骨科杂志2010，30，6： | 24 |
| 3 | GAD-7量表精确诊断广泛性焦虑障碍显示文摘问题:广泛性焦虑障碍(GAD)-7量表的诊断精确性如何?
方法
设计:采用盲法比较GAD-7量表与DSM—Ⅳ中的GAD标准。 | Spitzer RL Kroenke K Williams IB JB 苏丹 | 2007 | 英国医学杂志中文版2007，10，2： | 15 |
| 4 | 三维泊松方程数值模拟的多重网格方法显示文摘本文简要介绍了多重网格方法的基本思想和原理,然后应用多重网格(MG)方法求解三维泊松方程,网格尺度从17×17×17逐次增加至257×257×257,并与不完全Chelesky共轭梯度法(ICCG)、Gauss直接解法进行比较.结果表明,MG方法计算速度明显优于ICCG、Gauss方法,对于129×129×129网格的三维数值模拟费时43s,比ICCG法快7倍,而对于257×257×257超大型网格的三维数值模拟也仅需412 s. | 鲁晶津 吴小平 Klaus Spitzer | 2009 | 地球物理学进展2009，24，1： | 13 |
| 5 | 子宫颈上皮内瘤变或原位腺癌的处理(2006年版)显示文摘2006年9月18—19日,146名代表29个组织和专业学会的专家在Bethesda聚会,修改制订了有关如何处理宫颈癌筛查异常结果妇女的以循证医学为依据的共识指南。有关低度宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)的处理,变化较大。以往,需要根据阴道镜检查结果是否满意进行处理,对所有的CIN1妇女均可以采用破坏或者切除疗法。在新的指南中,不论阴道镜检查满意与否,对因低度宫颈细胞学结果转诊而明确的CIN1,细胞学随访是唯一的处理建议。 | 李志刚 Thomas C.Wright L.Stewart Massad Charles J.Dunton Mark Spitzer Edward J.Wilkinson Diane Solomon | 2008 | 循证医学2008，8，5： | 4 |
| 6 | Reliability of the ocular trauma score for the predictability of traumatic and post-traumatic retinal detachment after open globe injury显示文摘AIM: To elucidate the question of whether the ocular trauma score(OTS) and the zones of injury could be used as a predictive model of traumatic and post traumatic retinal detachment(RD) in patients with open globe injury(OGI).METHODS: A retrospective observational chart analysis of OGI patients was performed. The collected variables consisted of age, date, gender, time of injury, time until repair, mechanism of injury, zone of injury, injury associated vitreous hemorrhage, trauma associated RD, post traumatic RD, aphakia at injury, periocular trauma and OTS in cases of OGI. RESULTS: Totally 102 patients with traumatic OGI with a minimum of 12 mo follow-up and a median age at of 48.6 y(range: 3-104 y) were identified. Final best corrected visual acuity(BCVA) was independent from the time of repair, yet a statistically significant difference was present between the final BCVA and the zone of injury. Severe trauma presenting with an OTS score Ⅰ(P<0.0001) or Ⅱ(P<0.0001) revealed a significantly worse BCVA at last follow up when compared to the cohort with an OTS score >Ⅲ. OGI associated RD was observed in 36/102 patients(35.3%), whereas post traumatic RD(defined as RD following 14 d after OGI) occurred in 37 patients(36.3%). OGI associated RD did not correlate with the OTS and the zone of injury(P=0.193), yet post traumatic RD correlated significantly with zone Ⅲ injuries(P=0.013). CONCLUSION: The study shows a significant association between lower OTS score and zone Ⅲ injury with lower final BCVA and a higher number of surgeries, but only zone Ⅲ could be significantly associated with a higher rate of RD. | Simon Dulz Vasilis Dimopoulos Toam Katz Robert Kromer Eileen Bigdon Martin Stephan Spitzer Christos Skevas | 2021 | International Journal of Ophthalmology(English edition)2021，14，10： | 4 |
| 7 | Rotational electromagnetic stirring in continuous casting of round strands显示文摘 | Karl-Heinz Spitzer Mathias Dubke Klaus Schwerdtfeger | 1986 | Metallurgical Transactions B1986，，1： | 4 |
| 8 | 脂多糖对大鼠乳腺上皮细胞酪蛋白基因表达的影响显示文摘本试验旨在探讨脂多糖(LPS)对大鼠乳腺上皮细胞中αs1-酪蛋白(CSN1S1)、β-酪蛋白(CSN2)和乳清蛋白(α-LA)3种主要酪蛋白基因表达的影响。采用单因素试验设计,用实时荧光定量PCR(RT-PCR)法研究在催乳素诱导作用下,0、100、500、1000、5000和25000 ng/mL的LPS作用于HC11细胞3和24 h对酪蛋白基因(CSN1S1、CSN2和α-LA)、葡萄糖转运因子1(GLUT1)、葡萄糖转运因子8(GLUT8)、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)和肿瘤坏死因子-α(TNF-α)基因表达的影响。结果表明:不同剂量、不同作用时间的LPS作用于HC11细胞,均显著抑制了CSN2基因的表达;作用3 h时,500~1000 ng/mL的LPS显著增加了α-LA基因的表达量(P<0.05),作用24 h时,所有剂量的LPS均显著抑制了α-LA基因的表达(P<0.05);500~25000 ng/mL的LPS作用3 h时和所有剂量的LPS作用24 h时均显著增加了CSN1S1基因的表达量(P<0.05);LPS显著增加了TNF-α基因的表达量(P<0.05);1000 ng/mL的LPS作用3 h时和100~25000 ng/mL的LPS作用24 h时,均显著增加了IL-6基因的表达量(P<0.05);500~25000 ng/mL的LPS作用3 h时显著增加了IL-1β基因的表达量(P<0.05);从时间效应来看,总体趋势是3种细胞因子(IL-6、IL-1β、TNF-α)在作用24 h时的基因表达量均高于作用3 h时。大于5000 ng/mL的LPS作用3 h时显著增加了GLUT1基因的表达量(P<0.05),所有剂量LPS均显著抑制了GLUT8基因的表达(P<0.05)。综上,在大鼠乳腺上皮细胞中,LPS对不同酪蛋白基因的表达有不同的影响,LPS能抑制CSN2和α-LA基因的表达,却能增强CSN1S1基因的表达。 | 田青 SPITZER A J 赵凤启 | 2020 | 动物营养学报2020，32，7： | 4 |
| 9 | Secreted MD-2 is a large polymeric protein that efficiently confers lipopolysaccharide sensitivity to Toll-like receptor 4显示文摘 | Visintin A Mazzoni A Spitzer J A | 2001 | Proc Natl Acad Sci U S A2001，98，12： | 2 |
| 10 | Formation mechanisms of sub-micron pharmaceutical composite particles derived from far-and near-field Raman microscopy显示文摘Surface enhanced Raman spectroscopy(SERS) and confocal Raman microscopy are applied to investigate the structure and the molecular arrangement of sub-micron furosemide and polyvinylpyrrolidone(furosemide/PVP) particles produced by spray flash evaporation(SFE). Morphology, size and crystallinity of furosemide/PVP particles are analyzed by scanning electron microscopy(SEM) and X-ray powder diffraction(XRPD). Far-field Raman spectra and confocal far-field Raman maps of furosemide/PVP particles are interpreted based on the far-field Raman spectra of pure furosemide and PVP precursors.Confocal far-field Raman microscopy shows that furosemide/PVP particles feature an intermixture of furosemide and PVP molecules at the sub-micron scale. SERS and surface-enhanced confocal Raman microscopy(SECo RM) are performed on furosemide, PVP and furosemide/PVP composite particles sputtered with silver(40 nm). SERS and SECo RM maps reveal that furosemide/PVP particle surfaces mainly consist of PVP molecules. The combination of surface and bulk sensitive analyses reveal that furosemide/PVP sub-micron particles are formed by the agglomeration of primary furosemide nanocrystals embedded in a thin PVP matrix. Interestingly, both far-field Raman microscopy and SECo RM provide molecular information on a statistically-relevant amount of sub-micron particles in a single microscopic map;this combination is thus an effective and time-saving tool for investigating organic sub-micron composites. | Jakob Hübner Jean-Baptiste Coty Yan Busby Denis Spitzer | 2021 | Journal of Pharmaceutical Analysis2021，11，4： | 2 |
| 11 | Survey: Interpolation methods in medical image processing 显示文摘 | LEHMANN T M GONNER C SPITZER K | 1999 | IEEE Transactions on Medical Imaging1999，18，11： | 1 |
| 12 | Effects of two different doses of amino acid supplementation on growth and blood amino acid levels in premature neonates admitted to the neonatal intensive care unit:a randomized,controlled trial显示文摘 | Clark RH Chace DH Spitzer AR | 2007 | Pediatrics2007，120，6： | 1 |
| 13 | Pathway engineering for production of aromatics in Escherichia coli:confirunation of stoichiometric analysis by independent modulation of aroG, tktA,and Ppe activities显示文摘 | Patnaik R Spitzer R G Liao J | 1995 | Biotechnol Bioeng1995，46，： | 1 |
| 14 | Repolarizing K^+ currents in rabbit heart purkinje cells 显示文摘 | Cordeiro JM Spitzer KW Giles WR | 1998 | Journal of Physiology1998，508，3： | 1 |
| 15 | Histamine regulates cytokine production in maturing dendritic cells,resulting in altered T cell polarization显示文摘 | Mazzoni A Young HA Spitzer JH | 2001 | J Clin Invest2001，108，12： | 1 |
| 16 | Toll-like receptorl inhibits Toll-like receptor 4 signaling in endothelis cells显示文摘 | Spitzer J H Visintin A Mazzoni A | 2002 | Eur J Immunol2002，32，4： | 1 |
| 17 | The visible human dataset:the anatomical platform for human simulation显示文摘 | Spitzer VM Whitlock DG | 1998 | The Anatomical Record1998，253，2： | 1 |
| 18 | The apolipoprotein E and betafibrinogen G/A - 455 gene polymorphisms are associated with ischemic stroke involving large - vessel disease显示文摘 | Kessler C Spitzer C Stauske D | 1997 | Arterlo-scler Thromb Vase Biol1997，17，： | 1 |
| 19 | Measuring the quality of life of cancer patients:a concise QL-Index for use by physicians显示文摘 | Spitzer WO Dobson AJ Hall J | 1981 | J Chronic Dis1981，34，12： | 1 |
| 20 | Liver transplantation at the extremes of the body mass index 显示文摘 | Dick AA Spitzer AL Seifert CF el al | 2009 | Liver Transpl2009，15，8： | 1 |
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