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| 1 | 2种HPLC-柱后衍生化-荧光检测法测定陈皮中黄曲霉毒素的比较显示文摘目的:对陈皮中黄曲霉毒素测定的2种柱后衍生化方法(碘衍生化和电化学衍生化)进行比较。方法:样品经过免疫亲和柱净化,HPLC-柱后衍生化-荧光检测器检测。采用Diamonsil ODS C18(5μm,4.6 mm×200 mm)色谱柱,荧光检测,激发波长360 nm,发射波长450 nm。柱后衍生化系统(1)碘衍生化:以甲醇-乙腈-水(25∶18∶57)为流动相,流速0.8 mL.min-1;衍生化溶液为0.05%碘溶液,流速0.3 mL.min-1,衍生化反应温度70℃;(2)电化学衍生化:以甲醇-乙腈-水(20∶20∶60)为流动相(每1 L流动相中加入溴化钾120 mg和4 mol.L-1硝酸350μL),流速1.0 mL.min-1。结果:碘衍生化,黄曲霉毒素G2、B2在2~36 pg,黄曲霉毒素G1、B1在2~120 pg范围内线性关系良好;电化学衍生化,黄曲霉毒素G2、B2在1.2~36 pg,黄曲霉毒素G1、B1在2~120 pg范围内线性关系良好,r>0.9997;回收率在60%~101%之间。结论:2种衍生化方法的测定结果比较接近,且电化学衍生化方法较灵敏,操作简单、分析速度快,也适用于陈皮中黄曲霉毒素的测定。 | 沙东旭 Uwe Gasser 孙苓苓 张满来 侯峰 康强 王维宁 | 2013 | 药物分析杂志2013，33，8： | 11 |
| 2 | 高沉积率激光金属沉积Inconel 718的孔隙率控制显示文摘为降低高沉积率激光金属沉积(Laser Metal Deposition,LMD)工艺中材料的孔隙率,研究了以镍基高温合金Inconel 718(IN718)为粉末沉积材料的高沉积率LMD工艺中主要工艺参数对材料孔隙率的影响,以及通过调整工艺参数降低材料孔隙率的方法。以目标沉积率为2kg/h的LMD工艺为基础,通过参数固化和分离的手段开展了高沉积率LMD的镀层实验,研究了主要工艺参数即激光功率、扫描速度及送粉量对LMD镀层材料孔隙率的影响,分析了不同参数下各镀层的横截面孔隙率及镀层孔隙率。实验显示:当激光功率从1 440 W增加到4 214 W时,镀层材料的孔隙率从约1.5%降低至0.02%左右;当扫描速度为500mm/min至5 000mm/min时,镀层材料孔隙率始终保持为0.07%至0.18%左右;当送粉量从0.64kg/h增加至6.48kg/h时,镀层材料孔隙率从约0.01%增加至0.84%左右。可见在高沉积率LMD工艺中,扫描速度对材料孔隙率无明显影响,而提高激光功率、限制送粉量均可有效降低LMD材料孔隙率,提高横截面孔隙率的一致性。 | 仲崇亮 付金宝 丁亚林 Andres Gasser | 2015 | 光学精密工程2015，23，11： | 7 |
| 3 | Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling显示文摘 | Kandice R. Levental Hongmei Yu Laura Kass Johnathon N. Lakins Mikala Egeblad Janine T. Erler Sheri F.T. Fong Katalin Csiszar Amato Giaccia Wolfgang Weninger Mitsuo Yamauchi David L. Gasser Valerie M. Weaver | 2009 | Cell2009，，5： | 4 |
| 4 | Nuclear organization in genome stability: SUMO connections显示文摘染色质动力学和原子组织为基因规定和 DNA 复制,而且为染色体稳定性的维护是不仅重要的最近的调查结果表演。在酵母,原子毛孔借助于指向相扑的 Ubiquitin ligases (STUbLs ) 的 evolutionarily 保存的家庭在染色体稳定性的维护起一个作用。有被转移到原子毛孔的 DNA 裂缝的一个班的酵母 Slx5/Slx8 STUbL 伙伴。机能上地, Slx5/Slx8 被一条不平常的调停再结合的小径为 telomere 维护需要。哺乳动物的 STUbL RNF4 把原子身体与 Promyelocytic 白血球过多症(PML ) 联系并且响应导致砷的应力调整 PML/PML-fusion 蛋白质稳定性。由在 telomerase 缺乏的肿瘤的 ALT 小径的 PML 身体支持 telomere 维护的一个子类。通过在酵母的毛孔子单元的任何一个损失的原子组织的不安,或在人的 PML 身体不安,能导致基因扩大,删除, translocations 或端对端的 telomere 在精选修理事件的 subnuclear 组织的熔化事件,因此含有的相扑和 STUbLs。 | Shigeki Nagai Niloofar Davoodi Susan M Gasser | 2011 | Cell Research2011，21，3： | 3 |
| 5 | Empirical estimates of regional carbon budgets imply reduced global soil heterotrophic respiration显示文摘Resolving regional carbon budgets is critical for informing land-based mitigation policy.For nine regions covering nearly the whole globe,we collected inventory estimates of carbon-stock changes complemented by satellite estimates of biomass changes where inventory data are missing.The net land–atmospheric carbon exchange(NEE)was calculated by taking the sum of the carbon-stock change and lateral carbon fluxes from crop and wood trade,and riverine-carbon export to the ocean.Summing up NEE from all regions,we obtained a global‘bottom-up'NEE for net land anthropogenic CO_(2)uptake of–2.2±0.6 Pg C yr^(-1)consistent with the independent top-down NEE from the global atmospheric carbon budget during 2000–2009.This estimate is so far the most comprehensive global bottom-up carbon budget accounting,which set up an important milestone for global carbon-cycle studies.By decomposing NEE into component fluxes,we found that global soil heterotrophic respiration amounts to a source of CO_(2)of 39 Pg C yr^(-1)with an interquartile of 33–46 Pg C yr^(-1)—a much smaller portion of net primary productivity than previously reported. | Philippe Ciais Yitong Yao Thomas Gasser Alessandro Baccini Yilong Wang Ronny Lauerwald Shushi Peng Ana Bastos Wei Li Peter A.Raymond Josep G.Canadell Glen P.Peters Rob J.Andres Jinfeng Chang Chao Yue A.Johannes Dolman Vanessa Haverd Jens Hartmann Goulven Laruelle Alexandra G.Konings Anthony W.King Yi Liu Sebastiaan Luyssaert Fabienne Maignan Prabir K.Patra Anna Peregon Pierre Regnier Julia Pongratz Benjamin Poulter Anatoly Shvidenko Riccardo Valentini Rong Wang Grégoire Broquet Yi Yin Jakob Zscheischler Bertrand Guenet Daniel SGoll Ashley-P.Ballantyne Hui Yang Chunjing Qiu Dan Zhu | 2021 | National Science Review2021，8，2： | 3 |
| 6 | Cholestasis and metabolic bone disease – a clinical review显示文摘 | Rudolf W. Gasser | 2008 | Wiener Medizinische Wochenschrift (-)2008，，1920： | 3 |
| 7 | DNA technological progress toward advanced diagnostic tools to support human hookworm control显示文摘 | R.B. Gasser C. Cantacessi A. Loukas | 2007 | Biotechnology Advances2007，，1： | 2 |
| 8 | Regulatory function of self-restricted MHC class Ⅱ allopeptide-specific TH· clones in vivo显示文摘 | Gasser M Kist-van-Holthe J | 2001 | J Clin Invest2001，107，7： | 1 |
| 9 | Genotyping Taenia tapeworms by singles-trand conformation pol-ymorphism of mitochondrial DNA显示文摘 | GASSER R B ZHU X WOODS W | 1999 | Electrophore-sis1999，20，14： | 1 |
| 10 | Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95-2 显示文摘 | Cong L Gasser J Zhao J | 2007 | Endocr Relat Cancer2007，14，3： | 1 |
| 11 | NADH dehydrogenase subunit 1 and cytochrome coxidase subunit I sequences compared for members of the genus Taenia(Cestoda) 显示文摘 | GASSER R B ZHU X Q MCMANUS D P | 1999 | Int J Parasitol1999，29，： | 1 |
| 12 | Small-bowel disease: comparison of MR enteroclysis imaging with conventional enteroclysis and surgical findings显示文摘 | Umschaden HW Szolar D Gasser J | 2000 | Radiology2000，215，： | 1 |
| 13 | Effects of gene dosage,promoters,and substrates on unfolded protein stress of recombinant Pichia pastoris显示文摘 | Hohenblum H Gasser B Maurer M | 2004 | Biotechnol Bioeng2004，85，4： | 1 |
| 14 | Small-bowel disease:comparison of MR enteroclysis images with conventional enteroclysis and surgical findings显示文摘 | Umschaden HW Szolar D Gasser J | 2000 | Radiology2000，215，： | 1 |
| 15 | The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor 显示文摘 | Gasser S Orsulic S Brown EJ | 2005 | Nature2005，436，7054： | 1 |
| 16 | Identification of Nematodirus species (Nematoda: Molineidae) from wild ruminants in Italy using ribosomal DNA markers显示文摘 | Gasser R B Roca L Zhu X Q | 1999 | Int J Parasitol1999，29，： | 1 |
| 17 | NADH dehydrogenase subunit 1 and cytochrome c oxidase subunit 1 sequences compared for members of the genus Taenia (Cestoda)显示文摘 | Gasser R B Zhu XQ Mcmanus D P | 1999 | Int J Parasitol1999，29，12： | 1 |
| 18 | Light quarks at low tempera- tures显示文摘 | Gasser J Leutwyler H | 1987 | Phys Lett B1987，184，： | 1 |
| 19 | Complete reversal of paraplegia after thoracic endovascular aortic repair in a patient with complicated acute aortic dissection using immediate cerebrospinal fluid drainage显示文摘 | Holger Eggebrecht Dirk B?se Thomas Gasser Jaroslav Benedik Petra Mummel Oliver Müller Philipp Kahlert Konstantinos Tsagakis Heinz G. Jakob Raimund Erbel | 2009 | Clinical Research in Cardiology2009，，12： | 1 |
| 20 | Aortic development and anomalies显示文摘 | Kau T Sinzig M Gasser J | 2007 | Semin Intervent Radiol2007，24，2： | 1 |
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