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| 1 | Effects of resveratrol in experimental and clinical non-alcoholic fatty liver disease显示文摘The prevalence of obesity and related conditions like non-alcoholic fatty liver disease(NAFLD) is increasing worldwide and therapeutic options are limited.Alternative treatment options are therefore intensively sought after.An interesting candidate is the natural polyphenol resveratrol(RSV) that activates adenosinmonophosphate-activated protein kinase(AMPK) and silent information regulation-2 homolog 1(SIRT1).In addition,RSV has known anti-oxidant and anti-inflammatory effects.Here,we review the current evidence for RSVmediated effects on NAFLD and address the different aspects of NAFLD and non-alcoholic steatohepatitis(NASH) pathogenesis with respect to free fatty acid(FFA) flux from adipose tissue,hepatic de novo lipogenesis,inadequate FFA β-oxidation and additional intra- and extrahepatic inflammatory and oxidant hits.We review the in vivo evidence from animal studies and clinical trials.The abundance of animal studies reports a decrease in hepatic triglyceride accumulation,liver weight and a general improvement in histological fatty liver changes,along with a reduction in circulating insulin,glucose and lipid levels.Some studies document AMPK or SIRT1 activation,and modulation of relevant markers of hepatic lipogenesis,inflammation and oxidation status.However,AMPK/SIRT1-independent actions are also likely.Clinical trials are scarce and have primarily been performed with a focus on overweight/obese participants without a focus on NAFLD/NASH and histological liver changes.Future clinical studies with appropriate design are needed to clarify the true impact of RSV treatment in NAFLD/NASH patients. | Sara Heebll Karen Louise Thomsen Steen B Pedersen Hendrik Vilstrup Jacob George Henning Grnbk | 2014 | World Journal of Hepatology2014，6，4： | 11 |
| 2 | Down-regulation of factor IXa in thefactor Xase complex by protein Z-dependent protease inhibitor显示文摘 | Heeb M J Cabral K M Ruan L | 2005 | JBiol Chem2005，280，33： | 1 |
| 3 | The immunological function of allosuckling 显示文摘 | Roulin A Heeb P | 1999 | Ecology Letters1999，2，： | 1 |
| 4 | Characterization of a new kerati nolytic bacterium that completely degrades native feather ker- atin 显示文摘 | Riffel A Lucas F Heeb P | 2003 | Archives of Microbiology2003，179，4： | 1 |
| 5 | Anaerobic degradation of decabromodiphenyl ether 显示文摘 | Gerecke AC Hartmann PC Heeb NV | 2005 | Environ Sci Technol2005，39，4： | 1 |
| 6 | Protein S binds to and inhibits factor Xa显示文摘 | Rosing J Bakker HM | 1994 | Proc Natl Acacl Sci U S A1994，91，7： | 1 |
| 7 | Characterization of a new keratinolytic bacterium that completely degrades native feather keratin 显示文摘 | Riffel A Lucas F Heeb P | 2003 | Arch Microbiol2003，179，： | 1 |
| 8 | Low protein Z levelsand risk of ischemic stroke:differences by diabetic status and gender显示文摘 | Heeb M J Paganini-Hill A Griffin J H | 2002 | Blood Cells Mol Dis2002，29，2： | 1 |
| 9 | Regio- and stereoselective isomerization of hexabromocyclododecanes ( HBCDs ) : Kinetics and mechanism of beta-HBCD racemization显示文摘 | Heeb N V Schweizer W B Mattrel P | 2008 | Chemosphere2008，71，8： | 1 |
| 10 | Three-dimensional interconnect analysis using partial element equivalent circuits显示文摘 | Heeb H Ruehli A E | 1992 | IEEE Transactions on Circuits and Systems Ⅰ:Fundamental Theory and Applications1992，39，11： | 1 |
| 11 | Structure elucidation of hexabromocyclododecanes-a class of compounds with a complex stere- ochemistry显示文摘 | Heeb N V Schweizer W B Kohler M | 2005 | Chemosphere2005，61，1： | 1 |
| 12 | Nitrogen form affects yield and taste of tomatoes显示文摘 | HEEB A LUNDE B ERICSSON T | 2005 | Journal of the science and agriculture2005，85，： | 1 |
| 13 | Solid-state conformations and absolute configurations of (+) and (-) alpha-, beta-, and gamma- hexabromocyclododecanes(HBCDs)显示文摘 | Heeb N V Schweizer W B Mattrel P | 2007 | Chemosphere2007，68，5： | 1 |
| 14 | Anaerobic degrada- tion of decabromodiphenyl ether显示文摘 | Gerecke A C Hartmann P C Heeb N V | 2005 | Environmental Sci Technol2005，39，4： | 1 |
| 15 | Role of natriuretic peptides in cGMP production in fetal cardiac bypass 显示文摘 | Heeb EA Baker RS Lam C | 2009 | Ann Thorac Surg2009，87，3： | 1 |
| 16 | Low protein Z levels and risk of ischemic stroke : differences by diabetic status and gender 显示文摘 | Heeb M J Paganini - Hill A Griffin JH | 2002 | Blood Cells Mol Dis2002，29，2： | 1 |
| 17 | Innovation and vertical integration in complementary markets显示文摘 | Heeb R | 2003 | Journal of Economics & Management Strategy2003，12，3： | 1 |
| 18 | Anaerobic Degradation of Decabromodiphenyl Ether显示文摘 | Gerecke A C Hartmann P C Heeb N V | 2005 | Environ Sci Technol2005，39，4： | 1 |
| 19 | Determination of nitrated phenoliccompounds in rain by liquid chromatography/atmosphericpressure chemical ionization mass spectrometry 显示文摘 | KOHLER M HEEB N V | 2003 | Anal Chem2003，75，13： | 1 |
| 20 | Effects of nitrate-,ammonium-,and organic-nitrogen-based fertilizers on growth and yield of tomatoes显示文摘 | HEEB A LUNDEG(A)RDH B ERICSSON T | | 0，，01： | 1 |
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