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| 1 | RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings显示文摘在有前列腺癌症的不同赛跑的病人之中有显著不同;然而,位于这差别下面的机制仍然保持不清楚。这里,我们在场 transcriptome 的一处全面风景用 RNA-seq,越过关于基因熔化的前列腺癌症 transcriptomes 的揭示巨大的差异,长 noncoding RNA (长 ncRNA ) ,其他的拼接和体的变化从中国人口 14 主要前列腺癌症和他们的配对的正常对应物介绍。14 个肿瘤(21.4%) 中的三个在中国病人怀有 TMPRSS2 尔格熔化,和这熔化的低流行进一步在一个另外的肿瘤集合(10/54=18.5%) 被证实。尤其是,二新奇基因熔化, CTAGE5-KHDRBS3 (20/54=37%) 和 USP9Y-TTTY15 (19/54=35.2%) ,在我们的耐心的队经常发生了。介绍的进一步系统的 transcriptional 识别了是在肿瘤表示的差别的众多的长 ncRNAs。在长 ncRNA 和基因的表示之间的关联的分析建议长 ncRNAs 可以在 transcriptional 规定以外有功能。这研究在中国人口产出新卓见进前列腺癌症的致病。 | Shancheng Ren Zhiyu Peng Jian-Hua Mao Yongwei Yu Changjun Yin Xin Gao Zilian Cui Jibin Zhang Kang Yi Weidong Xu Chao Chen Fubo Wang Xinwu Guo Ji Lu Jun Yang Min Wei Zhijian Tian Yinghui Guan Liang Tang Chuanliang Xu Linhui Wang Xu Gao Wei Tian Jian Wang Huanming Yang Jun Wang Yinghao Sun | 2012 | Cell Research2012，22，5： | 66 |
| 2 | Controlled synthesis of single cobalt atom catalysts via a facile one-pot pyrolysis for efficient oxygen reduction and hydrogen evolution reactions显示文摘Metal-nitrogen doped carbon catalysts(M-N/C) with abundantly accessible M-Nxsites, particularly single metal atom M-N/C(SAM-N/C), have been developed as a substitute for expensive Pt-based catalysts.These catalysts are used to increase the efficiency of otherwise sluggish oxygen reduction reactions(ORR) and hydrogen evolution reactions(HER). However, although the agglomerated metal nanoparticles are usually easy to form, they are very difficult to remove due to the protective surface-coating carbon layers, a factor that significantly hampers SAM-N/C fabrication. Herein, we report a one-step pyrolysis approach to successfully fabricate single cobalt atom Co-N/C(SACo-N/C) by using a Co2+-SCN-coordination compound as the metal precursor. Thanks to the decomposition of Co2+-SCN-compound at lower temperature than that of carbon layer deposition, Co-rich particles grow up to larger ones before carbon layers formation. Even though encapsulated by the carbon layers, it is difficult for the large Co-rich particle to be completely sealed. And thus, it makes the Co atoms possible to escape from incomplete carbon layer, to coordinate with nitrogen atoms, and to form SACo-N/C catalysts. This SACo-N/C exhibits excellent performances for both ORR(half-wave potential of 0.878 V) and HER(overpotential at 10 mA/cm2 of178 m V), and is thus a potential replacement for Pt-based catalysts. When SACo-N/C is integrated into a Zn-O2 battery, battery with high open-circuit voltage(1.536 V) has high peak power density(266 mW/cm2)and large gravimetric energy density(755 mA h/gZn) at current densities of 100 mA/cm2. Thus, we believe that this strategy may offer a new direction for the effective generation of SAM-N/C catalysts. | Yao Wang Linhui Chen Zhanxin Mao Lishan Peng Rui Xiang Xianyi Tang Jianghai Deng Zidong Wei Qiang Liao | 2019 | Science Bulletin2019，64，15： | 10 |
| 3 | Dark matter direct search sensitivity of the PandaX-4T experiment显示文摘The Panda X-4T experiment, a 4-ton scale dark matter direct detection experiment, is being planned at the China Jinping Underground Laboratory. In this paper we present a simulation study of the expected background in this experiment. In a 2.8-ton fiducial mass and the signal region between 1-10 keV electron equivalent energy, the total electron recoil background is found to be 4.9 × 10^(-5) kg^(-1) d^(-1) keV^(-1). The nuclear recoil background in the same region is 2.8 × 10^(-7) kg^(-1) d^(-1) keV^(-1). With an exposure of 5.6 ton-years, the sensitivity of Panda X-4 T could reach a minimum spin-independent dark matter-nucleon cross section of 6 × 10^(-48) cm^2 at a dark matter mass of 40 Ge V/c^2. | HongGuang Zhang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui BinBin Dong DeQing Fang ChangBo Fu Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo ZhiFan Guo Ke Han ChangDa He ShengMing He Di Huang XingTao Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju ShaoLi Li Yao Li Heng Lin HuaXuan Liu JiangLai Liu YuGang Ma YaJun Mao KaiXiang Ni JinHua Ning XiangXiang Ren Fang Shi AnDi Tan AnQing Wang Cheng Wang HongWei Wang Meng Wang QiuHong Wang SiGuang Wang XiuLi Wang XuMing Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu JuMin Yuan JianFeng Yue Dan Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，3： | 6 |
| 4 | Stable Carbon Isotopic Compositions of Methylated-MTTC in Crude Oils from Saline Lacustrine Depositional Environment:Source Implications显示文摘显著地高的丰富的 methyl-MethylTrimethylTridecylChromans (MTTC ) 从 Jizhong 消沉和 Jianghan 盆在原油在芳香的烃部分被检测了。这些混合物的分发被 methyl-MTTC 和 dimethyl-MTTC 系列统治,它在早阶段显示亢奋的盐的 depositional 环境的 diagenetic 产品并且显示出 methylation 的低度。显著地高的丰富的 methyl-MTTC 的出现主要取决于好保藏条件与一强烈减少,亢奋盐并且水列 depositional 环境和随后的非集中的 diagenetic 转变。稳定的碳在二件样品的 methyl-MTTCs 和 dimethyl-MTTCs 的同位素的作文与稳定的碳远不同 C_(30 ) 的同位素的作文惊讶明显的细菌生物的续生说的格子(多达 4.11 ‰和 5.75 ‰,分别地) 。这显然证明 methyl-MTTC 和 dimethyl-MTTCs 不能具有细菌起源,它与关于非光合的细菌产品或可能的重做细菌的产品的以前的观点不同。相反,稳定的碳在二件样品的 methyl-MTTC 和 dimethyl-MTTCs 的同位素的作文类似于一样的标记碳的 n 链烷的(显示他们分享一样的来源起源的 nC_(27 )-nC_(28)-nC(29)), 。特别在从 Zhao61 好、稳定的碳的原油,同位素的作文也类似于有 aaa-20R 异构体的一样的标记碳的 steranes 的(主要不到 0.4 ‰) 。在盐的湖上的以前的研究的结果的考虑生态的沉积,作者认为在盐的湖沉积的 methyl-MTTC 和 dimethyl-MTTCs 应该具有海藻的生物的续生说起源。 | LU Hong HOU Linhui CHEN Tengshui PENG Ping' an SHENG Guoying | 2007 | Acta Geologica Sinica(English Edition)2007，81，6： | 3 |
| 5 | Matched Field Localization Based on CS-MUSIC Algorithm显示文摘The problem caused by shortness or excessiveness of snapshots and by coherent sources in underwater acoustic positioning is considered.A matched field localization algorithm based on CS-MUSIC(Compressive Sensing Multiple Signal Classification) is proposed based on the sparse mathematical model of the underwater positioning.The signal matrix is calculated through the SVD(Singular Value Decomposition) of the observation matrix.The observation matrix in the sparse mathematical model is replaced by the signal matrix,and a new concise sparse mathematical model is obtained,which means not only the scale of the localization problem but also the noise level is reduced;then the new sparse mathematical model is solved by the CS-MUSIC algorithm which is a combination of CS(Compressive Sensing) method and MUSIC(Multiple Signal Classification) method.The algorithm proposed in this paper can overcome effectively the difficulties caused by correlated sources and shortness of snapshots,and it can also reduce the time complexity and noise level of the localization problem by using the SVD of the observation matrix when the number of snapshots is large,which will be proved in this paper. | GUO Shuangle TANG Ruichun PENG Linhui JI Xiaopeng | 2016 | Journal of Ocean University of China2016，15，2： | 1 |
| 6 | Maternal genetic history of ancient Tibetans over the past 4000 years显示文摘The settlement of the Tibetan Plateau epitomizes human adaptation to a high-altitude environment that poses great challenges to human activity.Here,we reconstruct a 4000-year maternal genetic history of Tibetans using 128 ancient mitochondrial genome data from 37 sites in Tibet.The phylogeny of haplotypes M9a1a,M9a1b,D4g2,G2a’c,and D4i show that ancient Tibetans share the most recent common ancestor with ancient Middle and Upper Yellow River populations around the Early and Middle Holocene.In addition,the connections between Tibetans and Northeastern Asians vary over the past 4000 years,with a stronger matrilineal connection between the two during 4000 BPe3000 BP,and a weakened connection after 3000 BP,that are coincident with climate change,followed by a reinforced connection after the Tubo period(1400 BPe1100 BP).Besides,an over 4000-year matrilineal continuity is observed in some of the maternal lineages.We also find the maternal genetic structure of ancient Tibetans is correlated to the geography and interactions between ancient Tibetans and ancient Nepal and Pakistan populations.Overall,the maternal genetic history of Tibetans can be characterized as a long-term matrilineal continuity with frequent internal and external population interactions that are dynamically shaped by geography,climate changes,as well as historical events. | Ganyu Zhang Can Cui Shargan Wangdue Hongliang Lu Honghai Chen Lin Xi Wei He Haibing Yuan Tinley Tsring Zujun Chen Feng Yang Tashi Tsering Shuai Li Norbu Tashi Tsho Yang Yan Tong Xiaohong Wu Linhui Li Yuanhong He Peng Cao Qingyan Dai Feng Liu Xiaotian Feng Tianyi Wang Ruowei Yang Wanjing Ping Ming Zhang Xing Gao Yichen Liu Wenjun Wang Qiaomei Fu | 2023 | Journal of Genetics and Genomics2023，50，10： | 1 |
| 7 | Extracting the Subsonic Anti-Symmetric Lamb Wave from a Submerged Thin Spherical Shell Backscattering Through Iterative Time Reversal显示文摘The extraction of the weakly excited anti-symmetric Lamb wave from a submerged thin spherical shell backscattering is very difficult if the carrier frequency of the incident short tone burst is not at its frequency of greatest enhancement. Based on a single channel iterative time reversal technique, a method for isolating the subsonic anti-symmetric Lamb wave is proposed in this paper. The approach does not depend on the form function of a thin shell and any other priori knowledge, and it is also robust in the presence of some stochastic noise. Both theoretical and numerical results show that the subsonic anti-symmetric Lamb wave can be identified, even when the carrier frequency of the incident short tone burst is away from the frequency of greatest enhancement. The phenomenon may also be observed even in the case that the subsonic anti-symmetric Lamb wave is submerged in the noise, other than the case with the Signal to Noise Ratio being less than 10 d B, when the amplitude of the noise is comparable with the specular wave. In this paper, each iteration process contains a traditional transmission and time reversal transmission steps. The two steps can automatically compensate the time delay of the subsonic anti-symmetric Lamb wave relative to the specular wave and within-mode dispersion in the forward wave propagation. | YU Xiaotao PENG Linhui YU Gaokun | 2014 | Journal of Ocean University of China2014，13，4： | 1 |
| 8 | Engineering of Reversible Luminescent Probes for Real-Time Intravital Imaging of Liver Injury and Repair显示文摘As the major organ for drug metabolism and detoxification,the liver is prone to damage and severely impaired functionality.The treatment of liver diseases is based on a clear understanding of the process underlying liver injury and repair.However,intravital real-time imaging of liver injury and repair is still limited due to the lack of in vivo reversible visualization methods.To this end,we proposed a rational design strategy for the development of a reversible upconversion luminescence nanoprobe that allows real-time and in vivo imaging of liver injury and repair processes.As a proof of concept,we first developed a small molecule probe NB3 which can reversibly respond to related analytes of early liver injury[peroxynitrite(ONOO−)]and liver repair[glutathione(GSH)].The small molecule probe was then integrated with a core–shell upconversion nanoparticle to form a sophisticated nanoprobe.Compared with traditional small molecule probes,this nanoprobe exhibited a higher selectivity to ONOO−,longer retention time in liver,and wider dynamic response range to GSH after oxidation by ONOO−.The novel nanoprobe facilitated the successful monitoring and discrimination among the different degrees of liver injury and repair in a mouse model. | Xiao Liu Linhui He Xiangyang Gong Yue Yang Dan Cheng Juanjuan Peng Lu Wang Xiao-Bing Zhang Lin Yuan | 2022 | CCS Chemistry2022，4，1： | 1 |
| 9 | CENP-A的Ser68位动态磷酸化调控它在着丝粒区域的细胞周期依赖性装配显示文摘细胞出版社《发育细胞》创刊于2001年,本刊致力于搭建细胞生物学与发育生物学两大学科之间的桥梁。受过专业博士训l练的科学编辑与作者、审稿人、编委会成员共同合作,及时发布横跨两个领域令人振奋的研究成果,强调两个领域之间共同面临的问题以及相互之间的关系。该杂志2015年公布的影响因子为9.708。 | Zhouliang Yu Xiang Zhou Wenjing Wang Wenqiang Deng Junnan Fang Hao Hu Zichen Wang Shangze Li Lei Cui Jing Shen Linhui Zhai Shengyi Peng Jiemin Wong Shuo Dong Zengqiang Yuan Guangshuo Ou Xiaodong Zhang Ping Xu Jizhong Lou Na Yang Ping Chen Rui-Ming Xu 李国红 | 2016 | 科学新闻2016，0，1： | 1 |
| 10 | An improved evaluation of the neutron background in the PandaX-Ⅱ experiment显示文摘In dark matter direct detection experiments,neutron is a serious source of background,which can mimic the dark matter-nucleus scattering signals.In this paper,we present an improved evaluation of the neutron background in the PandaX-II dark matter experiment by a novel approach.Instead of fully relying on the Monte Carlo simulation,the overall neutron background is determined from the neutron-induced high energy signals in the data.In addition,the probability of producing a dark-matter-like background per neutron is evaluated with a complete Monte Carlo generator,where the correlated emission of neutron(s)andγ(s)in the(α,n)reactions and spontaneous fissions is taken into consideration.With this method,the neutron backgrounds in the Run 9(26-ton-day)and Run 10(28-ton-day)data sets of PandaX-II are estimated to be(0.66±0.24)and(0.47±0.25)events,respectively. | QiuHong Wang Abdusalam Abdukerim Wei Chen Xun Chen YunHua Chen XiangYi Cui YingJie Fan DeQing Fang ChangBo Fu LiSheng Geng Karl Giboni Franco Giuliani LinHui Gu XuYuan Guo Ke Han ChangDa He Di Huang Yan Huang YanLin Huang Zhou Huang Peng Ji XiangDong Ji YongLin Ju YiHui Lai Kun Liang HuaXuan Liu JiangLai Liu WenBo Ma YuGang Ma YaJun Mao Yue Meng Parinya Namwongsa KaiXiang Ni JinHua Ning XuYang Ning XiangXiang Ren ChangSong Shang Lin Si AnDi Tan AnQing Wang HongWei Wang Meng Wang SiGuang Wang XiuLi Wang Zhou Wang MengMeng Wu ShiYong Wu JingKai Xia MengJiao Xiao PengWei Xie BinBin Yan JiJun Yang Yong Yang ChunXu Yu Jumin Yuan Dan Zhang HongGuang Zhang Tao Zhang Li Zhao QiBin Zheng JiFang Zhou Ning Zhou XiaoPeng Zhou | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，3： | 0 |
| 11 | Determination of Double Beta Decay Half-Life of 136Xe with the PandaX-4T Natural Xenon Detector显示文摘Precise measurement of two-neutrino double beta decay(DBD)half-life is an important step for the searches of Majorana neutrinos with neutrinoless double beta decay.We report the measurement of DBD half-life of 136xe using the Pandax-4T dual-phase Time Projection Chamber(TPC)with 3.7-tonne natural xenon and the first 94.9-day physics data release. | Lin Si Zhaokan Cheng Abdusalam Abdukerim Zihao Bo Wei Chen Xun Chen Yunhua Chen Chen Cheng Yunshan Cheng Xiangyi Cui Yingjie Fan Deqing Fang Changbo Fu Mengting Fu Lisheng Geng Karl Giboni Linhui Gu Xuyuan Guo Ke Han Changda He Jinrong He Di Huang Yanlin Huang Zhou Huang Ruquan Hou Xiangdong Ji Yonglin Ju Chenxiang Li Jiafu Li Mingchuan Li Shu Li Shuaijie Li Qing Lin Jianglai Liu Xiaoying Lu Lingyin Luo Yunyang Luo Wenbo Ma Yugang Ma Yujun Mao Yue Meng Nasir Shaheed Xiaofeng Shang Xuyang Ning Ningchun Qi Zhicheng Qian Xiangxiang Ren Changsong Shang Guofang Shen Wenliang Sun Andi Tan Yi Tao Anqing Wang Meng Wang Qiuhong Wang Shaobo Wang Siguang Wang Wei Wang Xiuli Wang Zhou Wang Yuehuan Wei Mengmeng Wu Weihao Wu Jingkai Xia Mengjiao Xiao Xiang Xiao Pengwei Xie Binbin Yan Xiyu Yan Yong Yang Chunxu Yu Jumin Yuan Ying Yuan Zhe Yuan Dan Zhang Minzhen Zhang Peng Zhang Shibo Zhang Shu Zhang Tao Zhang Li Zhao Qibin Zheng Jifang Zhou Ning Zhou Xiaopeng Zhou Yong Zhou | 2023 | Research2023，，2： | 0 |
| 12 | Sound scattering at fluid-fluid rough surface显示文摘Extinction theorem was used to deduce the first order scattering cross-section including the double scattering effects for the fluid-fluid rough surface.If the dou- ble scattering effects are neglected in the present method,the scattering cross-section agrees with the result obtained by the perturbation method based on Rayleigh hypothesis.Calculations of scattering strength were carried out,and comparisons with the first-order perturbation method based on Rayleigh hypothe- sis were also done.The results show that double scattering effects are obvious with the increase of the root mean square of surface height and the grazing angle when the valid condition k1h<1 is satisfied. | YU GaoKun PENG LinHui | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，1： | 0 |
| 13 | Experimental study for frequency spectrum of turbulent boundary layer pressure fluctuation显示文摘An experimental study on TBL (turbulent boundary layer) pressure fluctuation frequeny spectrum of a revolution body is presented. With the measured results, a relation of convective frequency fo of the models is obtained. Relations of turbuleat wall-pressure fluctuation spectrum in transition region and development region to frequency and speed are obtained | PENG Linhui LU Jianhui (Ocean University of Qingdao Qingdao 266003) ZHU Xiqing SUN Yudong (CSSRC Wuxi 214082) | 1999 | Chinese Journal of Acoustics1999，18，3： | 0 |
| 14 | Dynamic changes of glial fibrillary acidic protein and nestin in the hippocampus of adult rat brain following ischemic vascular dementia显示文摘Vascular dementia produced by permanent ligation of bilateral common carotid arteries involves progressive deterioration of intellectual and cognitive function in rats,which are closely associated with the hippocampus.This study used immunohistochemical analysis to detect the expression of glial fibrillary acidic protein and nestin in the hippocampus in a vascular dementia model.The results revealed that both glial fibrillary acidic protein and nestin expression were increased 1 day after permanent ligation of the bilateral common carotid arteries,compared with a sham-operated group.The expression of glial fibrillary acidic protein peaked at 7 days post-surgery.The expression of nestin was a little weaker than that of glial fibrillary acidic protein,and peaked at 14 days(P < 0.01).The expression of both proteins slightly decreased at 21 and 28 days,accompanied by recovery of cerebral blood flow.In conclusion,this study demonstrated that glial fibrillary acidic protein and nestin exhibited dynamic expression in the rat hippocampus after permanent ligation of bilateral common carotid arteries.This finding suggests that dynamic alterations in protein expres-sion play an important role in the pathogenesis of vascular dementia. | Tianping Yu | 2011 | Neural Regeneration Research2011，6，8： | 0 |
| 15 | Definition and verification of novel metastasis and recurrence related signatures of ccRCC: A multicohort study显示文摘Background:Cancer metastasis and recurrence remain major challenges in renal carcinoma patient management.There are limited biomarkers to predict the metastatic probability of renal cancer,especially in the early-stage subgroup.Here,our study applied robust machine-learning algorithms to identify metastatic and recurrence-related signatures across multiple renal cancer cohorts,which reached high accuracy in both training and testing cohorts.Methods:Clear cell renal cell carcinoma(ccRCC)patients with primary or metastatic site sequencing information from eight cohorts,including one outhouse cohort,were enrolled in this study.Three robust machine-learning algorithms were applied to identify metastatic signatures.Then,two distinct metastatic-related subtypes were identified and verified;matrix remodeling associated 5(MXRA5),as a promising diagnostic and therapeutic target,was investigated in vivo and in vitro.Results:We identified five stable metastasis-related signatures(renin,integrin subunit beta-like 1,MXRA5,mesenchyme homeobox 2,and anoctamin 3)from multicenter cohorts.Additionally,we verified the specificity and sensibility of these signatures in external and out-house cohorts,which displayed a satisfactory consistency.According to these metastatic signatures,patients were grouped into two distinct and heterogeneous ccRCC subtypes named metastatic cancer subtype 1(MTCS1)and type 2(MTCS2).MTCS2 exhibited poorer clinical outcomes and metastatic tendencies than MTCS1.In addition,MTCS2 showed higher immune cell infiltration and immune signature expression but a lower response rate to immune blockade therapy than MTCS1.The MTCS2 subgroup was more sensitive to saracatinib,sunitinib,and several molecular targeted drugs.In addition,MTCS2 displayed a higher genome mutation burden and instability.Furthermore,we constructed a prognosis model based on subtype biomarkers,which performed well in training and validation cohorts.Finally,MXRA5,as a promising biomarker,significantly suppressed malignant ability,including the cell migration and proliferation of ccRCC cell lines in vitro and in vivo.Conclusions:This study identified five robust metastatic signatures and proposed two metastatic probability clusters with stratified prognoses,multiomics landscapes,and treatment options.The current work not only provided new insight into the heterogeneity of renal cancer but also shed light on optimizing decision‐making in immunotherapy and chemotherapy. | Aimin Jiang Qingyang Pang Xinxin Gan Anbang Wang Zhenjie Wu Bing Liu Peng Luo Le Qu Linhui Wang | 2022 | Cancer Innovation2022，1，2： | 0 |
| 16 | Experimental Study on the Identification of Scholte Waves Based on Acoustic Pressure Field Measurement显示文摘Scholte waves at the seafloor interface are generally identified by their velocity features and seismic fields,which are measured using ocean bottom seismometers and geophones.These methods are effective in cases where there is a considerable difference between the velocities of Scholte and acoustic waves in water.However,they are ineffective when the velocities of these two types of waves are close to each other.Thus,in this paper,a method based on acoustic pressure field measurement for identifying Scholte waves is proposed according to their excitation and propagation characteristics.The proposed method can overcome the limitations on the velocities of two types of waves.A tank experiment is designed and conducted according to the proposed method,and an ocean environment is scaled down to the laboratory size.Acoustic measurements are obtained along virtual arrays in the water column using a robotic apparatus.Experiments show that changes in Scholte wave amplitudes,depending on different source depths and propagation distances,are consistent with the theoretical results.This means that Scholte waves generated at the seafloor interface are successfully measured and identified in the acoustic pressure field. | LIANG Minshuai PENG Linhui | 2023 | Journal of Ocean University of China2023，22，5： | 0 |
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