|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Additive manufacturing of high-strength CrMnFeCoNi high-entropy alloys-based composites with WC addition显示文摘Laser melting deposition with WC addition has been developed to fabricate high-strength CrMnFeCoNibased high-entropy alloys-based composites.By this technique,a microstructure of compact refined equiaxed grains can be achieved,and the tensile strength can be remarkably improved.The sample with 5 wt%WC addition shows a promising mechanical performance with a tensile strength of 800 MPa and an elongation of 37%.The improvement in mechanical property may be attributed to the formation of Cr(23)C6 reinforcement precipitates,which could promote the heterogeneous nucleation of grains and hinder the propagation of slip bands. | Jinfeng Li Shuo Xiang Hengwei Luan Abdukadir Amar Xue Liu Siyuan Lu Yangyang Zeng Guomin Le Xiaoying Wang Fengsheng Qu Chunli Jiang Guannan Yang | 2019 | Journal of Materials Science & Technology2019，35，11： | 13 |
| 2 | Advantage in Bright-blood and Black-blood Magnetic Resonance Imaging with High-resolution for Analysis of Carotid Atherosclerotic Plaques显示文摘 | Mei Li Wei-Jie Le Xiao-Feng Tao Ming-Hua Li Yue-Hua Li Nan Qu | 2015 | Chinese Medical Journal2015，，18： | 12 |
| 3 | Onco-miR-24 regulates cell growth and apoptosis by targeting BCL2L11 in gastric cancer显示文摘胃的癌症是世界范围的最普通的恶意之一;然而,在 tumorigenesis 的分子的机制仍然需要探索。BCL2L11 属于 BCL-2 家庭,并且充当内在的 apoptotic 串联的一个中央管理者并且调停房间 apoptosis。尽管 miRNAs 被报导了涉及癌症开发的每个阶段,在 GC 的 miR-24 的角色还没被报导。在现在的学习,当 BCL2L11 的表示在 GC 的肿瘤纸巾被禁止时, miR-24 被发现起来调整。研究从在 vitro 并且在显示出的 vivo,那 miR-24 调整 BCL2L11 表示由与 mRNA 的 3UTR 直接有约束力,因此支持房间生长,移植当禁止房间 apoptosis 时。因此, miR-24 是能是为未来的潜在的药目标的新奇 onco-miRNA 临床的使用。 | Haiyang Zhang Jingjing Duan Yanjun Qu Ting Deng Rui Liu Le Zhang Ming Bai Jialu Li Tao Ning Shaohua Ge Xia Wang ZhenzhenWang~ Qian Fan Hongli Li Guoguang Ying Dingzhi Huang Yi Ba | 2016 | Protein & Cell2016，7，2： | 11 |
| 4 | A human circulating immune cell landscape in aging and COVID-19显示文摘Age-associated changes in immune cells have been linked to an increased risk for infection.However,a global and detailed characterization of the changes that human circulating immune cells undergo with age is lacking.Here,we combined scRNA-seq,mass cytometry and sCATAC-seq to compare immune cell types in peripheral blood collected from young and old subjects and patients with COVID-19.We found that the immune cell landscape was reprogrammed with age and was characterized by T cell polarization from naive and memory cells to effector,cytotoxic,exhausted and reg-ulatory cells,along with increased late natural killer cells,age-associated B cells,inflammatory monocytes and age-associated dendritic cells.In addition,the expression of genes,which were implicated in coron-avirus susceptibility,was upregulated in a cell subtype-specific manner with age.Notably,COVID-19 promoted age-induced immune cell polarization and gene expression related to inflammation and cellular senes-cence.Therefore,these findings suggest that a dysreg-ulated immune system and increased gene expression associated with SARS-CoV-2 susceptibility may at least partially account for COVID-19 vulnerability in the elderly. | Yingfeng Zheng Xiuxing Liu Wenqing Le Lihui Xie He Li Wen Wen Si Wang Shuai Ma Zhaohao Huang Jinguo Ye Wen Shi Yanxia Ye Zunpeng Liu Moshi Song Weiqi Zhang Jing-Dong J.Han Juan Carlos lzpisua Belmonte Chuanle Xiao Jing Qu Hongyang Wang Guang-Hui Liu Wenru Su | 2020 | Protein & Cell2020，11，10： | 10 |
| 5 | Elevated levels of interleukin-1β, interleukin-6, tumor necrosis factor-α and vascular endothelial growth factor in patients with knee articular cartilage injury显示文摘BACKGROUND Inflammatory cytokines play a vital role in the occurrence of osteoarticular injury and inflammation. Whether inflammation-associated factors interleukin-1β(IL- 1β), IL-6, tumor necrosis factor-α(TNF-α) and vascular endothelial growth factor (VEGF) are involved in the pathogenesis of keen articular cartilage injury remains poorly understood. AIM To measure the levels of inflammatory factors [IL-1β, IL-6, TNF-α and VEGF] in patients with knee articular cartilage injury. METHODS Fifty-five patients with knee articular cartilage injury were selected as patient groups, who were divided into three grades [mild (n = 20), moderate (n = 19) and severe (n = 16)] according to disease severity and X-ray examinations. Meanwhile, 30 healthy individuals who underwent physical examination were selected as the control group. The levels of IL-1β, IL-6, TNF-α and VEGF were measured by ELISA and immunohistochemical staining. RESULTS Compared with the control group, patient groups displayed significantly higher levels of IL-1β, IL-6, TNF-α and VEGF, and the extent of increase was directly proportional to the severity of injury (P < 0.05). In addition, the number of cells with positive staining of IL-1β, IL-6, TNF-α and VEGF in the synovial membrane were significantly increased, along with increased disease severity (P < 0.05). After treatment, the scores of visual analogue scale and the Western Ontario and McMaster University of Orthopaedic Index in patient groups were 2.26 ± 1.13 and 15.56 ± 7.12 points, respectively, which were significantly lower than those before treatment (6.98 ± 1.32 and 49.48 ± 8.96). Correlation analysis suggested that IL-1β and TNF-α were positively correlated with VEGF. CONCLUSION IL-1β, IL-6, TNF-α and VEGF levels are increased in patients with knee articular cartilage injury, and are associated with the disease severity, indicating they might play an important role in the occurrence and development of knee articular cartilage injury. Furthermore, therapeutically targeting them might be a novel approach for the treatment of keen articular cartilage injury. | Zhen-Wei Wang Le Chen Xiao-Rui Hao Zhen-An Qu Shi-Bo Huang Xiao-Jun Ma Jian-Chuan Wang Wei-Ming Wang | 2019 | World Journal of Clinical Cases2019，7，11： | 8 |
| 6 | Inhibition of corneal fibrosis by Smad7 in rats after photorefractive keratectomy显示文摘 | WANG Ti ZHOU Xing-tao YU Yan ZHU Jing-yin DAI Jin-hui QU Xiao-mei LE Qi-hua CHU Ren-yuan | 2013 | Chinese Medical Journal2013，，8： | 8 |
| 7 | Coexpression of MYC and BCL-2 predicts prognosis in primary gastrointestinal diffuse large B-cell lymphoma显示文摘AIM:To investigate whether MYC and BCL-2 coexpression has prognostic significance in primary gastrointestinal diffuse large B-cell lymphoma(PGI-DLBCL)patients,and explore its associations with patients’clinical parameters.METHODS:Fresh and paraffin-embedded tumor tissue samples from 60 PGI-DLBCL patients who had undergone surgery at the Tianjin Medical University Cancer Institute and Hospital from January 2005 to May 2010 were obtained,and 30 lymphoid tissue samples from reactive lymph nodes of age-and sexmatched patients represented control samples.Staging and diagnostic procedures were conducted according to the Lugano staging system.All patients had been treated with three therapeutic modalities:surgery,chemotherapy,or radiotherapy.Expression of MYC and BCL-2 were detected at both protein and m RNA levels by immunohistochemistry and real-time RT-PCR.RESULTS:Positive expression levels of MYC and BCL-2proteins were detected in 35%and 45%of patients,respectively.MYC+/BCL-2+protein was present in30%of patients.MYC and BCL-2 protein levels were correlated with high MYC and BCL-2 m RNA expression,respectively(both P<0.05).We found that advancedstage disease(atⅡE-Ⅳ)was associated with MYC and BCL-2 coexpression levels(P<0.05).In addition,MYC+/BCL-2+patients had more difficulty in achieving complete remission than others(P<0.05).Presenceof MYC protein expression only affected overall survivaland progression-free survival(PFS)when BCL-2 proteinwas coexpressed.The adverse prognostic impact ofMYC+/BCL-2+protein on PFS remained significant(P<0.05)even after adjusting for age,Lugano stage,international prognostic index,and BCL-2 proteinexpression in a multivariable model.CONCLUSION:MYC+/BCL-2+patients have worsechemotherapy response and poorer prognosis thanpatients who only express one of the two proteins,suggesting that assessment of MYC and BCL-2 expressionby immunohistochemistry has clinical significance inpredicting clinical outcomes of PGI-DLBCL patients. | Bing Xia Le Zhang Shan-Qi Guo Xiao-Wu Li Fu-Lian Qu Hai-Feng Zhao Lian-Yu Zhang Bao-Cun Sun James You Yi-Zhuo Zhang | 2015 | World Journal of Gastroenterology2015，21，8： | 7 |
| 8 | Expression of Smad7 inhibits fibrogenic responses of keratocytes to transforming growth factor β2显示文摘背景转变生长因素(TGF ) 是在纤维变性的发展的最重要的生长因素之一并且在角膜上结疤。Smad7,禁止的 Smad,能禁止 TGF 信号办理。在最近的年里,一些机关上的纤维变性的抑制上的调停 lentiviral 的 Smad7 的效果被学习了,当很少在角膜上对效果被知道时。试图在 TGF 2 在 vitro.Methods Keratocytes 导致的 keratocyte 增长和纤维变性上决定调停 lentiviral 的 Smad7 基因表示的效果的这研究从与表示 lentiviral 向量(Lv-Smad7 ) 或非工作的控制向量(Lv 空白) 的 Smad7 从 Sprague-Dawley (SD ) 老鼠和 transfected 孤立的 comeal 织物是有教养的。跟随暴露到 TGF2, keratocytes 被处理让 immunoblotting 估计 TGF/Smad 发信号的 Smad2 同样下游的事件的 phosphorylation。fibrotic 标记的表示光滑的肌肉肌动朊(-SMA), 类型骨胶原(骨胶原) 被西方的弄污和量的实时聚合酶链反应(PCR ) 测量。全面房间增长被 3-(4,5-dimethyl-thiazol-2-yl ) 决定 -2,5-dipheny1tetrazolium 溴化物(MTT ) 试金和房间的表示在 Smad7 基因转移压制了 TGF/Smad 由 Smad2 的下面调整的 phosphorylation 在 keratocytes 发信号的 mRNA 和蛋白质 levels.Results 的周期相关的标记 Ki67。包括 Ki67 的房间增长和纤维变性的标记, -SMA, 骨胶原被 Smad 7 的介绍禁止进 TGF 暴露的 keratocytes。因而,房间增长的率是 attenuated.Conclusion Smad7 基因转移到 TGF2 的 keratocytes 的禁止的 fibrogenic 回答。 | WANG Ti ZHOU Xing-tao YU Yan DAI Jin-hui QU Xiao-mei LE Qi-hua CHU Ren-yuan | 2011 | Chinese Medical Journal2011，，13： | 6 |
| 9 | Selection of water source for water transfer based on algal growth potential to prevent algal blooms显示文摘Water transfer is becoming a popular method for solving the problems of water quality deterioration and water level drawdown in lakes. However, the principle of choosing water sources for water transfer projects has mainly been based on the effects on water quality, which neglects the influence in the variation of phytoplankton community and the risk of algal blooms. In this study, algal growth potential(AGP) test was applied to predict changes in the phytoplankton community caused by water transfer projects. The feasibility of proposed water transfer sources(Baqing River and Jinsha River) was assessed through the changes in both water quality and phytoplankton community in Chenghai Lake, Southwest China. The results showed that the concentration of total nitrogen(TN) and total phosphorus(TP) in Chenghai Lake could be decreased to 0.52 mg/L and 0.02 mg/L respectively with the simulated water transfer source of Jinsha River. The algal cell density could be reduced by 60%, and the phytoplankton community would become relatively stable with the Jinsha River water transfer project, and the dominant species of Anabaena cylindrica evolved into Anabaenopsis arnoldii due to the species competition. However, the risk of algal blooms would be increased after the Baqing River water transfer project even with the improved water quality. Algae gained faster proliferation with the same dominant species in water transfer source. Therefore, water transfer projects should be assessed from not only the variation of water quality but also the risk of algal blooms. | Yongjun Song Jing Qi Le Deng Yaohui Bai Huijuan Liu Jiuhui Qu | 2021 | Journal of Environmental Sciences2021，33，5： | 3 |
| 10 | Autoregressive neural networks with exogenous variables for indoor temperature prediction in buildings显示文摘Thermal models of buildings are helpful to forecast their energy use and to enhance the control of their mechanical systems.However,these models are building-specific and require a tedious,error-prone and time-consuming development effort relying on skilled building energy modelers.Compared to white-box and gray-box models,data-driven(black-box)models require less development time and a minimal amount of information about the building characteristics.In this paper,autoregressive neural network models are compared to gray-box and black-box linear models to simulate indoor temperatures.These models are trained,validated and compared to actual experimental data obtained for an existing commercial building in Montreal(QC,Canada)equipped with roof top units for air conditioning.Results show that neural networks mimic more accurately the thermal behavior of the building when limited information is available,compared to gray-box and black-box linear models.The gray-box model does not perform adequately due to its under-parameterized nature,while the linear models cannot capture non-linear phenomena such as radiative heat transfer and occupancy.Therefore,the neural network models outperform the alternative models in the presented application,reaching a coefficient of determination R2 up to 0.824 and a root mean square error down to 1.11℃,including the error propagation over time for a 1-week period with a 5-minute time-step.When considering a 50-hour time horizon,the best neural networks reach a much lower root mean square error of around 0.6℃,which is suitable for applications such as model predictive control. | Benoit Delcroix Jérôme Le Ny Michel Bernier Muhammad Azam Bingrui Qu Jean-Simon Venne | 2021 | Building Simulation2021，14，1： | 3 |
| 11 | A Modified Self-adaptive Method for Mapping Annual 30-m Land Use/Land Cover Using Google Earth Engine:A Case Study of Yangtze River Delta显示文摘Annual Land Use/Land Cover(LULC)change information at medium spatial resolution(i.e.,at 30 m)is used in applications ranging from land management to achieving sustainable development goals related to food security.However,obtaining annual LULC information over large areas and long periods is challenging due to limitations on computational capabilities,training data,and workflow design.Using the Google Earth Engine(GEE),which provides a catalog of multi-source data and a cloud-based environment,we developed a novel methodology to generate a high accuracy 30-m LULC cover map collection of the Yangtze River Delta by integrating free and public LULC products with Landsat imagery.Our major contribution is a hybrid approach that includes three major components:1)a high-quality training dataset derived from multi-source LULC products,filtered by k-means clustering analysis;2)a yearly 39-band stack feature space,utilizing all available Landsat data and DEM data;and 3)a self-adaptive Random Forest(RF)method,introduced for LULC classification.Experimental results show that our proposed workflow achieves an average classification accuracy of 86.33%in the entire Delta.The results demonstrate the great potential of integrating multi-source LULC products for producing LULC maps of increased reliability.In addition,as the proposed workflow is based on open source data and the GEE cloud platform,it can be used anywhere by anyone in the world. | QU Le’an LI Manchun CHEN Zhenjie ZHI Junjun | 2021 | Chinese Geographical Science2021，31，5： | 2 |
| 12 | A mumps model with seasonality in China显示文摘Background:Mumps,an infectious viral disease,classically manifested by inflammation of salivary glands and is best known as a common childhood viral disease with no specific treatment.Although it can be protected by vaccine,there are more than 100,000 reported mumps cases according to the Chinese Center for Disease Control and Prevention.However,the factors and mechanisms behind the persistence and prevalence of mumps have not been well understood.Methods:A mumps model with seasonal fluctuation is formulated and investigated.We evaluate the basic reproduction numberℛ0 and analyze the dynamical behavior of the model.We also use the model to simulate the monthly data of mumps cases and carry out some sensitivity analysis ofℛ0 in terms of various model parameters.Results:It is shown that there exists only disease-free solution which is globally asymptotically stable ifℛ0<1,and there exists a positive periodic solution ifℛ0>1.ℛ0 is a threshold parameter,and its magnitude determines the extinction or persistence of the disease.Conclusion:Our analysis shows that vaccination rate and invalid vaccination rate play important roles in the spread of mumps.Hence,Our study suggests to increase the vaccine coverage and make two doses of MMR(Measles,mumps and rubella vaccine)vaccine freely available in China. | Qianqian Qu Cong Fang Le Zhang Wanru Jia Jie Weng Yong Li | 2017 | Infectious Disease Modelling2017，2，1： | 2 |
| 13 | Numerical investigation of entropy generation and heat transfer of pulsating flow in a horizontal channel with an open cavity显示文摘In this study, the entropy generation and the heat transfer of pulsating air flow in a horizontal channel with an open cavity heated from below with uniform temperature distribution are numerically investigated. A numerical method based on finite volume method is used to discretize the governing equations. At the inlet of the channel, pulsating velocity is imposed for a range of Strouhal numbers St_p from 0 to 1 and amplitude A_p from 0 to 0.5. The effects of the governing parameters, such as frequency and amplitude of the pulsation, Richardson number, Ri, and aspect ratio of the cavity, L/H, on the flow field, temperature distribution, average Nusselt number and average entropy generation, are numerically analyzed. The results indicate that the heat transfer and entropy generation are strongly affected by the frequency and amplitude of the pulsation and this depends on the Richardson number and aspect ratio of the cavity. The pulsation is more effective with the aspect ratio of the cavity L/H= 1.5 in terms of heat transfer enhancement and entropy generation minimization. | Fatma Zamzari Zouhaier Mehrez Afif El Cafsi Ali Belghith Patrick Le Quéré | 2017 | Journal of Hydrodynamics2017，29，4： | 2 |
| 14 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 15 | DNA vaccines targeting amyloid-βoligomer ameliorate cognitive deficits of aged APP/PS1/tau triple-transgenic mouse models of Alzheimer’s disease显示文摘The amyloid-β(Aβ)oligomer,rather than the Aβmonomer,is considered to be the primary initiator of Alzheimer’s disease.It was hypothesized that p(Aβ3-10)10-MT,the recombinant Aβ3-10 gene vaccine of the Aβoligomer has the potential to treat Alzheimer’s disease.In this study,we intramuscularly injected the p(Aβ3-10)10-MT vaccine into the left hindlimb of APP/PS1/tau triple-transgenic mice,which are a model for Alzheimer’s disease.Our results showed that the p(Aβ3-10)10-MT vaccine effectively reduced Aβoligomer levels and plaque deposition in the cerebral cortex and hippocampus,decreased the levels tau protein variants,reduced synaptic loss,protected synaptic function,reduced neuron loss,and ameliorated memory impairment without causing any cerebral hemorrhaging.Therefore,this novel DNA vaccine,which is safe and highly effective in mouse models of Alzheimer’s disease,holds a lot of promise for the treatment of Alzheimer’s disease in humans. | Sha Sha Xiao-Na Xing Tao Wang Ying Li Rong-Wei Zhang Xue-Li Shen Yun-Peng Cao Le Qu | 2022 | Neural Regeneration Research2022，17，10： | 1 |
| 16 | Constructing a large-scale Chinese-English parallel corpus 显示文摘 | Le Sun Song Xue Weimin Qu Xiaofeng Wang Yufang Sun | 2002 | Coiling-2002: Third Workshop on Asian Language resources and International Standarization2002，31，： | 1 |
| 17 | Effects of temperature on the growth of pollack ( Pollachius pollachius ) juveniles显示文摘 | J. Person-Le Ruyet V. Buchet B. Vincent H. Le Delliou L. Quéméner | 2005 | Aquaculture2005，，2： | 1 |
| 18 | An idiopathic hypogonadotropic hypogonadism patient with metabolic disorder and diabetes: case report显示文摘 | Man-Na Zhang Bin Su Chun-Hua Qian Le Bu Xiao-Yun Cheng Wen-Jun Li Shen Qu | 2015 | Asian Journal of Andrology2015，17，2： | 1 |
| 19 | Effects of repetitive transcrani- al magnetic stimulation on hand function recovery and ex- cit ability of the motor cortex after stroke: A metaanalysis 显示文摘 | LE Q QU Y TAO Y | 2014 | Am J Phys Med Rehabi12014，93，5： | 1 |
| 20 | Locomotion is increased in A1 I-lesioned mice with iron deprivation: a possible animal model for restless legs syndrome显示文摘 | Qu S Le W Zhang X | 2007 | J Neuropathol Exp Neurol2007，66，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员