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| 1 | 酸性矿山废水污染的水稻田土壤中重金属的微生物学效应显示文摘采样调查了广东大宝山地区受酸性采矿废水长期污染的亚热带水稻田的土壤理化性质 ,重金属 Cu、Pb、Zn、Cd的全量及其 DTPA浸提量 ,以及微生物生物量及其呼吸活性等指标。利用主成分和逐步回归分析了影响土壤重金属的有效性及其微生物学效应的因素。结果表明 :土壤高含硫 ,强酸性 ,有机碳、全氮较低 ,4种金属的全量普遍超标。DTPA可提取态金属含量较高 ,不仅与其全量呈显著正相关 ,而且与土壤酸度和粘粒含量正相关 ,和 Mn含量负相关。过量的金属显著降低了土壤微生物生物量 C、N、微生物商、生物量 N/全 N比 ,并抑制了微生物呼吸强度和对有机碳的矿化率 ,导致了土壤 C/N比的升高。同时 ,金属对微生物群落及生理代谢指标 ,如微生物生物量 C/N比和代谢商的影响不显著。 DTPA可提取态金属 ,特别是 DTPA- Cu是导致微生物生物量和活性指标变化的主要因素。以有机碳 (或全氮 )为基数的复合微生物指标降低了土壤性质差异造成的干扰 ,较单一指标更能准确指示微生物对金属胁迫的反应。土壤硫没有对金属有效性和微生物指标产生明显影响 。 | 李永涛 Thierry Becquer Cécile Quantin Marc Benedetti Patric kLavelle 戴军 | 2004 | 生态学报2004，24，11： | 31 |
| 2 | Immune precision medicine for cancer:a novel insight based on the efficiency of immune effector cells显示文摘Cancer cell growth is associated with immune surveillance failure.Nowadays,restoring the desired immune response against cancer cells remains a major therapeutic strategy.Due to the recent advances in biological knowledge,efficient therapeutic tools have been developed to support the best bio-clinical approaches for immune precision therapy.One of the most important successes in immune therapy is represented by the applicational use of monoclonal antibodies,particularly the use of rituximab for B-cell lymphoproliferative disorders.More recently,other monoclonal antibodies have been developed,to inhibit immune checkpoints within the tumor microenvironment that limit immune suppression,or to enhance some immune functions with immune adjuvants through different targets such as Toll-receptor agonists.The aim is to inhibit cancer proliferation by the diminishing/elimination of cancer residual cells and clinically improving the response duration with no or few adverse effects.This effect is supported by enhancing the number,functions,and activity of the immune effector cells,including the natural killer(NK)lymphocytes,NKT-lymphocytes,γδT-lymphocytes,cytotoxic T-lymphocytes,directly or indirectly through vaccines particularly with neoantigens,and by lowering the functions of the immune suppressive cells.Beyond these new therapeutics and their personalized usage,new considerations have to be taken into account,such as epigenetic regulation particularly from microbiota,evaluation of transversal functions,particularly cellular metabolism,and consideration to the clinical consequences at the body level.The aim of this review is to discuss some practical aspects of immune therapy,giving to clinicians the concept of immune effector cells balancing between control and tolerance.Immunological precision medicine is a combination of modern biological knowledge and clinical therapeutic decisions in a global vision of the patient. | Jean-François Rossi Patrice Céballos Zhao-Yang Lu | 2019 | Cancer Communications2019，39，1： | 6 |
| 3 | Laparoscopic subtotal colectomy for acute or severe colitis complicating inflammatory bowel disease: A case-matched study in 88 patients显示文摘 | Cécile Marceau Arnaud Alves Mehdi Ouaissi Yoram Bouhnik Patrice Valleur Yves Panis | 2007 | Surgery2007，，5： | 2 |
| 4 | Accurnulation of an endogenous in hibitors of nitric oxide synthesis in chronic renalfailure显示文摘 | Patric V Anna L Alison C | 1992 | Lancet1992，339，8795： | 1 |
| 5 | Comparison of elemental contents in O-and C-horizon soils from the surroundings of Nikel,Kola Peninsula,using different grain size fractions and extractions显示文摘 | Reimann C Patrice de Caritat Heikki Niskavaara | 1998 | Geoderma1998，84，： | 1 |
| 6 | Growth regulators have rapid effects on photosynthetic unloading from seed coats of Phaseolus vulgaris L显示文摘 | CLIFFORD P E OFFLER C E PATRIC J M | 1986 | Plant Physiology1986，80，： | 1 |
| 7 | Groundwater sampling and analysis:A field guide显示文摘 | Baskaran S Andrew J F Patrice D C | 2009 | Geoscience Austral-ia2009，27，： | 1 |
| 8 | Long-period fiber gratings for structural bend sensing 显示文摘 | Patric H J Chang C C Vohra S T | 1998 | Electron Lett1998，34，18： | 1 |
| 9 | Novel two-step SnOJSnO water-splitting cycle for solar ther- mochemical production of hydrogen 显示文摘 | STEPHANE A PATRICE C FLORENT L | 2008 | International Journal of Hydrogen Energy2008，33，： | 1 |
| 10 | Effect of soluble additives on enzyme thermoand/or baro-deactivation显示文摘 | VIOLAINE A PATRICE G DIDIER C | 1999 | Journal of Molecular Cat- alysis B:Enzymatic1999，7，： | 1 |
| 11 | lnterleukin-10 messenger ribonucleic acid in human placenta:implications of a role for interleukin-10 in fetal allograft protection显示文摘 | Patric C Reter L Stephen K | 1995 | Am J Obstet Gynecol1995，17，： | 1 |
| 12 | etsl -casein is required for the effi- cient transport of I- and K-casein from the endoplasmic reticulum to the Golgi apparatus of mammary epithelial cells 显示文摘 | Eric C Patrice M Michele O B | 1999 | Journal of Cell Science1999，112，： | 1 |
| 13 | Effect of instant controlled pressure drop treatments on the oligosaccharides extractability and microstructure of Tephrosia purpurea seeds显示文摘 | Bouthaina Ben Amor Cécile Lamy Patrice Andre Karim Allaf | 2008 | Journal of Chromatography A2008，，2： | 1 |
| 14 | Microinjection molding of thermoplastic polymers: morphological comparison with conventional injection molding 显示文摘 | JULIEN G THIERRY C PATRICE M | 2009 | Journal of Micromechanics and Microengineering2009，19，02： | 1 |
| 15 | Quantitative Genetic Bases of Anthocyanin Variation in Grape (Vitis vinifera L. ssp. sativa) Berry: A Quantitative Trait Locus to Quantitative Trait Nucleotide Integrated Study显示文摘 | Fournier-Level Alexandre Le Cunff Lo?c Gomez Camila Doligez Agnès Ageorges Agnès Roux Catherine Bertrand Yves Souquet Jean-Marc Cheynier Véronique This Patrice | 2009 | Genetics2009，，3： | 1 |
| 16 | Plasmid-mediated quinolone resistance determinants among enterobacterial isolates from outpatients in Brazil显示文摘 | Laurent P Vincent C Patrice N | 2008 | J Antimicrob Chemother2008，62，3： | 1 |
| 17 | Modelling of a water treatment plant: a multi-model representation 显示文摘 | Jose R Gerard G Patrice C | 2001 | Environmetrics2001，12，7： | 1 |
| 18 | Erk1/2-depemlent phosphorylation of Gα-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer ceils 显示文摘 | Eric OD Sophie P Patrice C | 2000 | The Journal Of Biological Chemistry2000，275，39： | 1 |
| 19 | A continuous epidemic in Africa显示文摘 | NAIDOO A PATRIC K C | 2002 | J RSoc Health2002，122，2： | 1 |
| 20 | Assessment of exposure to traffic pollution using the ExTra index: study of validation 显示文摘 | Patrice R Mireille C Stepanie G | 2003 | Environmental Research2003，93，： | 1 |
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