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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Recurrent ectopic pancreatitis of the jejunum and mesentery over a 30-year period显示文摘BACKGROUND:Ectopic pancreas is defined as pancreatic tissue found outside its usual anatomical position,with no ductal or vascular communication with the native pancreas. We describe a case of ectopic pancreas of the small bowel and mesentery causing recurrent episodes of pancreatitis, initially suspected on computed tomography(CT)and magnetic resonance cholangiopancreatography(MRCP),and confirmed on histological review of the resection. METHODS:A 67-year-old woman presented with clinical symptoms and biochemical evidence of pancreatitis.She had similar episodes over the past 30 years with unrevealing investigations,and was concluded to have idiopathic pancreatitis. She underwent CT and MRCP,with findings suggestive of ectopic pancreas,a diagnosis confirmed on histology of the resection. RESULTS:MRCP identified a mass in the proximal small bowel mesentery isointense to the native pancreas,with a small duct draining into a proximal jejunal loop.The resected specimen consisted of normal parenchyma with lobulated acinar tissue with scattered islets of Langerhans,an occasional ductular structure,and admixed areas of adipose tissue.The patient remained asymptomatic with normal biochemistry six months post-operatively. CONCLUSION:In an individual with abdominal pain,elevated serum amylase/lipase,but imaging findings of a normal native pancreas,ectopic pancreatitis should be considered,and can be evaluated by CT and MRCP. | John CT Wong Charlotte Robinson Edward C Jones Alison Harris Charles Zwirewich Robert Wakefield Richard K Simons Eric M Yoshida | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，2： | 4 |
| 3 | Hepatic stem cells显示文摘 | Alison M Sarraf C | 1998 | J Hepatol1998，29，： | 2 |
| 4 | Pericytes synthesize renin显示文摘AIM: To investigate renin expression in pericytes during normal kidney development and after deletion of angiotensinogen, the precursor for all angiotensins.METHODS: We examined the distribution of renin expressing cells by immunoshistochemistry in the interstitial compartment of wild type(WT) and angiotensinogen deficient(AGT-/-) mice at different developmental stages from embryonic day 18(E18: WT, n = 4; AGT-/-, n = 5) and at day 1(P1: WT, n = 5; AGT-/-, n = 5), 5(P5: WT, n = 7; AGT-/-, n = 8), 10(P10: WT, n = 3; AGT-/-, n = 5), 21(P21: WT, n = 7; AGT-/-, n = 5), 45(P45: WT, n = 3; AGT-/-, n = 3), and 70(P70: WT, n = 2; AGT-/-, n = 2) of postnatal life. We quantified the number of pericytes positive for renin at all the developmental stages mentioned above and comparedthe results of AGT-/- mice to their WT counterparts.RESULTS: In WT mice, renal interstitial pericytes synthesize renin in early life supporting a lineage relationship with renin cells in the vasculature. The number of pericytes positive for renin per area of 0.32 mm2(density) in WT mice was maintained from fetal life till weaning age(E18 = 4.25 ± 0.63, P1 = 3.75 ± 0.48, P5 = 3.75 ± 0.48, P10 = 4 ± 0.71, P21 = 3.8 ± 0.58) and markedly decreased in adult life(P45 = 1.2 ± 0.37, P70 = 0.8 ± 0.20). On the other hand, in AGT-/- mice the density of pericytes expressing renin was not significantly different from WT mice at E18 and P1: E18 = 5.75 ± 0.50 vs 4.25 ± 0.63(P = 0.106), P1 = 9.25 ± 3.50 vs 3.75 ± 0.48(P = 0.175) but significantly increased from P5 till P70: P5 = 38.25 ± 5 vs 3.75 ± 0.48(P = 0.0004), P10 = 173 ± 7.50 vs 4 ± 0.70(P = 5.24567 × 10-7), P21 = 83 ± 6.70 vs 3.8 ± 0.58(P = 2.97358 × 10-6), P45 = 49 ± 3.50 vs 1.2 ± 0.37(P = 8.18274 x 10-7) and P70 = 17.8 ± 2.30 vs 0.8 ± 0.20(P = 3.51151 × 10-5). The AGT-/- mice showed a marked increase in the number of pericytes per field studied starting from P5, reaching its peak at P10, and then a gradually decreasing until P70. CONCLUSION: Interstitial pericytes synthesize renin during development and the number of renin-expressing pericytes increases in response to a homeostatic threat imposed early in life such as lack of angiotensinogen. | Alison C Berg Catalina Chernavvsky-Sequeira Jennifer Lindsey R Ariel Gomez Maria Luisa S Sequeira-Lopez | 2013 | World Journal of Nephrology2013，2，1： | 2 |
| 5 | Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial显示文摘 | Matthew T Seymour Lindsay C Thompson Harpreet S Wasan Gary Middleton Alison E Brewster Stephen F Shepherd M Sinead O’Mahony Timothy S Maughan Mahesh Parmar Ruth E Langley | 2011 | The Lancet2011，，9779： | 2 |
| 6 | Accurnulation of an endogenous in hibitors of nitric oxide synthesis in chronic renalfailure显示文摘 | Patric V Anna L Alison C | 1992 | Lancet1992，339，8795： | 1 |
| 7 | A Space-charge Based Method for the Estimation of Apparent Mobility and Trap Depth as Markers for Insulation Degradation-theo- retical Basis and Experimental Validation 显示文摘 | Mazzanti G Montanari G C Alison J M | 2003 | IEEE Transac- tions on Dielectrics and Electrical Insulation2003，10，2： | 1 |
| 8 | A point mutation in a Drosophila GABA receptor confers insecticide resistance 显示文摘 | Ffrench-Constant Richard H Rocheleau Thomas A Steichen Jessica C Chalmers Alison E | 1993 | Nature (London)1993，363，： | 1 |
| 9 | Liquid chromatographic method with immunoaffinity column cleanup for determination of ochratoxin A in barley:collaborative study显示文摘 | A Catherine Entwisle Alison C Williams | 2000 | J AOAC Int2000，83，6： | 1 |
| 10 | Pluripotential liver stem cells: facultative stem cells located in the biliary tree显示文摘 | ALISON M R GOLDIN M H SARRAF C E | 1996 | Cell Prolif1996，29，7： | 1 |
| 11 | The prognostic significance of thrombocytosis in epithelial ovarian carcinoma显示文摘 | Andrew J Li Alison C Madden Ilana Cass Ronald S Leuchter Leo D Lagasse Beth Y Karlan | 2003 | Gynecologic Oncology2003，，1： | 1 |
| 12 | Affirming Authenticity : Consuming Cultural Heritage 显示文摘 | Alison J Mclntosh Richard C Prentice | 1999 | Annals of Tourism Research1999，26，3： | 1 |
| 13 | Educating undergraduate medical students about oncology : a literature review 显示文摘 | Judith C Jane D Alison J | 2006 | J Clin Oncol2006，24，12： | 1 |
| 14 | Com-parative toxicity and carcinogenicity of two chlorinated paraffins in F344N rats and B6C3F1 mice显示文摘 | Bucher J R Alison R H Montgomery C A | | 0，，03： | 1 |
| 15 | Application of liver stem cells for cell therapy显示文摘 | ALISON MR CHOONGB C LIMC S | 2007 | Sem Cell Devel Biol2007，18，： | 1 |
| 16 | Galectin-3 regulates myofibroblast activation and hepatic fibrosis显示文摘 | Neil C Alison C Sarah L | 2006 | Proc Natl Acad Sci U S A2006，103，13： | 1 |
| 17 | High rates of genital Mycoplasma infe ction in the highlands of Papua New Guinea determined both by culture and by a c ommercial detection kit显示文摘 | Alison c Megan p Mition Y | 1997 | J Microb1997，35，1： | 1 |
| 18 | Cultivar and environment effects on annual ryegrass forage yield,yield distribution,and nutritive value显示文摘 | Redfearn D D Venuto B C Pitman W D Alison M W Ward J D | 2002 | Crop Science2002，42，6： | 1 |
| 19 | The use of willingness-to-pay approaches in mammal conservation显示文摘 | Alison C Emma J V H | 2001 | Mammal Bev2001，31，2： | 1 |
| 20 | A Space-charge Based Method for the Estimation of Apparent Mobility and Trap Depth as Markers for Insulation Degradation-theoretical Basis and Experimental Validation显示文摘 | Mazzanti G Montanari G C Alison J M | 2003 | IEEE Transactions on Dielectrical and Electrical Insulation2003，10，2： | 1 |
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