|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Stem cell therapy for chronic skin wounds in the era of personalized medicine:From bench to bedside显示文摘With the significant financial burden of chronic cutaneous wounds on the healthcare system,not to the personal burden mention on those individuals afflicted,it has become increasingly essential to improve our clinical treatments.This requires the translation of the most recent benchtop approaches to clinical wound repair as our current treatment modalities have proven insufficient.The most promising potential treatment options rely on stem cellbased therapies.Stem cell proliferation and signaling play crucial roles in every phase of the wound healing process and chronic wounds are often associated with impaired stem cell function.Clinical approaches involving stem cells could thus be utilized in some cases to improve a body’s inhibited healing capacity.We aim to present the laboratory research behind the mechanisms and effects of this technology as well as current clinical trials which showcase their therapeutic potential.Given the current problems and complications presented by chronic wounds,we hope to show that developing the clinical applications of stem cell therapies is the rational next step in improving wound care. | Elam Coalson Elliot Bishop Wei Liu Yixiao Feng Mia Spezia Bo Liu Yi Shen Di Wu Scott Du Alexander J.Li Zhenyu Ye Ling Zhao Daigui Cao Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Rex C.Haydon Lewis Shi Aravind Athiviraham Michael J.Lee Jennifer Moriatis Wolf Guillermo A.Ameer Tong-Chuan He Russell R.Reid | 2019 | Genes & Diseases2019，6，4： | 6 |
| 3 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 4 | Uterine rupture : risk factors and pregnancy outcome 显示文摘 | Ofir K Sheiner E Levy A | 2003 | Am J Obstet Gynecol2003，189，4： | 1 |
| 5 | Catalytic Microcapsules Assembled from Enzyme-Nanoparticle Conjugates at Oil-Water Interfaces显示文摘 | Samanta B Yang X Ofir Y | 2009 | Angew Chem Int Ed2009，48，： | 1 |
| 6 | Negative and positive regulation by transcription factor cAMP response element-binding protein is modulated by phosphorylation 显示文摘 | Lamph W W Dwarki V J Ofir R | 1990 | Proc Natl Acad Sci USA1990，87，11： | 1 |
| 7 | The effect of clopidogrel and aspirin on blood loss in hip fracture surgery显示文摘 | Ofir Chechik Ran Thein Gil Fichman Amir Haim Tomer Ben Tov Ely L. Steinberg | 2011 | Injury2011，，11： | 1 |
| 8 | Comparing pretreatment by iron of electro-flocculation and chemical flocculation显示文摘 | Ofir E Oren Y Adin A | 2007 | Desalination2007，204，123： | 1 |
| 9 | Thrombophilic risk factors for placental stillbirth显示文摘 | Simchen MJ Ofir K Moran O | | 0，，： | 1 |
| 10 | PLA2G6 mutation underlies infantile neuroaxonal dystrophy显示文摘 | KhateebS Flusser H Ofir R | 2006 | Am J Hum Genet2006，79，5： | 1 |
| 11 | Potential use of cutinase in enzymatic scouring of cotton fiber cuticle显示文摘 | Ofir Degani Shimon Gepstein Carlos G. Dosoretz | 2002 | Applied Biochemistry and Biotechnology (-)2002，，1： | 1 |
| 12 | ApoE ε4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory显示文摘 | Ofir L Ana LJ Joram F | 2003 | Neurobiology of Disease2003，13，： | 1 |
| 13 | Changes in fetal heart rate and uterine patterns associated with uterine rupture显示文摘 | Sheiner E Levy A Ofir K | 2004 | J Reprod Med2004，49，5： | 1 |
| 14 | Polymer and Bio- polymer Mediated Self-assembly of Gold Nanoparticles显示文摘 | OFIR Y SAMANTA B ROTELLO V M | 2008 | Chemical Society Reviews2008，37，9： | 1 |
| 15 | Downregulation of Microglial Activation by Achillolide A显示文摘 | Anat Elmann Alona Telerman Sharon Mordechay Hilla Erlank Miriam Rindner Yoel Kashman Rivka Ofir | 2015 | Planta Med2015，，： | 1 |
| 16 | The Robustnoss of the Effects of Consumers' Participation in Market Research:The Case of Service Quality Evaluations显示文摘 | Ofir Chezy Simonson Itamar Yoon Song-Oh | 2009 | Joumal of Marketing2009，73，6： | 1 |
| 17 | Meconium Ileus Caused by Mutations in GUCY2C , Encoding the CFTR-Activating Guanylate Cyclase 2C显示文摘 | Hila Romi Idan Cohen Daniella Landau Suliman Alkrinawi Baruch Yerushalmi Reli Hershkovitz Nitza Newman-Heiman Garry R. Cutting Rivka Ofir Sara Sivan Ohad S. Birk | 2012 | The American Journal of Human Genetics2012，，5： | 1 |
| 18 | A single dose of platelet-rich plasma improves the organization and strength of a surgically repaired rotator cuff tendon in rats显示文摘 | Oleg Dolkart Ofir Chechik Yaron Zarfati Tamar Brosh Fadi Alhajajra Eran Maman | 2014 | Archives of Orthopaedic and Trauma Surgery2014，，9： | 1 |
| 19 | Retrospective study of the associations between hepatitis C virus infection and metabolic factors显示文摘AIM To evaluate the bidirectional association between metabolic syndrome(MS) components and antiviral treatment response for chronic hepatitis C virus(HCV) infection. METHODS This retrospective cohort study included 119 HCV + patients treated with pegylated-interferon-α and ribavirin. Metabolic characteristics and laboratory data were collected from medical records. Differences in baseline clinical and demographic risk factors between responders and non-responders were assessed using independent samples t-tests or χ~2 tests. The effects of sustained viral response(SVR) to antiviral treatment on de novo impairments in MS components, including impaired fasting glucose(IFG) and type 2 diabetes mellitus(T2DM), were assessed using univariable and multivariable logistic regression analysis, while the effect of MS components on SVR was assessed using univariable logistic regression analysis. RESULTS Of the 119 patients, 80(67%) developed SVR over the average 54 ± 13 mo follow-up. The cumulative risks for de novo T2DM and IFG were 5.07-(95%CI: 1.261-20.4, P = 0.022) and 3.87-fold higher(95%CI: 1.484-10.15, P = 0.006), respectively for non-responders than responders, when adjusted for the baseline risk factors age, sex, HCV genotype, high viral load, and steatosis. Post-treatment triglyceride levels were significantly lower in non-responders than in responders(OR = 0.27; 95%CI: 0.069-0.962, P = 0.044). Age and HCV genotype 3 were significantly different between responders and non-responders, and MS components were not significantly associated with SVR. Steatosis tended to attenuate SVR(OR = 0.596; 95%CI: 0.331-1.073, P = 0.08).CONCLUSION SVR was associated with lower de novo T2DM and IFG incidence and higher triglyceride levels. Patients infected with HCV should undergo T2DM screening and antidiabetic treatment. | Shira Yair-Sabag Elchanan Nussinson Ofir Ben-Assuli Fahmi Shibli Azmi Shahbari Shira Zelber-Sagi | 2016 | World Journal of Hepatology2016，8，30： | 1 |
| 20 | Inhibition of serotonin re-uptake by licorice constituents显示文摘 | Ofir R Tamir S Khatib S Vaya J | 2003 | J Mol Neurosci2003，20，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员