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| 1 | CD74 is a survival receptor on colon epithelial cells显示文摘AIM: To investigate the expression and function of CD74 in normal murine colon epithelial cells (CEC) and colon carcinoma cells. METHODS: Expression of CD74 mRNA and protein were measured by reverse transcriptase-polymerase chain reaction (RT-PCR), Western blotting and fluorescence-activated cell sorter (FACS). The effect of migration inhibitory factor (MIF) on the survival of normal CEC from C57BL/6, NOD/SCID, and CD74 def icient mice both in vitro and in vivo, and on the CT26 carcinoma cell line was analyzed by (quantitative) qRT-PCR, RTPCR, Western blotting and FACS. RESULTS: CD74 was found to be expressed on normalCEC. Stimulation of CD74 by MIF induced a signaling cascade leading to up-regulation of Bcl-2 expression, resulting in a signif icant increased survival of CEC. CD74 was also expressed on the CT26 colon carcinoma cell line and its stimulation by MIF resulted in enhanced cell survival, up-regulation of Akt phosphorylation and Bcl-2 expression. | Nitsan Maharshak Sivan Cohen Frida Lantner Gili Hart Richard Bucala Idit Shachar | 2010 | World Journal of Gastroenterology2010，16，26： | 9 |
| 2 | Metal-dependent anaerobic methane oxidation in marine sediment:insights from marine settings and other systems显示文摘Anaerobic oxidation of methane(AOM) plays a crucial role in controlling global methane emission. This is a microbial process that relies on the reduction of external electron acceptors such as sulfate, nitrate/nitrite, and transient metal ions. In marine settings, the dominant electron acceptor for AOM is sulfate, while other known electron acceptors are transient metal ions such as iron and manganese oxides. Despite the AOM process coupled with sulfate reduction being relatively well characterized,researches on metal-dependent AOM process are few, and no microorganism has to date been identified as being responsible for this reaction in natural marine environments. In this review, geochemical evidences of metal-dependent AOM from sediment cores in various marine environments are summarized. Studies have showed that iron and manganese are reduced in accordance with methane oxidation in seeps or diffusive profiles below the methanogenesis zone. The potential biochemical basis and mechanisms for metal-dependent AOM processes are here presented and discussed. Future research will shed light on the microbes involved in this process and also on the molecular basis of the electron transfer between these microbes and metals in natural marine environments. | Lewen Liang Yinzhao Wang Orit Sivan Fengping Wang | 2019 | Science China(Life Sciences)2019，62，10： | 7 |
| 3 | Potential antioxidant and cytoprotective effects of essential oil extracted from Cymbopogon citratus on OxLDL and H_(2)O_(2) LDL induced Human Peripheral Blood Mononuclear Cells(PBMC)显示文摘Cymbopogon citratus(lemon grass)is commonly used in traditional folk medicine.The essential oil extracted from C.citratus has been reported as a potential anti-oxidant and anti-inflammatory agent.This study has been designed to explore the protective effect of C.citratus(lemon grass)against modified LDL(OxLDL and H2O2 LDL)induced cytotoxicity in Peripheral Blood Mononuclear Cells(PBMC).The essential oil extracted from C.citratus(EOC)was subjected to FT-IR spectroscopic analysis for the identification of functional groups.In vitro antioxidant assays were carried out to assess the electron donating capability of EOC as compared with a known standard L-ascorbic acid.The cytoprotective effects of EOC were determined in PBMC induced with modified LDL.Spectra obtained from FT-IR analysis showed the presence of functional groups in EOC such as H-bonded,O-H stretching,N-H stretching,aldehyde-C-H stretching,aldehyde/ketone-C=O stretching,-C=C-stretching,-CH_(3) bending,-C-H in plane bending.EOC has greater antioxidant property when compared with the standard L-ascorbic acid.EOC at all test concentrations demonstrated free radical scavenging activity and cytoprotective effect when challenged against modified LDL in PBMC.The above results show EOC as a promising antioxidant and cytoprotective agent. | S.Jamuna Sakeena Sadullah M.S. R.Ashokkumar Gokul Shanmuganathan Senguttuvan Sivan Mozhi Niranjali Devaraj S. | 2017 | Food Science and Human Wellness2017，6，2： | 3 |
| 4 | Endothelial cell-derived GABA signaling modulates neuronal migration and postnatal behavior显示文摘服的外皮为集成是必要的并且为大多数行为被要求的信息处理。当神经原从室的地区连续地移居联合进特定的外皮的层时,服的外皮的精致地精确的 laminar 组织在胚胎的开发期间产生。当时指南为设计神经原移植责骂的光线的神经胶质行为, pre-formed 脉管的网络为 GABAergic interneuron 移植提供支持和指导暗示。这研究提供新奇概念、机械学的卓见进 vascular-neuronal 相互作用的这个范例,揭示伽马氨基丁酸并且它经由胚胎的前脑 endothelial 房间的调停受体的发信号的新机制。与二个新 endothelial 房间的使用,特定的有条件的老鼠 GABA 小径当模特儿(Gabrb3 Tie2-Cre 和 Vgat 我们显示出的 Tie2-Cre ), 从 endothelial 房间的伽马氨基丁酸版本的那部分或完全的损失在 embryogenesis 期间导致脉管的缺点并且损害长途的移植并且外皮的 interneurons 放。使不安的 endothelial 的下游的效果导出房间的伽马氨基丁酸发信号是批评的,导致上次修改到外皮的电路和坚持的行为的赤字。而且,我们说明在支持他们血大脑障碍性质的迁居, angiogenesis 和获得的前脑 endothelial 房间发信号的伽马氨基丁酸的激活的新机制。我们的调查结果揭开并且阐明在从表明小径的古典 neuronal 伽马氨基丁酸是不同的并且在 neuropsychiatric 疾病的病原学和 pathophysiology 上打开新灯的 CNS 表明小径的新奇 endothelial 伽马氨基丁酸例如孤独性光谱混乱,癫痫,焦虑,消沉和精神分裂症。 | Suyan Li Peeyush Kumar Sampada Joshee Timo Kirschstein Sivan Subburaju Jahan S Khalili Jonas Kloepper Chuang Du Abdallah Elkhal Gabor Szabo Rakesh K Jain Rudiger Kohling Anju Vasudevan | 2018 | Cell Research2018，28，2： | 3 |
| 5 | “Hot”electrons in metallic nanostructures—nonthermal carriers or heating?显示文摘Understanding the interplay between illumination and the electron distribution in metallic nanostructures is a crucial step towards developing applications such as plasmonic photocatalysis for green fuels,nanoscale photodetection and more.Elucidating this interplay is challenging,as it requires taking into account all channels of energy flow in the electronic system.Here,we develop such a theory,which is based on a coupled Boltzmann-heat equations and requires only energy conservation and basic thermodynamics,where the electron distribution,and the electron and phonon(lattice)temperatures are determined uniquely.Applying this theory to realistic illuminated nanoparticle systems,we find that the electron and phonon temperatures are similar,thus justifying the(classical)singletemperature models.We show that while the fraction of high-energy“hot”carriers compared to thermalized carriers grows substantially with illumination intensity,it remains extremely small(on the order of 10^(-8)).Importantly,most of the absorbed illumination power goes into heating rather than generating hot carriers,thus rendering plasmonic hot carrier generation extremely inefficient.Our formulation allows for the first time a unique quantitative comparison of theory and measurements of steady-state electron distributions in metallic nanostructures. | Yonatan Dubi Yonatan Sivan | 2019 | Light(Science & Applications)2019，8，1： | 3 |
| 6 | Connecting Malfunctioning Glial Cells and Brain Degenerative Disorders显示文摘The DNA damage response(DDR) is a complex biological system activated by different types of DNA damage.Mutations in certain components of the DDR machinery can lead to genomic instability disorders that culminate in tissue degeneration,premature aging,and various types of cancers.Intriguingly,malfunctioning DDR plays a role in the etiology of late onset brain degenerative disorders such as Parkinson's,Alzheimer's,and Huntington's diseases.For many years,brain degenerative disorders were thought to result from aberrant neural death.Here we discuss the evidence that supports our novel hypothesis that brain degenerative diseases involve dysfunction of glial cells(astrocytes,microglia,and oligodendrocytes).Impairment in the functionality of glial cells results in pathological neuro-glial interactions that,in turn,generate a ‘‘hostile' environment that impairs the functionality of neuronal cells.These events can lead to systematic neural demise on a scale that appears to be proportional to the severity of the neurological deficit. | Natalie Kaminsky Ofer Bihari Sivan Kanner Ari Barzilai | 2016 | Genomics, Proteomics & Bioinformatics2016，14，3： | 2 |
| 7 | Attention deficit hyperactivity disorder and gastrointestinal morbidity in a large cohort of young adults显示文摘BACKGROUND Although the association of attention deficit hyperactivity disorder(ADHD)with psychiatric disorders is well known,its association with somatic diseases is unclear.Only few studies have investigated the gastrointestinal(GI)morbidity in adult patients with ADHD.AIM To measure gastrointestinal comorbidity and its burden on healthcare in young adults with ADHD.METHODS The cohort included subjects aged 17-35 years recruited to the Israel Defense Forces in 2007-2013,33380 with ADHD and 355652 without(controls).The groups were compared for functional and inflammatory conditions of the gastrointestinal tract and clinic and specialist visits for gastrointestinal symptoms/disease during service(to 2016).Findings were analyzed by generalized linear models adjusted for background variables.RESULTS Compared to controls,the ADHD group had more diagnoses of functional gastrointestinal disorders(referred to as FGID),namely,dyspepsia[odds ratio(OR):1.48,95%confidence interval(CI):1.40-1.57,P<0.001],chronic constipation(OR:1.64,95%CI:1.48-1.81,P<0.001),and irritable bowel syndrome(OR:1.67,95%CI:1.56-1.80,P<0.001)but not of organic disorders(inflammatory bowel disease,celiac disease).They had more frequent primary care visits for gastrointestinal symptoms[rate ratio(RR):1.25,95%CI:1.24-1.26,P<0.001]and referrals to gastrointestinal specialists(RR:1.96,95%CI:1.88-2.03,P<0.001)and more episodes of recurrent gastrointestinal symptoms(RR:1.29,95%CI:1.21-1.38,P<0.001).Methylphenidate use increased the risk of dyspepsia(OR:1.49,95%CI:1.28-1.73,P<0.001)and constipation(OR:1.42,95%CI:1.09-1.84,P=0.009).CONCLUSION ADHD in young adults is associated with an excess of FGID and increased use of related health services.Research is needed to determine if an integrative approach treating both conditions will benefit these patients and cut costs. | Sivan Kedem Shlomit Yust-Katz Dan Carter Zohar Levi Ron Kedem Adi Dickstein Salah Daher Lior H Katz | 2020 | World Journal of Gastroenterology2020，26，42： | 2 |
| 8 | Dynamic stability of a rotor blade using finite element analysis显示文摘 | NITHIAN TI SIVANER | 1981 | AIAAJ1981，20，5： | 1 |
| 9 | Analysis of hystereses in force length and force calcium relations显示文摘 | YANIV Y SIVAN R LANDESBERG A | 2005 | Am J Physiol (Heart Circ Physiol)2005，288，： | 1 |
| 10 | The possible role of competition between Trichoderma harzianum and Fusarium oxysporum on rhizosohere colonization显示文摘 | Sivan A | | 0，，02： | 1 |
| 11 | Altered event-related potentials in adults with ADHD during emotional faces processing显示文摘 | Sivan Raz Orrie Dan | 2014 | Clinical Neurophysiology2014，，： | 1 |
| 12 | The role ofhighly sratifled nutrient-rich small estuaries as a source ofdissolved inorganic nitrogen to coastal seawater, the Qishon(SE Mediterranean) case显示文摘 | ELIANI-RUSSAK E HERUT B SIVAN O | 2013 | Marine Pollution Bulletin2013，，1： | 1 |
| 13 | Management of benign ureteral strictures following radical cystectomy and urinary diversion for bladder cancer显示文摘 | Tal R Sivan B Kedar D | 2007 | J Urol2007，178，： | 1 |
| 14 | Self-assembled fmoc-peptides as a platform for the formation of nanostructures and hydrogels 显示文摘 | Ron O Lihi A A Sivan Z | 2009 | Biomacromolecules2009，10，9： | 1 |
| 15 | Integrated control of Fusarium crown and root rot of tomato with Trichoderma harzianum in combination with mythyl bromide or soil solarization显示文摘 | Sivan A and Chet I | 1993 | Crop Protection1993，12，5： | 1 |
| 16 | DNA -tern- plated assembly and electrode attachment of a conducting silver wire 显示文摘 | BRAUN E EICHEN Y SIVAN U | 1998 | Nature1998，391，6669： | 1 |
| 17 | Free fatty acids,insulin resistance,and pregnancy显示文摘 | Sivan E Boden G | 2003 | Curr Diab Rep2003，3，4： | 1 |
| 18 | Free fatty acids, insulin resistance, and Pregnancy显示文摘 | Sivan E Boden G | 2003 | Curr Diab Rep2003，3，4： | 1 |
| 19 | VEGF145,a secreted vascular endothelial growth factor isoform that binds to extracelluler matrix显示文摘 | Poltorak Z Cohen T Sivan R Kandelis Y | 1997 | Biol Chem1997，272，11： | 1 |
| 20 | VEGF145 ,a secreted vascular endothelial growth factor isoform that binds to extracellularmatrix 显示文摘 | Poltorak Z Cohen T Sivan R | 1997 | J Biol Chem1997，272，11： | 1 |
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