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| 1 | 地下水人工回灌堵塞问题研究进展显示文摘地下水人工回灌堵塞问题的产生与回灌水质、入渗介质的矿物成分及颗粒组成特征等多种因素有关,通常根据成因将堵塞分为物理堵塞、化学堵塞和生物堵塞3种类型。大颗粒悬浮物的物理堵塞效应与机理的研究比较成熟,但对于中间颗粒,尤其是胶体颗粒物的堵塞作用机制的研究还相对比较薄弱;化学堵塞的机理复杂,影响因素众多,水文地球化学模拟技术在化学堵塞机理的研究中显示了良好的应用前景;生物堵塞主要由回灌水中细菌和藻类等微生物的繁殖和代谢导致,大量的研究集中在细菌方面,对藻类引起的堵塞问题研究尚不深入;多种堵塞的相互作用过程和作用机理是目前研究的难点问题。堵塞预测的方法主要包括3种:①指标法(如MFI、悬浮物浓度、浊度、AOC、BFR等),简单实用,但不能对堵塞演化过程进行描述或对堵塞程度进行定量表达;②经验公式法,受特定场地的条件限制,难以直接推广和利用;③解析公式法,对堵塞机理的表达更加科学、合理,但模型的建立与求解难度较大。通过合理的水质预处理技术和合理的回灌工艺,可以有效延迟堵塞发生的时间、减缓堵塞累积的程度。开发快速、高效、简单的堵塞处理技术对于延长工程使用寿命和降低经济成本具有重要的现实意义。 | 杜新强 冶雪艳 路莹 迟宝明 Steffen Birk 杨悦锁 | 2009 | 地球科学进展2009，24，9： | 46 |
| 2 | Laparoscopic liver resection:Experience based guidelines显示文摘Laparoscopic liver resection(LLR) has been progressively developed along the past two decades. Despite initial skepticism, improved operative results made laparoscopic approach incorporated to surgical practice and operations increased in frequency and complexity. Evidence supporting LLR comes from case-series, comparative studies and meta-analysis. Despite lack of level 1 evidence, the body of literature is stronger and existing data confirms the safety, feasibility and benefits of laparoscopic approach when compared to open resection. Indications for LLR do not differ from those for open surgery. They include benign and malignant(both primary and metastatic) tumors and living donor liver harvesting. Currently, resection of lesions located on anterolateral segments and left lateral sectionectomy are performed systematically by laparoscopy in hepatobiliary specialized centers. Resection of lesions located on posterosuperior segments(1, 4a, 7, 8) and major liver resections were shown to be feasible but remain technically demanding procedures, which should be reserved to experienced surgeons. Hand-assisted and laparoscopy-assisted procedures appeared to increase the indications of minimally invasive liver surgery and are useful strategies applied to difficult and major resections. LLR proved to be safe for malignant lesions and offers some short-term advantages over open resection. Oncological results including resection margin status and long-term survival were not inferior to open resection. At present, surgical community expects high quality studies to base the already perceived better outcomes achieved by laparoscopy in major centers' practice. Continuous surgical training, as well as new technologies should augment the application of lap-aroscopic liver surgery. Future applicability of new technologies such as robot assistance and image-guided surgery is still under investigation. | fabricio ferreira coelho jaime arthur pirola kruger gilton marques fonseca raphael leonardo cunha araújo vagner birk jeismann marcos vinícius perini renato micelli lupinacci ivan cecconello paulo herman | 2016 | World Journal of Gastrointestinal Surgery2016，8，1： | 22 |
| 3 | 拉萨市拉鲁湿地植物群落与环境因素之间的关系及其分布格局显示文摘文章采用双向指示种分析(TWINSPAN)和典范对应分析(CCA)法,对拉鲁湿地植被群落组成、分布格局与环境因素之间的关系进行研究。结果表明,拉鲁湿地29种主要植物种隶属17科25属,其中最常见的种类有苔草、嵩草、芦苇、委陵菜和水蓼。TWINSPAN表明,28个样方分为四个主要样方组,分别代表不同的生境类型并与CCA排序结果基本一致。CCA分析反映了拉鲁湿地植物群落组成和分布格局随环境因子变化的趋势,并且由CCA渐进选择分析确定了影响拉鲁湿地植物群落组成和分布的主要环境因子,包括放牧、水位和践踏干扰等。 | 拉多 john birks 普布 巴桑 | 2009 | 西藏大学学报(社会科学版)2009，24，6： | 19 |
| 4 | Heat Shock Factors HsfB 1 and HsfB2b Are Involved in the Regulation of Pdf1.2 Expression and Pathogen Resistance in Arabidopsis显示文摘以便估计热的功能的角色在 Arabidopsis 的导致压力的班 B 热吃惊因素,我们调查了 AtHsfB1 和 AtHsfB2b 的 T-DNA 猛烈异种。在异种的 defensin 基因 Pdf1.2a/b 的基础 mRNA 水平的一条起来规定种的作为强壮揭示的两倍猛烈 hsfB1/hsfB2b 植物的 Micorarray 分析。Pdf 表示被 jasmonic 酸处理或感染进一步与 necrotrophic 真菌 Alternaria brassicicola 提高。单个变异的 hsfB2b 和双变异的 hsfB1/B2b 显著地在 A 以后在疾病抵抗被改进。brassicicola 感染。为和 Pdf1.2 的倡导者的 Hsf 的一个直接相互作用没有指示,它缺乏完美的 HSE 一致 Hsf 有约束力的序列。然而,在形成变化近来 HsfA2 依赖的 HSE 绑定在 hsfB1/B2b 植物被检测。这建议 HsfB1/B2b 可以在调整热吃惊反应的用以遮闭之物与班 A-Hsf 交往。Pdf 基因的鉴定作为 Hsf 依赖的否定规定的目标是为在关於生命、不能生活的回答的规定的 Hsf 的互联的第一条证据。 | Mukesh Kumar Wolfgang Busch Hannah Birke Birgit Kemmerling Thorsten Nurnberger Friedrich Schoffl | 2009 | Molecular Plant2009，2，1： | 15 |
| 5 | 基于孢粉的古气候参数定量重建:一种新思路及其在中国的应用实例显示文摘传统的孢粉-古气候定量重建评估主要衡量校准集对现代气候状况的模拟结果或化石样品与校准集样品的可比程度,客观上导致特定地点重建气候参数的取舍缺少明确标准.基于国际上通过随机数据开展定量重建显著性检验的新方法,充分利用中国环境梯度大、植被类型丰富、现代表土孢粉数据完善等优势,提出一种孢粉-古气候参数定量重建的新思路:首先确定控制化石孢粉组成变化最主要环境因子,随后通过限制其他环境因子来构造校准集以开展该因子的定量重建,最后完成重建结果显著性评估.将该思路应用于分别位于黄土高原东、西两侧的吕梁山公海和六盘山天池化石孢粉序列,所获得的年降水量P_(ann)定量重建不仅具有统计上的显著性(p<0.001),且相互间在共同时段表现出良好、稳定的相关关系,均指示了约3300cal a BP以来的东亚夏季风降水快速下降,显示其具备降低基于孢粉的古气候参数定量重建不确定性的较大潜力. | 陈建徽 吕飞亚 黄小忠 H J B Birks R J Telford 张生瑞 许清海 赵艳 王海鹏 周爱锋 黄伟 刘建宝 魏国英 | 2018 | 中国科学:地球科学2018，48，1： | 8 |
| 6 | 水力压裂监测新方法显示文摘深入了解水力压裂裂缝的几何形态和延伸情况有助于改善低渗油气藏压裂增产作业效果,改善油气井产能并提高油气采收率。应用地震方法对水力压裂裂缝进行监测和描述已经有多年了,而新的地震硬件和处理技术的出现使得这类监测更加有效、可靠。 | Les Bennett Joeol Le Calvez David R. ( Rich ) Sarver Kevin Tanner W.S.(Scott)Birk George Waters Julian Drew Gw e nola Michaud Paolo Primiero Leo Eisner Rob Jones David Leslie Michael John Williams Jim Govenlock Richard C. ( Rick ) Klein Kazuhiko Tezuka | 2007 | 国外测井技术2007，22，4： | 7 |
| 7 | A Review of Hepatitis B Virus and Hepatitis C Virus Immunopathogenesis显示文摘Despite the advances in therapy,hepatitis B virus(HBV)and hepatitis C virus(HCV)still represent a significant global health burden,both as major causes of cirrhosis,hepatocellular carcinoma,and death worldwide.HBV is capable of incorporating its covalently closed circular DNA into the host cell’s hepatocyte genome,making it rather difficult to eradicate its chronic stage.Successful viral clearance depends on the complex interactions between the virus and host’s innate and adaptive immune response.One encouraging fact on hepatitis B is the development and effective distribution of the HBV vaccine.This has significantly reduced the spread of this virus.HCV is a RNA virus with high mutagenic capacity,thus enabling it to evade the immune system and have a high rate of chronic progression.High levels of HCV heterogeneity and its mutagenic capacity have made it difficult to create an effective vaccine.The recent advent of direct acting antivirals has ushered in a new era in hepatitis C therapy.Sustained virologic response is achieved with DAAs in 85–99%of cases.However,this still leads to a large population of treatment failures,so further advances in therapy are still needed.This article reviews the immunopathogenesis of HBV and HCV,their properties contributing to host immune system avoidance,chronic disease progression,vaccine efficacy and limitations,as well as treatment options and common pitfalls of said therapy. | Corey Saraceni John Birk | 2021 | Journal of Clinical and Translational Hepatology2021，9，3： | 5 |
| 8 | Antimicrobial susceptibility patterns of Streptococcus pneumoniae over 6 years at Gondar University Hospital, Northwest Ethiopia显示文摘Objective:To assess the magnitude and antimicrobial susceptibility patterns ofStreptococcus pneumoniaeisolates from various clinical specimens.Methods:A record based on retrospectivestudy was conducted at Gondar University Teaching Hospital from September 2007 to January 2012.All patients who visited Gondar University Hospital and provided clinical specimens(body fluids,discharge,swab and blood)for routine bacteriological culturing and antimicrobial susceptibilitytesting were taken for analysis.Clinical specimens were processed for bacterial culture accordingto the standard procedures.Antimicrobial susceptibility test for isolated organisms was doneusing agar disk diffusion method.The data were entered and analyzed using SPSS software version16 package.Results:One hundred and fifty threeStreptococcus pneumoniaewere isolated frompatients who visited Gondar University Teaching Hospital bacteriology laboratory for culture.Majority of the pneumococcal isolates were from inpatients[111(72.5%)],and 74(48.4%)were frombody fluids.Out of the total isolates,93(61%)were found to be resistant to at least one antibioticused for susceptibility testing.Forty eight(43.2%)of the isolates were multi-drug resistant(resistantto two or more drugs).The resistance rate noted for both ciprofloxacin 17(11.1%)and ceftriaxone15(9.8%)were alarming.Conclusions:High proportions of the isolates tend to be increasinglyresistant to the commonly prescribed drugs.The recommended drug of choice like ciprofloxacinand ceftriaxone were found to be less susceptible in the study area.Based on the findings,wetherefore recommend that antimicrobial agents should be inspected for acceptable activity beforethey are prescribed and administered empirically.Further study with a better design and surveyof antimicrobial susceptibility at large scale shoule be performed to draw advanced information. | Belay Anagaw Mucheye Gezachew Fantahun Biadgelgene Berhanu Anagaw Tariku Geleshe Birke Taddese Birhanu Getie Mengistu Endris Andargachew Mulu Chandrashekhar Unakal | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，7： | 3 |
| 9 | Holocene moisture evolution in arid central Asia and its out-of-phase relationship with Asian monsoon history显示文摘 | Fahu Chen Zicheng Yu Meilin Yang Emi Ito Sumin Wang David B. Madsen Xiaozhong Huang Yan Zhao Tomonori Sato H. John B. Birks Ian Boomer Jianhui Chen Chengbang An Bernd Wünnemann | 2007 | Quaternary Science Reviews2007，，3： | 2 |
| 10 | Holocene moisture evolution in arid central Asia and its out-of-phase relationship with Asian monsoon history显示文摘 | Fahu Chen Zicheng Yu Meilin Yang Emi Ito Sumin Wang David B. Madsen Xiaozhong Huang Yan Zhao Tomonori Sato H. John B. Birks Ian Boomer Jianhui Chen Chengbang An Bernd Wünnemann | 2007 | Quaternary Science Reviews2007，，3： | 2 |
| 11 | In vitro and in vivo pharmacological characterization of BIIL 284, a novel and potent leukotriene B(4) receptor antagonist 显示文摘 | Birke F W Meade C J Anderskewitz R | 2001 | J Pharmacol Exp Ther2001，297，： | 2 |
| 12 | Nitrogen immobilization in paddy soils as affected by redox conditions and rice straw incorporation显示文摘 | Daniel Said-Pullicino Maria Alexandra Cucu Marcella Sodano Jago Jonathan Birk Bruno Glaser Luisella Celi | 2014 | Geoderma2014，，： | 2 |
| 13 | The HITRAN 2008 molecular spectroscopic database显示文摘 | L.S. Rothman I.E. Gordon A. Barbe D.Chris Benner P.F. Bernath M. Birk V. Boudon L.R. Brown A. Campargue J.-P. Champion K. Chance L.H. Coudert V. Dana V.M. Devi S. Fally J.-M. Flaud R.R. Gamache A. Goldman D. Jacquemart I. Kleiner N. Lacome W.J. Lafferty J | 2009 | Journal of Quantitative Spectroscopy and Radiative Transfer2009，，9： | 2 |
| 14 | Proton Pump Inhibitors: The Good, the Bad, and the Unwanted显示文摘 | Saman Chubineh John Birk | 2012 | Southern Medical Journal2012，，11： | 2 |
| 15 | Repeat hepatectomy for recurrent colorectal liver metastases:A comparative analysis of short-and long-term results显示文摘Background: Liver recurrence after resection of colorectal liver metastases(CRLM) is frequent. Repeat hepatectomy has been shown to have satisfactory perioperative results. However, the long-term outcomes and the benefts for patients with early recurrence have not been clarifed. The aim of this study was to compare the short-and long-term outcomes of patients undergoing single hepatectomy and repeat hepatectomy for CRLM. Additionally, the oncological outcomes of patients with early( ≤ 6 months) and late recurrence who underwent repeat hepatectomy were compared. Methods: Consecutive adult patients undergoing hepatectomy for CRLM between June 20 0 0 and February 2020 were included and divided into two groups: single hepatectomy and repeat hepatectomy. Results: A total of 709 patients were included: 649 in the single hepatectomy group and 60 in the repeat hepatectomy group. Patients in the repeat hepatectomy group underwent more cycles of preoperative chemotherapy [4(3-6) vs. 3(2-4), P = 0.003]. Patients in the single hepatectomy group more frequently underwent major hepatectomies(34.5% vs. 16.7%, P = 0.004) and had a greater number of lesions resected(2.9 ± 3.6 vs. 1.9 ± 1.8, P = 0.011). There was no increase in operative time, estimated blood loss, length of hospital stay, complications, or mortality in the repeat hepatectomy group. There were no differences in overall survival( P = 0.626) and disease-free survival( P = 0.579) between the two groups. Similarly, for patients underwent repeat hepatectomy, no difference was observed between the early and late recurrence groups in terms of overall survival( P = 0.771) or disease-free survival( P = 0.350). Conclusions: Repeat hepatectomy is feasible and safe, with similar short-and long-term outcomes when compared to single hepatectomy. Surgical treatment of early liver recurrence offers similar oncological outcomes to those obtained for late recurrence. | Paulo Figueiredo Costa Fabricio Ferreira Coelho Vagner Birk Jeismann Jaime Arthur Pirola Kruger Gilton Marques Fonseca Ivan Cecconello Paulo Herman | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，2： | 2 |
| 16 | Endlessly single- mode photonic crystal fiber显示文摘 | Birks TA | 1997 | Optics Letters1997，22，13： | 2 |
| 17 | Hepatitis C virus-induced hepatocarcinogenesis显示文摘 | Birke Bartosch Robert Thimme Hubert E. Blum Fabien Zoulim | 2009 | Journal of Hepatology2009，，4： | 2 |
| 18 | Camera models based on data from two calibration planes显示文摘 | MARTINS H A BIRK J R KELLEY R B | 1981 | Computer Graphics Image Processing1981，17，2： | 2 |
| 19 | Boosting cooperation by evolving trust 显示文摘 | Birk A | 2000 | Applied Artificial Intelligence2000，14，8： | 1 |
| 20 | Vaccination against autoimmune mouse diabetes with a T cell epitope of the human 65-kDa heat shock protein显示文摘 | Elias D Reshef T Birk OS | 1991 | Proc Natl Acad Sci USA1991，88，8： | 1 |
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