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| 1 | Stem cell-derived exosomes as a therapeutic tool for cardiovascular disease显示文摘Mesenchymal stem cells(MSCs) have been used to treat patients suffering from acute myocardial infarction(AMI) and subsequent heart failure. Although it was originally assumed that MSCs differentiated into heart cells such as cardiomyocytes, recent evidence suggests that the differentiation capacity of MSCs is minimal and that injected MSCs restore cardiac function via the secretion of paracrine factors. MSCs secrete paracrine factors in not only naked forms but also membrane vesicles including exosomes containing bioactive substances such as proteins, messenger RNAs, and microR NAs. Although the details remain unclear, these bioactive molecules are selectively sorted in exosomes that are then released from donor cells in a regulated manner. Furthermore, exosomes are specifically internalized by recipient cells via ligand-receptor interactions. Thus, exosomes are promising natural vehicles that stably and specifically transport bioactive molecules to recipient cells. Indeed, stem cell-derived exosomes have been successfully used to treat cardiovascular disease(CVD), such as AMI, stroke, and pulmonary hypertension, in animal models, and their efficacy has been demonstrated. Therefore, exosome administration may be a promising strategy for the treatment of CVD. Furthermore, modifications of exosomal contents may enhance their therapeutic effects. Future clinical studies are required to confirm the efficacy of exosome treatment for CVD. | Etsu Suzuki Daishi Fujita Masao Takahashi Shigeyoshi Oba Hiroaki Nishimatsu | 2016 | World Journal of Stem Cells2016，8，9： | 19 |
| 2 | Adipose tissue-derived stem cells as a therapeutic tool for cardiovascular disease显示文摘Adipose tissue-deried stem cells( ADSCs) are adult stem cells that can be easily harvested from subcutaneous adipose tissue. Many studies have demonstrated that ADSCs differentiate into vascular endothelial cells(VECs), vascular smooth muscle cells(VSMCs), and cardiomyocytes in vitro and in vivo. However, ADSCs may fuse with tissue-resident cells and obtain the corresponding characteristics of those cells. If fusion occurs, ADSCs may express markers of VECs, VSMCs, and cardiomyocytes without direct differentiation into these cell types. ADSCs also produce a variety of paracrine factors such as vascular endothelial growth factor, hepatocyte growth factor, and insulin-like growth factor-1 that have proangiogenic and/or antiapoptotic activities. Thus, ADSCs have the potential to regenerate the cardiovascular system via direct differentiation into VECs, VSMCs, and cardiomyocytes, fusion with tissueresident cells, and the production of paracrine factors. Numerous animal studies have demonstrated the efficacy of ADSC implantation in the treatment of acute myocardial infarction(AMI), ischemic cardiomyopathy(ICM), dilated cardiomyopathy, hindlimb ischemia, and stroke. Clinical studies regarding the use of autologous ADSCs for treating patients with AMI and ICM have recently been initiated. ADSC implantation has been reported as safe and effective so far. Therefore, ADSCs appear to be useful for the treatment of cardiovascular disease. However, the tumorigenic potential of ADSCs requires careful evaluation before their safe clinical application. | Etsu Suzuki Daishi Fujita Masao Takahashi Shigeyoshi Oba Hiroaki Nishimatsu | 2015 | World Journal of Cardiology2015，7，8： | 17 |
| 3 | Efficacy of multislice computed tomography for gastroenteric and hepatic surgeries显示文摘AIM: To determine the efficacy of multislice CT for gastroenteric and hepatic surgery.METHODS: Dual-phase helical computed tomography was performed in 50 of 51 patients who underwent gastroenteric and hepatic surgeries. Twenty-eight, eighteen and four patients suffering from colorectal cancer, gastric cancer,and liver cancer respectively underwent colorectal surgery (laparoscopic surgery: 6 cases), gastrectomy, and hepatectomy. Three-dimensional computed tomography imaging of the inferior mesenteric artery, celiac artery and hepatic artery was performed. And in the follow-up examination of postoperative patients, multiplanar reconstruction image was made in case of need.RESULTS: Scans in 50 patients were technically satisfactory and included in the analysis. Depiction of major visceral arteries, which were important for surgery and other treatments, could be done in all patients.Preoperative visualization of the left colic artery and sigmoidal arteries, the celiac artery and its branches, and hepatic artery was very useful to lymph node dissection,the planning of a reservoir and hepatectomy. And multiplanar reconstruction image was helpful to diagnosis for the postoperative follow-up of patients.CONCLUSION: Three-dimensional volume rendering or multiplanar reconstruction imaging performed by multislice computed tomography was very useful for gastroenteric and hepatic surgeries. | Hiroshi Ohtani Hidemi Kawajiri Yuichi Arimoto Koichi Ohno Yasuhisa Fujimoto Hiroko Oba Kenji Adachi Masaya Hirano Shoichi Terakawa Mitsuo Tsubakimoto | 2005 | World Journal of Gastroenterology2005，11，10： | 9 |
| 4 | Disease-Free Survival as a Surrogate for Overall Survival in Adjuvant Trials of Gastric Cancer: A Meta-Analysis显示文摘 | Koji Oba Xavier Paoletti Steven Alberts Yung-Jue Bang Jacqueline Benedetti Harry Bleiberg Paul Catalano Florian Lordick Stefan Michiels Satoshi Morita Yasuo Ohashi Jean-pierre Pignon Philippe Rougier Mitsuru Sasako Junichi Sakamoto Daniel Sargent Kohei Sh | 2013 | JNCI Journal of the National Cancer Institute2013，，21： | 3 |
| 5 | Hemorrhagic shock due to submucosal esophageal hematoma along with mallory-weiss syndrome:A case report显示文摘BACKGROUND Esophageal submucosal hematoma is a rare condition.Although the exact etiology remains uncertain,vessel fragility with external factors is believed to have led to submucosal bleeding and hematoma formation;the vessel was ruptured by a sudden increase in pressure due to nausea,and the hematoma was enlarged by antiplatelet or anticoagulant therapy.Serious conditions are rare,with a better prognosis.We present the first known case of submucosal esophageal hematoma-subsequent hemorrhagic shock due to Mallory-Weiss syndrome.CASE SUMMARY A 73-year-old female underwent endovascular treatment for an unruptured cerebral aneurysm.The patient received aspirin and clopidogrel before surgery and heparin during surgery,and was well during the surgery.Several hours after returning to the ICU,she complained of chest discomfort,vomited 500 m L of fresh blood,and entered hemorrhagic shock.Esophageal submucosal hematoma with Mallory-Weiss syndrome was diagnosed through an endoscopic examination and computed tomography.In addition to a massive fluid and erythrocyte transfusion,we performed a temporary compression for hemostasis with a Sengstaken-Blakemore(S-B)tube.Afterwards,she became hemodynamically stable.On postoperative day 1,we performed an upper gastrointestinal endoscopy and confirmed no expansion of the hematoma nor any recurring bleeding;therefore,we removed the S-B tube and clipped the gastric mucosal laceration at the esophagogastric junction.We started oral intake on postoperative day 10.The patient made steady progress,and was discharged on postoperative day 33.CONCLUSION We present the first known case of submucosal esophageal hematoma subsequent hemorrhagic shock due to Mallory-Weiss syndrome. | Jiro Oba Daisuke Usuda Shiho Tsuge Riki Sakurai Kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki Hayabusa Takano Shintaro Shimozawa Yuta Hotchi Kenki Usami Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Tomohisa Nomura Manabu Sugita | 2022 | World Journal of Clinical Cases2022，10，27： | 3 |
| 6 | Outcomes of hepatic resection for hepatolithiasis显示文摘 | Takahiro Uenishi Hiroyuki Hamba Shigekazu Takemura Kazuki Oba Masao Ogawa Takatsugu Yamamoto Shogo Tanaka Shoji Kubo | 2009 | The American Journal of Surgery2009，，2： | 3 |
| 7 | Chronic kidney disease and erectile dysfunction显示文摘Erectile dysfunction(ED) is a common condition among male chronic kidney disease(CKD) patients.Its prevalence is estimated to be approximately 80% among these patients.It has been well established that the production of nitric oxide from the cavernous nerve and vascular endothelium and the subsequent production of cyclic GMP are critically important in initiating and maintaining erection.Factors affecting these pathways can induce ED.The etiology of ED in CKD patients is multifactorial.Factors including abnormalities in gonadal-pituitary system,disturbance in autonomic nervous system,endothelial dysfunction,anemia(and erythropoietin deficiency),secondary hyperparathyroidism,drugs,zinc deficiency,and psychological problems are implicated in the occurrence of ED.An improvement of general conditions is the first step of treatment.Sufficient dialysis and adequate nutritional intake are necessary.In addition,control of anemia and secondary hyperparathyroidism is required.Changes of drugs that potentially affect erectile function may be necessary.Further,zinc supplementation may be necessary whenzinc deficiency is suspected.Phosphodiesterase type 5 inhibitors(PDE5Is) are commonly used for treating ED in CKD patients,and their efficacy was confirmed by many studies.Testosterone replacement therapy in addition to PDE5 Is may be useful,particularly for CKD patients with hypogonadism.Renal transplantation may restore erectile function.ED is an early marker of cardiovascular disease(CVD),which it frequently precedes; therefore,it is crucial to examine the presence of ED in CKD patients not only for the improvement of the quality of life but also for the prevention of CVD attack. | Etsu Suzuki Hiroaki Nishimatsu Shigeyoshi Oba Masao Takahashi Yukio Homma | 2014 | World Journal of Nephrology2014，3，4： | 3 |
| 8 | A Meta-Analysis of Randomized Controlled Trials that Compared Laparoscopy-Assisted and Open Distal Gastrectomy for Early Gastric Cancer显示文摘 | Hiroshi Ohtani Yutaka Tamamori Kozo Noguchi Takashi Azuma Shunsuke Fujimoto Hiroko Oba Tetsuya Aoki Mieko Minami Kosei Hirakawa | 2010 | Journal of Gastrointestinal Surgery2010，，6： | 3 |
| 9 | Angiotensin receptor blocker neprilysin inhibitors显示文摘Heart failure(HF)is a clinical syndrome that results from a structural or functional cardiac disorder that reduces the ability of the ventricle of the heart to fill with,or eject,blood.It is a multifaceted clinical condition that affects up to 2%of the population in the developed world,and is linked to significant morbidity and mortality;it is therefore considered a major concern for public health.Regarding the mechanism of HF,three neurohumoral factors-the reninangiotensin-aldosterone system,the sympathetic nervous system,and natriuretic peptides—are related to the pathology of chronic HF(CHF),and the targets of treatment.Angiotensin receptor blocker and neprilysin inhibitor(angiotensinreceptor neprilysin inhibitor),namely sacubitril/valsartan(SAC/VAL),has been introduced as a treatment for CHF.SAC/VAL is an efficacious,safe,and costeffective therapy that improves quality of life and longevity in patients with HF with reduced ejection fraction(HFrEF),and reduces hospital admissions.An inhospital initiation strategy offers a potential new avenue to improve the clinical uptake of SAC/VAL.In the last five years,SAC/VAL has been established as a cornerstone component of comprehensive disease-modifying medical therapy in the management of chronic HFrEF.On the other hand,further work,with carefully designed and controlled preclinical studies,is necessary for understanding the molecular mechanisms,effects,and confirmation of issues such as long-term safety in both human and animal models. | Daisuke Usuda Toshihiro Higashikawa Yuta Hotchi Kenki Usami Shintaro Shimozawa Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Toshihiko Yoshizawa Suguru Asako Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Jiro Oba Tomohisa Nomura Manabu Sugita | 2021 | World Journal of Cardiology2021，13，8： | 2 |
| 10 | Cochlear Receptor (Microphonic and Summating Potentials, Otoacoustic Emissions) and Auditory Pathway (Auditory Brain Stem Potentials) Activity in Auditory Neuropathy显示文摘 | A. Starr Y. Sininger T. Nguyen H. J. Michalewski S. Oba C. Abdala | 2001 | Ear and Hearing2001，，2： | 2 |
| 11 | Short-term results of a randomized study between laparoscopic and open surgery in elderly colorectal cancer patients显示文摘 | Shoichi Fujii Atsushi Ishibe Mitsuyoshi Ota Shigeru Yamagishi Kazuteru Watanabe Jun Watanabe Amane Kanazawa Yasushi Ichikawa Mari Oba Satoshi Morita Yojiro Hashiguchi Chikara Kunisaki Itaru Endo | 2014 | Surgical Endoscopy2014，，2： | 2 |
| 12 | Axillary lymph node dissection can be avoided in women with breast cancer with intraoperative, false-negative sentinel lymph node biopsies显示文摘 | Hiroyuki Takei Masafumi Kurosumi Takashi Yoshida Yuko Ishikawa Yuji Hayashi Jun Ninomiya Katsunori Tozuka Hanako Oba Kenichi Inoue Shigenori Nagai Yoshihiro Saito Tomoko Kazumoto Jun-ichi Saitoh Toshio Tabei | 2010 | Breast Cancer2010，，1： | 2 |
| 13 | Hyperdry human amniotic membrane application as a wound dressing for a full-thickness skin excision after a third-degree burn injury显示文摘Background:Severe burn injuries create large skin defects that render the host susceptible to bacterial infections.Burn wound infection often causes systemic sepsis and severe septicemia,resulting in an increase in the mortality of patients with severe burn injuries.Therefore,appropriate wound care is important to prevent infection and improve patient outcomes.However,it is difficult to heal a third-degree burn injury.The aim of this studywas to investigate whether hyperdry human amniotic membrane(HD-AM)could promote early granulation tissue formation after full-thickness skin excision in third-degree burn injury sites in mice.Methods:After the development of HD-AM and creation of a third-degree burn injury model,the HD-AM was either placed or not placed on the wound area in the HD-AM group or HD-AM group,respectively.The groups were prepared for evaluation on postoperative days 1,4 and 7.Azan staining was used for granulation tissue evaluation,and estimation of CD163,transforming growth factor beta-1(TGF-β1),vascular endothelial growth factor(VEGF),CD31,alpha-smooth muscle actin(α-SMA)and Iba1 expression was performed by immunohistochemical staining.Quantitative reverse-transcription polymerase chain reaction(PCR)was used to investigate gene expression of growth factors,cell migration chemokines and angiogenic and inflammatory markers.Results:The HD-AM group showed significant early and qualitatively good growth of granulation tissue on the full-thickness skin excision site.HD-AM promoted early-phase inflammatory cell infiltration,fibroblast migration and angiogenesis in the granulation tissue.Additionally,the early infiltration of cells of the immune system was observed.Conclusions:HD-AM may be useful as a new wound dressing material for full-thickness skin excision sites after third-degree burn injuries,and may be a new therapeutic technique for improving the survival rate of patients with severe burn injuries. | Jiro Oba Motonori Okabe Toshiko Yoshida Chika Soko Moustafa Fathy Koji Amano Daisuke Kobashi Masahiro Wakasugi Hiroshi Okudera | 2020 | Burns & Trauma2020，8，1： | 2 |
| 14 | MIP-lalpha utilizes both CCR1 and CCR5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells 显示文摘 | Oba Y Lee JW Ehrlich LA | 2005 | Exp Hematol2005，33，3： | 1 |
| 15 | Horizontal array beamforming in an azimuthally anisotropic internal wave field显示文摘 | Finette S Oba R | 2003 | J Acoust Soc Am2003，114，： | 1 |
| 16 | Antisense Inhibition of Macrophage Inflammatory Protein 1-α Blocks Bone Destruction in a Model of Myeloma Bone Disease 显示文摘 | Choi S J Oba Y Gazitt Y | 2001 | J Clin Invest2001，108，： | 1 |
| 17 | The duality of fish gonadotropin receptor:Cloning,functional characterization of a second gonaotropin receptor cDNA expressed in the ovary and testis of amago salmon (oncorhynchus rhodurus)显示文摘 | OBA Y HIRAI T YOSHIURA Y | 1999 | Biochem Biophys Res Commun1999，265，2： | 1 |
| 18 | Pharmacokinetic study of weekly admin is tration dose of paclitaxel in patients with advanced or recurrent gastric cancer in ]apan显示文摘 | Kobayashi M Oba K Sakamoto J et M | 2007 | Gastric Cancer2007，10，： | 1 |
| 19 | P2X4 receptor expression in a rat model of trigeminal neuropathic pain显示文摘 | Nakai K Nakae A Oba S Mashimo T Ueda K | 2010 | Neu- roreport2010，21，8： | 1 |
| 20 | Benefit of adju- vant chemotherapy for resectable gastric cancer: a meta- analysis显示文摘 | GASTRIC Group Paoletti X Oba K | 2010 | JAMA2010，303，7： | 1 |
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