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| 1 | Meta-analysis of short-term outcomes after laparoscopy-assisted distal gastrectomy显示文摘AIM: To elucidate the current status of laparoscopy-assisted distal gastrectomy (LADG) with regard to its short-term outcomes by comparing it with conventional open distal gastrectomy (CODG). METHODS: Original articles published from January 1991 to August 2006 were searched in the MEDLINE, EMBASE, and Cochrane Controlled Trials Register. Clinical appraisal and data extraction were conducted independently by 2 reviewers. A meta-analysis was performed using a random effects model. RESULTS: Outcomes of 1611 procedures from 4 randomized controlled trials and 12 retrospective studies were analyzed. Compared to CODG, LADG was a longer procedure (weighted mean difference [WMD] 54.3; 95% confidence interval [CI] 38.8 to 69.8; P < 0.001), but was associated with a lower associated morbidity (odds ratio [OR] 0.54; 95% CI 0.37 to 0.77; P < 0.001); this was most significant for postoperative ileus (OR 0.27; 95% CI 0.09 to 0.84; P = 0.02). There was no significant difference between the two groups in anastomotic, pulmonary, and wound complications and mortality. Duration from surgery to first passage of flatus was faster (WMD -0.68; 95% CI -0.85 to -0.50; P < 0.001) and the frequency of additional analgesic requirement (WMD -1.36; 95% CI -2.44 to -0.28; P = 0.01), and duration of hospital stay (WMD -5.51; 95% CI -7.61 to -3.42; P < 0.001) were significantly lower after LADG. However, a significantly higher number of lymph nodes were dissected by CODG (WMD -4.35; 95% CI -5.73 to -2.98; P < 0.001).CONCLUSION: LADG for early gastric cancer is associ-ated with a lower morbidity, less pain, faster bowel func-tion recovery, and shorter hospital stay. | Shunsuke Hosono Yuichi Arimoto Hiroshi Ohtani Yoshitetsu Kanamiya | 2006 | World Journal of Gastroenterology2006，12，47： | 41 |
| 2 | Efficacy and safety of emergency endoscopic retrograde cholangiopancreatography for acute cholangitis in the elderly显示文摘AIM To investigate the efficacy and safety of emergency endoscopic retrograde cholangiopancreatography(ERCP) in elderly patients with acute cholangitis. METHODS From June 2008 to May 2016, emergency ERCPs were performed in 207 cases of acute cholangitis at our institution. Patients were classified as elderly if they were aged 80 years and older(n = 102); controls were under the age of 80 years(n = 105). The patients' medical records were retrospectively reviewed for comorbidities, laboratory data, etiology of cholangitis(presence of biliary stones, biliary stricture and malignancy), details of the ERCP(therapeutic approaches, technical success rates, procedure duration), ERCP-related complications and mortality. RESULTS The frequency of comorbidities was higher in the elderly group than the control group(91.2% vs 67.6%). Periampullary diverticulum was observed in the elderly group at a higher frequency than the control group(24.5% vs 13.3%). Between the groups, there was no significant difference in the technical success rates(95.1% vs 95.2%) or endoscopicprocedure durations. With regard to the frequency of ERCP-related complications, there was no significant difference between the two groups(6.9% vs 6.7%), except for a lower rate of post-ERCP pancreatitis in the elderly group than in the control group(1.0% vs 3.8%). Neither angiographic nor surgical intervention was required in any of the cases with ERCP-related complications. There was no mortality during the observational periods. CONCLUSION Emergency ERCP for acute cholangitis can be performed safely even in elderly patients aged 80 years and older. | Gen Tohda Masahiro Ohtani Masaki Dochin | 2016 | World Journal of Gastroenterology2016，22，37： | 28 |
| 3 | Prognostic significance of the lymphocyte-to-monocyte ratio in patients with metastatic colorectal cancer显示文摘AIM:To evaluate the prognostic significance of the lymphocyte to monocyte ratio(LMR) in patients with unresectable metastatic colorectal cancer who received palliative chemotherapy.METHODS:A total of 104 patients with unresectable metastatic colorectal cancer who underwent palliative chemotherapy were enrolled. The LMR was calculated from blood samples by dividing the absolute lymphocyte count by the absolute monocyte count. Pretreatment LMR values were measured within one week before the initiation of chemotherapy,while posttreatment LMR values were measured eight weeks after the initiation of chemotherapy.RESULTS:The median pre-treatment LMR was 4.16(range:0.58-14.06). We set 3.38 as the cut-off level based on the receiver operating characteristic curve. Based on the cut-off level of 3.38,66 patients were classified into the high pre-treatment LMR group and 38 patients were classified into the low pretreatment LMR group. The low pre-treatment LMR group had a significantly worse overall survival rate(P = 0.0011). Moreover,patients who demonstrated low pre-treatment LMR and normalization after treatmentexhibited a better overall survival rate than the patients with low pre-treatment and post-treatment LMR values.CONCLUSION:The lymphocyte to monocyte ratio is a useful prognostic marker in patients with unresectable metastatic colorectal cancer who receive palliative chemotherapy. | Masatsune Shibutani Kiyoshi Maeda Hisashi Nagahara Hiroshi Ohtani Katsunobu Sakurai Sadaaki Yamazoe Kenjiro Kimura Takahiro Toyokawa Ryosuke Amano Hiroaki Tanaka Kazuya Muguruma Kosei Hirakawa | 2015 | World Journal of Gastroenterology2015，21，34： | 19 |
| 4 | Efficacy of multislice computed tomography for gastroenteric and hepatic surgeries显示文摘AIM: To determine the efficacy of multislice CT for gastroenteric and hepatic surgery.METHODS: Dual-phase helical computed tomography was performed in 50 of 51 patients who underwent gastroenteric and hepatic surgeries. Twenty-eight, eighteen and four patients suffering from colorectal cancer, gastric cancer,and liver cancer respectively underwent colorectal surgery (laparoscopic surgery: 6 cases), gastrectomy, and hepatectomy. Three-dimensional computed tomography imaging of the inferior mesenteric artery, celiac artery and hepatic artery was performed. And in the follow-up examination of postoperative patients, multiplanar reconstruction image was made in case of need.RESULTS: Scans in 50 patients were technically satisfactory and included in the analysis. Depiction of major visceral arteries, which were important for surgery and other treatments, could be done in all patients.Preoperative visualization of the left colic artery and sigmoidal arteries, the celiac artery and its branches, and hepatic artery was very useful to lymph node dissection,the planning of a reservoir and hepatectomy. And multiplanar reconstruction image was helpful to diagnosis for the postoperative follow-up of patients.CONCLUSION: Three-dimensional volume rendering or multiplanar reconstruction imaging performed by multislice computed tomography was very useful for gastroenteric and hepatic surgeries. | Hiroshi Ohtani Hidemi Kawajiri Yuichi Arimoto Koichi Ohno Yasuhisa Fujimoto Hiroko Oba Kenji Adachi Masaya Hirano Shoichi Terakawa Mitsuo Tsubakimoto | 2005 | World Journal of Gastroenterology2005，11，10： | 9 |
| 5 | The role of water in Earth’s mantle显示文摘Geophysical observations suggest that the transition zone is wet locally.Continental and oceanic sediment components together with the basaltic and peridotitic components might be transported and accumulated in the transition zone.Low-velocity anomalies at the upper mantle–transition zone boundary might be caused by the existence of dense hydrous magmas.Water can be carried farther into the lower mantle by the slabs.The anomalous Q and shear wave regions locating at the uppermost part of the lower mantle could be caused by the existence of fluid or wet magmas in this region because of the water-solubility contrast between the minerals in the transition zone and those in the lower mantle.δ-H solid solution AlO2H–MgSiO4H2 carries water into the lower mantle.Hydrogen-bond symmetrization exists in high-pressure hydrous phases and thus they are stable at the high pressures of the lower mantle.Thus,the δ-H solid solution in subducting slabs carries water farther into the bottom of the lower mantle.Pyrite FeO2Hx is formed due to a reaction between the core and hydrated slabs.This phase could be a candidate for the anomalous regions at the core–mantle boundary. | Eiji Ohtani | 2020 | National Science Review2020，7，1： | 6 |
| 6 | 天然树脂紫胶的热裂解-气相色谱特性(英文)显示文摘研究了有机碱试剂,氢氧化四甲铵(tetramethylammonium hydroxide TMAH)共存下的反应热裂解气相色谱(Py-GC)应用于天然树脂紫胶的化学组成分析。并在反应Py-GC测得的化学组成的基础上,应用主成分分析(principal component analysis,PCA)对印度和泰国产紫胶进行产地识别分析。 | 王丽丽 Yasuyuki Ishida Hajime Ohtani Shin Tsuge Toshihiro Nakayama | 2003 | 浙江科技学院学报2003，15，B11： | 5 |
| 7 | Hypoxia-inducible factor 1 alpha and vascular endothelial growth factor overexpression in ischemic colitis显示文摘AIM: To examine the etiology and pathophysiology in human ischemic colitis from the viewpoint of ischemic favors such as hypoxia-inducible factor 1 alpha (HIF-1alpha and vascular endothelial growth factor (VEGF).METHODS: Thirteen patients with ischemic colitis and 21 normal controls underwent colonoscopy. The follow-up colonoscopy was performed in 8 patients at 7 to 10 d after theoccurrence of ischemic colitis. Biopsy samples were subjected to real-time RT-PCR and immunohistochemistry to detect the expression of HIF-1 alpha and VEGF.RESULTS: HIF-1 alpha and VEGF expression were found in the normal colon tissues by RT-PCR and immunohistochemistry.HIF-1 alpha and VEGF were overexpressed in the lesions of ischemic colitis. Overexpressed HIF-1 alpha and VEGF RNA quickly decreased to the normal level in the scar regions at 7 to 10 d after the occurrence of ischemic colitis.CONCLUSION: Constant expression of HIF-1 alpha and VEGF in normal human colon tissue suggested that HIF-1alpha and VEGF play an important role in maintaining tissue integrity. We confirmed the ischemic crisis in ischemic colitis at the molecular level, demonstrating overexpression of HIF-1 alpha and VEGF in ischemic lesions. These ischemic factors may play an important role in the pathophysiology of ischemic colitis. | Tomoyuki Okuda Takeshi Azuma Masahiro Ohtani Ryuho Masaki Yoshiyuki Ito Yukinao Yamazaki Shigeji Ito Masaru Kuriyama | 2005 | World Journal of Gastroenterology2005，11，10： | 5 |
| 8 | A Meta-Analysis of Randomized Controlled Trials that Compared Laparoscopy-Assisted and Open Distal Gastrectomy for Early Gastric Cancer显示文摘 | Hiroshi Ohtani Yutaka Tamamori Kozo Noguchi Takashi Azuma Shunsuke Fujimoto Hiroko Oba Tetsuya Aoki Mieko Minami Kosei Hirakawa | 2010 | Journal of Gastrointestinal Surgery2010，，6： | 3 |
| 9 | Endoscopic stenting versus surgical gastroenterostomy for palliation of malignant gastroduodenal obstruction: a meta-analysis显示文摘 | Shunsuke Hosono Hiroshi Ohtani Yuichi Arimoto Yoshitetsu Kanamiya | 2007 | Journal of Gastroenterology2007，，4： | 3 |
| 10 | Effectiveness of therapeutic barium enema for diverticular hemorrhage显示文摘AIM:To evaluate the effectiveness of barium impaction therapy for patients with colonic diverticular bleeding.METHODS:We reviewed the clinical charts of patients in whom therapeutic barium enema was performed for the control of diverticular bleeding between August2010 and March 2012 at Yokohama Rosai Hospital.Twenty patients were included in the review,consisting of 14 men and 6 women.The median age of the patients was 73.5 years.The duration of the followup period ranged from 1 to 19 mo(median:9.8 mo).Among the 20 patients were 11 patients who required the procedure for re-bleeding during hospitalization,6patients who required it for re-bleeding that developed after the patient left the hospital,and 3 patients who required the procedure for the prevention of rebleeding.Barium(concentration:150 w%/v%)was administered per the rectum,and the leading edge of the contrast medium was followed up to the cecum by fluoroscopy.After confirmation that the ascending colon and cecum were filled with barium,the enema tube was withdrawn,and the patient’s position was changed every 20 min for 3 h.RESULTS:Twelve patients remained free of rebleeding during the follow-up period(range:1-19mo)after the therapeutic barium enema,including 9men and 3 women with a median age of 72.0 years.Re-bleeding occurred in 8 patients including 5 men and 3 women with a median age of 68.5 years:4developed early re-bleeding,defined as re-bleeding that occurs within one week after the procedure,and the remaining 4 developed late re-bleeding.The DFI(disease-free interval)decreased 0.4 for 12 mo.Only one patient developed a complication from therapeutic barium enema(colonic perforation).CONCLUSION:Therapeutic barium enema is effective for the control of diverticular hemorrhage in cases where the active bleeding site cannot be identified by colonoscopy. | Mizue Matsuura Masahiko Inamori Atsushi Nakajima Yasuhiko Komiya Yumi Inoh Keigo Kawasima Mai Naitoh Yuji Fujita Akiko Eduka Noriyoshi Kanazawa Shiori Uchiyama Rie Tani Kennichi Kawana Setsuya Ohtani Hajime Nagase | 2015 | World Journal of Gastroenterology2015，21，18： | 2 |
| 11 | Epidermal growth factor receptor expression in human pancreatic cancer:Significance for liver metastasis显示文摘 | Kosuke Tobita Hiroshi Kijima Shoichi Dowaki Hiroyuki Kashiwagi Yasuo Ohtani Yasuhisa Oida Hitoshi Yamazaki Masato Nakamura Yoshito Ueyama Makiko Tanaka Sadaki Inokuchi Hiroyasu Makuuchi | 2003 | International Journal of Molecular Medicine2003，，3： | 2 |
| 12 | Reaction times and anticipatory skills of karate athletes显示文摘 | SHUJI MORI YOSHIO OHTANI KUNIYASU IMANAKA | 2002 | Human Movement Sci2002，21，： | 1 |
| 13 | Histopathological findings of the noreflow phenomenon following coronary intervention for acute coronary syndrome 显示文摘 | Kawano H Hayashida T Ohtani H | 2005 | Int Heart J2005，46，2： | 1 |
| 14 | Liquid-phase Benzene Oxidation to Phenol with Molecular- oxygen catalyzed by Cu-Zeo- lites显示文摘 | Ohtani T Nishiyama S Tsuruya S Masai M | 1995 | Journal of Catalysis1995，155，1： | 1 |
| 15 | High temperature oxidation behaviour of (Ti1-xCrx)N coatings 显示文摘 | Ohtani Y Hofman S | 1996 | Thin Solid Films1996，287，： | 1 |
| 16 | Influence of boron ion implantation on the oxidation behavior of CVD-SiC coated carbon - carbon composites显示文摘 | ZHU Y C OHTANI S SATO Y | 2000 | Carbon2000，38，： | 1 |
| 17 | Characterization of ribonuclease HⅡ from Escherichia coli overproduced in a soluble form显示文摘 | Ohtani N Haruki M Muroya A | 2000 | J Biochem2000，127，5： | 1 |
| 18 | Infrequent stromal expression of gelatinase A and intact basement membrane in intraduetal neoplasms of the pancreas 显示文摘 | Saloh K Ohtani H Shimosegawa T el al | 1994 | Gastroenterology1994，107，5： | 1 |
| 19 | Attenuation of shock waves propagating over arrayed baffle plates 显示文摘 | Ohtomo E Ohtani K Takayama K | 2005 | Shock Waves2005，14，56： | 1 |
| 20 | Water solubility in Mg-perovskites and water storage capacity in the lower mantle 显示文摘 | Litasov K Ohtani E Langenhorst F | 2003 | Earth Planet Sci Lett2003，211，12： | 1 |
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