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| 1 | 头颈鳞状细胞癌组织与正常黏膜中血管生成因子1和2的表达显示文摘目的 研究血管生成因子1(angiopoietin -1,Ang -1)和2(Ang- 2)在头颈鳞状细胞癌(简称鳞癌)及健康黏膜组织中的表达及意义。方法 采用免疫组化法,观测了45例头颈部鳞癌组织和7例健康志愿者口腔黏膜组织中Ang -1和Ang- 2的表达及分布。分析了不同临床分期及不同病理分级的癌组织中Ang- 1和Ang -2表达水平及其意义。结果 Ang -1和Ang- 2在血管内皮细胞、健康黏膜上皮细胞及鳞癌细胞内均有表达;Ang -1在肿瘤的血管内皮细胞及癌细胞的阳性表达率分别为78% (35 /45)和87% (39 /45),Ang 2在肿瘤的血管内皮细胞及癌细胞的阳性表达率分别为69% (31 /45)和76% (34 /45),均高于健康黏膜的血管内皮细胞及上皮细胞内的表达(P<0 .05);肿瘤血管内皮细胞与鳞癌细胞内Ang-1、Ang -2的表达水平有关(P<0 .05);Ang- 1在肿瘤血管内皮细胞中的表达水平与肿瘤的临床分期有关,在ⅢⅣ期比在ⅠⅡ期高(P<0 .05);Ang -2在肿瘤的血管内皮细胞及鳞癌细胞中的表达也表现为ⅢⅣ期比ⅠⅡ期高(P<0. 05);Ang -1及Ang- 2的表达水平在高、中、低分化的癌组织中的差异无统计学意义(P>0 .05)。结论 肿瘤血管内皮细胞与鳞癌细胞内Ang- 1、Ang -2的表达水平有关,且分别高于健康黏膜的血管内皮细胞及上皮细胞的表达。晚期肿瘤的血管生成与Ang - | 郑美桦 Florian Veelken Daniel Lábbe Wilhelm Bloch Olaf Michel | 2005 | 中华耳鼻咽喉头颈外科杂志2005，40，5： | 7 |
| 2 | Landscape diagnosis on different space and time scales-a challenge for landscape planning 显示文摘 | OLAF B RUDOLF K ZDENEK L | 2006 | Landscape Ecol2006，21，： | 1 |
| 3 | Absorbance changes of carotenoids in different solvents显示文摘 | Zang L Y Sommerburg Olaf Van Kuijk Frederik J G M | 1997 | Free Radical Biology & Medicine1997，23，7： | 1 |
| 4 | Localization of underground hymn gas storage caverns in respect to performance criteria 显示文摘 | Dahlstrom L Olaf Swedenborg S Evans J | 2004 | Tunnelling and Underground Space Technology2004，19，45： | 1 |
| 5 | Photosynthetic stimulation under long-term CO2 enrichment and fertilization is sustained across a closed Populus canopy profile (EUROFACE)显示文摘 | Marion L Ingmar T Olaf R | 2007 | New Phytologist2007，173，： | 1 |
| 6 | Catheter-directed Venous Thrombolysis in acute iliofemoral vein thrombosis-the CaVenT Study: Rationale and design of a multicenter, randomized, controlled, clinical trial (NCT00251771)显示文摘 | Tone Enden Leiv Sandvik Nils-Einar Kl?w Geir Hafsahl P?l Andre Holme Lars Olaf Holmen Waleed Ghanima Anne Mette Njaastad Gunnar Sandb?k Carl-Erik Slagsvold Per Morten Sandset | 2007 | American Heart Journal2007，，5： | 1 |
| 7 | An eigenvalue sensitivity approach to location and controller design of controllable series capacitors for damping power system oscillations 显示文摘 | ROUCO L PAC OLAF L | 1997 | IEEE Trans on Power Systems1997，12，4： | 1 |
| 8 | cervical intraevithelial neoplasia llI: long-term follow-up after cold-knife conization with involved margins显示文摘 | Olaf R Manfred L Hellmuth P | 2002 | Obstet Gynecol2002，99，2： | 1 |
| 9 | Catheter-directed Venous Thrombolysis in acute iliofemoral vein thrombosis-the CaVenT Study: Rationale and design of a multicenter, randomized, controlled, clinical trial (NCT00251771)显示文摘 | Tone Enden Leiv Sandvik Nils-Einar Kl?w Geir Hafsahl P?l Andre Holme Lars Olaf Holmen Waleed Ghanima Anne Mette Njaastad Gunnar Sandb?k Carl-Erik Slagsvold Per Morten Sandset | 2007 | American Heart Journal2007，，5： | 1 |
| 10 | Hexabromocyclododecane (HBCD) Stereoisomers in U.S. Food from Dallas, Texas显示文摘 | Schecter Arnold Szabo David T Miller James Gent Tyra L Malik-Bass Noor Petersen Malte Paepke Olaf Colacino Justin A Hynan Linda S Harris T Robert Malla Sunitha Birnbaum Linda S | 2012 | EN2012，，9： | 1 |
| 11 | Identification of Pistacia X Saportae Burnat (Anacardiaceae) by RAPD analysis and morphological characters显示文摘 | Olaf W Pedro S G Juan G et a l | 2001 | Scientia Horticulturae2001，91，： | 1 |
| 12 | Comparable Biomechanical Results for a Modified Single-Row Rotator Cuff Reconstruction Using Triple-Loaded Suture Anchors Versus a Suture-Bridging Double-Row Repair显示文摘 | Olaf Lorbach Matthias Kieb Florian Raber Lüder C. Busch Dieter Kohn Dietrich Pape | 2012 | Arthroscopy: The Journal of Arthroscopic and Related Surgery2012，，2： | 1 |
| 13 | 显示文摘 | Andrei L | 2003 | Appl Catal A2003，255，2： | 1 |
| 14 | Characterization and stability of N-terminally pegylated rhG-CSF显示文摘 | Olaf B K Darid N B Scott L L | | 0，，07： | 1 |
| 15 | Expression and gene polymorphisms of the chemokine CXCL5 in colorectalcancer patients显示文摘 | Jan Dimberg Olaf Dienus Sture L?fgren Anders Hugander Dick W?gs?ter | 2007 | International Journal of Oncology2007，，1： | 1 |
| 16 | Cervical intraepithelial neoplasia Ⅲ: long term follow-up after cold-knife conization with involved margins显示文摘 | Olaf R Manfred L Hellmuth P | 2002 | Obstet Gynecol2002，99，2： | 1 |
| 17 | Cervical intraepithelial neoplasia Ⅲ: long-Term outcome after cold-knife conization with clear margins显示文摘 | Olaf R Hellmuth P Manfred L | 2001 | Obstet Gyneeol2001，97，3： | 1 |
| 18 | Syk and CARD9 dependent coupling of innate immunity to the induction of T helper cells that produce interleukin- 17显示文摘 | Salome L Olaf G | 2007 | Nat Immunol2007，8，6： | 1 |
| 19 | Fatal oc-cupational accidents in Danish fishing vessels 1989-2005显示文摘 | LaursenLise H Hansen Henrik L Jensen Olaf C | 2008 | International Journal of Injury Control and Safety Pro-motion2008，15，2： | 1 |
| 20 | Strong geometrical dependence of the absorption of light in arrays of semiconductor nano-wires显示文摘 | Diedenhofen Silke L /anssen Olaf T A Grzegorz Grzela | 2011 | ACS Nano2011，5，3： | 1 |
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