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| 1 | Circulating inflammatory factors associated with worse long-term prognosis in colorectal cancer显示文摘AIM To investigate association of circulating inflammatory factors at the time of colorectal cancer(CRC) surgery with survival.METHODS Plasma levels from 174 CRC patients(69 females and 105 men), with median age 70 years(range 29-90), localized in the colon(n = 105) or rectum(n = 69), with stage Ⅰ(n = 24), stage Ⅱ(n = 54), stage Ⅲ(n = 67) and stage Ⅳ(n = 29) were measured using commercially available Bio-Plex Pro? Human Chemokine Panel 40-Plex, including 40 different chemokines, cytokines and interleukins. The prognostic association of each inflammatory factor was analysed as CRC-specific and total mortality.RESULTS Out of 174 patients, 66 died during the follow-up, 40 because of CRC specific mortality. High tertile levels of 8 factors were significantly associated with increased CRC-specific mortality, of which CCL1, CCL20, CCL24, CX3CL1, IL-4 and TNF-α remained significant in a multivariate Cox regression analysis. High tertile levels of 14 factors were associated with increased total mortality, of which CCL1, CCL15, CCL20, CX3CL1, CXCL13, IFN-γ, IL-2, IL-4 and IL-10 remained significant after adjustment for clinical covariates. For most of the inflammatory factors the association between higher tertile levels and an increased mortality in general appeared two years after surgery. High tertile levels of TNF-α and CCL24 were exclusively associated with CRC-specific mortality. The distribution of these factors were not associated with TNM stage with exception for CCL20.CONCLUSION High plasma levels of inflammatory factors are associated with increased risk of mortality among CRC patients and could be potential biomarkers for revealing prognosis. | Renate S Olsen Johnny Nijm Roland E Andersson Jan Dimberg Dick Wagsater | 2017 | World Journal of Gastroenterology2017，23，34： | 8 |
| 2 | Association of gene and protein expression and genetic polymorphism of CC chemokine ligand 4 in colorectal cancer显示文摘BACKGROUND Leukocytes,such as T cells and macrophages,play an important role in tumorigenesis.CC chemokine ligand(CCL)4,which is produced by lymphocytes and macrophages,has been found to be expressed in the mucosa of the gastrointestinal tract and is a potent chemoattractant for various leukocytes.AIM To examine CCL4 expression and its genetic polymorphism rs10491121 in patients with colorectal cancer(CRC)and evaluate their prognostic significance.METHODS Luminex technology was used to determine CCL4 Levels in CRC tissue(n=98),compared with paired normal tissue,and in plasma from patients with CRC(n=103),compared with healthy controls(n=97).Included patients had undergone surgical resection for primary colorectal adenocarcinomas between 1996 and 2019 at the Department of Surgery,Ryhov County Hospital,Jönköping,Sweden.Reverse transcription quantitative PCR was used to investigate the CCL4 gene expression in CRC tissue(n=101).Paired normal tissue and TaqMan single nucleotide polymorphism assays were used for the CCL4 rs10491121 polymorphism in 610 CRC patients and 409 healthy controls.RESULTS The CCL4 protein and messenger RNA expression levels were higher in CRC tissue than in normal paired tissue(90%,P<0.001 and 45%,P<0.05,respectively).CRC tissue from patients with localized disease had 2.8-fold higher protein expression levels than that from patients with disseminated disease.Low CCL4 protein expression levels in CRC tissue were associated with a 30%lower cancer-specific survival rate in patients(P<0.01).The level of plasma CCL4 was 11%higher in CRC patients than in healthy controls(P<0.05)and was positively correlated(r=0.56,P<0.01)with the CCL4 protein level in CRC tissue.The analysis of CCL4 gene polymorphism rs10491121 showed a difference(P<0.05)between localized disease and disseminated disease in the right colon,with a dominance of allele A in localized disease.Moreover,the rate of the A allele was higher among CRC patients with mucinous cancer than among those with nonmucinous cancer.CONCLUSION The present study indicates that the CRC tissue levels of CCL4 and CCL4 gene polymorphism rs10491121,particularly in the right colon,are associated with clinical outcome in CRC patients. | Levar Shamoun Kalle Landerholm Amanda Balboa Ramilo Roland E Andersson Jan Dimberg Dick Wågsäter | 2021 | World Journal of Gastroenterology2021，27，30： | 2 |
| 3 | A Study on the influence of fucosterol on thermal polymerisation of purified high oleic sunflower triacylglycerols显示文摘 | Lampi A M Dimberg L H Eldin A K | 1999 | J Sci Food Agric1999，79，： | 1 |
| 4 | Mutation analysis of the 13RAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas 显示文摘 | Fransen K Klintenas M Osterstrom A Dimberg J Monstein H J Sederkvist P | 2004 | Carcinogenesis2004，25，： | 1 |
| 5 | Prevalence of ma- locclusion traits and sucking habits among 3-year-old children显示文摘 | Dimberg L Bondemark L Stiderfeldt B | 2010 | Swed Dent J2010，34，1： | 1 |
| 6 | On the TRAIL tosuccessful cancer therapy? Predicting and counteracting resistanceagainst TRAIL-based therapeutics显示文摘 | Dimberg LY Anderson CK Camidge R | 2013 | Oncogene2013，32，11： | 1 |
| 7 | A study on the influence of fucosterol on thermal polymerisation of purified high oleic sunflower triacylglycerols 显示文摘 | LAMPI A M DIMBERG L H KAMAL- ELDIN A | 1999 | J Sci Food Agric1999，79，4： | 1 |
| 8 | Evidence against an effect of endothelin-1 on blood coagulation,fibrinolysis,and endothelial cell integrity in healthy men显示文摘 | Kapiotis JB Szalay T Dimberger E | 1997 | Arterioscler Thromb Vasc Biol1997，17，11： | 1 |
| 9 | Levels of avenanthramides and activity of hydroxycinnamoyl - CoA: hydroxyanthranilate N - hydroxycinnamoyl transferase ( HHT ) in steeped or germinated oat samples 显示文摘 | Bryngelsson S Ishihara A Dimberg L H | 2003 | Cereal Chemistry2003，80，3： | 1 |
| 10 | VEGF receptor signalling; in control of vascular function 显示文摘 | Olsson AK Dimberg A Kreuger J | 2006 | Nat Rev Mol Cell Bio12006，7，： | 1 |
| 11 | FGFR-1regulates angiogenesis through cytokines interleukin-4 and pleiotrophin显示文摘 | Magnusson PU Dimberg A Mellberg S | 2007 | Blood2007，110，13： | 1 |
| 12 | Retinoid acidinduced cell cycle arrest of human myeloid cell lines is associated with sequential down-regulation of c-Myc and cyclin E and posttranscriptional up-regulation of p27 (kip1)显示文摘 | Dimberg A Bahram F Karlberg I | 2002 | Blood2002，99，6： | 1 |
| 13 | An operational definition of a statistically meaningful trend 显示文摘 | BRYHN A C DIMBERG P H | 2011 | PLoS ONE2011，6，4： | 1 |
| 14 | {alpha} B-crystallin promotes tumor angiogenesis by increasing vascular survival during tube morphogenesis 显示文摘 | Dimberg A Rylova S Dieterich LC | 2007 | Blood2007，111，4： | 1 |
| 15 | VEGF receptor signalling-in control of vascular function显示文摘 | Olsson AK Dimberg A Kreuger J | | 0，，04： | 1 |
| 16 | VEGF receptor signaling-in control Of vascular function显示文摘 | Olsson AK Dimberg A Kreuger J | 2006 | Nat RevMol Cell Biol2006，7，5： | 1 |
| 17 | Analysis of MICA gene transcripts in human rectal cancers显示文摘 | Dimberg J Hugander A | 2003 | Anticancer Research2003，23，3： | 1 |
| 18 | Expression of chemokin6 receptor CXCR6 in human colorectal adenocarcinomas显示文摘 | Wagsater D Dimberg J | 2004 | Anti- cancer Res2004，24，6： | 1 |
| 19 | Retinoic acid-induced cell cycle arrest of human myeloid cell lines is associated with sequential down-regulation of c-Myc and cyclin E and posttranscriptional up-regulation of p27Kip1 显示文摘 | Dimberg A Bahram F Karlberg I | 2002 | Blood2002，99，6： | 1 |
| 20 | Avenanthramides - a group of phenolic antioxidants in oats 显示文摘 | Dimberg H L Theander O Lingnert H | 1993 | Cereal Chemistry1993，70，： | 1 |
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