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1Current status of intravenous tissue plasminogen activator dosage for acute ischaemic stroke:an updated systematic review显示文摘The optimal dose of recombinant tissue plasminogen activator(rtPA)for acute ischaemic stroke(AIS)remains controversial,especially in Asian countries.We aimed to update the evidence regarding the use of low-dose versus standard-dose rtPA.We performed a systematic literature search across MEDLINE,Embase,Cochrane Central Register of Controlled Trials(CENTRAL),PsycINFO and Cumulative Index to Nursing and Allied Health Literature(CINAHL)from inception to 22 August 2016 to identify all related studies.The outcomes were death or disability(defined by modified Rankin Scale 2-6),death,and symptomatic intracerebral haemorrhage(sICH).Where possible,data were pooled for meta-analysis with ORs and corresponding 95% CIs by means of random-effects or fixed-effects meta-analysis.We included 26 observational studies and 1 randomised controlled trial with a total of 23210 patients.Variable doses of rtPA were used for thrombolysis of AIS in Asia.Meta-analysis shows that low-dose rtPA was not associated with increased risk of death or disability(OR 1.13,95% CI 0.95 to 1.33),or death(OR 0.86,95% CI 0.74 to 1.01),or decreased risk of sICH(OR 1.06,95% CI 0.65 to 1.72).The results remained consistent when sensitivity analyses were performed including only low-dose and standard-dose rtPA or only Asian studies.Our review shows small difference between the outcomes or the risk profile in the studies using low-dose and/or standard-dose rtPA for AIS.Low-dose rtPA was not associated with lower risk of death or disability,death alone,or sICH.Xia Wang Shoujiang You Shoichiro Sato Jie Yang Cheryl Carcel Danni Zheng Sohei Yoshimura Craig S Anderson Else Charlotte Sandset Thompson Robinson John Chalmers Vijay K Sharma 2018Stroke & Vascular Neurology2018,3,1:10
2Coagulation activation inyoung survivors of myocardial infarction(MI)-apopulation-basedcase-control study显示文摘Brodin E Borvik T Sandset PM 2004Thromb Haemost2004,92,:1
3The angiotensin-re- ceptor blocker candesartan for treatment of acute stroke (SCAST) : a randomised, placebo-controlled, double-blind tri- al显示文摘Sandset EC Philip MW Boysen G 2011Lancet2011,377,9767:1
4Infarction(MI)-a population-based case-cortrol study显示文摘 BORVIK T SANDSET PM 2004Thromb-Haemost2004,92,:1
5Fibrinogen and fibrininduce synthesis of pminilammatory cytokines fwm 1 80-1ated peripheral blood mononuclear cells 显示文摘Jensen T Kierulf P Sandset PM 2007Thrmnb Haemost2007,9,7:1
6Tissue factor pathway inhibitor (TFPI)-an update显示文摘Sandset PM 1996Haemostasis1996,26,:1
7A sensitive assay of sic extrinsic coagualation pathway inhibitor(EPI)in plasma fractions显示文摘 Abildgaard U Pettersen M 1987Thromb Res1987,47,4:1
8Venous thromboembolism associated with preg- nancy and hormonal therapy 显示文摘Jacobsen AF Sandset PM 2012Best Pract Res Clin Haematol2012,25,3:1
9Fibrinogen and fi- brin induce synthesis of proinflammatory cytokines from iso- lated peripheral blood mononuclear cells 显示文摘Jensen T Kierulf P Sandset PM 2007Thromb Hae- most2007,97,:1
10Coagulation inhibitor levels in pneumonia and stroke:Changes due to consumption and acute phase realtion显示文摘Sandset PM Andersson TR 1989J Intern Med1989,225,:1
11D-dimer levels and stroke progression in patients with acute ischemic stroke and atrial fibrillation显示文摘Krarup LH Sandset EC Sandset PM 2011Acta Neurologica Scandinavica2011,124,1:1
12Coagulat ion inhibition and activation in pancreatic cancer显示文摘 Odegaard OR Sandset PM 1992Cancer1992,70,:1
13The angiotensin-receptor blocker candesartan for treatment of acute stroke (SCAST):a randomised, placebo-controlled, double-blind trial显示文摘Sandset EC Bath PM Boysen G 2011Lancet2011,377,:1
14Reduction of factor FⅦa activity during heparin therapy, evidence for assay intemcions with tissue factor pathway inhibitorand antithrombin显示文摘Hansen JB Svensson B Sandset PM 2000Thromb Res2000,111,38:1
15A unique,low dose of intravenous enoxaparin in elective percutaneous coronary intervention显示文摘Hansen JB Sandset PM Huseby KR 2002J Am Coll Cardiol2002,40,:1
16Are there Patients with acute ischemic stroke and atrial fibrillation that benefit from low molecular weight heparin显示文摘O’Donnell MJ Berge E Sandset PM 2006Stroke2006,37,2:1
17The angiotensin_receptor blocker candesartan for treatment of acute stroke(SCAST):a randomized,placebocontrolled,double_blind trial显示文摘Sandset EC Bath PM Boysen QJatuzis D 2011Lancet2011,377,9767:1
18Incidence and risk patterns of venous thromboembolism in pregnancy and puerperium-a register-based case-control study 显示文摘Jacobsen A F Skjeldestad F E Sandset P M 2008Am J Obstet Gynecol2008,198,2:1
19Venous thromboembolism associatedwith pregnancy and hormonal therapy 显示文摘Anne FJ Per Morten Sandset 2012Best Practice & Re-search Clinical Haematology2012,25,3:1
20Catheter-directed Venous Thrombolysis in acute iliofemoral vein thrombosis-the CaVenT Study: Rationale and design of a multicenter, randomized, controlled, clinical trial (NCT00251771)显示文摘Tone Enden Leiv Sandvik Nils-Einar Kl?w Geir Hafsahl P?l Andre Holme Lars Olaf Holmen Waleed Ghanima Anne Mette Njaastad Gunnar Sandb?k Carl-Erik Slagsvold Per Morten Sandset 2007American Heart Journal2007,,5:1
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