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| 1 | Prospective evaluation of small bowel preparation with bisacodyl and sodium phosphate for capsule endoscopy显示文摘AIM: To determine the effect of Prepacol?, a com- bination of sodium phosphate and bisacodyl, on transit and quality of capsule endoscopy (CE). METHODS: Fivety two consecutive patients were included in this prospective study. CE was performed following a 12 h fasting period. Twenty six patients were randomized for additional preparation with Prepacol?. The quality of CE was assessed separately for the proximal and the distal small bowel by 3 experienced endoscopists on the basis of a graduation which was initially developed with 20 previous CE. RESULTS: Preparation with Prepacol? accelerated small bowel transit time (262 ± 55 min vs 287 ± 97 min), but had no effect on the quality of CE. Visibility was significantly reduced in the distal compared to the proximal small bowel. CONCLUSION: The significantly reduced visibility of CE in the distal small bowel allocates the need for a good preparation. Since Prepacol? has no beneficial effect on CE the modality of preparation and the ideal time of application remains unclear. Further standardized examinations are necessary to identify sufficient preparation procedures and to determine the impact of the volume of the preparation solution. | Andreas Franke Frank Hummel Phillip Knebel Christoph Antoni Ulrich Bcker Manfred V Singer Matthias Lhr | 2008 | World Journal of Gastroenterology2008，14，13： | 5 |
| 2 | Enhanced expression of interleukin-18 in serum and pancreas of patients with chronic pancreatitis显示文摘AIM: To investigate interleukin-18 (IL-18) in patients with chronic panreatitis (CP). METHODS: We studied 29 patients with CP and 30 healthy controls. Peripheral blood mononuclear cells (PBMC) were isolated and incubated with 50 mmol/L ethanol, lipopolysaccharide (LPS) (doses 25 g/L, 250 g/L, 2500 g/L) and both agents for 24 h. Levels of IL-18 in the supernatants, and levels of IL-18, IL-12, interferon (IFN)-γ and soluble CD14 in the serum were analysed by ELISA technique. Expression of IL-18 in PBMC was investigated by reverse-transcription (RT)-PCR. IL-18 protein levels in CP tissue and in normal pancreas were studied by ELISA technique. IL-18 levels in PBMC and pancreatic tissue were determined by Westernblot. Im-munohistochemistry for pancreatic IL-18 expression was performed. RESULTS: In patients, IL-18 serum levels were signifi-cantly enhanced by 76% (mean: 289.9 ± 167.7 ng/L) compared with controls (mean: 165.2 ± 43.6 ng/L; P < 0.0005). IL-12 levels were enhanced by 25% in patients (18.3 ± 7.3 ng/L) compared with controls (14.7 ± 6.8ng/L, P = 0.0576) although not reaching the statistical significance. IFN-γ and soluble CD14 levels were not in-creased. In vitro, LPS stimulated significantly and dose-dependently IL-18 secretion from PBMC. Incubation with ethanol reduced LPS-stimulated IL-18 secretion by about 50%. The mRNA expression of IL-18 in PBMC and the response of PBMC to ethanol and LPS was similar in CP patients and controls. In PBMC, no significant differences in IL-18 protein levels were detected between patients and controls. IL-18 protein levels were increased in CP tissues compared to normal pancreatic tissues. IL-18 was expressed by pancreatic acinar cells and by infiltrating inflammatory cells within the pancreas. CONCLUSION: IL-18 originates from the chronically inflammed pancreas and appears to be involved in the fibrotic destruction of the organ. | Alexander Schneider Stephan L Haas Ralf Hildenbrand Sren Siegmund Iris Reinhard Helmut Nakovics Manfred V Singer Peter Feick | 2006 | World Journal of Gastroenterology2006，12，40： | 4 |
| 3 | PI 3-kinase pathway is responsible for antiapoptotic effects of atrial natriuretic peptide in rat liver transplantation显示文摘AIM:To investigate the in vivo effect of atrial natriureticpeptide(ANP)and its signaling pathway during ortho-topic rat liver transplantation.METHODS:Rats were infused with NaCl,ANP(5 μg/kg),wortmannin(WM,16 μg/kg),or a combination ofboth for 20 min.Livers were stored in UW solution(4°C)for 24 h,transplanted and reperfused.Apoptosis wasexamined by caspase-3 activity and TUNEL staining.Phosphorylation of Akt and Bad was visualized by West-ern blotting and phospho-Akt-localization by confocalmicroscopy.RESULTS:ANP-pretreatment decreased caspase-3activity and TUNEL-positive cells after cold ischemia,indicating antiapoptotic effects of ANP in vivo.The an-tiapoptotic signaling of ANP was most likely caused byphosphorylation of Akt and Bad,since pretreatment withPI 3-kinase inhibitor WM abrogated the ANP-inducedreduction of caspase-3 activity.Interestingly,analysis ofliver tissue by confocal microscopy showed translocationof phosphorylated Akt to the plasma membrane of hepa-tocytes evoked by ANP.CONCLUSION:ANP activates the PI-3-kinase pathwayin the liver in vivo leading to phosphorylation of Bad, an event triggering antiapoptotic signaling cascade inischemic liver. | Uwe Grutzner Melanie Keller Michael Bach Alexandra K Kiemer Herbert Meissner Manfred Bilzer Stefan Zahler Alexander L Gerbes Angelika M Vollmar | 2006 | World Journal of Gastroenterology2006，12，7： | 3 |
| 4 | Endometrial receptivity in an in vitro fertilization program as assessed by spiral artery blood flow, endometrial thickness, endometrial volume, and uterine artery blood flow显示文摘 | Ralf L Schild Christine Knobloch Christoph Dorn Rolf Fimmers Hans van der Ven Manfred Hansmann | 2001 | Fertility and Sterility2001，，2： | 2 |
| 5 | Performance, structure, and mechanism of CeO 2 in HCl oxidation to Cl 2显示文摘 | Amol P. Amrute Cecilia Mondelli Maximilian Moser Gerard Novell-Leruth Núria López Dirk Rosenthal Ramzi Farra Manfred E. Schuster Detre Teschner Timm Schmidt Javier Pérez-Ramírez | 2011 | Journal of Catalysis2011，，： | 2 |
| 6 | Examining the global environmental impact of regional consumption activities-Part 1: A technical note on combining input-output and ecological footprint analysis显示文摘 | Karen T Manfred L Thomas W John B | 2007 | Ecological Economics2007，62，： | 1 |
| 7 | Environmental impact assessment including indirect effects-a case study using input-output analysis显示文摘 | MANFRED L SHAUNA A M BRITTA K | 2003 | Environmental Impact Assessment Review2003，23，3： | 1 |
| 8 | Synthese von monomeren auf der basis yon naphthalin und fluoren 显示文摘 | Manfred L Hallensleben Hartrnut Kansy | 1989 | Makromol Chem1989，190，： | 1 |
| 9 | Decompression sickness in a sea-hedgehog diver显示文摘 | Giovita AP Aurelio P L Manfrè | | 0，，01： | 1 |
| 10 | An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow显示文摘 | Manfred BL Nicole K Alexandra L | 1999 | J Immunol Methods1999，223，1： | 1 |
| 11 | A consistent input-output formulation of shared consumer and producer responsibility 显示文摘 | Blanca G Manfred L | 2005 | Economic Systems Research2005，17，4： | 1 |
| 12 | Shared producer and consumerresponsibility: theory and practice 显示文摘 | Manfred L Joy M Fabian S | 2007 | Ecological Economics2007，61，1： | 1 |
| 13 | Granulocyte colony-stimulating factor to prevent the progression of systemic nonresponsiveness in systemic inflammatory response syndrome and sepsis显示文摘 | Manfred W Lyle L M Schneider E M | 1999 | Blood1999，93，2： | 1 |
| 14 | MR dacryocystography:comparison with dacryocystography and CT dacryocystography显示文摘 | Manfrè L de Maria M Todaro E Mangiameli A Ponte F Lagalla R | | 0，，06： | 1 |
| 15 | A modified ecological footprint method and its application to Australia 显示文摘 | Manfred L | 2001 | Ecological Economics2001，，7： | 1 |
| 16 | A new and efficient algorithm for the inverse kinematics of a general serial 6R manipulator显示文摘 | Manfred L Husty Martin Pfurner Hans-Peter Schrocker | 2007 | Mechanism and Machine Theory2007，42，1： | 1 |
| 17 | Some recent trends in research and technology of advanced thermal barrier coatings显示文摘 | Uwe Schulz Christoph Leyens Klaus Fritscher Manfred Peters Bilge Saruhan-Brings Odile Lavigne Jean-Marc Dorvaux Martine Poulain Remy Mévrel Micha?l Caliez | 2002 | Aerospace Science and Technology2002，，1： | 1 |
| 18 | Nanosatellite and microsystem technology capabilitis, limitation and applications显示文摘 | M Seven K Manfred L Norbert | 2005 | Acta Astron2005，39，4： | 1 |
| 19 | Isolation and characterization of a 2-(2, 4-dichlorophenoxy) propionic acid-degrading soil bacterium显示文摘 | Manfred H Gtinther D Michael L | 1990 | Applied Microbiology and Biotechnology1990，33，2： | 1 |
| 20 | Zika virus in Gabon(Central Africa)-2007:a new threat from Aedes albopictus?显示文摘 | Grard G Mélanie C Illich Manfred M DieudonnéN Statiana MO Davy J Didier F Christophe P Eric Maurice L | 2014 | PLoS Negl Trop Dis2014，8，2： | 1 |
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