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| 1 | 酒精对男性生殖功能有何影响?一个文献综述显示文摘酒精被广泛使用,而其对男性生殖功能的影响仍然存在争议。多年来,已经有许多研究调查了酒精对精子参数男性不育症的影响。本文综述了主要的临床前和临床证据。对实验动物进行的研究已经表明,富含乙醇的饮食会导致精子参数异常,导致很多改变,包括抑制生殖道,降低小鼠卵母细胞体外受精率。这些影响在停止酒精消费后是部分可逆的。大多数研究显示酒精对男性参数呈现负面影响。这已被报道与低睾酮症和低于正常和升高的促性腺激素水平有关,暗示着一个联合中枢的、酒精产生的睾丸损害效应。然而,饮洒似乎并没有对生育有太大的影响,无论是在体外授精过程中还是在基于人口的研究中。最后,遗传背景和其他因素,饮酒相关情况会影响睾丸损害的程度。总之,饮酒与精子参数的恶化有关,且这种恶化在停止饮酒后部分可逆。 | Sandro La Vignera Rosita A Condorelli Giancarlo Balercia Enzo Vicari Aldo E Calogero | 2013 | Asian Journal of Andrology2013,15,2: | 9 |
| 2 | Seminal vesicles and diabetic neuropathy: ultrasound evaluation in patients with couple infertility and different levels of glycaemic control显示文摘这研究的目的是与糖尿病 mellitus (DM ) 和糖尿病的神经病(DN ) 评估不肥沃的病人的精囊(SV ) 的超声特征并且在与 glycaemic 控制有关的超声特征调查可能的变化。完成这,有类型 2 DM 的 45 个不肥沃的病人和征兆的 DN 被选择。有没有 DM 的自发的 oligoasthenoteratozoospermia 的二十个健康的肥沃的人和 20 个病人代表了控制组。DM 病人任意地根据 glycaemic 控制水平被划分成三个组(A=glycosylated 血色素 < 7 %在 7 % 之间的 B=glycosylated 血色素;并且 10 %C=glycosylated 血色素 > 10 %) 。病人们经历了前列腺小囊的 transrectal ultrasonography 和精子分析。下列 SV 超声参数被记录:(i) 身体 antero 以后的直径(APD ) ;(ii ) 宫底 APD;(iii ) 正确、左的 SV 的顶骨厚度;并且(iv ) 在两 SV 以内的多不的区域的数字。我们然后计算了下列参数:(i) 宫底 / 身体(F/B ) 比率;(ii ) 在权利和左 SV 之间的顶骨厚度的差别;并且(iii )pre 射精并且 ejaculatory 以后 APD 差别。所有 DM 病人与控制相比有更高的 F/B 比率(P< 0.05 ) 。组 C 与另外的 DM 组相比有更高的 F/B 比率(P< 0.05 ) 。有的所有 DM 病人一更低 pre 射精并且与控制相比的身体 SV APD 的 ejaculatory 以后差别(P< 0.05 ) 。组 A 和 B 有一类似 pre 射精并且身体 SV APD 的 ejaculatory 以后差别,而这差别在组 C 是更低的(P< 0.05 ) 。在结论,有 DN 的不肥沃的 DM 病人显示出功能的弛缓暗示的古怪 SV 超声特征,并且低 glycaemic 控制与这些特征的更大的表示被联系。 | Sandro La Vignera Rosita A Condorelli Enzo Vicari Rosario D'Agata Aldo E Calogero | 2011 | Asian Journal of Andrology2011,13,6: | 8 |
| 3 | 伴随自主神经病变的二型糖尿病人中雄附腺炎症的发病率显示文摘雄附腺炎(MAGI)在二型糖尿病人(DM2)当中可能被漏诊。近期文献报道TDM2中MAGI的发病率是43%。以往的研究证明糖尿病患者的自主神经病变与精子囊泡的特有超声波有关。本项研究意在评估二类DM2患者(是否具有自主神经病变)的MAGI发病率并测定各自的超声特征。共60例DM2患者(平均年龄42.0±6.0岁)根据是否具有自主神经病变分为二组(A组具有可能的神经病变症状共28人,B组无神经病变症状共32人)。结果发现A组较B组有更高的MAGI发病率及精囊炎的超声频率。此外,A组患者精液中的淋巴细胞聚焦浓度显著高于B组。 | Rosita A Condorelli Enzo Vicari Aldo E Calogero Sandro La Vignera | 2014 | Asian Journal of Andrology2014,16,5: | 6 |
| 4 | Acquired premature ejaculation and male accessory gland infection: relevance of ultrasound examination显示文摘我们以前与男附件腺感染(东方三博士) 在病人之中表明了早泄(PE ) 的高频率。这研究的目的是评估有东方三博士和获得的早泄(无尾猿) 的病人的特征联系了的超声(美国)(MAGI-APEpos ) 。与有没有代表控制组的 PE (MAGI-PEneg ) 的东方三博士的 50 个病人相比的 50 个 MAGI-APEpos 病人的美国评估。无尾猿的诊断通过 Intravaginal 射精潜伏时间(IELT ) 的评估被做并且与问询表 PEDT (早泄诊断工具) 证实了。主要结果措施被暗示的美国标准的频率代表 P (前列腺炎) , V (vesiculitis ) ,和在 MAGI-APEpos 和 MAGI-PEneg 病人的 E (附睾炎) 。MAGI-APEpos 病人显示出与 MAGI-PEneg 病人相比显著地更高的美国标准的一个全部的数字。MAGI-APEpos 显示出 V 和 E (东方三博士的复杂形式) 的美国标准的更高的频率。在 MAGI-APEpos 组,最后,它被发现在 epididymis 的尾的道和精囊的 APD 的 anteroposterior 直径(APD ) 之间,以及在直径和 PEDT 分数之间的一种积极关系。MAGI-APEpos 病人与 MAGI-PEneg 病人相比有古怪美国描述。根据这些结果, epididymal 并且小囊的道应该与东方三博士和无尾猿在病人的实际临床的途径被考虑的 prostato 的美国评估。特别地,它能是对在这些病人的这个临床的问题的可能的 pathophysiological 解释的支持。 | Sandro La Vignera Rosita A Condorelli Enzo Vicari Vincenzo Favilla Giuseppe Morgia Aldo E Calogero | 2016 | Asian Journal of Andrology2016,18,5: | 5 |
| 5 | 慢性细菌性前列腺炎和肠易激综合征:利福昔明联合益生菌VSL#3的治疗效果显示文摘本研究评价了利福昔明联合益生菌VSL#3对慢性前列腺炎转化为微生物性前列腺精囊炎(PV)或前列腺精囊附睾炎(PVE)的作用。106例伴有细菌学治愈的慢性细胞性前列腺炎和肠易激综合征的男性不育患者随机予以利福昔明(200mg,20:/日,每月服用7日,持续12个月)和益生菌VSL#3(450×10^9CFU/日)治疗及无处理。95名患者(89.6%)完成治疗计划,纳入本研究。将患者分为四组:A组前6个月予治疗,后6月无治疗(n=26);B组予12个月治疗(n=22);C组前6个月不予治疗后6个月予治疗(n=23);D组在12个月内均无治疗(n=24)。A组和B组患者慢性前列腺炎发生率最高(分别为88.5%和86.4%)。相反,D组患者前列腺炎发生率最低(33.4%)。前列腺炎进展为PV的发生率在B组(15.5%)和C组(13.6%)低于D组(45.8%)。B组和C组最终无患者进展为PVE,而D组有20.8%诊断为PVE。长期服用利福昔明联合益生菌VSL#3能有效降低伴有治愈的CBP伴IBS的男性不育患者的前列腺炎进展为更复杂形式的男性附属性腺感染。 | Enzo Vicari Sandro La Vignera Roberto Castiglione Rosita A Condorelli Lucia O Vicari Aldo E Calogero | 2014 | Asian Journal of Andrology2014,16,5: | 3 |
| 6 | Transrectal ultrasonography in infertile patients with persistently elevated bacteriospermia显示文摘瞄准:为了识别并且定义前列腺和精囊,在失败了到的有长期的男附件腺感染(东方三博士) 的病人的畸形对抗菌剂治疗作出回应。方法:我们与东方三博士选择了 67 个连续病人并且固执地提高了 bacteriospermia (≥
10 6 殖民地形成单位[CFU ]/mL ) 在三堂抗菌素功课以后。十四个不肥沃的病人与起始长期微生物引起(≥
10 6 CFU/mL ) 东方三博士对抗菌剂治疗作出回应(<
10 3 CFU/mL ) 担任了一个控制组。所有病人和控制经历了 transrectal ultrasonography (TRUS ) 扫描和精液分析。有低精液的血浆体积的病人(<
1.5 mL ) 经历 pre 射精并且 ejaculatory 以后 TRUS 检查。结果:TRUS 揭示了指示的多重畸形:(i) 双性人旁边地扩大了 prostato-vesiculitis (组 A:52 个盒子, 77.6%)( 九个这些病人也有 micro-emphyse-matous 前列腺脓肿) ;并且(i i ) 有射精管的单方或双边的亚阻塞的 prostato-vesiculitis (组 B:15 个盒子, 22.4%) 。吝啬的精子集中,全部的精子数字,精液体积和 pH 价值比在组 B 在组 A 是显著地更高的。另外,前面的活动性和正常的百分比形成的精子比在控制显著地更坏,而白血球集中在组 A 是显著地更高的。组 B 病人有所有精子参数,而是他们的 pH 值,与那些显著地不同控制。结论:尽管当微生物引起的东方三博士被怀疑时,抗菌素治疗被认为合适,根据常规标准仅仅说明对抗菌素的差的回答是不可能的(临床的历史,物理并且精液符号) 。因此, TRUS 可能在这些病人的后续是有用的。 | Sandro La Vignera Aldo E. Calogero Alessandro Arancio Roberto Castiglione Gaetano De Grande Enzo Vicari | 2008 | Asian Journal of Andrology2008,10,5: | 3 |
| 7 | FSH dosage effect on conventional sperm parameters:a meta-analysis of randomized controlled studies显示文摘Follicle-stimulating hormone(FSH)represents a therapeutic option in normogonadotropic patients with idiopathic oligozoospermia.The aim of this review was to evaluate the possible dose-and drug-dependent efficacy of FSH treatment on conventional sperm parameters.We performed a comprehensive systematic review via a meta-analysis of all available randomized controlled trials,in which FSH administration was compared with placebo or no treatment when administered to normogonadotropic patients with idiopathic oligozoospermia.Of the 971 articles that were retrieved,5 were fin ally included,in eluding a total of 372 patie nts and 294 controls.Overall,FSH treatment was effective in ameliorating the sperm concentration,total count,progressive motility,but not normal forms.On the basis of the weekly dosage,the studies were classified into those using low(175-262.5 IU per week),intermediate(350-525 IU per week),and high(700-1050 IU per week)doses.At low doses,FSH improved only sperm motility.At intermediate doses,FSH ameliorated sperm concentration and morphology.Total sperm count and progressive motility showed a trend toward the increase.At high doses,FSH increased sperm concentration,total sperm count,and progressive motility.Sperm morphology showed a trend toward the increase.Finally,both highly purified FSH(hpFSH)and recombinant human FSH(rhFSH)improved sperm concentration,total sperm count,progressive motility,but not morphology.No different efficacy was observed between these two preparations.This meta-analysis provides evidence in favor of high FSH doses.The FSH efficacy was not related to the preparation type(recombinant vs highly purified).Further studies are needed to evaluate the effectiveness of Iong-standing treatment regimes. | Rossella Cannarella Sandro La Vignera Rosita A Condorelli Laura M Mongioi Aldo E Calogero | 2020 | Asian Journal of Andrology2020,22,3: | 2 |
| 8 | Next-generation sequencing:toward an increase in the diagnostic yield in patients with apparently idiopathic spermatogenic failure显示文摘A large proportion of patients with idiopathic spermatogenic failure(SPGF;oligozoospermia or nonobstructive azoospermia[NOA])do not receive a diagnosis despite an extensive diagnostic workup.Recent evidence has shown that the etiology remains undefined in up to 75%of these patients.A number of genes involved in germ-cell proliferation,spermatocyte meiotic divisions,and spermatid development have been called into play in the pathogenesis of idiopathic oligozoospermia or NOA.However,this evidence mainly comes from case reports.Therefore,this study was undertaken to identify the molecular causes of SPGF.To accomplish this,15 genes(USP9Y,NR5A1,KLHL10,ZMYND15,PLK4,TEX15,TEX11,MEIOB,SOHLH1,HSF2,SYCP3,TAF4B,NANOS1,SYCE1,and RHOXF2)involved in idiopathic SPGF were simultaneously analyzed in a cohort of 25 patients with idiopathic oligozoospermia or NOA,accurately selected after a thorough diagnostic workup.After next-generation sequencing(NGS)analysis,we identified the presence of rare variants in the NR5A1 and TEX11 genes with a pathogenic role in 3/25(12.0%)patients.Seventeen other different variants were identified,and among them,13 have never been reported before.Eleven out of 17 variants were likely pathogenic and deserve functional or segregation studies.The genes most frequently mutated were MEIOB,followed by USP9Y,KLHL10,NR5A1,and SOHLH1.No alterations were found in the SYCP3,TAF4B,NANOS1,SYCE1,or RH0XF2 genes.In conclusion,NGS technology,by screening a specific custom-made panel of genes,could help increase the diagnostic rate in patients with idiopathic oligozoospermia or NOA. | Rossella Cannarella Rosita A Condorelli Stefano Paolacci Federica Barbagallo Giulia Guerri Matteo Bertelli Sandro La Vignera Aldo E Calogero | 2021 | Asian Journal of Andrology2021,23,1: | 2 |
| 9 | Effects of Tumour Necrosis Factor-α on Human Sperm Motility and Apoptosis显示文摘 | Anna Perdichizzi Ferdinando Nicoletti Sandro La Vignera Nunziata Barone Rosario D’Agata Enzo Vicari Aldo E. E. Calogero | 2007 | Journal of Clinical Immunology2007,,2: | 2 |
| 10 | Ultrasound characterization of the seminal vesicles in infertile patients with type 2 diabetes mellitus显示文摘 | La Vignera S Vicari E Condorelli R | 2011 | Eur J Radiol2011,80,2: | 1 |
| 11 | Oxidative stress and medical antioxidant treatment in male infertility显示文摘 | Lanzafame F M La Vignera S Vicari E | 2009 | Re- prod Biomed Online2009,19,5: | 1 |
| 12 | Prevalence of Ureaplasma urealyticum and Mycoplasma hominis infection in unselected infertile men 显示文摘 | Salmeri M Valenti D La Vignera S | 2012 | Chemother2012,24,2: | 1 |
| 13 | Diabetes mellitus and spermparameters显示文摘 | La Vignera S Condorelli R Vieari E | 2012 | J Androl2012,33,2: | 1 |
| 14 | Negative effect of increased body weight on sperm conventional and nonconventional flow cytometric sperm parameters 显示文摘 | La Vignera S Condorelli R A Vicari E | 2012 | J Androl2012,33,1: | 1 |
| 15 | Oxidative stress and medical antioxidant treatment in male infertility显示文摘 | Lanzafame FM La Vignera S Vicari E | 2009 | Reprod Biomed Online2009,19,5: | 1 |
| 16 | High prevalence of thyroid dysfunction in pregnant women显示文摘 | Altomare M La Vignera S Asero P | 2013 | J Endocrinol Invest2013,36,6: | 1 |
| 17 | Oxidative stress and medical antioxidant treatment in male infertility 显示文摘 | Lanzafame FM La Vignera S Vicari E | 2009 | Reprod Bi- orned Online2009,19,5: | 1 |
| 18 | Endothelial dys- function and subclinical hypothyroidism: a brief review显示文摘 | La Vignera S Condorelli R Vicari E | 2012 | J Endocrinol Invest2012,35,1: | 1 |
| 19 | Prevalence of Ureaplasma urealyticum and Mycoplasma hominisinfection in unselected infertile men显示文摘 | Mario Salmeri Daniela Valenti Sandro La Vignera | 2012 | Journal of Chemotherapy2012,24,2: | 1 |
| 20 | Oxida- live stress and medical antioxidant treatment ill male infertility 显示文摘 | LANZAFAMEFM LA VIGNERAS V etal | 2009 | Reprod Biomed Online2009,19,5: | 1 |