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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | The Mediterranean diet improves hepatic steatosis and insulin sensitivity in individuals with non-alcoholic fatty liver disease显示文摘 | Marno C. Ryan Catherine Itsiopoulos Tania Thodis Glenn Ward Nicholas Trost Sophie Hofferberth Kerin O’Dea Paul V. Desmond Nathan A. Johnson Andrew M. Wilson | 2013 | Journal of Hepatology2013，，1： | 6 |
| 3 | Cytoplasmic expression of p27^(kip1) is associated with a favourable prognosis in colorectal cancer patients显示文摘AIM: To evaluate the prognostic significance of p27kip1 in colorectal cancer patients. METHODS: Cytoplasmic and nuclear p27kip1 expression was evaluated in 418 colorectal cancers using tissue microarrays. Data were associated with known patient and tumor variables and long-term patient outcomes, providing further insight into the mechanisms by which p27kip1 may influence tumor development. RESULTS: Nuclear and cytoplasmic p27Kip1 expressions were detected in 59% and 19% of tumors respectively. Cytoplasmic p27Kip1 was almost invariably associated with positive nuclear p27Kip1 expression. Neither case correlat- ed with known clinical or pathological variables, includ- ing tumor stage, grade or extramural vascular invasion. Furthermore, nuclear p27kip1 expression had no impact on survival. However, we identified a significant correla- tion between expression of cytoplasmic p27kip1 and longer disease-specific survival times. On multivariate analysis, TNM stage and extramural vascular invasion were highly significant independent prognostic factors, with positive cytoplasmic p27 expression showing a trend towards im- proved patient survival (P = 0.059).CONCLUSION: These findings support the recent evi- dence that cytoplasmic p27kip1 has a distinct and impor- tant biological role that can influence tumor outcome. | Nicholas FS Watson Lindy G Durrant John H Scholefield Zahra Madjd Duncan Scrimgeour Ian Spendlove Ian O Ellis Poulam M Patel | 2006 | World Journal of Gastroenterology2006，12，39： | 3 |
| 4 | CpG Island methylation in sporadic colorectal cancers and its relationship to microsatellite instability显示文摘 | Nicholas Hawkins Mark Norrie Kay Cheong Elisa Mokany Su-Lyn Ku Alan Meagher Terence O’connor Robyn Ward | 2002 | Gastroenterology2002，，： | 2 |
| 5 | The International Position on Laparoscopic Liver Surgery: The Louisville Statement, 2008显示文摘 | Joseph F. Buell Daniel Cherqui David A. Geller Nicholas O’Rourke David Iannitti Ibrahim Dagher Alan J. Koffron Mark Thomas Brice Gayet Ho Seong Han Go Wakabayashi Giulio Belli Hironori Kaneko Chen-Guo Ker Olivier Scatton Alexis Laurent Eddie K. Abdalla Pr | 2009 | Annals of Surgery2009，，3： | 2 |
| 6 | The International Position on Laparoscopic Liver Surgery: The Louisville Statement, 2008显示文摘 | Joseph F. Buell Daniel Cherqui David A. Geller Nicholas O'Rourke David Iannitti Ibrahim Dagher Alan J. Koffron Mark Thomas Brice Gayet Ho Seong Han Go Wakabayashi Giulio Belli Hironori Kaneko Chen-Guo Ker Olivier Scatton Alexis Laurent Eddie K. Abdalla Pr | 2009 | Annals of Surgery2009，，3： | 2 |
| 7 | Autoantigen based vac- cines for type 1 diabetes显示文摘 | Nicholas D Odumosu O Langridge W H | 2011 | Discov Med2011，11，59： | 1 |
| 8 | Circulating CD 56dim natural killer cells and CD 56+ T cells that produce interferon‐ γ or interleukin‐10 are expanded in asymptomatic, E antigen‐negative patients with persistent hepatitis B virus infection显示文摘 | M. J. Conroy R. Mac Nicholas R. Grealy M. Taylor J. A. Otegbayo S. O’Dea F. Mulcahy T. Ryan S. Norris D. G. Doherty | 2015 | J Viral Hepat2015，，3： | 1 |
| 9 | Laparoscopic right hepatectomy: Surgical technique显示文摘 | Nicholas O’Rourke F.R.A.C.S. George Fielding F.R.C.S. F.R.A.C.S | 2004 | Journal of Gastrointestinal Surgery2004，，2： | 1 |
| 10 | Structural and mechanistic investigation of a phosphatemodified HZSM-5 catalyst for methanol conversion显示文摘 | Abubakar S M Marcus D M Lee J C Ehresmann J O Chen C Y Kletnieks P W Guenther D R Hayman M J Pavlova M Nicholas J B Haw J F | | 0，，10： | 1 |
| 11 | Development and validation of a method for analysis of 'dioxin-like' PCBs inenvironmental samples from the steel industry显示文摘 | ERIC A DAVID A NICHOLAS O | 2004 | Chemosphere2004，54，1： | 1 |
| 12 | Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles显示文摘 | Donald E O Nicholas A P | 2006 | Int J Pharm2006，307，1： | 1 |
| 13 | A highly modular adaptive lattice algorithm for multi-channel least squares filtering显示文摘 | George O G Nicholas K | 1995 | IEEE Trans Signal Processing1995，46，1： | 1 |
| 14 | In Search of the Drivers of High Growth in Manufacturing SMEs显示文摘 | Nicholas O' Rcgan Abby C-hobadian David Gallenr | 2006 | Technovatian2006，，26： | 1 |
| 15 | Laparoscopic right hepatectomy: Surgical technique显示文摘 | Nicholas O’Rourke F.R.A.C.S. George Fielding F.R.C.S. F.R.A.C.S | 2004 | Journal of Gastrointestinal Surgery2004，，2： | 1 |
| 16 | Development and validation of a method for analysis of 'dioxin-like' PCBs in environmental samples from the steel industry显示文摘 | David RA Nicholas O | 2004 | Chemosphere2004，54，： | 1 |
| 17 | A generalized Petri net modeling approach for the control of re-entrant flow semiconductor wafer fabrication显示文摘 | Nicholas G O Jonathan D G Adrienne A | 2001 | Robotics and Computer Integrated Manufacturing2001，17，： | 1 |
| 18 | A New Business Model for Baby Prams Based on Leasing and Product Remanufacturing 显示文摘 | Mont O Carl A D Nicholas J | 2006 | Journal of Cleaner Production2006，14，17： | 1 |
| 19 | Food -poisoning due to copper in the morining tea显示文摘 | Nicholas P O | 1968 | Lancet1968，，2： | 1 |
| 20 | The wetting and bonding of diamonds by copper-base binary alloys 显示文摘 | Scott O M Nicholas M | 1975 | J Mater Sci1975，10，： | 1 |
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