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| 1 | Optimizing hepatitis C virus treatment through pharmacist interventions: Identification and management of drug-drug interactions显示文摘AIM To quantify drug-drug-interactions(DDIs) encountered in patients prescribed hepatitis C virus(HCV) treatment, the interventions made, and the time spent in this process.METHODS As standard of care, a clinical pharmacist screened for DDIs in patients prescribed direct acting antiviral(DAA) HCV treatment between November 2013 and July 2015 at the University of Colorado Hepatology Clinic. HCV regimens prescribed included ledipasvir/sofosbuvir(LDV/SOF), paritaprevir/ritonavir/ombitasvir/dasabuvir(OBV/PTV/r + DSV), simeprevir/sofosbuvir (SIM/SOF), and sofosbuvir/ribavirin (SOF/RBV). This retrospective analysis reviewed the work completed by the clinical pharmacist in order to measure the aims identified for the study. The number and type of DDIs identified were summarized with descriptive statistics.RESULTS Six hundred and sixty four patients(83.4% Caucasian, 57% male, average 56.7 years old) were identified; 369 for LDV/SOF, 48 for OBV/PTV/r + DSV, 114 for SIM/SOF, and 133 for SOF/RBV. Fifty-one point five per cent of patients were cirrhotic. Overall, 5217 medications were reviewed (7.86 medications per patient) and 781 interactions identified (1.18 interactions per patient). The number of interactions were fewest for SOF/RBV (0.17 interactions per patient) and highest for OBV/PTV/r + DSV (2.48 interactions per patient). LDV/SOF and SIM/SOF had similar number of interactions (1.28 and 1.48 interactions per patient, respectively). Gastric acid modifiers and vitamin/herbal supplements commonly caused interactions with LDV/SOF. Hypertensive agents, analgesics, and psychiatric medications frequently caused interactions with OBV/PTV/r + DSV and SIM/SOF. To manage these interactions, the pharmacists most often recommended discontinuing the medication (28.9%), increasing monitoring for toxicities (24.1%), or separating administration times (18.2%). The pharmacist chart review for each patient usually took approximately 30 min, with additional time for more complex patients. CONCLUSION DDIs are common with HCV medications and management can require medication adjustments and increased monitoring. An interdisciplinary team including a clinical pharmacist can optimize patient care. | Jacob A Langness Matthew Nguyen Amanda Wieland Gregory T Everson Jennifer J Kiser | 2017 | World Journal of Gastroenterology2017，23，9： | 5 |
| 2 | Use of the Endocuff during routine colonoscopy examination improves adenoma detection: A meta-analysis显示文摘AIM To perform meta-analysis of the use of Endocuff during average risk screening colonoscopy.METHODS Scopus, Cochrane databases, MEDLINE/Pub Med, and CINAHL were searched in April 2016. Abstracts from Digestive Disease Week, United European Gastroenterology, and the American College of Gastroenterology meeting were also searched from 2004-2015. Studies comparing EC-assisted colonoscopy(EAC) to standard colonoscopy, for any indication, were included in the analysis. The analysis was conducted by using the Mantel-Haenszel or DerS imonian and Laird models with the odds ratio(OR) to assess adenoma detection, cecal intubation rate, and complications performed. RESULTS Nine studies(n = 5624 patients) were included in the analysis. Compared to standard colonoscopy, procedures performed with EC had higher frequencies for adenoma(OR = 1.49, 95%CI: 1.23-1.80; P = 0.03), and sessile serrated adenomas detection(OR = 2.34 95%CI: 1.63-3.36; P < 0.001). There was no significant difference in cecal intubation rates between the EACgroup and standard colonoscopy(OR = 1.26, 95%CI: 0.70-2.27, I2 = 0%; P = 0.44). EAC was associated with a higher risk of complications, most commonly being superficial mucosal injury without higher frequency for perforation.CONCLUSION The use of an EC on colonoscopy appears to improve pre-cancerous polyp detection without any difference in cecal intubation rates compared to standard colonoscopy. | Matthew Chin William Karnes M Mazen Jamal John G Lee Robert Lee Jason Samarasena Matthew L Bechtold Douglas L Nguyen | 2016 | World Journal of Gastroenterology2016，22，43： | 4 |
| 3 | GD2+ cancer stem cells in triple-negative breast cancer:mechanisms of resistance to breast cancer therapies显示文摘Research has led to the development of tailored treatment options for different cancers in different patients.Despite some treatments being able to provide remarkable responses,nearly all current treatments encounter the same issue:resistance.Here,we discuss our experiences with how breast cancers resist therapies.The focus of our discussion revolves around the cancer stem cell subpopulation and their mechanisms for resistance. | Khoa Nguyen Emily McConnell Orielle Edwards Bridgette M.Collins-Burow Matthew E.Burow | 2022 | Cancer Drug Resistance2022，5，3： | 2 |
| 4 | Bleeding risk with clopidogrel and percutaneous endoscopic gastrostomy显示文摘AIM To compare bleeding within 48 h in patients undergoing percutaneous endoscopic gastrostomy(PEG) with or without clopidogrel.METHODS After institutional review board approval, a retrospective study involving a single center was conducted on adult patients having PEG(1/08-1/14). Patients were divided into two groups: Clopidogrel group consisting of those patients taking clopidogrel within 5 d of PEG and the non-clopidogrel group including those patients not taking clopidogrel within 5 d of the PEG.RESULTS Three hundred and nineteen PEG patients were found. One hundred and sixty-eight males and 151 females with mean body mass index 28.47 ± 9.75 kg/m2 and mean age 65.03 ± 16.11 years were identified. Thirtythree patients were on clopidogrel prior to PEG with 286 patients not on clopidogrel. No patients in either group developed hematochezia, melena, or hematemesiswithin 48 h of percutaneous endoscopic gastrostomy(PEG). No statistical differences were observed between the two groups with 48 h for hemoglobin decrease of > 2 g/dL(2 vs 5 patients; P = 0.16), blood transfusions(2 vs 7 patients; P = 0.24), and repeat endoscopy for possible gastrointestinal bleeding(no patients in either group). CONCLUSION Based on the results, no significant post-procedure bleeding was observed in patients undergoing PEG with recent use of clopidogrel. | Umair Sohail Chela Harleen Amin O Mahdi Murtaza Arif Douglas L Nguyen Matthew L Bechtold | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，16： | 2 |
| 5 | Comparison of laparoscopic versus open appendectomy for acute nonperforated and perforated appendicitis in the obese population显示文摘 | Hossein Masoomi Ninh T. Nguyen Matthew O. Dolich Lauren Wikholm Nassim Naderi Steven Mills Michael J. Stamos | 2011 | The American Journal of Surgery2011，，6： | 2 |
| 6 | Modeling of cast systems using smoothed-particle hydrodynamics显示文摘 | Paul Cleary Mahesh Prakash Joseph Ha Matthew Sinnott Thang Nguyen John Grandfield | 2004 | JOM2004，，3： | 1 |
| 7 | Enhanced pre-synaptic glutamate release in deep-dorsal horn contributes to calcium channel alpha-2-delta-1 protein-mediated spinal sensitization and behavioral hypersensitivity显示文摘 | Nguyen D Deng P Matthews E A | | 0，，： | 1 |
| 8 | Prophylactic tracheal intubation for upper GI bleeding: A meta-analysis显示文摘AIM: To evaluate usefulness of prophylactically intubating upper gastrointestinal bleeding(UGIB) patients. METHODS: UGIB results in a significant number of hospital admissions annually with endoscopy being the key intervention. In these patients, risks are associated with the bleeding and the procedure, including pulmonary aspiration. However, very little literature is available assessing the use of prophylactic endotracheal intubation on aspiration in these patients. A comprehensive search was performed in May 2014 in Scopus, CINAHL, Cochrane databases, Pub Med/Medline, Embase, and published abstracts from national gastroenterology meetings in the United States(2004-2014). Included studies examined UGIB patients and compared prophylactic intubation to no intubation before endoscopy. Meta-analysis was conducted using Rev Man 5.2 by Mantel-Haenszel and Der Simonian and Laird models with results presented as odds ratio for aspiration, pneumonia(within 48 h), and mortality. Funnel plots were utilized for publication bias and I2 measure of inconsistency for heterogeneity assessments. RESULTS: Initial search identified 571 articles. Of these articles, 10 relevant peer-reviewed articles in English and two relevant abstracts were selected to review by two independent authors(Almashhrawi AA and Bechtold ML). Of these studies, eight were excluded: Five did not have a control arm, one was a letter the editor, one was a survey study, and one was focused on prevention of UGIB. Therefore, four studies(N = 367) were included. Of the UGIB patients prophylactically intubated before endoscopy, pneumonia(within 48 h) was identified in 20 of 134(14.9%) patients as compared to 5 of 95(5.3%) patients that were not intubated prophylactically(P = 0.02). Despite observed trends, no significantdifferences were found for mortality(P = 0.18) or aspiration(P = 0.11).CONCLUSION: Pneumonia within 48 h is more likely in UGIB patients who received prophylactic endotracheal intubation prior to endoscopy. | Ashraf A Almashhrawi Rubayat Rahman Samuel T Jersak Akwi W Asombang Alisha M Hinds Hazem T Hammad Douglas L Nguyen Matthew L Bechtold | 2015 | World Journal of Meta-Analysis2015，3，1： | 1 |
| 9 | Anticoagulation monitoring during extracorporeal membrane oxygenation:Is anti-factor Xa assay (heparin level) a better test?显示文摘 | Trung Nguyen Matthew Musick Jun | 2014 | Pedi- atric Critical Care Medicine:A Journal of the Soeiety of Critical Care Medicine and the World Federation of Pedi- atric Intensive and Critical Care Societies2014，15，2： | 1 |
| 10 | Enhanced pre-synaptic glutamate release in deep--dorsal horn contributes to calcium chan- nel alpha-2-delta-1 protein-mediated spinal sensitization and be- havioral hypersensitivity显示文摘 | Nguyen D Deng P Matthews EA | 2009 | Mol Pain2009，5，： | 1 |
| 11 | Struetrue and membrane topology of TAPA-1 显示文摘 | Shoshana L Nguyen VQ Matthew L | 1991 | J Bio Chem1991，266，14： | 1 |
| 12 | A Prospective, Randomized, Controlled Trial of Single-Incision Laparoscopic (SILS) versus Conventional 3-port Laparoscopic Appendectomy for the Treatment of Acute Appendicitis显示文摘 | Jonathan T. Carter Jennifer A. Kaplan Jason N. Nguyen Matthew Y.C. Lin Stanley J. Rogers Hobart W. Harris | 2013 | Journal of the American College of Surgeons2013，，： | 1 |
| 13 | Fitness and physical activity in youth with type 1 diabetes mellitus in good or poor glycemic control显示文摘 | Thanh Nguyen Joyce Obeid Rachel G Walker Matthew P Krause Thomas J Hawke Karen McAssey John Vandermeulen Brian W Timmons | 2015 | Pediatr Diabetes2015，，1： | 1 |
| 14 | Does Laparoscopic Appendectomy Impart an Advantage over Open Appendectomy in Elderly Patients?显示文摘 | Hossein Masoomi Steven Mills Matthew Dolich Noor Ketana Joseph Carmichael Ninh Nguyen Michael Stamos | 2012 | World Journal of Surgery2012，，7： | 1 |
| 15 | Primary Endpoint Results of a Phase II Study of Vascular Endothelial Growth Factor Trap-Eye in Wet Age-related Macular Degeneration显示文摘 | David M. Brown Jeffrey S. Heier Thomas Ciulla Matthew Benz Prema Abraham George Yancopoulos Neil Stahl Avner Ingerman Robert Vitti Alyson J. Berliner Ke Yang Quan Dong Nguyen | 2011 | Ophthalmology2011，，6： | 1 |
| 16 | FungalTraits:a user-friendly traits database of fungi and fungus-like stramenopiles显示文摘The cryptic lifestyle of most fungi necessitates molecular identification of the guild in environmental studies.Over the past decades,rapid development and affordability of molecular tools have tremendously improved insights of the fungal diversity in all ecosystems and habitats.Yet,in spite of the progress of molecular methods,knowledge about functional properties of the fungal taxa is vague and interpretation of environmental studies in an ecologically meaningful manner remains challenging.In order to facilitate functional assignments and ecological interpretation of environmental studies we introduce a user friendly traits and character database FungalTraits operating at genus and species hypothesis levels.Combining the information from previous efforts such as FUNGuild and FunFun together with involvement of expert knowledge,we reannotated 10,210 and 151 fungal and Stramenopila genera,respectively.This resulted in a stand-alone spreadsheet dataset covering 17 lifestyle related traits of fungal and Stramenopila genera,designed for rapid functional assignments of environmental stud-ies.In order to assign the trait states to fungal species hypotheses,the scientific community of experts manually categorised and assigned available trait information to 697,413 fungal ITS sequences.On the basis of those sequences we were able to summarise trait and host information into 92,623 fungal species hypotheses at 1%dissimilarity threshold. | Sergei Põlme Kessy Abarenkov RHenrik Nilsson Björn D.Lindahl Karina Engelbrecht Clemmensen Havard Kauserud Nhu Nguyen Rasmus Kjøller Scott T.Bates Petr Baldrian Tobias Guldberg Frøslev Kristjan Adojaan Alfredo Vizzini Ave Suija Donald Pfister Hans-Otto Baral Helle Järv Hugo Madrid Jenni Nordén Jian-Kui Liu Julia Pawlowska Kadri Põldmaa Kadri Pärtel Kadri Runnel Karen Hansen Karl-Henrik Larsson Kevin David Hyde Marcelo Sandoval-Denis Matthew E.Smith Merje Toome-Heller Nalin N.Wijayawardene Nelson Menolli Jr Nicole K.Reynolds Rein Drenkhan Sajeewa S.N.Maharachchikumbura Tatiana B.Gibertoni Thomas Læssøe William Davis Yuri Tokarev Adriana Corrales Adriene Mayra Soares Ahto Agan Alexandre Reis Machado Andrés Argüelles-Moyao Andrew Detheridge Angelina de Meiras-Ottoni Annemieke Verbeken Arun Kumar Dutta Bao-Kai Cui C.K.Pradeep César Marín Daniel Stanton Daniyal Gohar Dhanushka N.Wanasinghe Eveli Otsing Farzad Aslani Gareth W.Griffith Thorsten H.Lumbsch Hans-Peter Grossart Hossein Masigol Ina Timling Inga Hiiesalu Jane Oja John Y.Kupagme József Geml Julieta Alvarez-Manjarrez Kai Ilves Kaire Loit Kalev Adamson Kazuhide Nara Kati Küngas Keilor Rojas-Jimenez Krišs Bitenieks Laszlo Irinyi LászlóGNagy Liina Soonvald Li-Wei Zhou Lysett Wagner M.Catherine Aime MaarjaÖpik María Isabel Mujica Martin Metsoja Martin Ryberg Martti Vasar Masao Murata Matthew PNelsen Michelle Cleary Milan C.Samarakoon Mingkwan Doilom Mohammad Bahram Niloufar Hagh-Doust Olesya Dulya Peter Johnston Petr Kohout Qian Chen Qing Tian Rajasree Nandi Rasekh Amiri Rekhani Hansika Perera Renata dos Santos Chikowski Renato L.Mendes-Alvarenga Roberto Garibay-Orijel Robin Gielen Rungtiwa Phookamsak Ruvishika S.Jayawardena Saleh Rahimlou Samantha C.Karunarathna Saowaluck Tibpromma Shawn P.Brown Siim-Kaarel Sepp Sunil Mundra Zhu-Hua Luo Tanay Bose Tanel Vahter Tarquin Netherway Teng Yang Tom May Torda Varga Wei Li Victor Rafael Matos Coimbra Virton Rodrigo Targino de Oliveira Vitor Xavier de Lima Vladimir S.Mikryukov Yongzhong Lu Yosuke Matsuda Yumiko Miyamoto Urmas Kõljalg Leho Tedersoo | 2020 | Fungal Diversity2020，，6： | 1 |
| 17 | The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen显示文摘 | Matthew P. Goetz Stacey K. Knox Vera J. Suman James M. Rae Stephanie L. Safgren Matthew M. Ames Daniel W. Visscher Carol Reynolds Fergus J. Couch Wilma L. Lingle Richard M. Weinshilboum Emily G. Barr Fritcher Andrea M. Nibbe Zeruesenay Desta Anne Nguyen D | 2007 | Breast Cancer Research and Treatment2007，，1： | 1 |
| 18 | 2014年美国纽波特沙门菌感染暴发与黄瓜的关联性显示文摘2014年8月,美国国家食源性疾病分子分型监测网络(national molecular subtyping network for foodborne disease surveillance)———PulseNet,发现多个州出现纽波特沙门菌血清型聚集性感染,检测到的脉冲场凝胶电泳(pulse-field gel electrophoresis,PFGE)带型(限制性内切酶Xba I,带型为JJPX01.0061)难以鉴别。与疾病暴发相关的PF-GE带型曾与德玛瓦半岛地区弗吉尼亚东海岸生产销售的西红柿具有相关性,但尚未发现与黄瓜或其他农产品的相关性。 | Kristina M. Angelo Alvina Chu Madhu Anand Thai-An Nguyen Lyndsay Bottichio Matthew Wise Ian Williams Sharon Seelman Rebecca Bell Marianne Fatica Susan Lance Deanna Baldwin Kyle Shannon Hannah Lee Eija Trees Errol Strain Laura Gieraltowski 罗宝章(翻译) 厉曙光(审校) | 2018 | 上海预防医学2018，30，10： | 1 |
| 19 | ^(68)Ga-PSMA PET/CT versus CT and bone scan for investigation of PSA failure post radical prostatectomy显示文摘Objective:To evaluate the use of Gallium-68 prostate-specific membrane antigen positron emission tomography/computed tomography(^(68)Ga-PSMA PET/CT),compared with conventional CT abdomen/pelvis(CTAP)and whole body single photon emission CT bone scan(BS),for detection of local or distant metastasis following biochemical failure/recurrence in post-prostatectomy patients.Methods:We conducted a review of our prospectively maintained,institutional database to identify 384 patients with post-prostatectomy biochemical failure/recurrence who underwent PSMA PET/CT,CTAP and BS from February 2015 to August 2017 in Nepean Hospital,tertiary referral centre.The results of the three imaging modalities were analysed for their ability to detect local recurrence and distant metastases.PSMA PET/CT and CTAP imaging were separately performed on the same day and the BS was performed within several days(mostly in 24 h).Difference in detection rates was determined between the modalities and the Chi square test was used to determine significance.Results:A total of 384 patients were identified with a median prostate-specific antigen(PSA)of 0.465 ng/mL(interquartile range =0.19-2.00 ng/mL).Overall,PSMA PET/CT was positive for 245(63.8%)patients whereas CTAP and BS were positive in 174 patients(45.3%).A total of 98 patients(25.5%)had local or distant metastasis detected on PSMA only,while 20 patients(5.2%)had recurrences detected on CTAP but not on PSMA PET/CT.Conclusion:The use of PSMA PET/CT has a higher detection rate of predicted local or distant metastasis compared to CTAP and BS in the staging of patients with biochemical recurrences after radical prostatectomy. | Yuigi Yuminaga Chris Rothe Jonathan Kam Kieran Beattie Mohan Arianayagam Chuong Bui Bertram Canagasingham Richard Ferguson Mohamed Khadra Raymond Ko Ken Le Diep Nguyen Celi Varol Matthew Winter | 2021 | Asian Journal of Urology2021，8，2： | 1 |
| 20 | An enormous hepatitis B virus-related liver disease burden projected in Vietnam by 2025 显示文摘 | Van Thi Thuy Nguyen Matthew G Law Gregory J Dore | 2008 | Liver International2008，28，4： | 1 |
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