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| 1 | 在在一个第三级的肝中心的 hepatocellular 癌的对比超声: 第一印度经验显示文摘 AIM: To assess the role of contrast enhanced ultrasonography in evaluation of hepatocellular carcinoma (HCC) at the first Indian tertiary liver center. METHODS: Retrospective analysis of contrast enhanced ultrasound (CEUS) examinations over 24 mo for diagnosis, surveillance, characterization and follow up of 50 patients in the context of HCC was performed. The source and indication of referrals, change in referral rate, accuracy and usefulness of CEUS in a tertiary liver center equipped with a 64 slice dual energy computer tomography (CT) and 3 tesla magnetic resonance imaging (MRI) were studied. Sonovue (BR1, Bracco, Italy, a second generation contrast agent) was used for contrast US studies. Contrast enhanced CT/MRI or both were performed in all patients. The findings were taken as a baseline reference and correlation was done with respect to contrast US. Contrast enhanced MRI was performed using hepatocyte specific gadobenate dimeglumine (Gd-BOPTA). Iomeron (400 mg; w/v) was used for dynamic CT examinations. RESULTS: About 20 (40%) of the examinations were referred from clinicians for characterization of a mass from previous imaging. About 15 (30%) were performed for surveillance in chronic liver disease; 5 (10%) examinations were performed for monitoring lesions after radiofrequency ablation (RFA); 3 (6%) were post trans-arterial chemoembolization (TACE) assessments and 3 (6%) were patients with h/o iodinated contrast allergy. About 2(4%) were performed on hemodynamically unstable patients in the intensive care with raised alpha fetoprotein and 2(4%) patients were claustrophobic. The number of patients referred from clinicians steadily increased from 12 in the first 12 mo of the study to 38 in the last 12 mo. CEUS was able to diagnose 88% of positive cases of HCC as per reference standards. In the surveillance group, specificity was 53.3% vs 100% by CT/MRI. Post RFA and TACE specificity of lesion characterization by CEUS was 100% in single/large mass assessment, similar to CT/MRI. For non HCC lesions such as regenerative and dysplastic nodules, the specificity was 50% vs 90% by CT/MRI. The positive role of CEUS in imaging spectrum of HCC included a provisional urgent diagnosis of an incidentally detected mass. It further led to a decrease in time for further management. A confident diagnosis on CEUS was possible in cases of characterization of an indeterminate mass, in situations where the patient was unfit for CT/MRI, was allergic to iodinated contrast or had claustrophobia, etc.CEUS was also cost effective, radiation free and an easy modality for monitoring post RFA or TACE lesions. CONCLUSION: CEUS is a valuable augmentation to the practice of ultrasonography, and an irreplaceable modality for confounding cases and interpretation of indeterminate lesions in imaging of HCC. | Shalini Thapar Laroia Simranjeet Singh Bawa Deepak Jain Amar Mukund Shiv Sarin | 2013 | World Journal of Radiology2013，5，6： | 5 |
| 2 | Influence of different solvents in extraction of phenolic compounds from vegetable residues and their evaluation as natural sources of antioxidants显示文摘 | Neha Babbar Harinder Singh Oberoi Simranjeet Kaur Sandhu Vinod Kumar Bhargav | 2014 | Journal of Food Science and Technology2014，，10： | 1 |
| 3 | Selenium in agriculture: a nutrient or contaminant for crops?显示文摘 | Navneet Kaur Shuchi Sharma Simranjeet Kaur Harsh Nayyar | 2014 | Archives of Agronomy and Soil Science2014，，12： | 1 |
| 4 | Influence of different solvents in extraction of phenolic compounds from vegetable residues and their evaluation as natural sources of antioxidants显示文摘 | Neha Babbar Harinder Singh Oberoi Simranjeet Kaur Sandhu | 2014 | Journal of Food Science and Technology2014，，10： | 1 |
| 5 | Phytochemistry and ethnomedicinal qualities of metabolites from Phyllanthus emblica L.:A review显示文摘Phyllanthus emblica or Indian gooseberry is an integrated part of Ayurvedic and Traditional Chinese Medicines.For several decades,the well-known ancient herb has been extensively utilized in traditional medicine to cure diseases like fever,diabetes,constipation,jaundice,ulcers,biliousness,anemia,anorexia,and dyspepsia.In the traditional system,Indian gooseberry has various ethnomedicinal applications.In the Ayurvedic system,different methods of administration(anupan)have shown different ethnomedicinal properties of Indian gooseberry.Seventy well-known chemical components in Indian gooseberry have been identified through phytochemical evaluation,among which the flavonoids and phenols are most prominent.From the toxicity perspective,it is considered a safe herb in India,and is taken as a food supplement in European countries.The wide-spectrum pharmacological activities of the crude extracts and isolates of Indian gooseberry are attributed to the predominance of phenols and flavonoids.Thus,it is important to study the exact mechanism of the activity of the phytochemicals in Indian gooseberry,especially in anti-cancer activities.Extract of Indian gooseberry enhances proliferation in several cancer cells in vitro,including stem cells like ovarian cancer(OC)cells,and also has been observed to possess anti-proliferative characteristics in vivo.This review intends to explore the therapeutic potential of Indian gooseberry based on scientific reports and attempts to find the gaps for future research. | VIJAY KUMAR PRAVEEN C.RAMAMURTHY SIMRANJEET SINGH DALJEET SINGH DHANJAL PARUL PARIHAR DEEPIKA BHATIA RAM PRASAD JOGINDER SINGH | 2023 | BIOCELL2023，47，5： | 0 |
| 6 | Folate-producing rhizobacteria of Hippophae rhamnoides L.from Indian trans-Himalaya low atmospheric zone显示文摘Hippophae rhamnoides L.is a plant of immense ethnopharmacological importance and is a known source for various valuable biochemicals and nutraceuticals.The production of folate,a vitamin involved in several vital functions,in this plant is rather poorly understood.Herein,we investigate the hypothesis that rhizobial bacteria serve the plant in this essential vitamin’s biosynthesis.Bacterial strains of Bacillus,Azorhizobium,Frankia,Paenibacillus,Brevibacillus and Pseudomonas,were isolated from the rhizosphere of the plant.HPLC and LCMS were used to trace the production of intra and extra-cellular folate by representative rhizospheric bacterial strains in vitro.From the seventeen functionally characterized bacterial strains of the plant’s rhizosphere,thirteen produced significant amounts of folate.Azorhizobium BR5401 produced the maximum amount of folic acid(424μg/mL),and Bacillus GY779 was the only strain capable of producing both intracellular and extra-cellular folic acid.The Open Reading Frame coding for dihydroneopterin aldolase,an enzyme involved in folate biosynthesis,was found in one of the representative isolates.Our experimental findings help us to suggest that the folate synthesized by rhizobial bacteria is transported to the plant,highlighting a significant benefit of coexistence. | POOJA BHADRECHA MADHU BALA VIKAS KAUSHIK NASEEM A.GAUR SIMRANJEET SINGH JOGINDER SINGH MANOJ KUMAR | 2021 | BIOCELL2021，45，2： | 0 |
| 7 | Impact of metal oxide nanoparticles on cotton(Gossypium hirsutum L.):a physiological perspective显示文摘Cotton production substantiated a crucial part in the escalating economic development of many countries.To realize the increasing global demand for cotton,the emphasis should be laid on to improve cotton fiber growth and production.The bioengineered transgenic cotton proved expedient in resolving inadequacies of conventional cotton,but still required improvements to encounter heightened demand of textile industries.One possible solution pertaining to this has been provided by nanoscience in the form of metal or metal oxide nanoparticles.These metal oxide nanoparticles have easy access to the various parts of cotton plants through its transportation system,and thus significantly influence several parameters relative to the growth and production of cotton fiber.This review summarizes the distribution and accumulation of metal oxide nanoparticles in cotton plant and its impact on different plant growth-promoting factors,which resulted in the improved cotton yields. | SINGH BRAR Ravinderdeep KUMAR Avneesh KAUR Simranjeet SAHA Sandip KUMAR Anuj KUMAR Sandeep | 2021 | Journal of Cotton Research2021，4，2： | 0 |
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