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1Recent advances in endovascular techniques for management of acute nonvariceal upper gastrointestinal bleeding显示文摘Over the past two decades,transcatheter arterial embolization has become the first-line therapy for the management of upper gastrointestinal bleeding that is refractory to endoscopic hemostasis.Advances in catheter-based techniques and newer embolic agents, as well as recognition of the effectiveness of minimally invasive treatment options,have expanded the role of interventional radiology in the management of hemorrhage for a variety of indications,such as peptic ulcerbleeding,malignant disease,hemorrhagic Dieulafoy lesions and iatrogenic or trauma bleeding.Transcatheter interventions include the following:selective embolization of the feeding artery,sandwich coil occlusion of the gastroduodenal artery,blind or empiric embolization of the supposed bleeding vessel based on endoscopic findings and coil pseudoaneurysm or aneurysm embolization by three-dimensional sac packing with preservation of the parent artery.Transcatheter embolization is a fast,safe and effective,minimally invasive alternative to surgery when endoscopic treatment fails to control bleeding from the upper gastrointestinal tract.This article reviews the various transcatheter endovascular techniques and devices that are used in a variety of clinical scenarios for the management of hemorrhagic gastrointestinal emergencies.Romaric F Loffroy Basem A Abualsaud Ming D Lin Pramod P Rao 2011World Journal of Gastrointestinal Surgery2011,3,7:28
2Gait Recognition by Cross Wavelet Transform and Graph Model显示文摘In this paper, a multi-view gait based human recognition system using the fusion of two kinds of features is proposed.We use cross wavelet transform to extract dynamic feature and bipartite graph model to extract static feature which are coefficients of quadrature mirror filter(QMF)-graph wavelet filter bank. Feature fusion is done after normalization. For normalization of features, min-max rule is used and mean-variance method is used to find weights for normalized features. Euclidean distance between each feature vector and center of the cluster which is obtained by k-means clustering is used as similarity measure in Bayesian framework. Experiments performed on widely used CASIA B gait database show that, the fusion of these two feature sets preserve discriminant information. We report 99.90 % average recognition rate.Sagar Arun More Pramod Jagan Deore 2018IEEE/CAA Journal of Automatica Sinica2018,5,3:8
3A phase Ⅱ study of gemcitabine and carboplatin combination chemotherapy in gallbladder carcinoma显示文摘BACKGROUND: Patients with carcinoma of the gallbladder have advanced, unresectable tumor at the time of presentation and face a dismal prognosis in the absence of a standard palliative chemotherapy regimen. This study was undertaken to evaluate the efficacy and safety of combined chemotherapy of gemcitabine and carboplatin in 20 patients with advanced gallbladder carcinoma. METHODS: The criteria of eligibility included chemonaive patients with unresectable gallbladder cancer, bidimensionaIly measurable disease, Zubrod’s performance status≤2, and adequate major organ function. The patients received gemcitabine (1000 mg/m^2) on days 1 and 8, and carboplatin (target AUC of 5.0 mg/ml) on day 1, in a 21-day cycle. CT was used for response assessment. RESULTS: In this group of 20 patients with advanced gallbladder carcinoma 6 were men and 14 women, with a median age of 55 years. The stage of the tumor at presentation was IVB in 14 patients (70%), IVA in 3 (15%) and Ⅲ in 3 (15%). Four patients (21%) achieved a complete response, and 3 (15.7%), a partial response; an overall response rate was 36.7%. The median time to progression of the tumor was 33.8 weeks, and 1-year survival rate of the patients was 43.3%. Anemia of WHO grade Ⅲ or Ⅳ was seen in 2 patients (10%) and 1 patient (5%), respectively. Grade Ⅲ neutropenia and thrombocytopenia were observed in 2 patients (10%) and 1 patient (5%), respectively. CONCLUSION: With mild toxicity, combined chemotherapy of gemcitabine and carhoplatin is effective in the treatment of advanced gallbladder carcinoma.Pramod Kumar Julka Tarun Puri Goura Kishore Rath 2006Hepatobiliary & Pancreatic Diseases International2006,5,1:7
4Tuning the particle size and morphology of high energetic material nanocrystals显示文摘Morphology controlled synthesis of nanoparticles of powerful high energetic compounds(HECs) such as l,3,5-trinitro-l,3,5-triazinane(RDX) and 1,3,5,7-tetranitro-l,3,5,7-tetrazocane(HMX) were achieved by a simple solvent—antisolvent interaction(SAI) method at 70 ℃.The effects of different solvents on particle size and morphology of the prepared nano-HECs were studied systematically.Particle size and morphology of the nano-HECs was characterized using field emission scanning electron microscopy(FE-SEM) imaging.X-ray diffraction(XRD) and Fourier transform infrared(FTIR) spectroscopy studies revealed that RDX and HMX were precipitated in their most stable polymorphic forms,i.e.a and P,respectively.Thermogravimetric analysis coupled with differential scanning calorimetry(TGA-DSC) studies showed that the thermal response of the nanoparticles was similar to the respective raw-HECs.HEC nanoparticles with spherical and rod shaped morphology were observed under different solvent conditions.The mean particle size also varied considerably with the use of different solvents.Raj KUMAR Prem Felix SIRIL Pramod SONI 2015Defence Technology(防务技术)2015,11,4:7
5Endoscopic ultrasound guided thrombin injection of angiographically occult pancreatitis associated visceral artery pseudoaneurysms:Case series显示文摘Pseudoaneurysm is a known complication of pancreatitis associated with significant mortality and morbidity. Imaging plays an important role in the diagnosis and management. Computed tomography(CT) helps localize the lesion and the severity of the background pancreatitis but digital subtraction angiography with coil embolization is recommended to avoid bleeding and inadvertent surgery. However, in cases where angiographic coil embolization is not feasible due to technical reasons, thrombin injection via CT or ultrasound guidance remains a viable option and often described in literature. In this series, effort has been made to highlight the role of endoscopic ultrasound guided thrombin instillation especially in patients with poorly visualized pseudoaneurysm on ultrasound thereby avoiding surgery and the associated mortality and morbidity.Shivanand Gamanagatti Usha Thingujam Pramod Garg Surajkumar Nongthombam Nihar Ranjan Dash 2015World Journal of Gastrointestinal Endoscopy2015,7,13:6
6慢性胰腺炎──病因、发病机制及治疗的认识现状显示文摘Rakesh K Tandon Pramod K Garg 蒋晓玲 2002胃肠病学2002,7,1:6
7Endovascular management in abdominal visceral arterial aneurysms:A pictorial essay显示文摘Visceral artery aneurysms(VAAs) include aneurysms of the splanchnic circulation and those of the renal artery.Their diagnosis is clinically important because of the associated high mortality and potential complications.Splenic,superior mesenteric,gastroduodenal,hepatic and renal arteries are some of the common arteries affected by VAAs.Though surgical resection and anastomosis still remains the treatment of choice in some of the cases,especially cases involving the proximal arteries,increasingly endovascular treatment is being used for more distal vessels.We present a pictorial review of various intra-abdominal VAAs and their endovascular management.Manisha Jana Shivanand Gamanagatti Amar Mukund Sujoy Paul Pankaj Gupta Pramod Garg Tushar K Chattopadhyay Peush Sahni 2011World Journal of Radiology2011,3,7:5
8Geochemistry of Kasnau-Matasukh lignites, Nagaur Basin, Rajasthan (India)显示文摘Prakash K. Singh Pramod K. Rajak ramod K. Rajak Vijay K. Singh Amiya S. Naik 2016International Journal of Coal Science & Technology2016,3,2:4
9Gastric conduit perforation显示文摘As patients with carcinoma of the esophagus live longer, complications associated with the use of a gastric conduit are increasing. Ulcers form in the gastric conduit in 6.6% to 19.4% of patients. There are a few reports of perforation of a gastric conduit in the English literature. Almost all of these were associated with serious complications. We report a patient who developed a tension pneumothorax consequent to spontaneous perforation of an ulcer in the gastric conduit 7 years after the index surgery in a patient with carcinoma of the gastroesophageal junction. He responded well to conservative management. Complications related to a gastric conduit can be because of multiple factors. Periodic endoscopic surveillance of gastric conduits should be considered as these are at a higher risk of ulcer formation than a normal stomach. Long term treatment with proton pump inhibitors may decrease complications. There are no guidelines for the treatment of a perforated gastric conduit ulcer and the management should be individualized.Nilesh Patil Arvind Kaushal Amit Jain Sundeep Singh Saluja Pramod Kumar Mishra 2014World Journal of Clinical Cases2014,2,8:4
10Management of splenic artery aneurysm associated with extrahepatic portal vein obstruction显示文摘BACKGROUND: Splenic artery aneurysms although rare are clinically significant in view of their propensity for spontaneous rupture and life-threatening bleeding. While portal hypertension is an important etiological factor, the majority of reported cases are secondary to cirrhosis of the liver. We report three cases of splenic artery aneurysms associated with extrahepatic portal vein obstruction and discuss their management. METHODS: The records of three patients of splenic artery aneurysm associated with extrahepatic portal vein obstruction managed from 2003 to 2010 were reviewed retrospectively. The clinical presentation, surgical treatment and outcome were analyzed. RESULTS: The aneurysm was >3 cm in all patients. The clinical symptoms were secondary to extrahepatic portal vein obstruction (hematemesis in two, portal biliopathy in two) while the aneurysm was asymptomatic. Doppler ultrasound demonstrated aneurysms in all patients. A proximal splenorenal shunt was performed in two patients with excision of the aneurysm in one patient and ligation of the aneurysm in another one. The third patient had the splenic vein replaced by collaterals and hence underwent splenectomy with aneurysmectomy. All patients had an uneventful post-operative course. CONCLUSIONS: Splenic artery aneurysms are associated with extrahepatic portal vein obstruction. Surgery is the mainstay of treatment. Although technically difficult, it can be safely performed in an experienced center with minimal morbidity and good outcome.Pramod Kumar Mishra Sundeep Singh Saluja Ashok K Sharma Premanand Pattnaik 2012Hepatobiliary & Pancreatic Diseases International2012,11,3:4
11Prospects to the formation and control of potential dimer impurity E of pantoprazole sodium sesquihydrate显示文摘Pantoprazole sodium, a substituted benzimidazole derivative, is an irreversible proton pump inhibitor which is primarily used for the treatment of duodenal ulcers, gastric ulcers, and gastroesophageal reflux disease (GERD). The monographs of European Pharmacopoeia (Ph. Eur.) and United States Pharmacopoeia (USP) specify six impurities, viz.;impurities A, B, C, D, E and F, respectively for its active pharmaceutical ingredient (API). The identification and synthesis of all impurities except impurity E are well described in the literature;however, there is no report related to impurity E. The prospects to the formation and controlling of impurity E up to -0.03% in the synthesis of pantoprazole sodium sesquihydrate (PAN) were discussed in detail for the first time. The present work described the journey towards the successful development of an optimal preparation procedure of dimer impurity E. The most plausible mechanism involved in the formation of impurity E has been proposed.Arun Kumar Awasthi Lalit Kumar Punit Tripathi Madhava Golla Cirandur Suresh Reddy Pramod Kumar 2019Journal of Pharmaceutical Analysis2019,9,3:4
12Effect of Low Level Subchronic Microwave Radiation on Rat Brain显示文摘Objective The present study was designed to investigate the effects of subchronic low level microwave radiation(MWR) on cognitive function,heat shock protein 70(HSP70) level and DNA damage in brain of Fischer rats.Methods Experiments were performed on male Fischer rats exposed to microwave radiation for 90 days at three different frequencies: 900,1800,and 2450 MHz.Animals were divided into 4 groups: Group I: Sham exposed,Group II: animals exposed to microwave radiation at 900 MHz and specific absorption rate(SAR) 5.953 × 10-4 W/kg,Group III: animals exposed to 1800 MHz at SAR 5.835 × 10-4 W/kg and Group IV: animals exposed to 2450 MHz at SAR 6.672 × 10-4 W/kg.All the animals were tested for cognitive function using elevated plus maze and Morris water maze at the end of the exposure period and subsequently sacrificed to collect brain tissues.HSP70 levels were estimated by ELISA and DNA damage was assessed using alkaline comet assay.Results Microwave exposure at 900-2450 MHz with SAR values as mentioned above lead to decline in cognitive function,increase in HSP70 level and DNA damage in brain.Conclusion The results of the present study suggest that low level microwave exposure at frequencies 900,1800,and 2450 MHz may lead to hazardous effects on brain.Pravin Suryakantrao Deshmukh Kanu Megha Namita Nasare Basu Dev Banerjee Rafat Sultana Ahmed Mahesh Pandurang Abegaonkar Ashok Kumar Tripathi Pramod Kumari Mediratta 2016Biomedical and Environmental Sciences2016,29,12:4
13BIM技术在轨道车辆运维方面研究综述显示文摘基于国内外相关研究,梳理了近年来BIM技术在轨道车辆运维领域的研究现状,总结归纳了该领域的理论、技术及应用研究成果。研究结果表明:BIM技术在轨道车辆运维的应用研究框架包括理论、技术和应用3个层次;理论研究集中在车辆建模、数据库建立和运营、维护方面;技术研究集中在三维CAD、平台建设、数字化管理和车辆部件监测等领域;应用研究主要体现在列车的日常运营、维护和价值方面;由于相关研究起步较晚,已有成果还存在一些不足;在理论方面,轨道车辆的建模和数据库建立精细化程度不高,运维全生命周期整体性不足;在技术方面,模型共享、软件协同、信息管理及车辆监测等方面需进一步研究与完善;在应用方面,轨道车辆运维的可视化程度、成本管理及软件开发研究需要更加具体和专业化,细化到各个层面;未来的研究应加强BIM多专业之间的协同设计及数据的规范化,实现与新信息技术的融合,构建智能的综合性管理平台,实现BIM软件更深度的二次开发;将理论、技术与应用结合起来,构建完整的轨道车辆BIM运维体系,完善基于BIM的可视化管理系统,加强对轨道车辆运维中所有服务对象、数据、业务功能一体化管理,提高轨道车辆运维的效率,为轨道车辆运维提供研究基础和理论依据,确保轨道车辆的安全运行。雷斌 温岩 李佳晨 曹振 PRAMOD KUMAR Gupta 麻建省 雷东波 刘阳 2021交通运输工程学报2021,21,6:3
14Cloning & sequence identification of Hsp27 gene and expression analysis of the protein on thermal stress in Lucilia cuprina显示文摘Hsp27,高度保存的小分子的重量热吃惊蛋白质,广泛地被知道发展地被调整并且加热可诱导。它在 thermotolerance 的角色也被含有。这研究是我们的更早的研究的一本续集在一个绵羊害虫, Lucilia cuprina (绿头苍蝇) 它展出不平常地高的适应性到许多环境压力,包括的热和化学药品在开发和热改编理解热吃惊基因 / 蛋白质和他们的角色的分子的组织。在这份报告,我们的目的是在热改编另外的种类和它的角色与那些理解 Lucilia hsp27 基因 / 蛋白质的进化关系。我们顺序描绘了 Lchsp27 基因(编码区域) 并且象热吃惊条件一样在正常下面在各种各样的幼虫、成年的纸巾分析了它的表示。Lchsp27 的长编码的区域展出了的 678 位/秒的核苷酸顺序分析有果蝇(90.09%) 的最近进化的最近,属于一样的顺序,双翅目。然而,在所有幼虫、成年的纸巾在 Lchsp27 基因的表示引起重要改进的热吃惊在纸巾检验了特定的举止。显著地,在里面肾小体小管当 hsp27 抄本(mRNA ) 的导致热的水平显得作为与控制相比增加了时,蛋白质水平仍然保持未改变、原子局部性。我们推断那 Lchsp27 特别地,可以在夏天月期间在细胞的动态平衡的维护有重要角色,当苍蝇仍然保持在它的自然产地暴露了到高热时。Manish K. Singh Pramod K. Tiwari 2016Insect Science2016,23,4:3
15Modified Atmosphere Packaging Technology of Fresh and Fresh-cut Produce and the Microbial Consequences—A Review显示文摘Oluwafemi J. Caleb Pramod V. Mahajan Fahad Al-Julanda Al-Said Umezuruike Linus Opara 2013Food and Bioprocess Technology2013,,2:3
16Role of angiogenesis and angiogenic factors in acute and chronic wound healing显示文摘Angiogenesis plays a crucial role in wound healing by forming new blood vessels from preexisting vessels by invading the wound clot and organizing into a microvascular network throughout the granulation tissue.This dynamic process is highly regulated by signals from both serum and the surrounding extracellular matrix environment.Vascular endothelial growth factor,angiopoietin,fibroblast growth factor and transforming growth factor-beta are among the potent angiogenic cytokines in wound angiogenesis.Specific endothelial cell ECM receptors are critical for morphogenetic changes in blood vessels during wound repair.In particular integrin(αvβ3)receptors for fibrin and fibronectin,appear to be required for wound angiogenesis:αvβ3 is focally expressed at the tips of angiogenic capillary sprouts invading the wound clot,and any functional inhibitors ofαvβ3 such as monoclonal antibodies,cyclic RGD peptide antagonists,and peptidomimetics rapidly inhibit granulation tissue formation.In spite of clear knowledge about influence of many angiogenic factors on wound healing,little progress has been made in defining the source of these factors,the regulatory events involved in wound angiogenesis and in the clinical use of angiogenic stimulants to promote repair.Thittamaranahalli Muguregowda Honnegowda Pramod Kumar Echalasara Govindarama Padmanabha Udupa Sudesh Kumar Udaya Kumar Pragna Rao 2015Plastic and Aesthetic Research2015,2,1:3
17Effect of Semecarpus anacardium fruits on reproductive function of male albino rats显示文摘Aim: To evaluate the effect of an ethanolic extract of Semecarpus anacardium fruits on spermatogenesis in albino rats. Methods: Male albino rats were fed with a 50 % ethanolic extract of Semecarpus anacardium fruit at 100 mg·kg^-l·day^-1, 200 mg·kg^-l·day^-1 and 300 mg·kg^-1·day^-1 for 60 days. Fertility test was performed after 60 days of treatment. Sperm motility and density were observed in the cauda epididymis. Biochemical and histological analyses of the blood and reproductive organs were done. Recovery of fertility was followed to evaluate the reversibility of drug action. Results: S. anacardium fruit extract administration resulted in spermatogenic arrest in albino rats. Thes perm motility and density was reduced significantly. The RBC and WBC counts, haemoglobin, haematocrit, blood sugar and urea were found to be within the normal range in the whole blood. The protein, cholesterol and glycogen in the testes and the fructose in the seminal vesicle were significantly decreased after the treatment. The fruit extract feeding caused marked reduction in the number of primary spermatocytes, secondary spermatocytes and spermatids.The number of mature Leydig cells was also decreased and degenerating cells increased proportionately. Conclusion:S. anacardium fruit extract causes spermatogenic arrest in albino rats. ( Asian J Androl 2003 Jun; 5: 121-124)Arti Sharma Pramod Kumar Verma V.P.Dixit 2003Asian Journal of Andrology2003,5,2:3
18Assessment of temporal dynamics of snow cover and its validation with hydro-meteorological data in parts of Chenab Basin, western Himalayas显示文摘The present investigation was conducted to analyze the temporal patterns of snow cover area%(SCA%), air temperature, snowfall and river discharge in parts of Chenab basin, western Himalayas. The relationship of mean SCA% with mean air temperature and river discharge was also tested using Pearson's product-moment correlation at 95% confidence limit and further sensitivity analysis of river discharge to SCA and SCA to air temperature was performed. Moderate Resolution Imaging Spectroradiometer(MODIS) 8-day surface reflectance product MOD09A1 was used to delineate SCA during the period 2000–2013. Moreover, variation in the lowest elevation from where snow cover area starts(LESCA) was also analyzed and its relationship with mean air temperature was also studied. Non-parametric method, Mann-Kendall test was employed to determine the trend in the SCA%, air temperature, snowfall and river discharge. The investigation carried out for three meteorological stations i.e. Batote, Reasi and Tandi revealed significant findings. At Batote and Reasi, statistically significant decreasing trends were observed over the period 2000 to 2012, for maximum, minimum and mean air temperature. Mean minimum SCA% exhibited a significant upward trend during 2000–2013 which is corroborated by the significantly increasing trend of mean annual snowfall(Tandi station) from 2000 to 2010. Further, significant decreasing trend of river discharge for the winter season at Batote station from 2000 to 2011 and decreasing trends in the maximum, minimum and mean air temperature at Batote and Reasi stations are also consistent with the increasing trend of SCA%. At both Batote and Reasi stations, mean SCA% exhibited significant negative relationship with the mean air temperature. On the other hand, LESCA exhibited positive correlation with the mean air temperature except in a few months, where negative relationship was seen. Sensitivity analysis of river discharge to SCA exhibited very low values of sensitivity coefficient in most of the months, indicating less sensitivity of river discharge to SCA. On the other hand, sensitivity coefficient of SCA to air temperature exhibited comparatively higher values which indicate SCA is more sensitive to air temperature.Retinder KOUR Nilanchal PATEL Akhouri Pramod KRISHNA 2016Science China Earth Sciences2016,59,5:3
19Bipolar radiofrequency ablation of tibialchondroblastomas: A report of three cases显示文摘Chondroblastoma is a rare benign cartilaginous neoplasm of bone. The recurrence rate is high and complications are frequent following open curettage with bone grafting which is the standard treatment forchondroblastomas. We performed radiofrequency ablation in three cases of tibialchondroblastoma using the bipolar system. One patient experienced residual pain for which repeat ablation was performed. No other complications were observed during follow-up. Radiofrequency ablation may offer an effective alternative for the treatment of selected cases of chondroblastoma. The lesion characteristics which are likely to influence treatment outcome and the advantages offered by the bipolar system are discussed.Prathiba Rajalakshmi Deep N Srivastava Shivanand Gamanagatti Pramod Kumar Julka Sushma Bhatnagar Shishir Rastogi 2012World Journal of Radiology2012,4,7:2
20Pathogenic mechanisms of acute pancreatitis显示文摘Raghuwansh P. Sah Pramod Garg Ashok K. Saluja 2012Current Opinion in Gastroenterology2012,,5:2
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