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| 1 | Identification of serum proteins discriminating colorectal cancer patients and healthy controls using surface-enhanced laser desorption ionisation-time of flight mass spectrometry显示文摘瞄准:为颜色检测新浆液简历标记由浆液蛋白质与提高表面的激光解吸附作用 ionisation 介绍的表面的癌症(CRC )-- 飞行团分光术(SELDI-TOF MS ) 的时间。方法:二个独立浆液样品集合与 ProteinChip 技术独立被分析(集合 A:40 CRC+49 健康控制;集合 B:37 CRC+31 健康控制) ,有一个弱阳离子的使用的芯片交换一半和缓冲区 pH 5。差别的歧视的力量表示了蛋白质与一个分类树算法被估计。产生分类树的敏感和特性被盲目地从集合 B 并且反过来也如此从集合 A 把数据用于产生的树获得。CRC 浆液蛋白质侧面也与从胸的那些相比,卵巢,前列腺,和非小的房间肺癌症。结果:Mass-to-charge 比率(m/z ) 3.1x10 (3 ) , 3.3x10 (3 ) , 4.5x10 (3 ) , 6.6x10 (3 ) 和 28x10 (3 ) 在最好执行的分类树上被用作分类器。树敏感和特性在 65% 和 90% 之间。大多数这些歧视的 m/z 价值在调查的另外的瘤类型也是不同的。M/z 3.3x10 (3 ) ,在大多数树上的主要分类器,是 6.6x10 (3 ) 的一种二倍地控告的形式 -Da 蛋白质。后者作为 apolipoprotein C-I 被识别。M/z 3.1x10 (3 ) 作为 apolipoprotein A-I 作为白朊,和 m/z 28x10 (3 ) 的 N 终端碎片被识别。结论:分类树模式分析跟随的 SELDI-TOF MS 是为为 CRC 发现新浆液标记的一种合适的技术。Biomarkers 能与高敏感和特性在独立样品集合被识别并且 reproducibly 检测了。尽管为 CRC 不特定,这些简历标记在监视的疾病和治疗有一个潜在的角色。 | Judith YMN Engwegen Helgi H Helgason Annemieke Cats Nathan Harris Johannes MG Bonfrer Jan HM Schellens Jos H Beijnen | 2006 | World Journal of Gastroenterology2006，12，10： | 45 |
| 2 | Spontaneous recovery from micronodular cirrhosis: Evidence for incomplete resolution associated with matrix cross-linking显示文摘 | Razao Issa Xiaoying Zhou Christothea M. Constandinou Jonathan Fallowfield Harry Millward-Sadler Marianna D.A. Gaca Emma Sands Ibnauf Suliman Nathan Trim Andreas Knorr Michael J.P. Arthur R.Christopher Benyon John P. Iredale | 2004 | Gastroenterology2004，，7： | 2 |
| 3 | Influence of Corneal Structure, Corneal Responsiveness, and Other Ocular Parameters on Tonometric Measurement of Intraocular Pressure显示文摘 | Aimee Teo Broman Nathan G. Congdon Karen Bandeen-Roche Harry A. Quigley | 2007 | Journal of Glaucoma2007，，7： | 1 |
| 4 | Comparison of the device physics principles of planar and radial p-n junction nanorod solar cells 显示文摘 | Kayes Brendan M Atwater Harry A Lewis Nathan S | 2005 | Journal of Applied Physics2005，97，11： | 1 |
| 5 | Surgical strategies for coexisting glaucoma and cataract显示文摘 | David S Friedman Henry D Jampel Lisa H Lubomski John H Kempen Harry Quigley Nathan Congdon Hani Levkovitch-Verbin Karen A Robinson Eric B Bass | 2002 | Ophthalmology2002，，： | 1 |
| 6 | Performance of a Fire-and- Forget Anti-Tank Missile with a Damaged Wing 显示文摘 | John Harris Nathan Slegers | 2009 | Mathematical and Computer Modelling2009，50，： | 1 |
| 7 | Risk Assessment Using a Novel Score to Predict Anastomotic Leak and Major Complications after Oesophageal Resection显示文摘 | Fergus Noble Nathan Curtis Scott Harris Jamie Kelly Ian Bailey James Byrne Timothy Underwood | 2012 | Journal of Gastrointestinal Surgery2012，，6： | 1 |
| 8 | Possible Mechanisms of Primary Angle-Closure and Malignant Glaucoma显示文摘 | Harry A. Quigley David S. Friedman Nathan G. Congdon | 2003 | Journal of Glaucoma2003，，2： | 1 |
| 9 | Biochar as bulking agent for poultry litter composting显示文摘 | Christoph Steiner Nathan Melear Keith Harris KC Das | 2011 | Carbon Management2011，，3： | 1 |
| 10 | Possible Mechanisms of Primary Angle-Closure and Malignant Glaucoma显示文摘 | Harry A. Quigley David S. Friedman Nathan G. Congdon | 2003 | Journal of Glaucoma2003，，2： | 1 |
| 11 | Possible mechanisms of primary angle-closure and malignant glaucoma显示文摘 | Harry AQ David SF Nathan GC | 2003 | Glaucoma2003，12，2： | 1 |
| 12 | Phase I Trial of Combretastatin A4 Phosphate (CA4P) in Combination with Bevacizumab in Patients with Advanced Cancer显示文摘 | Paul Nathan Martin Zweifel Anwar R. Padhani Dow-Mu Koh Matthew Ng David J. Collins Adrian Harris Craig Carden Jon Smythe Nita Fisher N. Jane Taylor J. James Stirling Shiao-Ping Lu Martin O. Leach Gordon J.S. Rustin Ian Judson | 2012 | Clinical Cancer Research2012，，： | 1 |
| 13 | Effect of serum concentration, method of trypsinization and fusion/activation utilizing transfected fetal cells to generate transgenic dairy goats by somatic cell nuclear transfer显示文摘 | David Melican Robin Butler Nathan Hawkins Li-How Chen Evelyn Hayden Margaret Destrempes Jennifer Williams Tanya Lewis Esmail Behboodi Carol Ziomek Harry Meade Yann Echelard William Gavin | 2004 | Theriogenology2004，，6： | 1 |
| 14 | Possible mechanisms of prima- ry angle-clousure and malignant glaucoma显示文摘 | Harry AQ David SF Nathan GC | 2003 | Glaucoma2003，12，2： | 1 |
| 15 | Management of proximal humeral fractures: Surgeons don’t agree显示文摘 | Charles J. Petit Peter J. Millett Nathan K. Endres David Diller Mitchel B. Harris Jon J.P. Warner | 2010 | Journal of Shoulder and Elbow Surgery2010，，3： | 1 |
| 16 | Hepatitis E virus: Western Cape, South Africa显示文摘AIM To conduct a prospective assessment of anti-hepatitis E virus(HEV) Ig G seroprevalence in the Western Cape Province of South Africa in conjunction with evaluating risk factors for exposure.METHODS Consenting participants attending clinics and wards of Groote Schuur, Red Cross Children's Hospital and their affiliated teaching hospitals in Cape Town, South Africa, were sampled. Healthy adults attending blood donor clinics were also recruited. Patients with known liver disease were excluded and all major ethnic/race groups were included to broadly represent local demographics. Relevant demographic data was captured at the time of sampling using an interviewer-administered confidential questionnaire. Human immunodeficiency virus(HIV) status was self-disclosed. HEV Ig G testing was performed using the Wantai? assay.RESULTS HEV is endemic in the region with a seroprevalence of 27.9%(n = 324/1161) 95%CI: 25.3%-30.5%(21.9% when age-adjusted) with no significant differences between ethnic groups or HIV status. Seroprevalence in children is low but rapidly increases in early adulthood. With univariate analysis, age ≥ 30 years old, pork and bacon/ham consumption suggested risk. In the multivariate analysis, the highest risk factor for HEV Ig G seropositivity(OR = 7.679, 95%CI: 5.38-10.96, P < 0.001) was being 30 years or older followed by pork consumption(OR = 2.052, 95%CI: 1.39-3.03, P < 0.001). A recent clinical case demonstrates that HEV genotype 3 may be currently circulating in the Western Cape.CONCLUSION Hepatitis E seroprevalence was considerably higher than previously thought suggesting that hepatitis E warrants consideration in any patient presenting with an unexplained hepatitis in the Western Cape, irrespective of travel history, age or ethnicity. | Richie G Madden Sebastian Wallace Mark Sonderup Stephen Korsman Tawanda Chivese Bronwyn Gavine Aniefiok Edem Roxy Govender Nathan English Christy Kaiyamo Odelia Lutchman Annemiek A van der Eijk Suzan D Pas Glynn W Webb Joanne Palmer Elizabeth Goddard Sean Wasserman Harry R Dalton C Wendy Spearman | 2016 | World Journal of Gastroenterology2016，22，44： | 0 |
| 17 | 就算长痘又何妨显示文摘青春年少时,相信谁都不可避免地长过痘痘吧?当痘痘悄然而至甚至'纷至沓来',霸占了你脸部的'一方净土'时,你会不忍直视它们吗?你会无比在意、不愿见人吗?其实,痘痘本没有那么可怕,就看你如何看待它。本文的主人公就是一位内心越来越强大的战'痘'者,一起来看看他是如何在战'痘'之路上成长的吧! | Nathan Harris 光炜 | 2016 | 新东方英语(中学版)2016，0，4： | 0 |
| 18 | Phosphorylated KDR can be located in the nucleus of neoplastic cells显示文摘KDR (kinase 插入领域受体) phosphorylation 导致最后带到房间增长和幸存的几效果。一旦它被激活, KDR 与原子核由交流的精确机制正在开始被理解,但是还没是完全 unravelled。二在在文学报导的动物细胞线上的 vitro 研究表明了那,跟随有 VEGF 的刺激, KDR 实际上是在原子核以内的 translocated。我们的目的是调查这 translocation 是否在 vitro 并且在 vivo 发生在人的房间。用扫描共焦的显微镜学的激光,在房间线和瘤样品的 phosphorylated 和全部的 KDR 的可变原子本地化被发现。在人的肿瘤的房间线, hypoxic 刺激极大地增加了全部的 KDR,但是少些的原子数量以便 phosphorylated 形式。仅仅在组织缺氧和 VEGF 刺激以后,有在这些房间的原子核观察的 phosphorylated 和全部的 KDR 的可比较地增加的表情。我们断定肿瘤的房间在原子核显示出总数和 phosphorylated KDR 的可变表情。要证实的原子地点遗体的精确功能的意思。 | Cristina Blazquez Nathan Cook Kingsley Micklem Adrian L Harris Kevin C Gatter Francesco Pezzella | 2006 | Cell Research2006，16，1： | 0 |
| 19 | 就算长痘又何妨显示文摘从去年的某个时候开始,我逐渐养成了不愿照镜子的习惯。令我一直无法正视自己的原因,是我脸上长了大红痘。 | Nathan Harris 光炜 | 2017 | 高中生(作文)2017，，2： | 0 |
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