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| 1 | Multicenter study of endoscopic preoperative biliary drainage for malignant distal biliary obstruction显示文摘AIM: To determine the optimal method of endoscopic preoperative biliary drainage for malignant distal biliary obstruction.METHODS: Multicenter retrospective study was conducted in patients who underwent plastic stent(PS) or nasobiliary catheter(NBC) placement for resectable malignant distal biliary obstruction followed by surgery between January 2010 and March 2012. Procedurerelated adverse events, stent/catheter dysfunction(occlusion or migration of PS/NBC, developmentof cholangitis, or other conditions that required repeat endoscopic biliary intervention), and jaundice resolution(bilirubin level < 3.0 mg/d L) were evaluated. Cumulative incidence of jaundice resolution and dysfunction of PS/NBC were estimated using competing risk analysis. Patient characteristics and preoperative biliary drainage were also evaluated for association with the time to jaundice resolution and PS/NBC dysfunction using competing risk regression analysis.RESULTS: In total, 419 patients were included in the study(PS, 253 and NBC, 166). Primary cancers included pancreatic cancer in 194 patients(46%), bile duct cancer in 172(41%), gallbladder cancer in three(1%), and ampullary cancer in 50(12%). The median serum total bilirubin was 7.8 mg/d L and 324 patients(77%) had ≥ 3.0 mg/d L. During the median time to surgery of 29 d [interquartile range(IQR), 30-39 d]. PS/NBC dysfunction rate was 35% for PS and 18% for NBC [Subdistribution hazard ratio(SHR) = 4.76; 95%CI: 2.44-10.0, P < 0.001]; the pig-tailed tip was a risk factor for PS dysfunction. Jaundice resolution was achieved in 85% of patients and did not depend on the drainage method(PS or NBC).CONCLUSION: PS has insufficient patency for preoperative biliary drainage. Given the drawbacks of external drainage via NBC, an alternative method of internal drainage should be explored. | Naoki Sasahira Tsuyoshi Hamada Osamu Togawa Ryuichi Yamamoto Tomohisa Iwai Kiichi Tamada Yoshiaki Kawaguchi Kenji Shimura Takero Koike Yu Yoshida Kazuya Sugimori Shomei Ryozawa Toshiharu Kakimoto Ko Nishikawa Katsuya Kitamura Tsunao Imamura Masafumi Mizuide Nobuo Toda Iruru Maetani Yuji Sakai Takao Itoi Masatsugu Nagahama Yousuke Nakai Hiroyuki Isayama | 2016 | World Journal of Gastroenterology2016，22，14： | 18 |
| 2 | IgG4-unrelated type 1 autoimmune pancreatitis显示文摘A 50-year-old male was referred to our hospital for the evaluation of hyperproteinemia.Fluorodeoxyglucose positron emission tomography revealed high fluorodeoxyglucose uptake in the pancreas,bilateral lacrimal glands,submandibular glands,parotid glands,bilateral pulmonary hilar lymph nodes,and kidneys.Laboratory data showed an elevation of hepatobiliary enzymes,renal dysfunction,and remarkably high immunoglobulin(Ig) G levels,without elevated serum IgG4.Abdominal computed tomography revealed swelling of the pancreatic head and bilateral kidneys.Endoscopic retrograde cholangiopancreatography showed an irregular narrowing of the main pancreatic duct in the pancreatic head and stricture of the lower common bile duct.Histological examination by endoscopic ultrasonography-guided fine-needle aspiration revealed findings of lymphoplasmacytic sclerosing pancreatitis without IgG4-positive plasma cells.Abnormal laboratory values and the swelling of several organs were improved by the treatment with steroids.The patient was diagnosed as having type 1 autoimmune pancreatitis(AIP) based on the International Consensus Diagnostic Criteria.Therefore,we encountered a case of compatible type 1 AIP without elevated levels of serum IgG4 or IgG4-positive plasma cells.This case suggests that AIP phenotypes are not always associated with IgG4. | Eriko Nakano Atsushi Kanno Atsushi Masamune Naoki Yoshida Seiji Hongo Shin Miura Tetsuya Takikawa Shin Hamada Kiyoshi Kume Kazuhiro Kikuta Morihisa Hirota Keisuke Nakayama Fumiyoshi Fujishima Tooru Shimosegawa | 2015 | World Journal of Gastroenterology2015，21，33： | 3 |
| 3 | Construction of on-line supercritical fluid extraction with reverse phase liquid chromatography–tandem mass spectrometry for the determination of capsaicin显示文摘A novel on-line system composed of supercritical fluid extraction(SFE), dilution line and reverse phase liquid chromatography/mass spectrometry(RPLC/MS) was constructed for on-line extraction and reverse phase separation of some fat-soluble components in foods. Three columns including a trap column,concentration column and analytical column were used for trapping the fat-soluble components, on-line enrichment and reverse phase separation, respectively. Capsaicinoids were on-line extracted by a CO_2 supercritical fluid, then concentrated and separated by using the C_(18) columns, finally detected by mass spectrometry(MS). Capsaicin eluted at 10.1 min and limit of detection(LOD, S/N=3) for the standard solution is 0.55pg. The linearity was calculated with a value of coefficient of determination(R^2)≥0.998 in the range of 1.1–8.5 ng. Concentrations of capsaicin in the green, yellow, and red bell peppers were determined to be 60.33 ng/g, 31.79 ng/g, 35.38ng/g, respectively. | Naoki Hamada Yuki Hashi Satoshi Yamaki Yanli Guo Lin Zhang Haifang Li Jin-Ming Lin | 2019 | Chinese Chemical Letters2019，30，1： | 2 |
| 4 | Short- and long-term outcomes of endoscopic papillary large balloon dilation with or without sphincterotomy for removal of large bile duct stones显示文摘 | Hirofumi Kogure Takeshi Tsujino Hiroyuki Isayama Naminatsu Takahara Rie Uchino Tsuyoshi Hamada Koji Miyabayashi Suguru Mizuno Dai Mohri Yoko Yashima Kazumichi Kawakubo Takashi Sasaki Natsuyo Yamamoto Yousuke Nakai Kenji Hirano Naoki Sasahira Minoru Tada K | 2013 | Scandinavian Journal of Gastroenterology2013，，1： | 1 |
| 5 | Dehydrogenation and Isomerization of n-Butane or Isobutane Over Cr Catalysts Supported on Zeolites显示文摘 | Megumu Inaba Kazuhisa Murata Masahiro Saito Isao Takahara Naoki Mimura Hideaki Hamada Yohei Kurata | 2002 | Catalysis Letters (-)2002，，3： | 1 |
| 6 | Management of the late effects of disconnected pancreatic duct syndrome: A case report显示文摘BACKGROUND There have been few reports about the late effects of disconnected pancreatic duct syndrome(DPDS). Although few reports have described the recurrence interval of pancreatitis, it might be rare for recurrence to occur more than 5 years later.Herein, we describe a case of recurrence in an 81-year-old man after the treatment of walled-off necrosis(WON) with pancreatic transection 7 years ago.CASE SUMMARY An 81-year-old man visited our hospital with chief complaints of fever and abdominal pain 7 years after the onset of WON due to severe necrotic pancreatitis. His medical history included an abdominal aortic aneurysm(AAA),hypertension, dyslipidemia, and chronic kidney disease. Computed tomography(CT) scan showed that the pancreatic fluid collection(PFC) had spread to the aorta with inflammation surrounding it, and CT findings suggested that bleeding occurred from the vasodilation due to splenic vein occlusion. First, we attempted to perform transpapillary drainage because of venous dilation around the residual stomach and the PFC. However, pancreatic duct drainage failed because of complete main pancreatic duct disruption. Second, we performed endoscopic ultrasound-guided drainage. After transmural drainage, the inflammation improved and stenting for the AAA was performed successfully. The inflammation was resolved, and he has been free from infection for more than 2 years after the procedure.CONCLUSION This case highlights the importance of continued follow-up of patients for recurrence after the treatment of WON with pancreatic transection. | Reiko Yamada Yuhei Umeda Yasunori Shiono Hiroaki Okuse Naoki Kuroda Junya Tsuboi Hiroyuki Inoue Yasuhiko Hamada Kyosuke Tanaka Noriyuki Horiki Yoshiyuki Takei | 2019 | World Journal of Clinical Cases2019，7，9： | 1 |
| 7 | Biochemical and apid formation advanced glycation end products by intermediate metabolites of glycolytic pathway and polyol pathway显示文摘 | Norie Araki Naoki Koh | | Biophysical Re-search Communications0，228，： | 1 |
| 8 | Recent progress and limitations of chemotherapy for pancreatic and biliary tract cancers显示文摘Gemcitabine chemotherapy has been the standard for advanced pancreatic cancer for more than a decade.New oral fluoropyrimidines such as S-1 and capecitabine are other key drugs.Gemcitabine plus erlotinib was the only combination therapy that significantly prolonged survival,although the effect was minimal.Little or no improvement in survival with recent moleculartargeted drugs might be attributed to the very high incidence of K-ras gene mutation in pancreatic cancer.Recently,the non-gemcitabine-based-regimen of FOLFIRINOX showed significantly greater overall survival compared with gemcitabine for the first time.For biliary tract cancer,gemcitabine plus cisplatin combination chemotherapy has been proved to significantly prolong survival and will become the standard therapy.Further improvement in survival is expected by the addition of cetuximab. | Minoru Tada Yousuke Nakai Takashi Sasaki Tsuyoshi Hamada Rie Nagano Dai Mohri Koji Miyabayashi Keisuke Yamamoto Hirofumi Kogure Kazumichi Kawakubo Yukiko Ito Natsuyo Yamamoto Naoki Sasahira Kenji Hirano Hideaki Ijichi Keishuke Tateishi Hiroyuki Isayama Masao Omata Kazuhiko Koike | 2011 | World Journal of Clinical Oncology2011，2，3： | 1 |
| 9 | Feasibility of a new self‐expandable metallic stent for patients with malignant colorectal obstruction显示文摘 | Shuntaro Yoshida Hirotsugu Watabe Hiroyuki Isayama Hirofumi Kogure Yousuke Nakai Natsuyo Yamamoto Takashi Sasaki Kazumichi Kawakubo Tsuyoshi Hamada Yukiko Ito Yoko Yashima Naoki Sasahira Kenji Hirano Yutaka Yamaji Minoru Tada Masao Omata Kazuhiko Koike | 2012 | Digestive Endoscopy2012，，2： | 1 |
| 10 | Duodenal metal stent placement is a risk factor for biliary metal stent dysfunction: an analysis using a time-dependent covariate显示文摘 | Tsuyoshi Hamada Yousuke Nakai Hiroyuki Isayama Takashi Sasaki Hirofumi Kogure Kazumichi Kawakubo Naoki Sasahira Natsuyo Yamamoto Osamu Togawa Suguru Mizuno Yukiko Ito Kenji Hirano Nobuo Toda Minoru Tada Kazuhiko Koike | 2013 | Surgical Endoscopy2013，，4： | 1 |
| 11 | miR-210 regulates the interaction between pancreatic cancer cells and stellate cells显示文摘 | Tetsuya Takikawa Atsushi Masamune Shin Hamada Eriko Nakano Naoki Yoshida Tooru Shimosegawa | 2013 | Biochemical and Biophysical Research Communications2013，，： | 1 |
| 12 | Results of the Tokyo Trial of Prevention of Post-ERCP Pancreatitis with Risperidone-2: a multicenter, randomized, placebo-controlled, double-blind clinical trial显示文摘 | Rie Uchino Hiroyuki Isayama Takeshi Tsujino Naoki Sasahira Yukiko Ito Saburo Matsubara Naminatsu Takahara Toshihiko Arizumi Nobuo Toda Dai Mohri Osamu Togawa Hiroshi Yagioka Yoshitsugu Yanagihara Katsuyoshi Nakajima Dai Akiyama Tsuyoshi Hamada Koji Miyaba | 2013 | Gastrointestinal Endoscopy2013，，6： | 1 |
| 13 | Disease-specific mortality among patients with intraductal papillary mucinous neoplasm of the pancreas显示文摘 | Kazumichi Kawakubo Minoru Tada Hiroyuki Isayama Naoki Sasahira Yousuke Nakai Naminatsu Takahara Rie Uchino Tsuyoshi Hamada Koji Miyabayashi Keisuke Yamamoto Suguru Mizuno Dai Mohri Hirofumi Kogure Takashi Sasaki Natsuyo Yamamoto Kenji Hirano Hideaki Ijich | 2013 | Clinical Gastroenterology and Hepatology2013，，： | 1 |
| 14 | A retrospective study of S-1 and oxaliplatin combination chemotherapy in patients with refractory pancreatic cancer显示文摘 | Naminatsu Takahara Hiroyuki Isayama Yousuke Nakai Takashi Sasaki Tsuyoshi Hamada Rie Uchino Suguru Mizuno Koji Miyabayashi Hirofumi Kogure Natsuyo Yamamoto Naoki Sasahira Kenji Hirano Hideaki Ijichi Keisuke Tateishi Minoru Tada Kazuhiko Koike | 2013 | Cancer Chemotherapy and Pharmacology2013，，5： | 1 |
| 15 | The common ?55 C/T polymorphism in the promoter region of the uncoupling protein 3 gene reduces prevalence of obesity and elevates serum high-density lipoprotein cholesterol levels in the general Japanese population显示文摘 | Taku Hamada Kazuhiko Kotani Shinji Fujiwara Yoshiko Sano Masayuki Domichi Kokoro Tsuzaki Naoki Sakane | 2008 | Metabolism2008，，3： | 1 |
| 16 | Uridine diphosphate glucuronosyl transferase 1 family polypeptide A1 gene (UGT1A1) polymorphisms are associated with toxicity and efficacy in irinotecan monotherapy for refractory pancreatic cancer显示文摘 | Naminatsu Takahara Yousuke Nakai Hiroyuki Isayama Takashi Sasaki Yumiko Satoh Daiya Takai Tsuyoshi Hamada Rie Uchino Suguru Mizuno Koji Miyabayashi Dai Mohri Kazumichi Kawakubo Hirofumi Kogure Natsuyo Yamamoto Naoki Sasahira Kenji Hirano Hideaki Ijichi Mi | 2013 | Cancer Chemotherapy and Pharmacology2013，，1： | 1 |
| 17 | Superiority of 10-mm-wide balloon over 8-mm-wide balloon in papillary dilation for bile duct stones: A matched cohort study显示文摘 | Dai Akiyama Tsuyoshi Hamada Hiroyuki Isayama Yousuke Nakai Takeshi Tsujino Gyotane Umefune Naminatsu Takahara Dai Mohri Hirofumi Kogure Saburo Matsubara Yukiko Ito Natsuyo Yamamoto Naoki Sasahira Minoru Tada Kazuhiko Koike | 2015 | Saudi Journal of Gastroenterology2015，，4： | 1 |
| 18 | Up-Regulation of MSX2 Enhances the Malignant Phenotype and Is Associated with Twist 1 Expression in Human Pancreatic Cancer Cells显示文摘 | Kennichi Satoh Shin Hamada Kenji Kimura Atsushi Kanno Morihisa Hirota Jun Umino Wataru Fujibuchi Atsushi Masamune Naoki Tanaka Koh Miura Shinichi Egawa Fuyuhiko Motoi Michiaki Unno Barbara K. Vonderhaar Tooru Shimosegawa | 2008 | The American Journal of Pathology2008，，4： | 1 |
| 19 | Impact of culprit plaque volume and composition on myocardial microcirculation following primary angioplasty in patients with ST-segment elevation myocardial infarction: Virtual histology intravascular ultrasound analysis显示文摘 | Kousei Ohshima Shuntaro Ikeda Hisaki Kadota Kenichi Yamane Naoki Izumi Kiyotaka Ohshima Mareomi Hamada | 2012 | International Journal of Cardiology2012，，： | 1 |
| 20 | Cavity volume of ruptured plaque is an independent predictor for angiographic no-reflow phenomenon during primary angioplasty in patients with ST-segment elevation myocardial infarction显示文摘 | Kousei Ohshima Shuntaro Ikeda Hisaki Kadota Kenichi Yamane Naoki Izumi Hiroshi Kawazoe Kiyotaka Ohshima Mareomi Hamada | 2011 | Journal of Cardiology2011，，1： | 1 |
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