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| 1 | Elucidation of the relationship of BNIP3 expression to gemcitabine chemosensitivity and prognosis显示文摘AIM: To evaluate the significance of BNIP3 in the pathogenesis of pancreatic cancer, we analyzed the relationship between the expression of BNIP3 and survival rate of the patients with pancreatic cancer, or chemosensitivities in pancreatic cancer cell lines, particularly for gemcitabine, the first-line anti-tumor drug for pancreatic cancer. METHODS: To compare the expression level of BNIP3 with the resistance to gemcitabine, eight pancreatic cancer cell lines were subjected to gemcitabine treatment and the quantitative real-time RT-PCR method was used to evaluate BNIP3 expression. Immunohistochemical analysis was also performed using 22 pancreatic cancer specimens to study relationship between BNIP3 expression and survival rate. RESULTS: Although no significantly positive association between BNIP3 mRNA level and gemcitabine chemosensitivity was observed, pancreatic cancer cell lines that were sensitive to gemcitabine treatment tended to show high levels of BNIP3 expression. The converse, an absence of BNIP3 expression, was not correlated with gemcitabine resistance. We further compared the BNIP3 expression profiles of resected primary pancreaticcancer specimens with the prognosis of the patients, and found a tendency of favorable prognosis and low BNIP3 expression. CONCLUSION: High levels of BNIP3 expression cannot be used as one of the predicting factors for gemcitabine chemosensitivity, and some yet to be known factors will have to fill the gap for the accurate prediction of pancreatic cancer chemosensitivity to gemcitabine. However, BNIP3 expression may have an impact on prediction of prognosis of patients with pancreatic cancer. | Masaharu Ishida Makoto Sunamura Toru Furukawa Masanori Akada Hiroko Fujimura Emiko Shibuya Shinichi Egawa Michiaki Unno Akira Horii | 2007 | World Journal of Gastroenterology2007，13，34： | 8 |
| 2 | 胆道肿瘤临床实践指南(英文第三版)显示文摘日本肝胆胰外科学会(JSHBPS)于2007年出版第一版胆道肿瘤(胆管癌、胆囊癌及壶腹癌)临床实践指南,于2014年更新第二版,2021年英文第三版胆道肿瘤临床实践指南围绕6个主题提出若干临床问题,基于相关循证医学证据并组织专家讨论后,最终确定推荐意见、推荐强度以及推荐说明。根据证据推荐分级的评估、制订与评价(GRADE)系统,推荐强度被分为1级(强)或者2级(弱)。英文第三版胆道肿瘤临床实践指南中提出的31个临床问题涵盖:(1)预防性治疗;(2)诊断;(3)胆道引流;(4)外科治疗;(5)化疗;(6)放疗。31个临床问题中,14个问题给予推荐强度为强的推荐意见,14个问题给予推荐强度为弱的推荐意见,剩余的3个问题未给予推荐意见。每条推荐意见都进行推荐强度说明。最新版指南基于循证医学证据,为临床提供了重要建议。未来与癌症登记数据库协作将是评估指南和建立新证据的关键。 | Masato Nagino Satoshi Hirano Hideyuki Yoshitomi Taku Aoki Katsuhiko Uesaka Michiaki Unno Tomoki Ebata Masaru Konishi Keiji Sano Kazuaki Shimada Hiroaki Shimizu Ryota Higuchi Toshifumi Wakai Hiroyuki Isayama Takuji Okusaka Toshio Tsuyuguchi Yoshiki Hirooka Junji Furuse Hiroyuki Maguchi Kojiro Suzuki Hideya Yamazaki Hiroshi Kijima Akio Yanagisawa Masahiro Yoshida Yukihiro Yokoyama Takashi Mizuno Itaru Endo 杨翼飞(译) 仇毓东(译) 赵梦珂(译) 伏旭(译) 蔡正华(译) 毛凉(审校) | 2021 | 中华消化外科杂志2021，20，4： | 7 |
| 3 | Granular cell tumor of the pancreas:A case report and review of literature显示文摘Granular cell tumors,also called Abrikossof's tumors,were originally described by Abrikossof A in 1926.The f irst case of a pancreatic granular cell tumor was described in 1975 and only 6 cases have been reported.We describe a case of granular cell tumor in the pancreas showing pancreatic duct obstruction.Because imaging studies showed f indings compatible with those of pancreatic carcinoma,the patient underwent distal pancreatectomy.Histological examination showed that the tumor consisted of a nested growth of large tumor cells with ample granular cytoplasm and small round nuclei.The tumor cells expressed S-100 protein and were stained with neuron-specific enolase and periodic acid-Schiff,but were negative for desmin,vimentin,and cytokeratin.The resected tumor was diagnosed as a granular cell tumor.To our knowledge,this is the seventh case of Granular cell tumor of the pancreas to be reported. | Atsushi Kanno Kennichi Satoh Morihisa Hirota Shin Hamada Jun Umino Hiromichi Itoh Atsushi Masamune Shinichi Egawa Fuyuhiko Motoi Michiaki Unno Kazuyuki Ishida Tooru Shimosegawa | 2010 | World Journal of Gastrointestinal Oncology2010，2，2： | 5 |
| 4 | Utility of co-transplanting mesenchymal stem cells in islet transplantation显示文摘Islet transplantation is characterized by the transplantation of isolated islets from donor pancreata into a diabetic recipient. Although it is a viable choice in the treatment of insulin dependent diabetes mellitus, most patients (approximately 90%) require insulin five years after transplantation. Recently, the co-transplantation of mesenchymal stem cells (MSCs) and islets in animal studies has revealed the effectiveness of MSCs co-transplantation for improving islet function. Themechanisms underlying the beneficial impact of MSCs include immunomodulation and the promotion of angiogenesis. In this review, we discuss MSCs and how they support improved graft survival and function. | Naoaki Sakata Masafumi Goto Gumpei Yoshimatsu Shinichi Egawa Michiaki Unno | 2011 | World Journal of Gastroenterology2011，17，47： | 5 |
| 5 | 包含的小岛移植: 过去,现在和未来显示文摘 Islet transplantation could become an ideal treatment for severe diabetes to prevent hypoglycemia shock and irreversible diabetic complications, once some of the major and unresolved obstacles are overcome, including limited donor supplies and side effects caused by permanent immunosuppressant use. Approximately 30 years ago, some groups succeeded in improving the blood glucose of diabetic animals by transplanting encapsulated islets with semi-permeable membranes consisting of polymer. A semi-permeable membrane protects both the inner islets from mechanical stress and the recipient’s immune system (both cellular and humoral immunities), while allowing bidirectional diffusion of nutrients, oxygen, glucose, hormones and wastes, i.e., immune-isolation. This device, which enables immune-isolation, is called encapsulated islets or bio-artificial pancreas. Encapsulation with a semipermeable membrane can provide some advantages: (1) this device protects transplanted cells from the recipient’s immunity even if the xenogeneic islets (from large animals such as pig) or insulin-producing cells are derived from cells that have the potential for differentiation (some kinds of stem cells). In other words, the encapsulation technique can resolve the problem of limited donor supplies; and (2) encapsulation can reduce or prevent chronic administration of immunosuppressants and, therefore, important side effects otherwise induced by immunosuppressants. And now, many novel encapsulated islet systems have been developed and are being prepared for testing in a clinical setting. | Naoaki Sakata Shoichiro Sumi Gumpei Yoshimatsu Masafumi Goto Shinichi Egawa Michiaki Unno | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，1： | 4 |
| 6 | 太阳大气锂和铍的衰减显示文摘本文根据我们的非局部对流理论,计算了太阳大气锂和铍的衰减.结果表明,对于符合日震学要求的太阳对流包层模型,铍没有明显的衰减,而锂的衰减则稍快了些.观测与理论之间的矛盾似乎表明在对流区底部应存在一个10~3—10~4高斯的中等强度的磁场.更精确测定太阳大气湍流速度和温度起伏随高度的变化对判断上述理论推断是非常有意义的. | 熊大闰 Masa-aki Kondo Wasaburo Unno | 1991 | 天文学报1991，32，4： | 4 |
| 7 | Pancreatic duct drainage using EUS-guided rendezvous technique for stenotic pancreaticojejunostomy显示文摘The patient was a 30-year-old female who had undergone excision of the extrahepatic bile duct and Rouxen-Y hepaticojejunostomy for congenital biliary dilatation at the age of 7.Thereafter,she suffered from recurrent acute pancreatitis due to pancreaticobiliary maljunction and received subtotal stomach-preserving pancreaticoduodenectomy.She developed a pancreatic fistula and an intra-abdominal abscess after the operation.These complications were improved by percutaneous abscess drainage and antibiotic therapy.How ever,upper abdominal discomfort and the elevation of serum pancreatic enzymes persisted due to stenosis from the pancreaticojejunostomy.Because we could not accomplish dilation of the stenosis by endoscopic retrograde cholangiopancreatography,we tried an endoscopic ultrasonography(EUS) guided rendezvous technique for pancreatic duct drainage.After transgastric puncture of the pancreatic duct using an EUS-fine needle aspiration needle,the guidewire was inserted into the pancreatic duct and finally reached to the jejunum through the stenotic anastomosis.We changed the echoendoscope to an oblique-viewing endoscope,then grasped the guidewire and withdrew it through the scope.The stenosis of the pancreaticojejunostomy was dilated up to 4 mm,and a pancreatic stent was put in place.Though the pancreatic stent was removed after three months,the patient remained symptomfree.Pancreatic duct drainage using an EUS-guided rendezvous technique was useful for the treatment of a stenotic pancreaticojejunostomy after pancreaticoduodenectomy. | Tetsuya Takikawa Atsushi Kanno Atsushi Masamune Shin Hamada Eriko Nakano Shin Miura Hiroyuki Ariga Jun Unno Kiyoshi Kume Kazuhiro Kikuta Morihisa Hirota Hiroshi Yoshida Yu Katayose Michiaki Unno Tooru Shimosegawa | 2013 | World Journal of Gastroenterology2013，19，31： | 3 |
| 8 | Long-term effects of lamivudine treatment in Japanese chronic hepatitis B patients显示文摘AIM:To analyze the association between the emergence of tyrosine-methionine-asparatate-asparatate(YMDD) mutants(reverse transcription;rtM204I/V) and deterioration of liver function during long-term lamivudine treatment of Japanese patients with chronic hepatitis B virus(HBV) infection.METHODS:The data of 61 consecutive Japanese patients with chronic hepatitis B who underwent continuous lamivudine treatment for more than 24 mo and had a virological response were analyzed.Analysis of YMDD mutants was done by real-time polymerase chain reaction with LightCycler probe hybridization assay for up to 90 mo(mean,50.8 mo;range,24-90 mo).RESULTS:A mixed mutant-type(YMDD + tyrosine-isoleucine-asparatate-asparatate:YIDD or tyrosine-valineasparatate-asparatate:YVDD) or a mutant-type(YIDD or YVDD) were found in 57.4% of 61 patients at 1 year,78.7% of 61 patients at 2 years,79.6% of 49 patients at 3 years,70.5% of 34 patients at 4 years,68.4% of 19 patients at 5 years,57.1% of 14 patients at 6 years,and 33.3% of 6 patients at 7 years.Of the 61 patients,56(92%) had mixed mutant-or a mutant-type.Only 5(8%) had no mutants at each observation point.Virological breakthrough was found in 26(46.4%) of 56 patients with YMDD mutants,20 of whom had a hepatitis flare-up:the remaining 30(53.6%) had neither a virological breakthrough nor a flare-up.All 20 patients who developed a hepatitis flare-up had a biochemical and virological response after adefovir was added to the lamivudine treatment.CONCLUSION:Our results suggest that it is possible to continue lamivudine treatment,even after the emergence of YMDD mutants,up to the time that the patients develop a hepatitis flare-up. | Masayuki Murata Norihiro Furusyo Mami Unno Eiichi Ogawa Kazuhiro Toyoda Hiroaki Taniai Hachiro Ohnishi Jun Hayashi | 2011 | World Journal of Gastroenterology2011，17，24： | 3 |
| 9 | Diagnosis of autoimmune pancreatitis by EUS-FNA by using a 22-gauge needle based on the International Consensus Diagnostic Criteria显示文摘 | Atsushi Kanno Kazuyuki Ishida Shin Hamada Fumiyoshi Fujishima Jun Unno Kiyoshi Kume Kazuhiro Kikuta Morihisa Hirota Atsushi Masamune Kennichi Satoh Kenji Notohara Tooru Shimosegawa | 2012 | Gastrointestinal Endoscopy2012，，3： | 3 |
| 10 | miR‐197 induces epithelial–mesenchymal transition in pancreatic cancer cells by targeting p120 catenin显示文摘 | Shin Hamada Kennichi Satoh Shin Miura Morihisa Hirota Atsushi Kanno Atsushi Masamune Kazuhiro Kikuta Kiyoshi Kume Jun Unno Shinichi Egawa Fuyuhiko Motoi Michiaki Unno Tooru Shimosegawa | 2013 | J Cell Physiol2013，，6： | 3 |
| 11 | Extracorporeal shock wave lithotripsy of pancreatic duct stones and patient factors related to stone disintegration显示文摘 | Yasuyuki Karasawa Shigeyuki Kawa Yuji Aoki Yasuhide Ochi Hiroshi Unno Kendo Kiyosawa Tomofumi Watanabe | 2002 | Journal of Gastroenterology2002，，5： | 2 |
| 12 | S-phase cells in the guinea pig endolymphatic sac显示文摘 | Hokunan K Unno T | 1994 | Acta Otolaryngol1994，114，： | 1 |
| 13 | Hepatic perfusion changes after transcatheter arterial embolization (TAE) of hepatocellular carcinoma:messurment by dynamic compoted tomography显示文摘 | Tsushima Y Unno Y Koiaumi J | 1998 | Dig Dis Sci1998，43，2： | 1 |
| 14 | Pentacyclic laddersiloxane 显示文摘 | Unno M Suto A Matsumoto H | 2002 | J Am Chem Soc2002，124，8： | 1 |
| 15 | FDG PET/CT Findings in Malignant Intraductal Papillary Mucinous Neoplasm of the Bile Ducts显示文摘 | Kentaro Takanami Tomomichi Hiraide Tomohiro Kaneta Hiroki Hayashi Michiaki Unno Fumiyoshi Fujishima Hiroshi Fukuda Shogo Yamada Shoki Takahashi | 2010 | Clinical Nuclear Medicine2010，，2： | 1 |
| 16 | Clinical features and treatment outcome of borderline resectable pancreatic head/body cancer: a multi-institutional survey by the Japanese Society of Pancreatic Surgery显示文摘 | Hiroyuki Kato Masanobu Usui Shuji Isaji Takukazu Nagakawa Keita Wada Michiaki Unno Akimasa Nakao Shuichi Miyakawa Tetsuo Ohta | 2013 | Journal of Hepato-Biliary-Pancreatic Sciences2013，，6： | 1 |
| 17 | Virtual angioscopy using 3-dimensional rotational digital subtraction angiography for endovascular assessment显示文摘 | Mitsuoka H Takei Y | 2002 | Journal of Endovascular Therapy2002，9，4： | 1 |
| 18 | Ouabain exacerbates botulinum neurotoxin-indueed muscle paralysis via progression of muscle atrophyin mice 显示文摘 | Fujikawa R Muroi Y Unno T | 2010 | J Toxieol Sci2010，35，6： | 1 |
| 19 | Nitric oxide donor-induced hyperpermeability of cultured intestinal epithelial monolayers:role of superoxide radical,hydorxyl radical,and peroxynitrite显示文摘 | Unno N Smith M | 1998 | Biochem Biophys Acta1998，1425，1： | 1 |
| 20 | Petasinine and petasinoside, two minor alkaloids possessing a new necine isolated from Petasites japonicus Maxim显示文摘 | Yamada K Tatematsu H Unno R Hirata Y | 1978 | Tetrahedron Lett1978，46，： | 1 |
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