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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Epigenetic profiles of pre-diabetes transitioning to type 2 diabetes and nephropathy显示文摘AIM: To examine DNA methylation profiles in a longitudinal comparison of pre-diabetes mellitus(Pre-DM) subjects who transitioned to type 2 diabetes mellitus(T2DM).METHODS: We performed DNA methylation study in bisulphite converted DNA from Pre-DM(n = 11) at baseline and at their transition to T2 DM using Illumina Infinium Human Methylation27 Bead Chip, that enables the query of 27578 individual cytosines at Cp G loci throughout the genome, which are focused on the promoter regions of 14495 genes.RESULTS: There were 694 Cp G sites hypomethylated and 174 Cp G sites hypermethylated in progression from Pre-DM to T2 DM, representing putative genes involved in glucose and fructose metabolism, inflammation, oxidative and mitochondrial stress, and fatty acid metabolism. These results suggest that this high throughput platform is able to identify hundreds of prospective Cp G sites associated with diverse genes that may reflect differences in Pre-DM compared with T2 DM. In addition, there were Cp G hypomethylation changes associated with a number of genes that may be associated with development of complications of diabetes, such as nephropathy. These hypomethylation changes were observed in all of the subjects.CONCLUSION: These data suggest that some epigenomic changes that may be involved in the progression of diabetes and/or the development of complications may be apparent at the Pre-DM state or during the transition to diabetes. Hypomethylation of a number of genes related to kidney function may be an early marker for developing diabetic nephropathy. | Thomas A Vander Jagt Monica H Neugebauer Marilee Morgan Donald W Bowden Vallabh O Shah | 2015 | World Journal of Diabetes2015，6，9： | 5 |
| 3 | The Treatment-Naive Microbiome in New-Onset Crohn’s Disease显示文摘 | Dirk Gevers Subra Kugathasan Lee A. Denson Yoshiki Vázquez-Baeza Will Van Treuren Boyu Ren Emma Schwager Dan Knights Se Jin Song Moran Yassour Xochitl C. Morgan Aleksandar D. Kostic Chengwei Luo Antonio González Daniel McDonald Yael Haberman Thomas Walter | 2014 | Cell Host & Microbe2014，，： | 3 |
| 4 | Study to Determine Adequate Margins in Radiotherapy Planning for Esophageal Carcinoma by Detailing Patterns of Recurrence After Definitive Chemoradiotherapy显示文摘 | Michael R. Button Carys A. Morgan Elizabeth S. Croydon S. Ashley Roberts Thomas D.L. Crosby | 2009 | International Journal of Radiation Oncology, Biology, Physics2009，，3： | 2 |
| 5 | Randomized, Placebo-Controlled Trial of Pioglitazone in Nondiabetic Subjects With Nonalcoholic Steatohepatitis显示文摘 | Guruprasad P. Aithal James A. Thomas Philip V. Kaye Adam Lawson Stephen D. Ryder Ian Spendlove Andrew S. Austin Jan G. Freeman Linda Morgan Jonathan Webber | 2008 | Gastroenterology2008，，4： | 2 |
| 6 | Dividend Stability, Dividend Yield and Stock Returns : UK Evidence 显示文摘 | Gwilym Oa Morgan G Thomas S | 2000 | Journal of Business Finance & Accounting2000，27，34： | 1 |
| 7 | Digoxin Use and Lower 30-day All-cause Readmission for Medicare Beneficiaries Hospitalized for Heart Failure显示文摘 | Ali Ahmed Robert C. Bourge Gregg C. Fonarow Kanan Patel Charity J. Morgan Jerome L. Fleg Inmaculada B. Aban Thomas E. Love Clyde W. Yancy Prakash Deedwania Dirk J. van Veldhuisen Gerasimos S. Filippatos Stefan D. Anker Richard M. Allman | 2014 | The American Journal of Medicine2014，，1： | 1 |
| 8 | A trypsin-solubilized laccase from pharate pupal integument of the tobacco homworm, Manduca sexta 显示文摘 | Thomas B R Yonekura M Morgan T D | 1989 | Insect Biochem1989，19，7： | 1 |
| 9 | Randomized, Placebo-Controlled Trial of Pioglitazone in Nondiabetic Subjects With Nonalcoholic Steatohepatitis显示文摘 | Guruprasad P. Aithal James A. Thomas Philip V. Kaye Adam Lawson Stephen D. Ryder Ian Spendlove Andrew S. Austin Jan G. Freeman Linda Morgan Jonathan Webber | 2008 | Gastroenterology2008，，4： | 1 |
| 10 | Vascular endothelial growth factor receptor tyro- sine kinase inhibitors : PTIC787/ZK 222584 显示文摘 | Thomas AL Morgan B Drevs J Unger C Wiedenmann B Van- hoefer U | 2003 | Semin Oncol2003，30，6： | 1 |
| 11 | Non surgical therapy for anal fissure显示文摘 | Nelson RL Thomas K Morgan J | 2012 | Cochrane Database Syst Rev2012，2，： | 1 |
| 12 | Attenuation of p53 expression protects against focal ischemic damage in transgenic mice显示文摘 | Crumrine RC Thomas AL Morgan PF | 1994 | J Cereb Blood Flow Metab1994，14，6： | 1 |
| 13 | Iron Levels in Hepatocytes and Portal Tract Cells Predict Progression and Outcomes of Patients With Advanced Chronic Hepatitis C显示文摘 | Richard W. Lambrecht Richard K. Sterling Deepa Naishadham Anne M. Stoddard Thomas Rogers Chihiro Morishima Timothy R. Morgan Herbert L. Bonkovsky | 2011 | Gastroenterology2011，，5： | 1 |
| 14 | The use of CT-MR image registration to define target volumes in pelvic radiotherapy in the presence of bilateral hip replacements 显示文摘 | Charnley N Morgan A Thomas E | 2005 | Br J Radi2005，78，7： | 1 |
| 15 | Transfer of plasmid pBC16 between Bacillus thuringiensis strains in nonsusceptible larvae显示文摘 | Thomas D J Morgan J A Whipps J M | | 0，，： | 1 |
| 16 | Hypertension,Age,and Location predict rupture of small intracranial aneurysms显示文摘 | BRUAN V N MICHAEL L D THOMAS MORGAN | 2005 | Neurosurgery2005，57，4： | 1 |
| 17 | Adult and children's exposure to 2,4-D from multiple sources and pathways显示文摘 | MORGAN M K SHELDON L S THOMAS K W | 2008 | J Expo Sci Environ Epidemiol2008，18，5： | 1 |
| 18 | A colorimetric method for the determination of glucosamine and chondrossmine显示文摘 | Elson LA Thomas W Morgan J | 1933 | Biochem J1933，27，： | 1 |
| 19 | Dynamic contrast-enhanced magnetic resonance imaging as a biomarker for the pharmacological response of PTK787/ZK222584 ,an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases, in patients with advanced colorectal cancer and liver metastases: results from two phase Ⅰ studies 显示文摘 | Morgan B Thomas AL Drevs J | 2003 | J Clin Oncol2003，21，21： | 1 |
| 20 | Discovery of azetidinone acids as conformationally-constrained dual PPARα/γ agonists显示文摘 | Wei Wang Pratik Devasthale Dennis Farrelly Liqun Gu Thomas Harrity Michael Cap Cuixia Chu Lori Kunselman Nathan Morgan Randy Ponticiello Rachel Zebo Litao Zhang Kenneth Locke Jonathan Lippy Kevin O’Malley Vinayak Hosagrahara Lisa Zhang Pathanjali Kadiyala | 2008 | Bioorganic & Medicinal Chemistry Letters2008，，6： | 1 |
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