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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Myopia显示文摘 | Ian G Morgan Kyoko Ohno-Matsui Seang-Mei Saw | 2012 | The Lancet2012，，9827： | 2 |
| 3 | Myopia显示文摘 | Ian G Morgan Kyoko Ohno-Matsui Seang-Mei Saw | 2012 | The Lancet2012，，9827： | 2 |
| 4 | Genetic influences on beef longissimus palatability in Charolais-and Limousin-sired steers and heifers显示文摘 | Wulf D M Tatum J D Green R D Morgan J B Golden B L and Smith G C | 1996 | J Anim Sci1996，74，： | 2 |
| 5 | A readout magnet for prepolarized MRI显示文摘 | Morgan P Conolly S Scott G | 1996 | Magn Reson Med1996，36，4： | 1 |
| 6 | Salinity effects on oxygen consumption,gill Na+,K+-ATPase and ion regulation in juvenile coho salmon显示文摘 | | 1998 | Joural of Fish Biology1998，53，5： | 1 |
| 7 | Asset and Liability Management Systemfor Towers Perrin-Tillinghast显示文摘 | Gould G Morgan C | 2000 | Interfaces2000，30，1： | 1 |
| 8 | Beneficial effect of micro- injected trehalose on the cryosurvival of human oocytes 显示文摘 | Erdag G Eroglu A Morgan J R | 2002 | Fer- til Steril2002，44，： | 1 |
| 9 | Biological costs and benefits to plant-microbe interactions in the rhizosphere 显示文摘 | Morgan J A W Bending G D White P J | 2005 | Journal of Experimental Botany2005，56，417： | 1 |
| 10 | Regional cerebral activation in irritable bowel syndrome and control sllbjeets with painful and nonpaiof-ul rectaldis tentiend 显示文摘 | Mortz H Morgan V Tamer G | 2010 | Gastroenterolog)2010，118，： | 1 |
| 11 | Carbon exchangerates in grazed and ungrazed pastures of Wyoming显示文摘 | Lecain D Morgan J Schuman G | 2000 | Journal of Range Management2000，53，2： | 1 |
| 12 | Solar assisted heat pump 显示文摘 | Morgan G | 1982 | Solar Energy1982，，28： | 1 |
| 13 | Survival of fetal skin grafts is prolonged on the human peripheral blood lymphocyte reconstituted- severe combined immunodeficient mouse/ skin allograft model显示文摘 | G Erdag J R Morgan | 2002 | Transplantation2002，73，： | 1 |
| 14 | Structure of the mammalian ribosome-channel complex at 17A resolution显示文摘 | Morgan D G Menetret J F Neuhof A | 2002 | J Mol Biol2002，324，4： | 1 |
| 15 | Dividend Stability, Dividend Yield and Stock Returns : UK Evidence 显示文摘 | Gwilym Oa Morgan G Thomas S | 2000 | Journal of Business Finance & Accounting2000，27，34： | 1 |
| 16 | Experimental and computational study of the structure and electrochemical properties of LiVl2 (PO4)3 compounds with the monoclinic and rhom bohedral structure显示文摘 | Morgan D Ceder G Saidi M Y | 2002 | Chem Mater2002，14，： | 1 |
| 17 | Biological costs and benefits to plant-microbe interactions in the rhizosphere显示文摘 | Morgan J A W Bending G D White P J | 2005 | Experimental Botany2005，56，417： | 1 |
| 18 | Hydrogen peroxide method intercomparision study in seawater 显示文摘 | Miller G W Morgan C A Kieber D J | 2005 | Marine Chemis- try2005，97，12： | 1 |
| 19 | Biology, eeology and prevalenee of dust mite 显示文摘 | Allan L G Morgan M S | 2003 | Immnuol Allergy Clin N Am2003，23，： | 1 |
| 20 | Biological costs and benefits to plant-microbe interactions in the rhizosphere显示文摘 | Morgan J A W Bending G D | 2005 | Journal of Experimental Botany2005，56，471： | 1 |
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