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| 1 | Hypoxic preconditioning stimulates angiogenesis in ischemic penumbra after acute cerebral infarction显示文摘Previous studies have demonstrated the protective effect of hypoxic preconditioning on acute cerebral infarction,but the mechanisms underlying this protection remain unclear.To investigate the protective mechanisms of hypoxic preconditioning in relation to its effects on angiogenesis,we induced a photochemical model of cerebral infarction in an inbred line of mice(BALB/c).Mice were then exposed to hypoxic preconditioning 30 minutes prior to model establishment.Results showed significantly increased vascular endothelial growth factor and CD31 expression in the ischemic penumbra at 24 and 72 hours post infarction,mainly in neurons and vascular endothelial cells.Hypoxic preconditioning increased vascular endothelial growth factor and CD31 expression in the ischemic penumbra and the expression of vascular endothelial growth factor was positively related to that of CD31.Moreover,hypoxic preconditioning reduced the infarct volume and improved neurological function in mice.These findings indicate that the protective role of hypoxic preconditioning in acute cerebral infarction may possibly be due to an increase in expression of vascular endothelial growth factor and CD31 in the ischemic penumbra,which promoted angiogenesis. | Sijie Li Yanbo Zhang Guo Shao Mingfeng Yang Jingzhong Niu Guowei Lv Xunming Ji | 2013 | Neural Regeneration Research2013，8，31： | 31 |
| 2 | Temperature variation of a thermionic cathode during electron emission显示文摘It is necessary to know the actual temperature of a thermionic cathode that works as the electron source in a microwave tube. It has been found that the temperature of the cathode drops markedly during the thermionic emission. For example, the temperature could fall by about 30oC under a current density of 2.92 A/cm2. Using the molecular thermodynamics, the dependence of the cathode temperature on the emission current density has been obtained. It has been theoretically pointed out that several factors, such as heating model and temperature coefficient of resis-tance of heater, can influence the cathode temperature. These theoretical conclu-sions were supported by the experimental results. | LIU YanWen TIAN Hong HAN Yong XU ZhenYing MENG MingFeng ZHANG HongLai | 2008 | Science China(Technological Sciences)2008，51，9： | 22 |
| 3 | Genome-wide identification, expression analysis of auxin-responsive GH_3 family genes in maize(Zea mays L.) under abiotic stresses显示文摘Auxin is involved in different aspects of plant growth and development by regulating the expression of auxinresponsive family genes. As one of the three major auxinresponsive families, GH3(Gretchen Hagen3) genes participate in auxin homeostasis by catalyzing auxin conjugation and bounding free indole-3-acetic acid(IAA) to amino acids.However, how GH3 genes function in responses to abiotic stresses and various hormones in maize is largely unknown.Here, the latest updated maize(Zea mays L.) reference genome sequence was used to characterize and analyze the Zm GH3 family genes from maize. The results showed that 13 Zm GH3 genes were mapped on fi ve maize chromosomes(total10 chromosomes). Highly diversi fi ed gene structures and tissue-speci fi c expression patterns suggested the possibility of function diversi fi cation for these genes in response to environmental stresses and hormone stimuli. The expression patterns of Zm GH3 genes are responsive to several abiotic stresses(salt, drought and cadmium) and major stress-relatedhormones(abscisic acid, salicylic acid and jasmonic acid)Various environmental factors suppress auxin free IAA contents in maize roots suggesting that these abiotic stresses and hormones might alter GH3-mediated auxin levels. The respon siveness of Zm GH3 genes to a wide range of abiotic stresses and stress-related hormones suggested that Zm GH3 s are involved in maize tolerance to environmental stresses. | Shangguo Feng Runqing Yue Sun Tao Yanjun Yang Lei Zhang Mingfeng Xu Huizhong Wang Chenjia Shen | 2015 | Journal of Integrative Plant Biology2015，57，9： | 17 |
| 4 | Spin-decoupled metasurface for simultaneous detection of spin and orbital angular momenta via momentum transformation显示文摘With inherent orthogonality,both the spin angular momentum(SAM)and orbital angular momentum(OAM)of photons have been utilized to expand the dimensions of quantum information,optical communications,and information processing,wherein simultaneous detection of SAMs and OAMs with a single element and a single-shot measurement is highly anticipated.Here,a single azimuthal-quadratic phase metasurface-based photonic momentum transformation(PMT)is illustrated and utilized for vortex recognition.Since different vortices are converted into focusing patterns with distinct azimuthal coordinates on a transverse plane through PMT,OAMs within a large mode space can be determined through a single-shot measurement.Moreover,spin-controlled dual-functional PMTs are proposed for simultaneous SAM and OAM sorting,which is implemented by a single spin-decoupled metasurface that merges both the geometric phase and dynamic phase.Interestingly,our proposed method can detect vectorial vortices with both phase and polarization singularities,as well as superimposed vortices with a certain interval step.Experimental results obtained at several wavelengths in the visible band exhibit good agreement with the numerical modeling.With the merits of ultracompact device size,simple optical configuration,and prominent vortex recognition ability,our approach may underpin the development of integrated and high-dimensional optical and quantum systems. | Yinghui Guo Shicong Zhang Mingbo Pu Qiong He Jinjin Jin Mingfeng Xu Yaxin Zhang Ping Gao Xiangang Luo | 2021 | Light(Science & Applications)2021，10，4： | 14 |
| 5 | Gabapentin inhibits central sensitization during migraine显示文摘Peripheral and central sensitizations are phenomena that occur during migraine.The role of gabapentin,a migraine preventive drug,on central sensitization remains unclear.In this study,a rat model of migraine was established by electrical stimulation of the trigeminal ganglion,and the animals were given intragastric gabapentin.Changes in amino acid content in the cerebrospinal fluid and protein kinase C membrane translocation in the spinal trigeminal nucleus were examined to clarify the mechanisms underlying the efficacy of gabapentin in the treatment of central sensitization during migraine.Electrophysiology,liquid chromatography-mass spectrometry and western blot analysis results revealed that gabapentin reduces neuronal excitability in the spinal nucleus in the trigeminal nerve,decreases excitatory amino acid content and inhibits the activation of protein kinase C.This provides evidence that excitatory amino acids and protein kinase C are involved in the formation and maintenance of central sensitization during migraine.Gabapentin inhibits migraine by reducing excitatory amino acid content in the cerebrospinal fluid and inhibiting protein kinase C activation. | Yanbo Zhang Guo Shao Wei Zhang Sijie Li Jingzhong Niu Dongmei Hu Mingfeng Yang Xunming Ji | 2013 | Neural Regeneration Research2013，8，32： | 12 |
| 6 | Serpentinization, abiogenic organic compounds, and deep life显示文摘The hydrocarbons and other organic compounds generated through abiogenic or inorganic processes are closely related to two science subjects,i.e.,energy resources and life’s origin and evolution.'The earth’s primordial abiogenic hydrocarbon theory'and'the serpentinization of abiogenic hydrocarbon theory'are the two mainstream theories in the field of related studies.Serpentinization generally occurs in slow expanding mid-ocean ridges and continental ophiolites tectonic environment,etc.The abiogenic hydrocarbons and other organic compounds formed through the serpentinization of ultramafic rocks provide energy and raw materials to support chemosynthetic microbial communities,which probably was the most important hydration reaction for the origin and early evolution of life.The superposition of biological and abiological processes creates big challenge to the identification of the abiogenic organic materials in serpentinite-hosted ecosystem.Whether abiotic(inorganic)process can form oil and gas resource is a difficult question that has been explored continuously by scientific community for more than a century but has not yet been solved.However,some important progress has been made.The prospecting practice of abiogenic hydrocarbons in commercial gases from the Songliao Basin,China,provides an important example for exploring abiogenic natural gas resources. | WANG XianBin OUYANG ZiYuan ZHUO ShengGuang ZHANG MingFeng ZHENG GuoDong WANG YongLi | 2014 | Science China Earth Sciences2014，57，5： | 11 |
| 7 | Acute calculous cholecystitis associated with hepatic artery pseudoaneurysm after percutaneous transhepatic gallbladder drainage in a diabetic patient显示文摘Patients with acute calculous cholecystitis are usually undertaken surgery laparoscopic cholecystectomy.However,there are controversies about the decision of operation for patients with high risk factors.Percutaneous transhepatic gallbladder drainage (PTGD) is palliative therapy to alleviate symptoms and physical signs.Since improved clinical outcome has been observed for PTGD,it was recommended as an initial therapeutic option for high risk patients who might need surgery.1 Percutaneous drainage in acute calculous cholecystitis for high risk patients is to be a safe and successful treatment option for patients less eligible for surgery.2 PTGD is relatively safe,but has certain complications.We provided a case report of acute calculous cholecystitis associated with hepatic artery pseudoaneurysm after PTGD in a diabetes mellitus patient.The liver vascular pseudoaneurysms and secondary changes of liver were documented by the imaging examination.The complex interactions among inflammation,bleeding,and diabetes mellitus were involved in this case. | Tian Hu Xia Mingfeng Zhang Shuai Li Jie Liu Ju | 2014 | Chinese Medical Journal2014，，17： | 9 |
| 8 | Crosstalk-free achromatic full Stokes imaging polarimetry metasurface enabled by polarization-dependent phase optimization显示文摘Imaging polarimetry is one of the most widely used analytical technologies for object detection and analysis.To date,most metasurface-based polarimetry techniques are severely limited by narrow operating bandwidths and inevitable crosstalk,leading to detrimental effects on imaging quality and measurement accuracy.Here,we propose a crosstalkfree broadband achromatic full Stokes imaging polarimeter consisting of polarization-sensitive dielectric metalenses,implemented by the principle of polarization-dependent phase optimization.Compared with the single-polarization optimization method,the average crosstalk has been reduced over three times under incident light with arbitrary polarization ranging from 9μm to 12μm,which guarantees the measurement of the polarization state more precisely.The experimental results indicate that the designed polarization-sensitive metalenses can effectively eliminate the chromatic aberration with polarization selectivity and negligible crosstalk.The measured average relative errors are 7.08%,8.62%,7.15%,and 7.59%at 9.3,9.6,10.3,and 10.6μm,respectively.Simultaneously,the broadband full polarization imaging capability of the device is also verified.This work is expected to have potential applications in wavefront detection,remote sensing,light-field imaging,and so forth. | Yaxin Zhang Mingbo Pu Jinjin Jin Xinjian Lu Yinghui Guo Jixiang Cai Fei Zhang Yingli Ha Qiong He Mingfeng Xu Xiong Li Xiaoliang Ma Xiangang Luo | 2022 | Opto-Electronic Advances2022，5，11： | 6 |
| 9 | Angle Dependence Analysis Method to Determine SNRArc Applied to GNSSMRSea Level Retrieval显示文摘The Global Navigation Satellite Systems(GNSS)broadcast radio signals are continuously at two or more frequencies in the L-band,and the multipath signals from sea surface recorded by off-the-shelf geodetic receivers have been demonstrated they can be used to estimate sea level,using a technology called GNSS multipath reflectometry(GNSS-MR).Before proceeding to estimate reflection parameters,the azimuth range and elevation angle range are needed to be defined,as only with suitable azimuths and elevation angles the sensing zones can be guaranteed on water.So,this study presents an angle dependence analysis method to jointly select the azimuth range and elevation angle range based on wavelet analysis which can describe the nonstationary power of different sinusoidal oscillations changed with elevation angle.The key of this method is to use one grid model to screen the spectrum power of multipath oscillation on different elevation angles and azimuths in this work.Then the elevation angles and the azimuths can be determined by searching grids with greater power.The GPS and GLONASS data of two MultiGNSS Experiment(MGEX)stations named BRST and MAYG was analyzed and used to retrieve.Firstly,the angle dependence analysis was carried out to determine the elevation range and azimuth range.Secondly,the sea levels were retrieved from individual signals.Finally,the retrievals of individual signals are combined to form a 10-min sea level retrieval series.The RMSEs of the combined retrievals are both less than 15 cm.The results show the effectiveness of the selection of angle range based on the angle dependence analysis method. | Xiaolei WANG Xiufeng HE Qin ZHANG Mingfeng SONG Zijin NIU | 2021 | Journal of Geodesy and Geoinformation Science2021，4，2： | 6 |
| 10 | Cooperation of PprI and DrRRA in response to extreme ionizing radiation in Deinococcus radiodurans显示文摘Deinococcus radiodurans possesses extreme resistance to ionizing radiation,and has been engineered for the remediation of toxic components in radioactive environments.We have previously shown that PprI(also named IrrE)and DrRRA are essential for the DNA protection and repair pathways that respond to ionizing radiation stress in this species.Here,we investigated the combined roles of PprI and DrRRA in resistance to gamma radiation(800 Gy).The double mutant,△drRRA△pprI,was more sensitive to gamma rays than either△drRRA or△pprI single mutants,and exhibited an elevated level of intracellular protein carbonylation,an extended delay in genome reconstitution and reduced transcriptional levels of certain DNA protection and repair proteins,such as kat,sod,recA and pprA.Interestingly,the induction of DrRRA by ionizing radiation was partially inhibited by the deletion of pprI. Taken together,these results suggest that DrRRA and PprI might have collaborative roles in the response of D.radiodurans to extreme ionizing radiation. | WANG LiangYan YIN LongFei XU GuangZhi LI MingFeng ZHANG Hui TIAN Bin HUA YueJin | 2012 | Chinese Science Bulletin2012，57，1： | 6 |
| 11 | Discrimination of False Negative Results in RT-PCR Detection of SARS-CoV-2 RNAs in Clinical Specimens by Using an Internal Reference显示文摘Reverse transcription-polymerase chain reaction(RT-PCR)is an essential method for specific diagnosis of SARS-CoV-2 infection.Unfortunately,false negative test results are often reported.In this study,we attempted to determine the principal causes leading to false negative results of RT-PCR detection of SARS-CoV-2 RNAs in respiratory tract specimens.Multiple sputum and throat swab specimens from 161 confirmed COVID-19 patients were tested with a commercialfluorescent RT-PCR kit targeting the ORF1 ab and N regions of SARS-CoV-2 genome.The RNA level of a cellular housekeeping gene ribonuclease P/MRP subunit p30(RPP30)in these specimens was also assessed by RT-PCR.Data for a total of 1052 samples were retrospectively re-analyzed and a strong association between positive results in SARS-CoV-2 RNA tests and high level of RPP30 RNA in respiratory tract specimens was revealed.By using the ROC-AUC analysis,we identified Ct cutoff values for RPP30 RT-PCR which predicted false negative results for SARS-CoV-2 RT-PCR with high sensitivity(95.03%–95.26%)and specificity(83.72%–98.55%)for respective combination of specimen type and ampli-fication reaction.Using these Ct cutoff values,false negative results could be reliably identified.Therefore,the presence of cellular materials,likely infected host cells,are essential for correct SARS-CoV-2 RNA detection by RT-PCR in patient specimens.RPP30 could serve as an indicator for cellular content,or a surrogate indicator for specimen quality.In addition,our results demonstrated that false negativity accounted for a vast majority of contradicting results in SARS-CoV-2 RNA test by RT-PCR. | Yafei Zhang Changtai Wang Mingfeng Han Jun Ye Yong Gao Zhongping Liu Tengfei He Tuantuan Li Mengyuan Xu Luping Zhou Guizhou Zou Mengji Lu Zhenhua Zhang | 2020 | Virologica Sinica2020，35，6： | 5 |
| 12 | Engineered trimeric ACE2 binds viral spike protein and locks it in'Thfee-up'conformation to potently inhibit SARS-CoV-2 infection显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has resulted in a severe global pandemic Following SARS-CoV,SARS-CoV-2 is yet another emerge nt beta-coronavirus threate ning human health.1 However,seventeen years after the SARS pandemic,no targeted vaccines or therapeutics have been approved for SARS,while some of them might have held promise for treating COVID-19.Many neutralizing antibodies against SARS-CoV-2 are currently being developed.However,RNA viruses are known to have high mutation rates. | Liang Guo Wenwen Bi Xinling Wang Wei Xu Renhong Yan Yuanyuan Zhang Kai Zhao Yaning Li Mingfeng Zhang Xia Cai Shibo Jiang Youhua Xie Qiang Zhou Lu Lu Bobo Dang | 2021 | Cell Research2021，31，1： | 5 |
| 13 | A DFT Study on the Adsorption Behavior of Sulfur and Nitrogen Compounds on the NiMoS Phase显示文摘The density functional theory(DFT)with dispersion corrections was used to study the adsorption behavior of sulfur and nitrogen compounds on NiMoS phase.The calculations were performed based on a hexagonal cluster model including the Mo-edge,the S-edge,and the rarely mentioned corner site.It was found that the adsorption of quinoline is stronger than that of benzothiophene at all the active sites.It indicated the origin of the inhibition effect of nitrogen compounds on HDS.And Ni atoms located around Mo-edge and corner site exhibit higher adsorption selectivity to sulfur compounds than the nitrogen ones.It means that the increase in Ni-promoting effect may weaken the inhibition effect of nitrogen compounds on HDS. | Wang Wei Li Huifeng Han Wei Zhang Le Zhao Xiaoguang Li Mingfeng | 2020 | China Petroleum Processing & Petrochemical Technology2020，22，1： | 5 |
| 14 | Study on Sulfidation Degree and Morphology of MoS_2 Catalyst Derived from Various Molybdate Precursors显示文摘The MoS_2 catalysts were prepared from various molybdate precursors including inorganic and organic molybdate compounds. The sulfidation degree and morphology of active phases of MoS_2 activated by various molybdate precursors in H_2S/H_2 stream at different temperatures were studied by X-ray photoelectron spectroscopy(XPS) and high-resolution transmission electron microscopy(HRTEM). The organic molybdate precursors lead to MoS_2 catalysts with higher sulfidation degree and smaller active phases to demonstrate higher catalytic activity during hydrodesulfurizaiton(HDS) of 4,6-DMDBT. | Zhang Le Li Mingfeng Nie Hong | 2014 | China Petroleum Processing & Petrochemical Technology2014，16，2： | 4 |
| 15 | RNA Interference-based Suppression of Phosphoenolpyruvate Carboxylase Results in Susceptibility of Rapeseed to Osmotic Stress显示文摘The diverse functions of phosphoenolpyruvate carboxylase(PEPCase;EC 4.1.1.31) in C3 plants are not as well understood as in C4 plants.To investigate the functions of PEPCase in C3 plants,rapeseed(Brassica napus L.) PEPCase gene(referred to as BNPE15) was silenced by the RNA interference(RNAi) technique.Under normal growth conditions,no significant difference in lipid content and fatty acid composition were found between wild-type(WT) and transgenic rapeseed plants.However,when these plants were subjected to osmotic stress induced by osmoticum polyethylene glycol(PEG-6000),membrane permeability and membrane lipid peroxidization in roots and leaves of transgenic plants were higher than those of WT plants.It suggested that transgenic plants are more susceptible to osmotic stress than WT plants.Taken together,the results showed that the suppression of PEPCase by RNAi leads to susceptibility to osmotic stress in rapeseed,and PEPCase is involved in the response of C3 plants to environmental stress. | Mei Chen Yunlai Tang Jingmei Zhang Mingfeng Yang Yinong Xu | 2010 | Journal of Integrative Plant Biology2010，52，6： | 4 |
| 16 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 17 | Tocilizumab in patients with moderate or severe COVID-19: a randomized, controlled, open-label, multicenter trial显示文摘Tocilizumab has been reported to attenuate the“cytokine storm”in COVID-19 patients.We attempted to verify the effectiveness and safety of tocilizumab therapy in COVID-19 and identify patients most likely to benefit from this treatment.We conducted a randomized,controlled,open-label multicenter trial among COVID-19 patients.The patients were randomly assigned in a 1:1 ratio to receive either tocilizumab in addition to standard care or standard care alone.The cure rate,changes of oxygen saturation and interference,and inflammation biomarkers were observed.Thirty-three patients were randomized to the tocilizumab group,and 32 patients to the control group.The cure rate in the tocilizumab group was higher than that in the control group,but the difference was not statistically significant(94.12%vs.87.10%,rate difference 95%CI−7.19%–21.23%,P=0.4133).The improvement in hypoxia for the tocilizumab group was higher from day 4 onward and statistically significant from day 12(P=0.0359).In moderate disease patients with bilateral pulmonary lesions,the hypoxia ameliorated earlier after tocilizumab treatment,and less patients(1/12,8.33%)needed an increase of inhaled oxygen concentration compared with the controls(4/6,66.67%;rate difference 95%CI−99.17%to−17.50%,P=0.0217).No severe adverse events occurred.More mild temporary adverse events were recorded in tocilizumab recipients(20/34,58.82%)than the controls(4/31,12.90%).Tocilizumab can improve hypoxia without unacceptable side effect profile and significant influences on the time virus load becomes negative.For patients with bilateral pulmonary lesions and elevated IL-6 levels,tocilizumab could be recommended to improve outcome. | Dongsheng Wang Binqing Fu Zhen Peng Dongliang Yang Mingfeng Han Min Li Yun Yang Tianjun Yang Liangye Sun Wei Li Wei Shi Xin Yao Yan Ma Fei Xu Xiaojing Wang Jun Chen Daqing Xia Yubei Sun Lin Dong Jumei Wang Xiaoyu Zhu Min Zhang Yonggang Zhou Aijun Pan Xiaowen Hu Xiaodong Mei Haiming Wei Xiaoling Xu | 2021 | Frontiers of Medicine2021，15，3： | 2 |
| 18 | Distribution of Asbestos Enterprises and Asbestosis Cases--China, 1997−2019显示文摘What is already known on this topic?Asbestos is classified as a Class I Carcinogen by the International Agency for Research on Cancer(IARC)because exposure causes mesothelioma and lung cancer in addition to asbestosis and plaques.So far,asbestos has been banned in 67 countries,but chrysotile,a commonly encountered form of asbestos,is still widely used in China and most developing countries.Most asbestos-caused cancers are not reported,recorded,and compensated in many countries.What is added by this report?Enterprises manufacturing asbestos products have been migrating from economically developed Eastern China to relatively underdeveloped central and western regions between 2010 and 2019.Asbestosis cases reported in Tianjin,Beijing,Shandong,Xinjiang,Gansu,Qinghai,and Sichuan accounted for a large proportion of the total cases in China,which was inconsistent with the distribution of asbestos-related enterprises(AREs).The reported asbestosis cases versus total pneumoconiosis cases declined from 2.81%to 0.39%from 2006–2017,and this proportion reached 0.69%in 2018.What are the implications for public health practice?Robust occupational and environmental health assessments and reporting are needed to define the epidemiology of asbestos-related lung diseases,and management of using asbestos and existing products containing asbestos need strengthening and follow-up.Enterprises should be encouraged to use safer substitutes and gradually ban asbestos materials in China. | Mingfeng Chen Huanqiang Wang Jianfang Zhang Chen Yu Weidong Liu Yunhao Xu | 2020 | China CDC weekly2020，2，18： | 2 |
| 19 | NSC-640358 acts as RXRa ligand to promote TNFa-mediated apoptosis of cancer cell显示文摘 | Fan Chen Jiebo Chen Jiacheng Lin Anton V. Cheltsov Lin Xu Ya Chen Zhiping Zeng Liqun Chen Mingfeng Huang Mengjie Hu Xiaohong Ye YuqiZhou Guanghui Wang Ying su Long Zhang Fangfang Zhou Xiao-kun Zhang HU Zhou | 2015 | Protein & Cell2015，6，9： | 2 |
| 20 | Asymptomatic patients and asymptomatic phases of Coronavirus Disease 2019(COVID-19):a population-based surveillance study显示文摘In this population-based study,we identified 307 confirmed COVID-19 cases from massive surveillance,including 129551 individuals screened at fever clinics or returning from Hubei and 3710 close contacts of confirmed COVID-19 patients.Among them,17 patients were asymptomatic at initial clinical assessment.These asymptomatic patients on admission accounted for a small proportion of all patients(5.54%)with relatively weak transmissibility,and the detection rate was 0.35 per 100 close contacts.Moreover,the dynamics of symptoms of the 307 patients showed that the interval from symptom remission to the final negativity of viral nucleic acid was 5.0 days(interquartile range 2.0 to 11.0 days),with 14 patients(4.56%)having re-detectable viral RNA after discharge.Overall;our findings suggested asymptomatic carriers and presymptomatic patients only accounted for a small proportion of COVID-19 patients.Also,the asymptomatic phase during recovery from COVID-19 implied that negativity in viral RNA is necessary as a de-isolation criterion and follow-up is recommended. | Xueying Zheng Sihui Luo Yong Sun Mingfeng Han Jian Liu Liangye Sun Liangming Zhang Ping Ling Yu Ding Tengchuan Jin Zhirong Liu Jianping Weng | 2020 | National Science Review2020，7，10： | 2 |
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