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| 1 | Antioxidant activity, mutagenicity/anti-mutagenicity, and clastogenicity/anti-clastogenicity of lutein from marigold flowers显示文摘 | Mingchen Wang Rong Tsao Shanfeng Zhang Ziming Dong Raymond Yang Jianhua Gong Yingxin Pei | 2006 | Food and Chemical Toxicology2006，，9： | 2 |
| 2 | Velocity anomaly analysis on low-amplitude structure and its application in Bohai Sea:a case study on QHD33-1S structure显示文摘Varying degree of velocity anomalies has been appeared in Shijiutuo uplift in Bohai Sea,which is mainly demonstrated in the inconsistent between seismic interpretation and the actual drilling depth.In this paper, QHD33-1S area is taken as the example.First of all,the main reason that causes the velocity anomaly phenomena is the effect of sand-formation ratio by forward model analysis,and then technical approaches to improve the accuracy of the velocity field and the degree of understanding of anomalies are further explored,resulting in more precise determination of horizontal variation trend of the velocity in QHD33-1S area.Consequences of actual applications indicate that through the accurate analysis of the velocity anomaly,we can not only realize the fine description of low-amplitude structure,but also the effective prediction of the hydrocarbon-bearing properties of the reservoir.Meanwhile,the results also have a certain significance for the other low-amplitude structures in Bohai Sea. | CHUAI Yuanyuan ZHOU Donghong LV Dingyou WANG Mingchen LI Ying | 2012 | Global Geology2012，15，4： | 2 |
| 3 | A Sub-100 mg Electromagnetically Driven Insect-inspired Flapping-wing Micro Robot Capable of Liftoff and Control Torques Modulation显示文摘Inspired by the unique,agile and efficient flapping flight of insects,we present a novel sub-100 mg,electromagnetically driven,tailless,flapping-wing micro robot.This robot utilizes two optimized electromagnetic actuators placed back to back to drive two wings separately,then kinematics of each wing can be independently controlled,which gives the robot the ability to generate all three control torques of pitch,roll and yaw for steering.To quantify the performance of the robot,a simplified aerodynamic model is used to estimate the generated lift and torques,and two customized test platforms for lift and torque measurement are built for this robot.The mean lift generated by the robot is measured to be proportional to the square of the input voltage amplitude.The three control torques are measured to be respectively proportional to three decoupled parameters of the control voltages,therefore the modulation of three control torques for the robot is independent,which is helpful for the further controlled flight.All these measured results fit well with the calculated results of the aerodynamic model.Furthermore,with a total weight of 96 mg and a wingspan of 3.5 cm,this robot can generate sufficient lift to take off. | Chenyang Wang Weiping Zhang Yang Zou Ran Meng Jiaxin Zhao Mingchen Wei | 2020 | Journal of Bionic Engineering2020，17，6： | 2 |
| 4 | A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1βand IL-6显示文摘Glycolytic metabolism enzymes have been implicated in the immunometabolism field through changes in metabolic status. PGK1 is a catalytic enzyme in the glycolytic pathway. Here, we set up a high-throughput screen platform to identify PGK1 inhibitors. DC-PGKI is an ATPcompetitive inhibitor of PGK1 with an affinity of Kd= 99.08 nmol/L. DC-PGKI stabilizes PGK1in vitro and in vivo, and suppresses both glycolytic activity and the kinase function of PGK1. In addition,DC-PGKI unveils that PGK1 regulates production of IL-1β and IL-6 in LPS-stimulated macrophages.Mechanistically, inhibition of PGK1 with DC-PGKI results in NRF2(nuclear factor-erythroid factor 2-related factor 2, NFE2L2) accumulation, then NRF2 translocates to the nucleus and binds to the proximity region of Il-1β and Il-6 genes, and inhibits LPS-induced expression of these genes. DC-PGKI ameliorates colitis in the dextran sulfate sodium(DSS)-induced colitis mouse model. These data support PGK1 as a regulator of macrophages and suggest potential utility of PGK1 inhibitors in the treatment of inflammatory bowel disease. | Liping Liao Wenzhen Dang Tingting Lin Jinghua Yu Tonghai Liu Wen Li Senhao Xiao Lei Feng Jing Huang Rong Fu Jiacheng Li Liping Liu Mingchen Wang Hongru Tao Hualiang Jiang Kaixian Chen Xingxing Diao Bing Zhou Xiaoyan Shen Cheng Luo | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 2 |
| 5 | Cost-effectiveness analysis on COVID-19 surveillance strategy of large-scale sports competition显示文摘Background:Nucleic acid test(NAT)could effectively control the spread of COVID-19 caused by large-scale sports competitions.However,quantitative analysis on the appropriate frequency of NAT is scarce,and the cost-effectiveness and necessity of high-frequency NAT remain to be fully explored and validated.This study aims to optimize the COVID-19 surveillance strategies through cost-effectiveness analysis for the Tokyo 2020 Olympic Games and the upcoming Beijing 2022 Olympic Winter Games.Methods:A total of 18 scenarios were designed regarding the NAT frequency,symptom monitoring,and strengthening close-contact control.An agent-based stochastic dynamic model was used to compare the cost-effectiveness of different NAT scenarios and optimize the surveillance strategies.The dynamics of the proposed model included the arrival and departure of agents,transmission of the disease according to Poisson processes,and quarantine of agents based on regular NATs and symptom onset.Accumulative infections,cost,and incremental cost-effectiveness ratio(ICER)were simulated in the frame of the model.ICER was used to compare the cost-effectiveness of different scenarios.Univariate sensitivity analysis was performed to test the robustness of the results.Results:In Scenario 16,where the competition-related personnel(CRP)received NAT daily and national sports delegation(NSD)with quarantined infections accepted an additional NAT daily,accumulative infection was 320.90(90 initial infections),the total cost was(United States Dollar)USD 8920000,and the cost of detecting out each infection was USD 27800.Scenario 16 would reduce the total cost by USD 22570000(avoid 569.61 infections),USD 1420000(avoid 47.2 infections)compared with Scenario 10(weekly NAT,strengthened close contact control)and Scenario 7(daily NAT,no strengthened close contact control),respectively.Sensitivity analysis showed that the result was most sensitive to the change in basic reproductive number.Conclusions:High-frequency NATs such as bidaily,daily,and twice a day were cost-effective.NAT daily for CRP with strengthening close-contact control could be prioritized in defense against COVID-19 at large-scale sports competitions.This study could assist policymakers by assessing the cost-effectiveness of NAT scenarios and provide the host country with an optimal COVID-19 surveillance strategy. | Xuechun Wang Yiru Cai Bo Zhang Xiangyu Zhang Lianhao Wang Xiangyu Yan Mingchen Zhao Yuan Zhang Zhongwei Jia | 2022 | Infectious Diseases of Poverty2022，11，2： | 2 |
| 6 | The co- ordinated control strategy in plug-in hybrid vehicle 显示文摘 | Wang Weihua Guo Mingchen Dong Xiao | 2013 | Applied mechanics and materials2013，392，： | 1 |
| 7 | IGFBP-rP1 induces p21 expression through a p53-independent pathway, leading to cellular senescence of MCF-7 breast cancer cells显示文摘 | Shuguang Zuo Chang Liu Jianguo Wang Fuqing Wang Wanling Xu Shao Cui Lei Yuan Xudong Chen Wenjuan Fan Mingchen Cui Guohua Song | 2012 | Journal of Cancer Research and Clinical Oncology2012，，6： | 1 |
| 8 | Ultrasound assisted crystallization of cephalexin monohydrate:Nucleation mechanism and crystal habit control显示文摘With the high-quality requirements for cephalexin monohydrate,developing a robust and practical crystallization process to produce cephalexin monohydrate with good crystal habit,appropriate aspect ratio and high bulk density as well as suitable flowability is urgently needed.This research has explored the influence of ultrasound on crystallization of cephalexin monohydrate in terms of nucleation mechanism and crystal habit control.The results of metastable zone width and induction time measurement showed the presence of ultrasound irradiation can narrow the metastable zone and shorten induction time.Cavitation phenomena generated by ultrasound were used to qualitatively explain the mechanism of ultrasound promoting nucleation of cephalexin monohydrate.Furthermore,on the basis of classical nucleation theory and induction time data,a series of nucleation-related parameters(such as crystalliquid interfacial tension,radius of the critical nucleus and etc.)were calculated and showed a decreasing trend under ultrasound irradiation.The diffusion coefficient of the studied system was also determined to increase by 72.73%under ultrasound.The changes in these parameters have quantitatively confirmed the mechanism of ultrasound influence on the nucleation process.In further,the calculated surface entropy factor has confirmed that the growth of cephalexin monohydrate follows continuous growth mechanism under the research conditions of this work.Through the exploration of crystallization conditions,it is found that suitable ultrasonic treatment,seeding,supersaturation control and removal of fine crystals are conducive to improving the quality of cephalexin monohydrate product.Optimizing the crystallization process coupled continuous ultrasound irradiation with fine-crystal dissolution policy has achieved the controllable production of monodisperse cephalexin monohydrate crystal with good performance. | Zeren Shang Mingchen Li Baohong Hou Junli Zhang Kuo Wang Weiguo Hu Tong Deng Junbo Gong Songgu Wu | 2022 | Chinese Journal of Chemical Engineering2022，35，1： | 1 |
| 9 | Antioxidant activity, mutagenicity/anti-mutagenicity, and clastogenicity/anti-clastogenicity of lutein from marigold flowers显示文摘 | WANG Mingchen TSAO R ZHANG Shanfeng | 2006 | Food and Chemical Toxicology2006，44，9： | 1 |
| 10 | B ultrasound-guided hyperthermic intraperitoneal perfusion chemotherapyfor the treatment of malignant ascites显示文摘 | Shuzhong Cui Mingchen Ba Yunqiang Tang Jifang Liu Yinbing Wu Bin Wang Xiangliang Zhang Hongsheng Tang Shizhen Zhong | 2012 | Oncology Reports2012，，4： | 1 |
| 11 | Antioxidant activity, mutagenicity/anti-mutagenicity, and clastogenicity/anticlastogenicity of lutein from marigold flowers显示文摘 | WANG Mingchen TSAO R ZHANG Shanfeng | 2006 | Food and Chemical Toxicology2006，44，： | 1 |
| 12 | Non-small cell lung cancers(NSCLCs)oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors显示文摘With the continuous in-depth study of the interaction mechanism between viruses and hosts,the virus has become a promising tool in cancer treatment.In fact,many oncolytic viruses with selectivity and effectiveness have been used in cancer therapy.Human enterovirus is one of the most convenient sources to generate oncolytic viruses,however,the high seroprevalence of some enteroviruses limits its application which urges to exploit more oncolytic enteroviruses. | Bopei Cui Lifang Song Qian Wang Kelei Li Qian He Xing Wu Fan Gao Mingchen Liu Chaoqiang An Qiushuang Gao Chaoying Hu Xiaotian Hao Fangyu Dong Jiuyue Zhou Dong Liu Ziyang Song Xujia Yan Jialu Zhang Yu Bai Qunying Mao Xiaoming Yang Zhenglun Liang | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 13 | Multifunctional Gd-CuS loaded UCST polymeric micelles for MR/PA imaging-guided chemo-photothermal tumor treatment显示文摘Hepatocellular carcinoma(HCC)is a life-threatening disease for which there is no effective treatment currently.Novel theranostics simultaneously having excellent imaging and therapeutic functions are highly desired in cancer therapy.Herein,we develop the sialic acid(SA)modified polymeric micelles at an upper critical solution temperature(UCST)of 43℃(sialic acid-poly(ethylene glycol)-poly(acrylamide-co-acrylonitrile),SA-PEG-p(AAm-co-AN)),which further encapsulated with doxorubicin(DOX)and Gd-CuS nanoparticles(Gd-CuS NPs)for chemo-photothermal treatment of HCC guided by magnetic resonance(MR)/photoacoustic(PA)dual-mode imaging.The resultant SA-PEG-p(AAm-co-AN)/DOX/Gd-CuS(SPDG)had an excellent photothermal conversion efficiency,enabling SPDG with an instantaneous release behavior of DOX under near-infrared(NIR)irradiation.This study also revealed that SPDG could actively target to HCC,which was due to that SA had a high affinity with E-selectin overexpressed at the tumor site.Moreover,benefiting from the HCC-targeted ability and NIR light-controlled on-demand delivery of DOX,SPDG showed a superior potential in MR/PA dual-mode imaging-guided chemo-photothermal treatment.Overall,our study reveals that the designed SPDG may be used as an ideal multifunctional nanoplatform for cancer theranostics. | Yan Du Di Liu Mingchen Sun Gaofeng Shu Jing Qi Yuchan You Yiting Xu Kai Fan Xiaoling Xu Feiyang Jin Jun Wang Qiying Shen Luwen Zhu Xiaoying Ying Jiansong Ji Liming Wu Daren Liu Yongzhong Du | 2022 | Nano Research2022，15，3： | 0 |
| 14 | A Pharmacological Study on Action Mechanism of Zhizi Ganjiang Decoction from Treatise on Cold Damage Diseases in Treating Sleep Disorders显示文摘[Objectives]To explore the molecular mechanism of Zhizi Ganjiang Decoction(ZZGJD)regulating sleep disorders based on the network pharmacology.[Methods]The BATMAN-TCM server was used to predict the potential targets of ZZGJD and constructed a compound-disease-target network map,and the GeneCards database was used to search for insomnia-related targets;with the aid of Cytoscape 3.5.1 software,the compound-insomnia target interaction network and protein-protein interaction(PPI)network were constructed,and gene ontology(GO)enrichment,Reactome pathway enrichment,and biological pathway enrichment analysis based on KEGG(Kyoto Encyclopedia of Genes and Enomes)was performed.[Results]The constructed PPI network of ZZGJD involves 204 nodes and 645 interaction relationships.Key nodes involve G protein-coupled receptors,rhodopsin-like adrenaline receptor families,zinc finger proteins,nuclear hormone receptor superfamilies,ligand-binding domains of hormone receptors,voltage-gated calcium(Ca^(2+))channel IQ domains,and neuropituitary hormones.The related entries of GO enrichment analysis pathway mainly involve G protein-coupled receptor activity,neurotransmitter receptor activity,adrenergic receptor activity,ammonium ion binding,catecholamine binding,G protein-coupled serotonin receptor activity,serotonin receptor activity,and steroid hormone receptors(SHRs)activity.Reactome pathway mainly involves amine ligand binding receptors,rhodopsin-like receptors,G protein-coupled receptor ligand binding,adrenergic receptors,neuronal systems and signal transduction,etc.KEGG channel analysis mainly involves neural activity ligand-receptor interaction,calcium ion messenger pathway,cAMP signaling pathway,serotonergic synapse,dopaminergic synapse,cGMP-PKG signaling pathway,and cholinergic synapse pathway,etc.[Conclusions]The potential targets of ZZGJD in the treatment of insomnia mainly involve G protein-coupled receptors,and regulate various neural receptor pathways such as calcium ion channels,serotonin,dopamine,and adrenergic receptors.INS,IGF-1,CTNNB1,ESR1,HIF-1A,etc.may be the key targets of ZZGJD in regulating sleep disorders,reflecting the multi-target and overall function characteristics of Chinese herbal compounds.ZZGJD is of great significance in the treatment of sleep disorders caused by blood sugar abnormality in patients with diabetes and perimenopausal hormones in women.This article is expected to It provide new ideas for in-depth study of the molecular mechanism of ZZGJD. | Xiaowei XIN Xuemei LIU Xuelian LIU Zhiwei YANG Fangang MENG Wenxiao WANG Xinxin WEI Daiming ZHANG Mingchen CAO | 2022 | Medicinal Plant2022，13，6： | 0 |
| 15 | Spatial distribution and export of nutrients and metal elements in the subterranean estuary of Daya Bay显示文摘Subterranean estuaries(STE)are important seawater-groundwater mixing zones with complex biogeochemical processes,which play a vital role in the migration and transformation of dissolved materials.In this study,we first investigated the spatial distributions of dissolved inorganic nitrogen(DIN),dissolved inorganic phosphorous(DIP),dissolved inorganic silicon(DSi)and metal elements(As,Ba,Cr,Cu,Fe,Mn,Ni,Pb,and Zn)in STE including upper intertidal,seepage face and subtidal zones.We then estimated submarine groundwater discharge(SGD)and associated nutrient and metal element fluxes.From the generalized Darcy’s law method,SGD was estimated to be 30.13 cm/d,which was about 7 times larger than the inflow(4.16 cm/d).The nutrient and metal fluxes from SGD were estimated to be(5.33±4.99)mmol/(m^(2)·d)for DIN,(0.22±0.03)mmol/(m^(2)·d)for DIP,(16.20±2.05)mmol/(m^(2)·d)for DSi,(1325.06±99.10)μmol/(m^(2)·d)for Fe,(143.41±25.13)μmol/(m^(2)·d)for Mn,(304.06±81.07)μmol/(m^(2)·d)for Zn,(140.21±13.33)μmol/(m^(2)·d)for Cu,(84.49±2.94)μmol/(m^(2)·d)for Pb,(37.38±5.51)μmol/(m^(2)·d)for Ba,(27.88±3.89)μmol/(m^(2)·d)for Cr,(10.10±6.33)μmol/(m^(2)·d)for Ni,and(6.25±3.45)μmol/(m^(2)·d)for As.The nutrient and metal fluxes from SGD were relatively higher than those from the inflow,suggesting that nearshore groundwater acted as the sources of nutrients and metal elements discharging into the sea.The environmental potential pollution of coastal seawater was evaluated by pollution factor index(Pi),comprehensive water quality index(CWQI),and ecological risk index(ERI).Pb mainly caused potential danger of nearshore environment with considerable contamination(Pi=5.78±0.19),heavy pollution(CWQI=4.09)and high ecological risk(ERI=18.00).This study contributed to better understanding the behavior of nutrients and metal elements and improving the sustainable management of STE under the pressure of anthropogenic activities and climate change. | Zhaoxi Liu Mingchen Ge Qianqian Wang Xuejing Wang Kai Xiao Gang Li Hailong Li | 2023 | Acta Oceanologica Sinica2023，42，8： | 0 |
| 16 | An investigation of long-term outcome of rabbit anti-thymocyte globulin and cyclosporine therapy for pediatric severe aplastic anemia显示文摘Children with severe aplastic anemia(SAA)face heterogeneous prognoses after immunosuppressive therapy(IST).There are few models that can predict the long-term outcomes of IST for these patients.The objective of this paper is to develop a more effective prediction model for SAA prognosis based on clinical electronic medical records from 203 children with newly diagnosed SAA.In the early stage,a novel model for long-term outcomes of SAA patients with IST was developed using machine-learning techniques.Among the indicators related to long-term efficacy,white blood cell count,lymphocyte count,absolute reticulocyte count,lymphocyte ratio in bone-marrow smears,C-reactive protein,and the level of IL-6,IL-8 and vitamin B12 in the early stage are strongly correlated with long-term efficacy(P<.05).Taken together,we analyzed the long-term outcomes of rabbit antithymocyte globulin and cyclosporine therapy for children with SAA through machine-learning techniques,which may shorten the observation period of therapeutic effects and reduce treatment costs and time. | Lixian Chang Mingchen Yan Jingliao Zhang Binghang Liu Li Zhang Ye Guo Jing Sun Yang Wan Meihui Yi Yang Lan Yuli Cai Yuanyuan Ren Haihui Zheng Aoli Zhang Zhenyu Li Jian Wang Yingrui Li Xiaofan Zhu | 2023 | Blood Science2023，5，3： | 0 |
| 17 | Full waveform inversion with spectral conjugategradient method显示文摘Spectral conjugate gradient method is an algorithm obtained by combination of spectral gradient method and conjugate gradient method,which is characterized with global convergence and simplicity of spectral gradient method,and small storage of conjugate gradient method.Besides,the spectral conjugate gradient method was proved that the search direction at each iteration is a descent direction of objective function even without relying on any line search method.Spectral conjugate gradient method is applied to full waveform inversion for numerical tests on Marmousi model.The authors give a comparison on numerical results obtained by steepest descent method,conjugate gradient method and spectral conjugate gradient method,which shows that the spectral conjugate gradient method is superior to the other two methods. | LIU Xiao LIU Mingchen SUN Hui WANG Qianlong | 2017 | Global Geology2017，20，1： | 0 |
| 18 | A Landscape Analysis on Virus:based on NCBI Database显示文摘Summary What is already known about this topic?Studies indicate that viruses could spread across species,but it is difficult to know when and where such small probability events occur because it is almost impossible to design an observational study on the whole landscape.What is added by this report?We did a comprehensive analysis on the National Center for Biotechnology Information database and tried to find the time,place,and host that the viruses stayed in their long evolutionary history.What are the implications for public health practice?Public databases are helpful to understand the risk of virus infection in humans and also a cost-effective method for monitoring public health and safety events. | Mingchen Zhao Jingyuan Chen Qiang Wang Zuhong Lu Zhongwei Jia | 2022 | China CDC weekly2022，4，7： | 0 |
| 19 | The overexpression of Rps14 in Lgr5+progenitor cells promotes hair cell regeneration in the postnatal mouse cochlea显示文摘Sensory hair cells(HCs)in the cochlea cannot regenerate spontaneously in adult mammals after being damaged by external or genetic factors.However,several genes and signaling pathways are reported to induce cochlear HC regeneration at the early neonatal stage.Rps14 encodes a ribosomal protein that is involved in the regulation of cell differentiation and proliferation in mammals.However,its roles in the cochlea have not been reported in vivo.Here,we specifically overexpressed Rps14 in Lgr5+progenitor cells in the newborn mouse cochlea and found that Rps14 conditional overexpression(cOE)mice had significantly increased the ectopic HCs,including inner and outer HCs.We further explored the source of these ectopic HCs and found no EdU+supporting cells observed in the Rps14 cOE mice.The lineage tracing results,on the other hand,revealed that Rps14 cOE mice had significantly more tdTomato+HCs in their cochleae than control mice.These results indicated that regenerated HCs by cOE of Rps14 are most likely derived from inducing the direct trans-differentiation of Lgr5+progenitor cells into HCs.Moreover,real-time qPCR results suggested that the transcription factor genes Atoh1 and Gfi1,which are important in regulating HC differentiation,were upregulated in the cochlear basilar membrane of Rps14 cOE mice.In summary,this study provides in vivo evidence that,in the postnatal mouse cochlea,Rps14 is a potential gene that can promote the spontaneous trans-differentiation of Lgr5+progenitor cells into HCs.This gene may one day be exploited as a therapeutic target for treating hearing loss. | Jingru Ai Pei Jiang Jingyuan Huang Hairong Xiao Yanqin Lin Mingchen Dai Yintao Wang Yuan Zhang Mengyao Tian Renjie Chai Shasha Zhang | 2023 | Engineered Regeneration2023，4，3： | 0 |
| 20 | Standardized neutralization antibody analytical procedure for clinical samples based on the AQbD concept显示文摘Dear Editor,Vaccination is an effective strategy for controlling the COVID-19 pandemic and reducing the number of cases of hospitalization and deaths.1 Neutralizing antibody(Ntab)is one of the key indicators for evaluating the effectiveness of COVID-19 vaccines.2 Over 40 COVID-19 vaccines have been approved for emergency use,marketing,or marketing with conditions,and the available Ntab data from clinical trials have been published. | Jianyang Liu Yu Bai Mingchen Liu Dejiang Tan Jing Li Zhongfang Wang Zhenglun Liang Miao Xu Junzhi Wang Qunying Mao | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 0 |
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