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| 1 | ACCELERATED LIFE TEST STUDIES OF NEW COATED DISPENSER CATHODES显示文摘The life of impregnated Ba-W cathodes with a new construction have been evaluated using an accelerated life test at three different temperatures (1170℃,1130℃,1090℃) and constant current density (2A/cm^2).According to the relationship of life with operating temperatures,an accelerated equation has been set up.The cathode life at normal operating temperature is deducted based on the accelerated equation.The results show that life of the novel cathode exceeds 190,000 hour at a current density of 2A/cm^2. | Zhang Mingchen Zhang Honglai Liu Pukun Su Xiaobao Li Yutao | 2007 | Journal of Electronics(China)2007，24，5： | 2 |
| 2 | A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1βand IL-6显示文摘Glycolytic metabolism enzymes have been implicated in the immunometabolism field through changes in metabolic status. PGK1 is a catalytic enzyme in the glycolytic pathway. Here, we set up a high-throughput screen platform to identify PGK1 inhibitors. DC-PGKI is an ATPcompetitive inhibitor of PGK1 with an affinity of Kd= 99.08 nmol/L. DC-PGKI stabilizes PGK1in vitro and in vivo, and suppresses both glycolytic activity and the kinase function of PGK1. In addition,DC-PGKI unveils that PGK1 regulates production of IL-1β and IL-6 in LPS-stimulated macrophages.Mechanistically, inhibition of PGK1 with DC-PGKI results in NRF2(nuclear factor-erythroid factor 2-related factor 2, NFE2L2) accumulation, then NRF2 translocates to the nucleus and binds to the proximity region of Il-1β and Il-6 genes, and inhibits LPS-induced expression of these genes. DC-PGKI ameliorates colitis in the dextran sulfate sodium(DSS)-induced colitis mouse model. These data support PGK1 as a regulator of macrophages and suggest potential utility of PGK1 inhibitors in the treatment of inflammatory bowel disease. | Liping Liao Wenzhen Dang Tingting Lin Jinghua Yu Tonghai Liu Wen Li Senhao Xiao Lei Feng Jing Huang Rong Fu Jiacheng Li Liping Liu Mingchen Wang Hongru Tao Hualiang Jiang Kaixian Chen Xingxing Diao Bing Zhou Xiaoyan Shen Cheng Luo | 2022 | Acta Pharmaceutica Sinica B2022，12，11： | 2 |
| 3 | Pyridinedegradation in the microbial fuel cells显示文摘 | ZHANG Cuiping LI Mingchen LIU Guangli | 2009 | Journal of Hazard-ous Materials2009，172，1： | 1 |
| 4 | IGFBP-rP1 induces p21 expression through a p53-independent pathway, leading to cellular senescence of MCF-7 breast cancer cells显示文摘 | Shuguang Zuo Chang Liu Jianguo Wang Fuqing Wang Wanling Xu Shao Cui Lei Yuan Xudong Chen Wenjuan Fan Mingchen Cui Guohua Song | 2012 | Journal of Cancer Research and Clinical Oncology2012，，6： | 1 |
| 5 | Electricity generation by two types of microbial fuel cells using nitrobenzene as the anodic or cathodic reactants显示文摘 | Jie Li Guangli Liu Renduo Zhang Yong Luo Cuiping Zhang Mingchen Li | 2010 | Bioresource Technology2010，，11： | 1 |
| 6 | Electricity generation from indole and microbial community analysis in the microbial fuel cell显示文摘 | Yong Luo Renduo Zhang Guangli Liu Jie Li Mingchen Li Cuiping Zhang | 2009 | Journal of Hazardous Materials2009，，1： | 1 |
| 7 | Pyridine degradation in the microbial fuel cells显示文摘 | Cuiping Zhang Mingchen Li Guangli Liu Haiping Luo Renduo Zhang | 2009 | Journal of Hazardous Materials2009，，1： | 1 |
| 8 | B ultrasound-guided hyperthermic intraperitoneal perfusion chemotherapyfor the treatment of malignant ascites显示文摘 | Shuzhong Cui Mingchen Ba Yunqiang Tang Jifang Liu Yinbing Wu Bin Wang Xiangliang Zhang Hongsheng Tang Shizhen Zhong | 2012 | Oncology Reports2012，，4： | 1 |
| 9 | Molecular Mechanism of Zhizi Ganjiang Decoction in Regulating Liver Cirrhosis Based on BATMAN-TCM Platform显示文摘[Objectives]To explore the molecular mechanism of Zhizi Ganjiang Decoction in the treatment of liver cirrhosis based on the network pharmacology.[Methods]The BATMAN-TCM server was used to predict the potential targets of Zhizi Ganjiang Decoction,and the GeneCards database searched for targets related to liver cirrhosis;Cytoscape 3.5.1 software was used to construct compound-cirrhosis target interaction network and protein interaction network;then gene ontology(GO)enrichment analysis,Reactome pathway enrichment analysis,and KEGG-based biological pathway enrichment analysis were performed.[Results]The compound-disease-target network of Zhizi Ganjiang Decoction was constructed.The PPI network of Zhizi Ganjiang Decoction targets constructed based on String contained 130 nodes and 689 interaction relationships.The key nodes mainly involved nuclear hormone receptor-like domain superfamily and ligand binding domain,serpentine type 7TM GPCR chemoreceptor and chemoreceptor Srx,rhodopsin family transmembrane receptors,zinc finger NHR/GATA type nuclear hormone receptors and ligand binding domains,PI3-kinase family p85 binding domain,phosphoinositide(PI)3-kinase catalytic domain and other categories.GO enrichment analysis pathway related entries mainly involved steroid hormone receptor activity,nuclear receptor activity,transcription factor activity,direct ligands regulation sequence-specific DNA binding,G protein-coupled amine receptor activity,steroid binding,catecholamine binding,neurotransmitter receptor activity,adrenergic receptor activity,ammonium ion binding,and oxidoreductase activity,etc.KEGG channel analysis mainly involved neuroactive ligand-receptor interaction,aldosterone regulates sodium reabsorption,regulates lipolysis in adipocytes,regulates inflammatory mediators of TRP channels,tyrosine metabolism,calcium signaling pathway,cAMP signaling pathway,and nonalcoholic fatty liver diseases.[Conclusions]The research results suggest that Zhizi Ganjiang Decoction regulates the process of liver cirrhosis mainly through aldosterone regulation of sodium reabsorption,regulation of lipolysis in adipocytes,regulation of inflammatory mediators of TRP channels,calcium signaling pathways,and nonalcoholic fatty liver diseases.This reflects the multi-target and holistic action characteristics of the Chinese herbal compounds,and is expected to provide new ideas for further research on the molecular mechanism of Zhizi Ganjiang Decoction. | Mingchen CAO Enze LI Zhiwei YANG Yanlin SHAO Fangang MENG Zenan ZHANG Wenjing LI Mengxiang FANG Yuefen LIU | 2023 | Medicinal Plant2023，14，2： | 0 |
| 10 | Description of space charge transport in oil‐paper insulation using adaptive time‐stepping transient upstream finite element method显示文摘The charge transport and accumulation in oil-paper can cause the insulation degradation.So far,the most widely used model to simulate space charge transport and accumulation is the bipolar charge transport(BCT)model,which can well simulate the space charge dynamics.However,there are two shortcomings in the algorithms for solving the BCT model.One is that there is almost no use of vectorisation technology,which may increase the complexity of the algorithm,the other is the usage of fixed step size which might bring extra computation cost.In view of this,an adaptive time‐stepping transient up-stream finite element method(FEM)is developed to solve the BCT model considering trapping/detrapping,as well as the recombination phenomenon under DC condition in this article.Then,a vectorisation technology is used in the method to optimise the al-gorithm.Moreover,the adaptive time‐stepping method is introduced in simulation to reduce computation time and calculation amount.Simulation results are obtained by programing and later presented,which are basically consistent with the corresponding experimental results.Therefore,the proposed method is expected to promote the opti-mization design of the oil-paper insulation system. | Jiefeng Liu Mingchen Shi Yiyi Zhang Bing Gao Wei Zhang Shuo Liang | 2022 | High Voltage2022，7，1： | 0 |
| 11 | IMPROVEMENT OF THE PERFORMANCE OF THE DISPENSER CATHODE WITH Re AS A MIDDLE LAYER显示文摘A new type of dispenser cathode with dual-layer (Os-W/Re) is developed. The cathode coated with Os-W/Re shows better emission performance than the cathode coated with Os-W alloy. X-ray Photoelectron Spectroscopy (XPS) spectra demonstrate that ternary alloy coating (Os-W-Re) formed on the surface of the cathode with dual-layer (Os-W/Re) after full activation is the major reason why it has better emission than the cathode with Os-W alloy. The surface of each variety of the cathode is characterized with Scanning Electron Microscope (SEM) before and after activation: the emitting surface of the cathode with Os-W alloy after ageing appeared non-adherence (flaking) in localized areas, which is one of the reasons for non-uniform emission. However, the surface of the cathode with dual-layer (Os-W/Re) does not present film peeling under the same conditions. Thus it ensures better emission uniformity and functional reliability for the dispenser cathode. | Li Yutao Zhang Honglai Liu Pukun Zhang Mingchen | 2006 | Journal of Electronics(China)2006，23，3： | 0 |
| 12 | Non-small cell lung cancers(NSCLCs)oncolysis using coxsackievirus B5 and synergistic DNA-damage response inhibitors显示文摘With the continuous in-depth study of the interaction mechanism between viruses and hosts,the virus has become a promising tool in cancer treatment.In fact,many oncolytic viruses with selectivity and effectiveness have been used in cancer therapy.Human enterovirus is one of the most convenient sources to generate oncolytic viruses,however,the high seroprevalence of some enteroviruses limits its application which urges to exploit more oncolytic enteroviruses. | Bopei Cui Lifang Song Qian Wang Kelei Li Qian He Xing Wu Fan Gao Mingchen Liu Chaoqiang An Qiushuang Gao Chaoying Hu Xiaotian Hao Fangyu Dong Jiuyue Zhou Dong Liu Ziyang Song Xujia Yan Jialu Zhang Yu Bai Qunying Mao Xiaoming Yang Zhenglun Liang | 2023 | Signal Transduction and Targeted Therapy2023，8，10： | 0 |
| 13 | Multifunctional Gd-CuS loaded UCST polymeric micelles for MR/PA imaging-guided chemo-photothermal tumor treatment显示文摘Hepatocellular carcinoma(HCC)is a life-threatening disease for which there is no effective treatment currently.Novel theranostics simultaneously having excellent imaging and therapeutic functions are highly desired in cancer therapy.Herein,we develop the sialic acid(SA)modified polymeric micelles at an upper critical solution temperature(UCST)of 43℃(sialic acid-poly(ethylene glycol)-poly(acrylamide-co-acrylonitrile),SA-PEG-p(AAm-co-AN)),which further encapsulated with doxorubicin(DOX)and Gd-CuS nanoparticles(Gd-CuS NPs)for chemo-photothermal treatment of HCC guided by magnetic resonance(MR)/photoacoustic(PA)dual-mode imaging.The resultant SA-PEG-p(AAm-co-AN)/DOX/Gd-CuS(SPDG)had an excellent photothermal conversion efficiency,enabling SPDG with an instantaneous release behavior of DOX under near-infrared(NIR)irradiation.This study also revealed that SPDG could actively target to HCC,which was due to that SA had a high affinity with E-selectin overexpressed at the tumor site.Moreover,benefiting from the HCC-targeted ability and NIR light-controlled on-demand delivery of DOX,SPDG showed a superior potential in MR/PA dual-mode imaging-guided chemo-photothermal treatment.Overall,our study reveals that the designed SPDG may be used as an ideal multifunctional nanoplatform for cancer theranostics. | Yan Du Di Liu Mingchen Sun Gaofeng Shu Jing Qi Yuchan You Yiting Xu Kai Fan Xiaoling Xu Feiyang Jin Jun Wang Qiying Shen Luwen Zhu Xiaoying Ying Jiansong Ji Liming Wu Daren Liu Yongzhong Du | 2022 | Nano Research2022，15，3： | 0 |
| 14 | A Pharmacological Study on Action Mechanism of Zhizi Ganjiang Decoction from Treatise on Cold Damage Diseases in Treating Sleep Disorders显示文摘[Objectives]To explore the molecular mechanism of Zhizi Ganjiang Decoction(ZZGJD)regulating sleep disorders based on the network pharmacology.[Methods]The BATMAN-TCM server was used to predict the potential targets of ZZGJD and constructed a compound-disease-target network map,and the GeneCards database was used to search for insomnia-related targets;with the aid of Cytoscape 3.5.1 software,the compound-insomnia target interaction network and protein-protein interaction(PPI)network were constructed,and gene ontology(GO)enrichment,Reactome pathway enrichment,and biological pathway enrichment analysis based on KEGG(Kyoto Encyclopedia of Genes and Enomes)was performed.[Results]The constructed PPI network of ZZGJD involves 204 nodes and 645 interaction relationships.Key nodes involve G protein-coupled receptors,rhodopsin-like adrenaline receptor families,zinc finger proteins,nuclear hormone receptor superfamilies,ligand-binding domains of hormone receptors,voltage-gated calcium(Ca^(2+))channel IQ domains,and neuropituitary hormones.The related entries of GO enrichment analysis pathway mainly involve G protein-coupled receptor activity,neurotransmitter receptor activity,adrenergic receptor activity,ammonium ion binding,catecholamine binding,G protein-coupled serotonin receptor activity,serotonin receptor activity,and steroid hormone receptors(SHRs)activity.Reactome pathway mainly involves amine ligand binding receptors,rhodopsin-like receptors,G protein-coupled receptor ligand binding,adrenergic receptors,neuronal systems and signal transduction,etc.KEGG channel analysis mainly involves neural activity ligand-receptor interaction,calcium ion messenger pathway,cAMP signaling pathway,serotonergic synapse,dopaminergic synapse,cGMP-PKG signaling pathway,and cholinergic synapse pathway,etc.[Conclusions]The potential targets of ZZGJD in the treatment of insomnia mainly involve G protein-coupled receptors,and regulate various neural receptor pathways such as calcium ion channels,serotonin,dopamine,and adrenergic receptors.INS,IGF-1,CTNNB1,ESR1,HIF-1A,etc.may be the key targets of ZZGJD in regulating sleep disorders,reflecting the multi-target and overall function characteristics of Chinese herbal compounds.ZZGJD is of great significance in the treatment of sleep disorders caused by blood sugar abnormality in patients with diabetes and perimenopausal hormones in women.This article is expected to It provide new ideas for in-depth study of the molecular mechanism of ZZGJD. | Xiaowei XIN Xuemei LIU Xuelian LIU Zhiwei YANG Fangang MENG Wenxiao WANG Xinxin WEI Daiming ZHANG Mingchen CAO | 2022 | Medicinal Plant2022，13，6： | 0 |
| 15 | Spatial distribution and export of nutrients and metal elements in the subterranean estuary of Daya Bay显示文摘Subterranean estuaries(STE)are important seawater-groundwater mixing zones with complex biogeochemical processes,which play a vital role in the migration and transformation of dissolved materials.In this study,we first investigated the spatial distributions of dissolved inorganic nitrogen(DIN),dissolved inorganic phosphorous(DIP),dissolved inorganic silicon(DSi)and metal elements(As,Ba,Cr,Cu,Fe,Mn,Ni,Pb,and Zn)in STE including upper intertidal,seepage face and subtidal zones.We then estimated submarine groundwater discharge(SGD)and associated nutrient and metal element fluxes.From the generalized Darcy’s law method,SGD was estimated to be 30.13 cm/d,which was about 7 times larger than the inflow(4.16 cm/d).The nutrient and metal fluxes from SGD were estimated to be(5.33±4.99)mmol/(m^(2)·d)for DIN,(0.22±0.03)mmol/(m^(2)·d)for DIP,(16.20±2.05)mmol/(m^(2)·d)for DSi,(1325.06±99.10)μmol/(m^(2)·d)for Fe,(143.41±25.13)μmol/(m^(2)·d)for Mn,(304.06±81.07)μmol/(m^(2)·d)for Zn,(140.21±13.33)μmol/(m^(2)·d)for Cu,(84.49±2.94)μmol/(m^(2)·d)for Pb,(37.38±5.51)μmol/(m^(2)·d)for Ba,(27.88±3.89)μmol/(m^(2)·d)for Cr,(10.10±6.33)μmol/(m^(2)·d)for Ni,and(6.25±3.45)μmol/(m^(2)·d)for As.The nutrient and metal fluxes from SGD were relatively higher than those from the inflow,suggesting that nearshore groundwater acted as the sources of nutrients and metal elements discharging into the sea.The environmental potential pollution of coastal seawater was evaluated by pollution factor index(Pi),comprehensive water quality index(CWQI),and ecological risk index(ERI).Pb mainly caused potential danger of nearshore environment with considerable contamination(Pi=5.78±0.19),heavy pollution(CWQI=4.09)and high ecological risk(ERI=18.00).This study contributed to better understanding the behavior of nutrients and metal elements and improving the sustainable management of STE under the pressure of anthropogenic activities and climate change. | Zhaoxi Liu Mingchen Ge Qianqian Wang Xuejing Wang Kai Xiao Gang Li Hailong Li | 2023 | Acta Oceanologica Sinica2023，42，8： | 0 |
| 16 | An investigation of long-term outcome of rabbit anti-thymocyte globulin and cyclosporine therapy for pediatric severe aplastic anemia显示文摘Children with severe aplastic anemia(SAA)face heterogeneous prognoses after immunosuppressive therapy(IST).There are few models that can predict the long-term outcomes of IST for these patients.The objective of this paper is to develop a more effective prediction model for SAA prognosis based on clinical electronic medical records from 203 children with newly diagnosed SAA.In the early stage,a novel model for long-term outcomes of SAA patients with IST was developed using machine-learning techniques.Among the indicators related to long-term efficacy,white blood cell count,lymphocyte count,absolute reticulocyte count,lymphocyte ratio in bone-marrow smears,C-reactive protein,and the level of IL-6,IL-8 and vitamin B12 in the early stage are strongly correlated with long-term efficacy(P<.05).Taken together,we analyzed the long-term outcomes of rabbit antithymocyte globulin and cyclosporine therapy for children with SAA through machine-learning techniques,which may shorten the observation period of therapeutic effects and reduce treatment costs and time. | Lixian Chang Mingchen Yan Jingliao Zhang Binghang Liu Li Zhang Ye Guo Jing Sun Yang Wan Meihui Yi Yang Lan Yuli Cai Yuanyuan Ren Haihui Zheng Aoli Zhang Zhenyu Li Jian Wang Yingrui Li Xiaofan Zhu | 2023 | Blood Science2023，5，3： | 0 |
| 17 | Full waveform inversion with spectral conjugategradient method显示文摘Spectral conjugate gradient method is an algorithm obtained by combination of spectral gradient method and conjugate gradient method,which is characterized with global convergence and simplicity of spectral gradient method,and small storage of conjugate gradient method.Besides,the spectral conjugate gradient method was proved that the search direction at each iteration is a descent direction of objective function even without relying on any line search method.Spectral conjugate gradient method is applied to full waveform inversion for numerical tests on Marmousi model.The authors give a comparison on numerical results obtained by steepest descent method,conjugate gradient method and spectral conjugate gradient method,which shows that the spectral conjugate gradient method is superior to the other two methods. | LIU Xiao LIU Mingchen SUN Hui WANG Qianlong | 2017 | Global Geology2017，20，1： | 0 |
| 18 | Influence of positive DC electric field on rime icing on the insulator and its experimental verification in the natural environment显示文摘The electric field imposes a significant effect on ice accretion on the insulator.The impact of an AC electric field on insulator icing in an artificial climate chamber has been addressed.Compared with AC,DC electric field exerts an attraction on supercooled water droplets,which is more detrimental to the power system.Moreover,the icing on energised insulators is rarely studied in the natural environment.In the present research,an electrical,fluid coupled‐field simulation was carried out on the insulator.The force characteristics and motion deviation features of water droplets at different positive DC electric field strengths were studied.On this basis,rime icing on the insulator energised with different positive DC voltages was investigated in the field.Results show that the charged droplet shifts along the electric field line under a positive DC voltage.The deviation degree of the droplet increases with the increment of the voltage and droplet size and decreases with an increase in wind speed.As the voltage rises,the surface roughness,icing amount and icing length of rime ice‐covered insulator increase.Consequently,compared with that without energisation,the local collision coefficient,icing amount and icing length increase by 17.6%,46.4%and 63.9%,respectively,under a 40 kV DC voltage. | Zongyuan Liu Yuyao Hu Xingliang Jiang Lei Chen Mingchen Chi Feiyan Han Chong Zhao | 2023 | High Voltage2023，8，5： | 0 |
| 19 | Standardized neutralization antibody analytical procedure for clinical samples based on the AQbD concept显示文摘Dear Editor,Vaccination is an effective strategy for controlling the COVID-19 pandemic and reducing the number of cases of hospitalization and deaths.1 Neutralizing antibody(Ntab)is one of the key indicators for evaluating the effectiveness of COVID-19 vaccines.2 Over 40 COVID-19 vaccines have been approved for emergency use,marketing,or marketing with conditions,and the available Ntab data from clinical trials have been published. | Jianyang Liu Yu Bai Mingchen Liu Dejiang Tan Jing Li Zhongfang Wang Zhenglun Liang Miao Xu Junzhi Wang Qunying Mao | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 0 |
| 20 | Removal of ions from produced water using Powder River Basin coal显示文摘In addition to being used as an energy source,coal also has significant potential for other,more sustainable uses including water treatment.In this study,we present a simple approach to treat water that was produced during oil production and contained a total dissolved solids(TDS)content of over 150 g/L using Powder River Basin(PRB)coal.PRB coal used as packing material in a flow-through column effectively removed 60%–80%of the cations and anions simultaneously.Additionally,71%–92%of the total organic carbon in the produced water was removed as was all of the total suspended solids.The removal mechanisms of both cations and anions were investigated.Cations were removed by ion exchange with protons from oxygen-containing functional groups such as carboxylic and phenolic hydroxyl groups.Anions,mainly Cl−1,appeared to be removed through either the formation of resonance structures as a result of delocalization of electrons within coal molecules or through ion–πinteractions.We propose that coal is a“pseudo-amphoteric”exchange material that can remove cations and anions simultaneously by exchanging ions with both ionized and non-ionized acids that are ubiquitous in coal structure or resonance effect. | Zaixing Huang Fangjing Liu Mingchen Tang Yangyan Gao David MBagley Xin He Alexander Goroncy Maohong Fan | 2022 | International Journal of Coal Science & Technology2022，9，1： | 0 |
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