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| 1 | Notch signaling pathway:architecture,disease,and therapeutics显示文摘The NOTCH gene was identified approximately 110 years ago.Classical studies have revealed that NOTCH signaling is an evolutionarily conserved pathway.NOTCH receptors undergo three cleavages and translocate into the nucleus to regulate the transcription of target genes.NOTCH signaling deeply participates in the development and homeostasis of multiple tissues and organs,the aberration of which results in cancerous and noncancerous diseases.However,recent studies indicate that the outcomes of NOTCH signaling are changeable and highly dependent on context.In terms of cancers,NOTCH signaling can both promote and inhibit tumor development in various types of cancer.The overall performance of NOTCH-targeted therapies in clinical trials has failed to meet expectations.Additionally,NOTCH mutation has been proposed as a predictive biomarker for immune checkpoint blockade therapy in many cancers.Collectively,the NOTCH pathway needs to be integrally assessed with new perspectives to inspire discoveries and applications.In this review,we focus on both classical and the latest findings related to NOTCH signaling to illustrate the history,architecture,regulatory mechanisms,contributions to physiological development,related diseases,and therapeutic applications of the NOTCH pathway.The contributions of NOTCH signaling to the tumor immune microenvironment and cancer immunotherapy are also highlighted.We hope this review will help not only beginners but also experts to systematically and thoroughly understand the NOTCH signaling pathway. | Binghan Zhou Wanling Lin Yaling Long Yunkai Yang Huan Zhang Kongming Wu Qian Chu | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 14 |
| 2 | Study on Biogenic Amines in Various Dry Salted Fish Consumed in China显示文摘This study was carried out to investigate the biogenic amines(BAs), physicochemical property and microorganisms in dry salted fish, a traditional aquatic food consumed in China. Forty three samples of dry salted fish were gathered from retail and wholesale markets and manufacturers, which had been produced in various regions in China. Cadaverine(CAD) and putrescine(PUT) were quantitatively the most common biogenic amines. About 14% of the samples exceeded the histamine content standards established by the FDA and/or EU. The highest histamine content was found in Silver pomfret(Pampus argenteus)(347.79 mg kg^(-1)). Five of forty three samples exceeded the acceptable content of TYR(100 mg kg^(-1)), and 23.26% of dried-salted fish contained high contents of biogenic amines(above 600 mg kg^(-1)). In addition, species, regions, pickling processes and drying methods made the physicochemical property, microorganisms and biogenic amines in dry salted fish to be different to some extents. The total plate count(TPC) was much higher than that of total halophilic bacteria in all samples. The biogenic amines, physicochemical property and microbiological counts exhibited large variations among samples. Furthermore, no significant correlation between biogenic amines and physicochemical property and TPC was observed. This study indicated that dry salted fish may still present healthy risk for BAs, depending on the processing methods, storage conditions among others. | WU Yanyan CHEN Yufeng LI Laihao YANG Xianqing YANG Shaoling LIN Wanling ZHAO Yongqiang DENG Jianchao | 2016 | Journal of Ocean University of China2016，15，4： | 8 |
| 3 | A Novel Catalyst CuCl/1,10-Phenanthroline/N-Methylimidazole for the Oxidative Carbonylation of Ethanol to Diethyl Carbonate显示文摘 | MO Wanling, LI Guangxing, ZHU Yongqiang, XIONG Hui, MEI Fuming (Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China) | 2003 | 催化学报2003，24，1： | 4 |
| 4 | Numerical Study of the Intensity Correlation between Secondary Flow and Heat Transfer of Circle Tube-Finned Heat Exchanger with Vortex Generators显示文摘The application of vortex generators in tube-finned heat exchangers is very universal.The vortex generators can generate secondary flow,and as we all know secondary flow can obviously strengthen heat transfer.To use vortex generators much more efficiently in the circle tube-finned heat exchangers,the intensity correlation study between secondary flow and heat transfer is needed.22 different structures of circle tube-finned heat exchangers were numerically studied,including the plain fin cases and the cases with vortex generators.In addition,the influence of fin spacing,transverse and longitudinal tube pitch,heights and attack angle of vortex generators,positions of vortex generators and shape of vortex generators on heat transfer and fluid flow are studied,too.The non-dimensional parameter Se is applied to quantify the secondary flow intensity.The results show that Se can describe the secondary flow intensity very well.There is very close corresponding relationship between overall averaged Nu and volumetrically averaged Se for all the researched cases and the relational expression is obtained.However,there is no one-to-one correlation not only between Re and f but also between volumetrically averaged Se and f for all the studied cases. | Yong Guan Wanling Hu Yun Zhang Kewei Song Liangbi Wang | 2020 | Computer Modeling in Engineering & Sciences2020，，4： | 3 |
| 5 | Effect of poly(ethylene oxide) with different molecular weights on the electrospinnability of sodium alginate显示文摘 | Huarong Nie Aihua He Wanling Wu Jianfen Zheng Shanshan Xu Junxing Li Charles C. Han | 2009 | Polymer2009，，20： | 2 |
| 6 | Safety and efficacy of obinutuzumab in Chinese patients with B-cell lymphomas: a secondary analysis of the GERSHWIN trial显示文摘Background:Patients with relapsed/refractory B-cell lymphomas have limited treatment options.GERSHWIN is an open-label,single-arm,phase Ib study of obinutuzumab monotherapy in Chinese patients with histologically docu-mented CD20+relapsed/refractory chronic lymphocytic leukemia(CLL),diffuse large B-cell lymphoma(DLBCL),or follicular lymphoma(FL).The primary outcome measure of pharmacokinetics has been previously reported.We now present data on the secondary endpoint measures(e.g.,safety,and efficacy and pharmacodynamics).Methods:Patients received 1000 mg obinutuzumab intravenously on days 1,8,and 15 of cycle 1(CLL patients;first dose split over 2 days),and on day 1 of cycles 2-8.Each cycle lasted for 21 days;the treatment period was 24 weeks.All subjects receiving at least one dose of obinutuzumab were included in the analysis of safety,efficacy,as well as pharmacodynamics.Results:A total of 48 patients(>18 years of age)were enrolled(CLL:12;DLBCL:23;FL:13).The subjects received a median of two lines of anticancer treatment prior to the enrollment.Thirty-five patients(72.9%)had at least one adverse event(AE).The most frequent AE was infusion-related reactions(15 patients;31.3%),followed by pyrexia(11 patients;22.9%).Treatment-related AEs were reported in 28 patients(58.3%),and included one death(interstitial lung disease).End-of-treatment(EoT)response rate was 33.3%.Best overall response rate was 47.9%.Most CLL patients achieved a partial response at EoT(58.3%).CD19+depletion occurred in 75.0%of the patients with CLL,and all patients with FL and DLBCL.Conclusions:The safety and efficacy of obinutuzumab monotherapy in Chinese patients with B-cell lymphomas were similar to that observed in previous studies in non-Chinese patients;no new safety signals were observed. | Yan Qin Yuqin Song Zhixiang Shen Xin Du Wei Ji Wanling Hsu Jun Zhu Yuankai Shi | 2018 | Cancer Communications2018，38，1： | 2 |
| 7 | The Impact of Cytoreductive Nephrectomy on Survival of Patients With Metastatic Renal Cell Carcinoma Receiving Vascular Endothelial Growth Factor Targeted Therapy显示文摘 | Toni K. Choueiri Wanling Xie Christian Kollmannsberger Scott North Jennifer J. Knox J. Geoffrey Lampard David F. McDermott Brian I. Rini Daniel Y.C. Heng | 2011 | The Journal of Urology2011，，1： | 2 |
| 8 | The right ventricular outflow tracts as an alternative permant pacing site:long-term follow-up显示文摘 | Beain ES Jones SM Wanl DE | 1991 | PACE1991，14，： | 1 |
| 9 | A physics-based analytical solution to the surface potential of polysilicon thin film transistors using the Lambert W function 显示文摘 | Chen Rongsheng Zheng Xueren Deng Wanling | 2007 | Solid-State Electronics2007，51，6： | 1 |
| 10 | Mast cells activation contribute to small intestinal ischemia reperfusion induced acute lung injury in rats显示文摘 | Pinjie Huang Dezhao Liu Xiaoliang Gan Rui Zhang Wanling Gao Zhengyuan Xia Ziqing Hei | 2012 | Injury2012，，8： | 1 |
| 11 | Concentration of brine by forward osmosis: Performance and influence of membrane structure显示文摘 | Wanling Tang How Yong Ng | 2008 | Desalination2008，，14： | 1 |
| 12 | Design and im- plementation of mine-map management information system based on B/S model显示文摘 | He Hujun Yan Yumei Li Wanling | 2012 | Applied Mechanics and Materials2012，，12： | 1 |
| 13 | Acute cardiogenic pulmonary edema treated with mechanical ventilation, factors determine inhospital mortality显示文摘 | Fedllo AJ Swinburne AJ Wanl Gw | 1991 | Chest1991，99，5： | 1 |
| 14 | Variations in growth traits and wood physicochemical properties among Pinus koraiensis families in Northeast China显示文摘This study aimed to explore and improve the different economic values of Pinus koraiensis(Siebold and Zucc.)by examining the variations in 6 growth traits and 9 physicochemical wood properties among 53 P.koraiensis half-sib families.Growth traits assessed included height,diameter at breast height,volume,degree of stem straight-ness,stem form,and branch number per node,while wood properties assessed included density,fiber length and width,fiber length to width ratio,and cellulose,hemicel-lulose,holocellulose,lignin,and ash contents.Except for degree of stem straightness and branch number per node,all other traits exhibited highly significant variations(P<0.01)among families.The coefficients of variation ranged from 5.3(stem form)to 66.7%(ash content),whereas,the herit-ability ranged from 0.136(degree of stem straightness)to 0.962(ash content).Significant correlations were observed among growth traits and wood physicochemical properties.Principal component analysis identified four distinct groups representing growth traits,wood chemical and physical properties,and stem form traits.Multi-trait comprehensive evaluation identified three groups of elite families based on breeding objectives,including rapid growth,improved timber production for building and furniture materials,and pulpwood production.These specific families should be used to establish new plantations. | Qinhui Zhang Xiaona Pei Xianbo Lu Chunli Zhao Guangzhi Dong Wanling Shi Liankui Wang Yanlong Li Xiyang Zhao Mulualem Tigabu | 2022 | Journal of Forestry Research2022，33，5： | 1 |
| 15 | Obinutuzumab治疗中国B细胞淋巴瘤患者的安全性和有效性:GERSHWIN试验的二次分析显示文摘背景与目的可供复发/难治性B细胞淋巴瘤患者选择的治疗方案很有限。GERSHWIN是一项研究obinutuzumab单药治疗经组织学确认的CD20+复发/难治性慢性淋巴细胞白血病(chronic lymphocytic leukemia,CLL)、弥漫性大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)或滤泡性淋巴瘤(follicular lymphoma,FL)中国患者的疗效的开放标签、单臂、Ib期研究。先前已经报道了药代动力学的主要结局指标,在本研究中我们将报道次要终点指标(例如安全性、有效性和药效学)。方法在第1疗程的第1、8和15 d以及第2–8疗程的第1 d分别对患者静脉注射1000 mg obinutuzumab(CLL患者的首次给药分2 d进行)。每疗程为21 d,治疗24周。注射至少1次obinutuzumab的所有受试者均被纳入安全性、有效性以及药效学分析。结果共纳入48例(> 18岁)(CLL:12例;DLBCL:23例;FL:13例)患者,入组前接受了中位数为二线的治疗。35例(72.9%)患者出现至少1次不良事件(adverse event,AE)。最常见的AE是输液相关反应(15例;31.3%),其次是发热(11例;22.9%)。有28例(58.3%)患者出现与治疗相关的AE,其中1例死亡(间质性肺病)。治疗结束时(End-of-treatment,EoT)缓解率为33.3%,最佳总缓解率为47.9%。大多数CLL患者在EoT部分缓解(58.3%)。75.0%CLL患者及全部FL和DLBCL患者均出现CD19+减少。结论 Obinutuzumab单药治疗中国B细胞淋巴瘤患者的安全性和有效性与以往非中国患者的研究结果相似,没有观察到新的安全性指标。 | Yan Qin Yuqin Song Zhixiang Shen Xin Du Wei Ji Wanling Hsu Jun Zhu Yuankai Shi | 2019 | 癌症2019，38，2： | 1 |
| 16 | Inhibition of aberrant Hif1αactivation delays intervertebral disc degeneration in adult mice显示文摘The intervertebral disc(IVD) is the largest avascular tissue. Hypoxia-inducible factors(HIFs) play essential roles in regulating cellular adaptation in the IVD under physiological conditions. Disc degeneration disease(DDD) is one of the leading causes of disability, and current therapies are ineffective. This study sought to explore the role of HIFs in DDD pathogenesis in mice. The findings of this study showed that among HIF family members, Hif1α was significantly upregulated in cartilaginous endplate(EP) and annulus fibrosus(AF) tissues from human DDD patients and two mouse models of DDD compared with controls. Conditional deletion of the E3 ubiquitin ligase Vhl in EP and AF tissues of adult mice resulted in upregulated Hif1α expression and age-dependent IVD degeneration. Aberrant Hif1α activation enhanced glycolytic metabolism and suppressed mitochondrial function. On the other hand, genetic ablation of the Hif1α gene delayed DDD pathogenesis in Vhl-deficient mice. Administration of 2-methoxyestradiol(2ME2), a selective Hif1α inhibitor, attenuated experimental IVD degeneration in mice. The findings of this study show that aberrant Hif1α activation in EP and AF tissues induces pathological changes in DDD, implying that inhibition of aberrant Hif1α activity is a potential therapeutic strategy for DDD. | Zuqiang Wang Hangang Chen Qiaoyan Tan Junlan Huang Siru Zhou Fengtao Luo Dali Zhang Jing Yang Can Li Bo Chen Xianding Sun Liang Kuang Wanling Jiang Zhenhong Ni Quan Wang Shuai Chen Xiaolan Du Di Chen Chuxia Deng Liangjun Yin Lin Chen Yangli Xie | 2022 | Bone Research2022，10，1： | 1 |
| 17 | Cancer statistics, 2011 : the impact of eliminating socioeconomic and racial dispari- ties on paremature cancer death 显示文摘 | Siegel R Wanl E Brawley O | 2011 | CA Cancer J Clin2011，61，4： | 1 |
| 18 | Spray freeze drying of small nucleic acids as inhaled powder for pulmonary delivery显示文摘The therapeutic potential of small nucleic acids such as small interfering RNA(siRNA) to treat lung diseases has been successfully demonstrated in many in vivo studies. A major barrier to their clinical application is the lack of a safe and efficient inhaled formulation.In this study, spray freeze drying was employed to prepare dry powder of small nucleic acids.Mannitol and herring sperm DNA were used as bulking agent and model of small nucleic acid therapeutics, respectively. Formulations containing different solute concentration and DNA concentration were produced. The scanning electron microscope(SEM) images showed that the porosity of the particles increased as the solute concentration decreased. Powders prepared with solute concentration of 5% w/v were found to maintain a balance between porosity and robustness. Increasing concentration of DNA improved the aerosol performance of the formulation. The dry powder formulation containing 2% w/w DNA had a median diameter of 12.5 μm, and the aerosol performance study using next generation impactor(NGI) showed an emitted fraction(EF) and fine particle fraction(FPF) of 91% and 28% respectively. This formulation(5% w/v solute concentration and 2% w/w nucleic acid) was adopted subsequently to produce siRNA powder. The gel retardation and liquid chromatography assays showed that the siRNA remained intact after spray freeze drying even in the absence of delivery vector. The siRNA powder formulation exhibited a high EF of 92.4%and a modest FPF of around 20%. Further exploration of this technology to optimise inhaled siRNA powder formulation is warranted. | Wanling Liang Alan Y.L.Chan Michael Y.T.Chow Fiona F.K.Lo Yingshan Qiu Philip C.L.Kwok Jenny K.W.Lam | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，2： | 1 |
| 19 | Acute cardiogenic pulmonary edema treated with mechanical ventilation:factors determing in-hospital mortality显示文摘 | Fedullo A J Swinburne A J Wanl G W | 1991 | Chest1991，99，： | 1 |
| 20 | Effect of TiO2/Al2O3 film coated diamond abrasive particles by sol-gel technique显示文摘 | HUWD WANL LIUXP | | 0，，13： | 1 |
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