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| 1 | Downstaging disease in patients with hepatocellular carcinoma outside up-to-seven criteria: Strategies using degradable starch microspheres transcatheter arterial chemo-embolization显示文摘AIM: To evaluate the downstaging rates in hepatitis C virus-patients with hepatocellular carcinoma(HCC), treated with degradable starch microspheres transcatheter arterial chemoembolization(DSM-TACE), to reach new-Milan-criteria(nM C) for transplantation. METHODS: This study was approved by the Ethics Committee of our institution. From September 2013 to March 2014 eight patients(5 men and 3 women) with liver cirrhosis and multinodular HCC, that did not meet n MC at baseline, were enrolled in this study. Patients who received any other type of treatment such as termal ablation or percutaneous ethanol injection were excluded. DSM-TACE was performed in all patients using Embo Cept? S and doxorubicin. Baseline and follow-up computed tomography or magnetic resonance imaging was assessed measuring the longest enhancing axial dimension of each tumor according to the modified Response Evaluation Criteria In Solid Tumors measure-ments, and medical records were reviewed.RESULTS: DSM-TACE was successfully performed in all patients without major complication. We treated 35 lesions(mean 4.3 per patient). Six of eight patients(75%) had their HCC downstaged to meet nM C. Every patient whose disease was downstaged eventually underwent transplantation. The six patients who received transplant were still living at the time of this writing, without recurrence of HCC. Baseline age(P = 0.25), Model for End-stage Liver Disease score(P = 0. 77), and α-fetoprotein level(P = 1.00) were similar between patients with and without downstaged HCC. CONCLUSION: DSM-TACE represents a safely and effective treatment option with similar safety and efficacy of conventional chemoembolization and could be successfully performed also for downstaging disease in patients without n MC, allowing them to reach liver transplantation. | Antonio Orlacchio Fabrizio Chegai Stefano Merolla Simona Francioso Costantino Del Giudice Mario Angelico Giuseppe Tisone Giovanni Simonetti | 2015 | World Journal of Hepatology2015，7，12： | 23 |
| 2 | 北京PM_(10)的生物活性与微量元素的相关性研究显示文摘在使用质粒DNA评价法对北京PM10的生物活性进行研究的基础上,结合PM10中微量元素分析结果,探讨了PM10对质粒DNA产生损伤的原因.研究表明北京不同季节、不同地区PM10对DNA的氧化性损伤有明显的差别.冬季市区和对照点PM10(全样)的TM50分别是900和74μg·mL-1,水溶组分的TM50分别是540和86μg·mL-1;夏季市区和对照点PM10(全样)的TM50分别是116和210μg·mL-1,水溶组分的TM50分别是180和306μg·mL-1;北京PM10的生物活性的差别主要来自PM10中微量元素含量的不同.PM10(全样)中Pb,Zn和As三种元素对质粒DNA氧化性损伤能力较强;而PM10水溶组分中Mn,V,Zn同TM50的相关性较高;Zn元素可能是导致PM10具有氧化性损伤能力的主要微量重金属元素. | 吕森林 邵龙义 吴明红 T. Jones L. Merolla R. J. Richard | 2006 | 中国科学(D辑)2006，36，8： | 11 |
| 3 | Correlation between plasmid DNA damage induced by PM_(10) and trace metals in inhalable particulate matters in Beijing air显示文摘Based on the study of Beijing PM10 bioreactivity with the newly developed plasmid DNA assay method, and analysis for trace elements of PM10, the cause of plasmid DNA damage by PM10 was investigated. The study showed that plasmid DNA oxidative damages by PM10 are of difference in different seasons at various areas. The concentrations of TM50 of PM10 in whole samples respectively collected at urban and comparison sites during winter were 900 μg mL?1 and 74 μg mL?1, while those in their corresponding soluble fractions were 540 μg mL?1 and 86 μg mL?1. In contrast, TM50 contents of PM10 from summer whole samples at urban areas and comparison sites were 116 μg mL?1 and 210 μg mL?1, whereas those in their soluble fractions were 180 μg mL?1 and 306 μg mL?1. The difference of bioreactivity of Beijing PM10 resulted from the variation of trace elements. The oxidative damage of plasmid DNA caused by Pb, Zn, As in PM10 (whole sample) was relatively strong. TM50 and Mn, V, Zn display stronger correlation in the soluble fraction. It implies that Zn could be the major trace element in Beijing PM10 which contributes to oxidative damage to plasmid DNA. | T. P. Jones L. Merolla R. J. Richard | 2006 | Science China Earth Sciences2006，49，12： | 7 |
| 4 | Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi‐targeted kinase inhibitors in pimasertib‐resistant human lung and colorectal cancer cells显示文摘 | Erika Martinelli Teresa Troiani Elena D’Aiuto Floriana Morgillo Donata Vitagliano Anna Capasso Sarah Costantino Loreta Pia Ciuffreda Francesco Merolla Loredana Vecchione Veerle Vriendt Sabine Tejpar Anna Nappi Vincenzo Sforza Giulia Martini Liberato Berri | 2013 | Int J Cancer2013，，9： | 2 |
| 5 | Gastrointestinal symptoms in infancy: A population-based prospective study显示文摘 | G. Iacono R. Merolla D. D’Amico E. Bonci F. Cavataio L. Di Prima C. Scalici L. Indinnimeo M.R. Averna A. Carroccio | 2005 | Digestive and Liver Disease2005，，6： | 2 |
| 6 | Gastrointestinalsymp- toms in infancy : a population - based prospective study 显示文摘 | Iacono G Merolla R D'Amico D | 2005 | Dig Liver Dis2005，37，43： | 1 |
| 7 | Shoulder arthroplasty in osteoarthritis: current concepts in biomechanics and surgical technique显示文摘 | Merolla G Nastrucci G Porcellini G | 2013 | Transl Med UniSa2013，6，： | 1 |
| 8 | Bioabsorbable Synthetic Plug in the Treatment of Anal Fistulas显示文摘 | Afshin Heydari Grazia Maria Attinà Enrico Merolla Micaela Piccoli Reza Fazlalizadeh Gianluigi Melotti | 2013 | Diseases of the Colon & Rectum2013，，6： | 1 |
| 9 | Bioabsorbable synthetic plug in the treatment of anal fistulas显示文摘 | Heydari A Attin a GM Merolla E | 2013 | Dis Colon Rectum2013，56，： | 1 |
| 10 | Artificial brains: A million spiking-neuron integrated circuit with a sealable ctmnnnaication network and interfaee显示文摘 | Merolla P A Arthur J V Alvarez-lcaza R | 2014 | Science2014，345，： | 1 |
| 11 | Gastrointestinal symptoms in infancy:a population-based prospective study显示文摘 | Iacono G Merolla R D'Amico D | 2005 | Dig Liver Dis2005，37，6： | 1 |
| 12 | Analysis of expiratory pattern for monitoring bronchial obstruction in school-age children显示文摘 | Cutrera R Filtchev S 1 Merolla R | 1991 | Pediatr Pulmonol1991，10，1： | 1 |
| 13 | Bronchoalveolar lavage studies in children without parenchymal lung disease: cellular constituents and protein levels 显示文摘 | Midulla F Villani A Merolla R | 1995 | Pediatr Pulmonol1995，20，2： | 1 |
| 14 | Analysis of expiratorypatteru for monitoring bronchial obstruction in school - age children显示文摘 | CUTRERA R FIHCHEV S I MEROLLA R | 1991 | Pediatr Pulmonol1991，10，1： | 1 |
| 15 | OPN/CD44v6overexpression in laryngeal dysplasia and correlation with clinical outcome显示文摘 | Staibano S Merolla F Testa D | 2007 | Br J Cancer2007，97，11： | 1 |
| 16 | Identification of sumoylation sites in CCDC6,the first identified RET partner gene in papillary thyroid carcinoma,uncovers a mode of regulating CCDC6 function on CREB1 transcriptional activity显示文摘 | Luise C Merolla F Leone V | 2012 | PLoS One2012，7，49： | 1 |
| 17 | Phase quantized SAR signal processing: Theory and experiments 显示文摘 | Franceschettii G Merolla S Tesauro M | 1999 | IEEE Transactions on Aerospace and Electronic System1999，，： | 1 |
| 18 | Variation in the source,metal content and bioreactivity of technogenic aerosols:a ease study from Port Talbot,Wales,UK显示文摘 | Moreno T Merolla L Gibbons W | 2004 | Sciences of the Total Environment2004，333，： | 1 |
| 19 | Analysis of expiratory pattern for monitoring bronchial obstruction in school-age children显示文摘 | Cutrera R Filtchev SI Merolla R | 1991 | Pediatr Pulmonol1991，10，1： | 1 |
| 20 | Pectoralis minor tendon transfer for irreparable anterosuperior cuff tears显示文摘 | Paolo Paladini Fabrizio Campi Giovanni Merolla Andrea Pellegrini Giuseppe Porcellini | 2013 | Journal of Shoulder and Elbow Surgery2013，，6： | 1 |
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