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| 1 | Prevalence of Helicobacter pylori infection and intestinal metaplasia in subjects who had undergone surgery for gastric adenocarcinoma in Northwest Italy显示文摘AIM: To investigate the seroprevalence of Helicobacter pylori(H pylorri) infection and its more virulent strains as well as the correlation with the histologic features among patients who had undergone surgery for gastric cancer (GC).METHODS: Samples from 317 (184 males, 133females, mean age 69±3.4 years) consecutive patients who had undergone surgery for gastric non-cardia adenocarcinoma were included in the study. Five hundred and fifty-five (294 males, 261 females, mean age 57.3±4.1 years) patients consecutively admitted to the Emergency Care Unit served as control. Histological examination of tumor, lymph nodes and other tissues obtained at the time of surgery represented the diagnostic 'gold standard'. An enzyme immunosorbent assay was used to detect serum anti-H pylori(IgG)antibodies and Western blotting technique was utilized to search for anti-CagA protein (IgG).RESULTS: Two hundred and sixty-one of three hundred and seventeen (82.3%) GC patients and 314/555 (56.5%)controls were seropositive for anti-H pylori (P<0.0001;OR, 3.58; 95%CI, 2.53-5.07). Out of the 317 cases, 267(84.2%) were seropositive for anti-CagA antibody vs 100 out of 555 (18%) controls (P<0.0001; OR, 24.30;95%CI, 16.5-35.9). There was no difference between the frequency of H pyloriin intestinal type carcinoma (76.2%) and diffuse type cancer (78.8%). Intestinal metaplasia (IM) was more frequent but not significant in the intestinal type cancer (83.4% vs 75.2% in diffuse type and 72.5% in mixed type). Among the patients examined for IM, 39.8% had IM type Ⅰ, 8.3% type Ⅱ and 51.9% type Ⅲ (type Ⅲ vs others, P = 0.4).CONCLUSION; This study confirms a high seroprevalence of H pyloriinfection in patients suffering from gastric adenocarcinoma and provides further evidence that searching for CagA status over H pylori infection might confer additional benefit in identifying populations at greater risk for this tumor. | Giorgio Palestro Rinaldo Pellicano Gian Ruggero Fronda Guido Valente Marco De Giuli Tito Soldati Agostino Pugliese Stefano Taraglio Mauro Garino Donata Campra Miguel Angel Cutufia Elena Margaria Giancarlo Spinzi Aldo Ferrara Giorgio Marenco Mario Rizzetto Antonio Ponzetto | 2005 | World Journal of Gastroenterology2005，11，45： | 5 |
| 2 | How to assess intestinal viability during surgery: A review of techniques显示文摘Objective and quantitative intraoperative methods of bowel viability assessment are essential in gastrointestinal surgery. Exact determination of the borderline of the viable bowel with the help of an objective test could result in a decrease of postoperative ischemic complications. An accurate, reproducible and cost effective method is desirable in every operating theater dealing with abdominal operations. Numerous techniques assessing various parameters of intestinal viability are described by the studies. However, there is no consensus about their clinical use. To evaluate the available methods, a systematic search of the English literature was performed. Virtues and drawbacks of the techniques and possibilities of clinical application are reviewed. Valuable parameters related to postoperative intestinal anastomotic or stoma complications are analyzed. Important issues in the measurement and interpretation of bowel viability are discussed. To date, only a few methods are applicable in surgical practice.Further studies are needed to determine the limiting values of intestinal tissue oxygenation and flow indicative of ischemic complications and to standardize the methods. | Linas Urbanaviius Piet Pattyn Dirk Van de Putte Donatas Venskutonis | 2011 | World Journal of Gastrointestinal Surgery2011，3，5： | 4 |
| 3 | Treatment strategies for multiple sclerosis:When to start,when to change,when to stop?显示文摘Multiple sclerosis(MS) is a chronic inflammatory condition of the central nervous system determined by a presumed autoimmune process mainly directed against myelin components but also involving axons and neurons. Acute demyelination shows as clinical relapses that may fully or partially resolve, while chronic demyelination and neuroaxonal injury lead to persistent and irreversible neurological symptoms, often progressing over time. Currently approved disease-modifying therapies are immunomodulatory or immunosuppressive drugs that significantly although variably reduce the frequency of attacks of the relapsing forms of the disease. However, they have limited efficacy in preventing the transition to the progressive phase of MS and are of no benefit after it has started. It is therefore likely that the potential advantage of a given treatment is condensed in a relatively limited window of opportunity for each patient, depending on individual characteristics and disease stage, most frequently but not necessarily in the early phase of the disease. In addition, a sizable proportion of patients with MS may have a very mild clinical course not requiring a disease-modifying therapy. Finally, individual response to existing therapies for MS varies significantly across subjects and the risk of serious adverse events remains an issue, particularly for the newest agents. The present review is aimed at critically describing current treatment strategies for MS with a particular focus on the decision of starting, switching and stopping commercially available immunomodulatory and immunosuppressive therapies. | Alberto Gajofatto Maria Donata Benedetti | 2015 | World Journal of Clinical Cases2015，3，7： | 2 |
| 4 | The genomics of desmoplastic small round cell tumor reveals the deregulation of genes related to DNA damage response, epithelial-mesenchymal transition, and immune response显示文摘Background:Desmoplastic small round cell tumor(DSRCT)is a rare,aggressive,and poorly investigated simple sarcoma with a low frequency of genetic deregulation other than an Ewing sarcoma RNA binding protein 1(EWSR1)-Wilm’s tumor suppressor(WT1)translocation.We used whole-exome sequencing to interrogate six consecutive pretreated DSRCTs whose gene expression was previously investigated.Methods:DNA libraries were prepared from formalin-fixed,paraffin-embedded archival tissue specimens following the Agilent SureSelectXT2 target enrichment protocol and sequenced on Illumina NextSeq 500.Raw sequence data were aligned to the reference genome with Burrows-Wheeler Aligner algorithm.Somatic mutations and copy number alterations(CNAs)were identified using MuTect2 and EXCAVATOR2,respectively.Biological functions associated with altered genes were investigated through Ingenuity Pathway Analysis(IPA)software.Results:A total of 137 unique somatic mutations were identified:133 mutated genes were case-specific,and 2 were mutated in two cases but in different positions.Among the 135 mutated genes,27%were related to two biological categories:DNA damage-response(DDR)network that was also identified through IPA and mesenchymal-epithelial reverse transition(MErT)/epithelial-mesenchymal transition(EMT)already demonstrated to be relevant in DSRCT.The mutated genes in the DDR network were involved in various steps of transcription and particularly affected pre-mRNA.Half of these genes encoded RNA-binding proteins or DNA/RNA-binding proteins,which were recently rec-ognized as a new class of DDR players.CNAs in genes/gene families,involved in MErT/EMT and DDR,were recurrent across patients and mostly segregated in the MErT/EMT category.In addition,recurrent gains of regions in chromosome 1 involving many MErT/EMT gene families and loss of one arm or the entire chromosome 6 affecting relevant immune-regulatory genes were recorded.Conclusions:The emerging picture is an extreme inter-tumor heterogeneity,characterized by the concurrent deregulation of the DDR and MErT/EMT dynamic and plastic programs that could favour genomic instability and explain the refractory DSRCT profile. | Andrea Devecchi Loris De Cecco Matteo Dugo Donata Penso Gianpaolo Dagrada Silvia Brich Silvia Stacchiotti Marialuisa Sensi Silvana Canevari Silvana Pilotti | 2018 | Cancer Communications2018，38，1： | 2 |
| 5 | Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi‐targeted kinase inhibitors in pimasertib‐resistant human lung and colorectal cancer cells显示文摘 | Erika Martinelli Teresa Troiani Elena D’Aiuto Floriana Morgillo Donata Vitagliano Anna Capasso Sarah Costantino Loreta Pia Ciuffreda Francesco Merolla Loredana Vecchione Veerle Vriendt Sabine Tejpar Anna Nappi Vincenzo Sforza Giulia Martini Liberato Berri | 2013 | Int J Cancer2013，，9： | 2 |
| 6 | Fuzzy Approach to Environmental Performance Evaluation 显示文摘 | Valeras Kildisas Donatas Levisauskas | 2005 | Environmental re- search engineering and management2005，1，31： | 1 |
| 7 | Synthesis and antimycotic activity of new unsymmetrical substituted zinc phthalocyanines显示文摘 | Barbara C Gabrio R Donata D | 2003 | Tetrahedron2003，59，10： | 1 |
| 8 | Surgical treatment of pressure ulcers:an 11-year experience at the Department of Plastic and Reconstructive Surgery of Hospital of Kaunas University of Medicine显示文摘 | Kstutis Maslauskas Donatas Samsanaviius Rytis Rimdeika | 2009 | Medicina (Kaunas)2009，45，4： | 1 |
| 9 | The tyrosine kinase inhibitor ZD6474 blocks proliferation of RETmutant medullary thyroid carcinoma cells显示文摘 | Donata Vitagliano Valentina De Falco Anna Tamburrino | 2011 | Endocrine RelatedCancer2011，18，1： | 1 |
| 10 | Progress in toxinformatics:the challenge of predicting acute toxicity显示文摘 | DONATAS Z PRANAS J ALANAS P | 2003 | Current Topics in Medicinal Chemistry2003，3，11： | 1 |
| 11 | Influence of Twisting on Linen Fancy Yarn Structure显示文摘 | Salvinija Petrulyte Donatas Petrulis | 2014 | Journal of Natural Fibers2014，，： | 1 |
| 12 | Progress in toxin formatics:the challenge of predicting acute toxicity显示文摘 | Donatas Z | 2003 | Current Topics Med Chem2003，3，11： | 1 |
| 13 | Impact of Complex Additive Consisting of Continuous Basalt Fibres and Si O2Microdust on Strength and Heat Resistance Properties of Autoclaved Aerated Concrete显示文摘 | Sinica Marijonas Georgij A Sezeman Donatas Mikulskis | 2014 | Construction and Building Materials2014，50，： | 1 |
| 14 | Synthesis and antimycotic activity of new unsymmetrical substituted zinc phthalocyanines 显示文摘 | Barbara C Gabrio R Donata D | 2003 | Tetrahedron2003，59，10： | 1 |
| 15 | Highly pathogenic avian influenza as a zoonotic agent 显示文摘 | DONATA KALTHOFF ANJA GLOBIG MARTIN BEER | 2010 | Veterinary Mi- crobiology2010，，140： | 1 |
| 16 | 显示文摘 | DONATAS Z PRANAS J ALANAS P | 2003 | Current Topics in Medicinal Chemistry2003，3，11： | 1 |
| 17 | What’s a cerebellar circuit doing in the auditory system?显示文摘 | Donata Oertel Eric D. Young | 2003 | Trends in Neurosciences2003，，2： | 1 |
| 18 | Metal Extraction from an Oil Matrix Use of a Temperature-sensitive Biphasic System显示文摘 | Donata Lerda Enrico Borgarello | 1990 | Colloids and Surface1990，48，： | 1 |
| 19 | Italian consensus guidelines for chronic pancreatitis显示文摘 | Luca Frulloni Massimo Falconi Armando Gabbrielli Ezio Gaia Rossella Graziani Raffaele Pezzilli Generoso Uomo Angelo Andriulli Gianpaolo Balzano Luigi Benini Lucia Calculli Donata Campra Gabriele Capurso Giulia Martina Cavestro Claudio De Angelis Luigi Ghe | 2010 | Digestive and Liver Disease2010，，： | 1 |
| 20 | Expression and characterization of anionic components in the tubulointerstitial compartment of rat kidney during polymicrobial sepsis显示文摘 | Chiara Adembri Valentina Selmi Luca Vitali Daniele Nosi Alessia Tani Giorgia Donata Zappoli Thyrion Giovanna Santoro Laura Bonaccini Gianfranco Avveduto Anna Lucia Caldini Eleonora Sgambati | 2013 | Acta Histochemica2013，，： | 1 |
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