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| 1 | Current therapeutic strategies for advanced pancreatic cancer: A review for clinicians显示文摘Pancreatic cancer(PC) would become the second leading cause of cancer death in the near future, despite representing only 3% of new cancer diagnosis. Survival improvement will come from a better knowledge of risk factors, earlier diagnosis, better integration of locoregional and systemic therapies, as well as the development of more efficacious drugs rising from a deeper understanding of disease biology. For patients with unresectable, non-metastatic disease, combined strategies encompassing primary chemotherapy and radiation seems to be promising. In fit patients, new polychemotherapy regimens can lead to better outcomes in terms of slight but significant survival improvement associated with a positive impact on quality of life. The upfront use of these regimes can also increase the rate of radical resections in borderline resectable and locally advanced PC. Second line treatments showed to positively affect both overall survival and quality of life in fit patients affected by metastatic disease. At present, oxaliplatin-based regimens are the most extensively studied. Nonetheless, other promising drugs are currently under evaluation. Presently, in addition to surgery and conventional radiation therapy, new locoregional treatment techniques are emerging as alternative options in the multimodal approach to patients or diseases not suitable for radical surgery. As of today, in contrast with other types of cancer, targeted therapies failed to show relevant activity either alone or in combination with chemotherapy and, thus, current clinical practice does not include them. Up to now, despite the fact of extremely promising results in different tumors, also immunotherapy is not in the actual therapeutic armamentarium for PC. In the present paper, we provide a comprehensive review of the current state of the art of clinical practice and research in PC aiming to offer a guide for clinicians on the most relevant topics in the management of this disease. | Rosella Spadi Federica Brusa Agostino Ponzetti Isabella Chiappino Nadia Birocco Libero Ciuffreda Maria Antonietta Satolli | 2016 | World Journal of Clinical Oncology2016，7，1： | 15 |
| 2 | 青少年及儿童近视进展及其危险因素显示文摘近视是全球重要的公共卫生问题。青少年及儿童近视患病率因在全球范围,尤其在亚洲地区,快速增长且影响因素复杂多样而受到广泛关注。尽管目前已有大量关于青少年及儿童近视进展及其危险因素的报道,然而由于人群、近视定义、睫状肌麻痹剂、验光方法等不同导致彼此间难以比较。本文就1990年至今关于青少年(〈18岁)和儿童近视进展及其与年龄、性别、屈光状态、近距工作、户外活动、父母近视或父母生育年龄等危险因素关系的报道进行总结。 | 林仲 梁远波 李晓霞 Balamurali Vasudevan Kenneth J Ciuffreda | 2015 | 中华实验眼科杂志2015，33，12： | 12 |
| 3 | Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi‐targeted kinase inhibitors in pimasertib‐resistant human lung and colorectal cancer cells显示文摘 | Erika Martinelli Teresa Troiani Elena D’Aiuto Floriana Morgillo Donata Vitagliano Anna Capasso Sarah Costantino Loreta Pia Ciuffreda Francesco Merolla Loredana Vecchione Veerle Vriendt Sabine Tejpar Anna Nappi Vincenzo Sforza Giulia Martini Liberato Berri | 2013 | Int J Cancer2013，，9： | 2 |
| 4 | Liver Environment and HCV Replication Affect Human T-Cell Phenotype and Expression of Inhibitory Receptors显示文摘 | Daniela C. Kroy Donatella Ciuffreda Jennifer H. Cooperrider Michelle Tomlinson Garrett D. Hauck Jasneet Aneja Christoph Berger David Wolski Mary Carrington E. John Wherry Raymond T. Chung Kenneth K. Tanabe Nahel Elias Gordon J. Freeman Rosemarie H. de Kru | 2014 | Gastroenterology2014，，2： | 2 |
| 5 | Myopes show increased susceptibility to nearwork after effects显示文摘 | Ciuffreda KJ Waallis DM | 1998 | Invest Ophthalmol Vis Sci1998，39，10： | 1 |
| 6 | The effect of retinal defocus on golf putting显示文摘 | Bulson RE Ciuffreda KJ Hung GK | 2008 | Ophthalmic Physiol Opt2008，28，4： | 1 |
| 7 | Contribution of accommodation and disparity-vergence to transient nearwork-induced myopia shifts显示文摘 | Rosenfield M Ciuffreda KJ Novogrodsky L | 1992 | Ophthalmic Physiol Opt1992，12，： | 1 |
| 8 | Model of human refractive error development显示文摘 | Hung GK Ciuffreda KJ | 1999 | Curr Eye Res1999，19，1： | 1 |
| 9 | Complete IH and 13C NMR spectral assignment of tt- and 13-adenosine, 2'-deoxyadenosine and their acetate derivatives 显示文摘 | Ciuffreda P Casati S Manzocchi A | 2007 | Magn Reson Chem2007，45，9： | 1 |
| 10 | Near- work-induced transient myopia ( NITM ) following marked and sustained, but interrupted, accommodation at near显示文摘 | Arunthavaraja M Vasudevan B Ciuffreda K J | 2010 | Ophthalmic Physiol Opt2010，30，6： | 1 |
| 11 | Quantitative analysis of the effect of near lens addition on accommodation and myopigenesis 显示文摘 | Hung GK Ciuffreda KJ | 2000 | Curr Eye Res2000，20，4： | 1 |
| 12 | Differential refractive susceptibil- ity to sustained nearwork 显示文摘 | Ciuffreda K J Lee M | 2002 | Ophthalmic Physiol Opt2002，22，5： | 1 |
| 13 | Blur discrimination of the human eye in the near retinal periphery显示文摘 | Wang B Ciuffreda KJ | | Optom Vis0，，： | 1 |
| 14 | Myopes show increased susceptibility to nearwork aftereffects 显示文摘 | Ciuffreda KJ Wallis DM | 1998 | Invest Ophthalmol Vis Sci1998，39，10： | 1 |
| 15 | Model of human refractive error development显示文摘 | Hung G K Ciuffreda K J | 1999 | Curr Eye Res1999，19，1： | 1 |
| 16 | Effect of near work-induced transi- ent myopia on distance retinal defocus patterns显示文摘 | Ciuffreda K J Vasudevan B | 2010 | Optometry2010，81，4： | 1 |
| 17 | Differential refractive susceptibility to sustained nearwork 显示文摘 | Ciuffreda KJ Lee M | 2002 | Ophthalmic Physiol Opt2002，22，5： | 1 |
| 18 | Adaptation model of near- work-induced transient myopia 显示文摘 | Hung G K Ciuffreda K J | 1999 | Ophthalmic Physiol Opt1999，19，2： | 1 |
| 19 | Effect of nearwork induced transi- ent myopia on distance retinal defocus patterns 显示文摘 | Ciuffreda K J Vasudevan B | 2010 | Optometry2010，81，15： | 1 |
| 20 | Immunohistochemical evidence for the occurrence of endothelin in the vascular endothelium of normal and inflamed human dental pulp显示文摘 | Casasco A Casasco M Ciuffreda M | 1992 | J Dent Res1992，71，3： | 1 |
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