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您的检索式：作者名="L. Merolla"
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| 1 | 北京PM_(10)的生物活性与微量元素的相关性研究显示文摘在使用质粒DNA评价法对北京PM10的生物活性进行研究的基础上,结合PM10中微量元素分析结果,探讨了PM10对质粒DNA产生损伤的原因.研究表明北京不同季节、不同地区PM10对DNA的氧化性损伤有明显的差别.冬季市区和对照点PM10(全样)的TM50分别是900和74μg·mL-1,水溶组分的TM50分别是540和86μg·mL-1;夏季市区和对照点PM10(全样)的TM50分别是116和210μg·mL-1,水溶组分的TM50分别是180和306μg·mL-1;北京PM10的生物活性的差别主要来自PM10中微量元素含量的不同.PM10(全样)中Pb,Zn和As三种元素对质粒DNA氧化性损伤能力较强;而PM10水溶组分中Mn,V,Zn同TM50的相关性较高;Zn元素可能是导致PM10具有氧化性损伤能力的主要微量重金属元素. | 吕森林 邵龙义 吴明红 T. Jones L. Merolla R. J. Richard | 2006 | 中国科学(D辑)2006，36，8： | 11 |
| 2 | Correlation between plasmid DNA damage induced by PM_(10) and trace metals in inhalable particulate matters in Beijing air显示文摘Based on the study of Beijing PM10 bioreactivity with the newly developed plasmid DNA assay method, and analysis for trace elements of PM10, the cause of plasmid DNA damage by PM10 was investigated. The study showed that plasmid DNA oxidative damages by PM10 are of difference in different seasons at various areas. The concentrations of TM50 of PM10 in whole samples respectively collected at urban and comparison sites during winter were 900 μg mL?1 and 74 μg mL?1, while those in their corresponding soluble fractions were 540 μg mL?1 and 86 μg mL?1. In contrast, TM50 contents of PM10 from summer whole samples at urban areas and comparison sites were 116 μg mL?1 and 210 μg mL?1, whereas those in their soluble fractions were 180 μg mL?1 and 306 μg mL?1. The difference of bioreactivity of Beijing PM10 resulted from the variation of trace elements. The oxidative damage of plasmid DNA caused by Pb, Zn, As in PM10 (whole sample) was relatively strong. TM50 and Mn, V, Zn display stronger correlation in the soluble fraction. It implies that Zn could be the major trace element in Beijing PM10 which contributes to oxidative damage to plasmid DNA. | T. P. Jones L. Merolla R. J. Richard | 2006 | Science China Earth Sciences2006，49，12： | 7 |
| 3 | Gastrointestinal symptoms in infancy: A population-based prospective study显示文摘 | G. Iacono R. Merolla D. D’Amico E. Bonci F. Cavataio L. Di Prima C. Scalici L. Indinnimeo M.R. Averna A. Carroccio | 2005 | Digestive and Liver Disease2005，，6： | 2 |
| 4 | Oxidative damages to DNA by indoor PM_(10)s: Their relationships with trace element compositions显示文摘Plasmid DNA assay and ICP-MS analysis were conducted in order to investigate the bioreactivity of inhalable particles (PM_ 10) and the relationship between bioreactivity and trace element compositions of PM_ 10 in Beijing air. A total of four PM_ 10 samples were carefully selected to represent the indoor and corresponding outdoor environments: one from urban smoker’s home, two from non-smoker’s homes, and the other from the outdoor. In general, the oxidative damage by indoor PM_ 10 was slightly higher than that of outdoor. Among the four sets of samples, the PM_ 10 from the smoker’s home had a lowest TD50 (toxic dose of PM_ 10 causing 50% DNA to be damaged), being 100 μg·mL -1, suggesting the highest bioreactivity. The heavy metals are believed to be the main reason for oxidative damage to plasmid DNA. The ICP-MS analysis combined with the DNA assay showed that the water-soluble zinc levels had better relationship with TD50 values than other elements, implying that water-soluble zinc might play an important role in the damage of DNA. It is concluded that the PM_ 10 in smoker’s home had the highest level of water-soluble zinc as well as the lowest TD50 (highest bioreactivity). Iron is considered to be one of the most bioreactive elements, but it will cause little damage to plasmid DNA, probably because iron is mainly in water-insoluble state in Beijing PM_ 10. | SHAO Longyi ZHAO Houyin T. P. JONES LU Senlin L. MEROLLA | 2005 | Progress in Natural Science:Materials International2005，15，8： | 1 |
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