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| 1 | miR-486 sustains NF-KB activity by disrupting multiple NF-KB-negative feedback loops显示文摘 | Libing Song Chuyong Lin Hul Gong Chanjuan Wang Liping Liu Jueheng Wu Sha Tao Bo Hu Shi-Yuan Cheng Mengfeng Li Jun Li | 2013 | Cell Research2013，23，2： | 6 |
| 2 | The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells显示文摘 | Song Li-Bing Li Jun Liao Wen-Ting Feng Yan Yu Chun-Ping Hu Li-Juan Kong Qing-Li Xu Li-Hua Zhang Xing Liu Wan-Li Li Man-Zhi Zhang Ling Kang Tie-Bang Fu Li-Wu Huang Wen-Lin Xia Yun-Fei Tsao Sai Wah Li Mengfeng Band Vimla Band Hamid Shi | 2009 | Journal of Clinical Investigation2009，，12： | 2 |
| 3 | Abrogation of VEGF expression in human head and neck squamous cell carcinoma decreases angiogenic activity in vitro and in vivo显示文摘 | Frank R Karl G Mengfeng LI | 2003 | International J Oncol2003，23，： | 1 |
| 4 | Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer cell proliferation in vitro and in vivo显示文摘Midline2 (MID2 ) 是连接到肿瘤前进和乳癌 1 的一个新奇交往搭挡的结合 ubiquitin E2 酶,早发作(BRCA1 ) 。然而,在乳癌的 MID2 的角色仍然保持未知。这研究在乳癌调查了 MID2 的表示,预示的价值,和角色。MID2 mRNA 和蛋白质的表示是显著地,在乳癌织物和确定的房间的 upregulated 在正常的胸与那相比排队上皮的房间和配对的邻近的非肿瘤织物(P < 0.001 ) 。Immunohistochemical 分析证明 MID2 是在 284 中的 272 个的 overexpressed (95.8%) paraffinembedded,转存的乳癌织物。而且,与先进临床的舞台增加的 MID2 表示(P < 0.001 ) 。高 MID2 表示显著地与先进临床的阶段和 T 被联系, N,和 M 阶段(所有 P < 0.05 ) 。Univariate 和 multivariate 分析显示那高 MID2 表情是为在全部队的差的全面幸存的一个独立预示的因素(93.73 对 172.1 个月;P < 0.001, logrank 测试) 并且在有阶段 Tis + 的亚群我 + II 和 III + IV。而且, 3-(4,5-dimethyl-2-thiazolyl )-2,5-diphenyl-2H-tetrazolium 溴化物殖民地形成,和抛锚无关的生长能力试金被进行。结果证明 MID2 表示的 siRNA silencing 显著地在 vitro 减少了 MCF-7 和 MDA-MB-231 细胞增长并且在 vivo 堵住了 MDA-MB-231 细胞异种皮移植肿瘤的生长(P < 0.05 ) 。这研究显示 MID2 可以在乳癌是一个新奇预示的标记和 interventional 目标。 | Lan Wang JuehengWu Jie Yuan Xun Zhu Hongmei Wu Mengfeng Li | 2016 | Frontiers of Medicine2016，10，1： | 1 |
| 5 | Targeting of DICE1 tumor suppressor by Epstein–Barr virus‐encoded miR‐BART3* microRNA in nasopharyngeal carcinoma显示文摘 | Ting Lei Kit‐San Yuen Rui Xu Sai Wah Tsao Honglin Chen Mengfeng Li Kin‐Hang Kok Dong‐Yan Jin | 2013 | Int J Cancer2013，，1： | 1 |
| 6 | Golgi phosphoprotein 3 ( GOLPH3 ) promotes hepatocellular carcinoma cell aggressiveness by activating the NF ‐κ B pathway显示文摘 | Ting Dai Dongsheng Zhang Muyan Cai Chanjuan Wang Zhiqiang Wu Zhe Ying Jueheng Wu Mengfeng Li Dan Xie Jun Li Libing Song | 2015 | Pathol2015，，3： | 1 |
| 7 | MiR-136 promotes apoptosis of glioma cells by targeting AEG-1 and Bcl-2显示文摘 | Yi Yang Jueheng Wu Hongyu Guan Junchao Cai Lishan Fang Jun Li Mengfeng Li | 2012 | FEBS Letters2012，，20： | 1 |
| 8 | Oncoprotein Bmi-1 Renders Apoptotic Resistance to Glioma Cells through Activation of the IKK-Nuclear Factor-κB Pathway显示文摘 | Jun Li Li-Yun Gong Li-Bing Song Li-Li Jiang Li-Ping Liu Jueheng Wu Jie Yuan Jun-Chao Cai Mian He Lan Wang Musheng Zeng Shi-Yuan Cheng Mengfeng Li | 2010 | The American Journal of Pathology2010，，2： | 1 |
| 9 | The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells显示文摘 | Song Li-Bing Li Jun Liao Wen-Ting Feng Yan Yu Chun-Ping Hu Li-Juan Kong Qing-Li Xu Li-Hua Zhang Xing Liu Wan-Li Li Man-Zhi Zhang Ling Kang Tie-Bang Fu Li-Wu Huang Wen-Lin Xia Yun-Fei Tsao Sai Wah Li Mengfeng Band Vimla Band Hamid Shi | 2009 | Journal of Clinical Investigation2009，，12： | 1 |
| 10 | The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells显示文摘 | Song Li-Bing Li Jun Liao Wen-Ting Feng Yan Yu Chun-Ping Hu Li-Juan Kong Qing-Li Xu Li-Hua Zhang Xing Liu Wan-Li Li Man-Zhi Zhang Ling Kang Tie-Bang Fu Li-Wu Huang Wen-Lin Xia Yun-Fei Tsao Sai Wah Li Mengfeng Band Vimla Band Hamid Shi | 2009 | Journal of Clinical Investigation2009，，12： | 1 |
| 11 | Modeling the impact of awareness programs on the transmission dynamics of dengue and optimal control显示文摘In this work,we first propose a mathematical model to study the impact of awareness programs on dengue transmission.The basic reproduction number Ro is derived.The existence and stability of equilibria are investigated.The uniform persistence is established when Ro is larger than one.Our results suggest that awareness programs have significant impacts on dengue transmission dynamics although they cannot affect Ro.When o is less than one,awareness programs can shorten the prevailing time effectively.When Ro is larger than one,awareness programs may destabilize the unique interior equilibrium and a stable periodic solution appears due to Hopf bifurcation.In particular,we find that the occurrence of Hopf bifurcation depends not only on the intensity of awareness programs but also on the level of Ro.Besides,large fuctuations in the number of infected individuals caused by the stable periodic solution may bring pressure on limited medical resources.Therefore,different from intuitive ideas,blindly increasing the intensity of awareness programs is not necessarily conducive to control the transmission of dengue.The decision-making department should decide to adopt different publicity strategies according to the current level of Ro.Finally,we consider the optimal control problem of the model and find the optimal control strategy corresponding to awareness programs by Pontryagin's Maximum Principle.The results manifest that the optimal control strategy can effectively mitigate the transmission of dengue. | Jingyuan Li Hui Wan Mengfeng Sun | 2023 | International Journal of Biomathematics2023，16，2： | 0 |
| 12 | Erratum to: Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer cell proliferation in vitro and in vivo显示文摘The immunohistochemistry(IHC)staining of MID2 in“ANT”from Patient 2 and“T”from Patient 6 in original Fig.2C(Page 45)should be corrected.The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. | Lan Wang Jueheng Wu Jie Yuan Xun Zhu Hongmei Wu Mengfeng Li | 2021 | Frontiers of Medicine2021，15，6： | 0 |
| 13 | Author Correction: miR-486 sustains NF-κB activity by disrupting multiple NF-κB-negative feedback loops显示文摘Correction to:Cell Research http://gffzzd3cc09b8251d45dfsbvfn0nn9k6op6vc9.ffgz.tsg.suse.edu.cn/10.1038/cr.2012.174,published online 18 December 2012 With this letter we the authors of article1 published in Cell Research request for correction to the paper.In the article above referred,it has come to our attention that the representative tube formation images of negative control(NC)was mistakenly used in the Fig.7G during figure assembly. | Libing Song Chuyong Lin Hui Gong Chanjuan Wang Liping Liu Jueheng Wu Sha Tao Bo Hu Shi-Yuan Cheng Mengfeng Li Jun Li | 2021 | Cell Research2021，31，10： | 0 |
| 14 | Up-regulation of miR-1245 by c-myc targets BRCA2 and impairs DNA repair显示文摘BRCA2,a clinical prognostic factor,is significantly up-regulated in mRNA level,while its protein expression is often decreased in sporadic breast cancer.However,how BRCA2 protein expressions are suppressed in these tumors remains unknown.In this study,we demonstrated that miR-1245 directly suppressed BRCA23′-UTR and translation,impaired homologous recombination(HR)-mediated repair,reduced DNA damage-induced Rad51 nuclear foci,and rendered cells hypersensitive to g-irradiation(IR),ul-timately inducing high chromosomal abnormalities in normal breast cells and breast cancer cells.Conversely,inhibiting miR-1245 in breast cancer cells enhanced BRCA2 levels and induced resistance to IR.Furthermore,we demonstrated that c-myc up-regulated miR-1245 expression via direct binding to the miR-1245 promoter,which led to down-regulation of BRCA2 and reduction in HR efficiency.Significantly,miR-1245 levels in primary breast tumors correlated with c-myc overexpression and BRCA2 suppression.These findings uncover a BRCA2 regulatory and signaling pathway in sporadic breast cancer and support a functionally and clinically relevant epigenetic mechanism in cancer pathogenesis. | Libing Song Ting Dai Yingjun Xie Chanjuan Wang Chuyong Lin Zhiqiang Wu Zhe Ying Jueheng Wu Mengfeng Li Jun Li | 2012 | Journal of Molecular Cell Biology2012，4，2： | 0 |
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