|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | LAG-3 expression on tumor-infiltrating T cells in soft tissue sarcoma correlates with poor survival显示文摘Objective: To elucidate the role and prognostic significance of lymphocyte activation-gene-3(LAG-3) in soft tissue sarcoma(STS).Methods: The expression of LAG-3 in patient and matched normal blood samples was analyzed by flow cytometry. The localization and prognostic values of LAG-3^+ cells in 163 STS patients were analyzed by immunohistochemistry. In addition, the expression of tumor-infiltrating CD3^+ T, CD4^+ T, and CD8^+ T cells and their role in the prognosis of STS were evaluated by immunohistochemistry. The effect of LAG-3 blockade was evaluated in an immunocompetent MCA205 fibrosarcoma mouse model.Results: Peripheral CD8^+ and CD4^+ T cells from STS patients expressed higher levels of LAG-3 than those from healthy donors.LAG-3 expression in STS was significantly associated with a poor clinical outcome(P = 0.038) and was correlated with high pathological grade(P < 0.001), advanced tumor stage(P = 0.016). Additionally, LAG-3 expression was highly correlated with CD8^+ T-cell infiltration(r = 0.7034, P < 0.001). LAG-3 was expressed in murine tumor-infiltrating lymphocytes, and its blockade decreased tumor growth and enhanced secretion of interferon-gamma by CD8^+ and CD4^+ T cells.Conclusions: LAG-3 blockade may be a promising strategy to improve the effects of targeted therapy in STS. | Yi Que Zhixin Fang Yuanxiang Guan Wei Xiao Bushu Xu Jingjing Zhao Huoying Chen Xinke Zhang Musheng Zeng Yao Liang Xing Zhang | 2019 | Cancer Biology & Medicine2019，16，2： | 9 |
| 2 | Regulation of TLR7/9 signaling in plasmacytoid dendritic cells显示文摘Plasmacytoid dendritic cells(pDCs),also known as type I interferon(IFN)-producing cells,are specialized immune cells characterized by their extraordinary capabilities of mounting rapid and massive type I IFN response to nu-cleic acids derived from virus,bacteria or dead cells.PDCs selectively express endosomal Toll-like receptor(TLR)7 and TLR9,which sense viral RNA and DNA re-spectively.Following type I IFN and cytokine responses,pDCs differentiate into antigen presenting cells and ac-quire the ability to regulate T cell-mediated adaptive immunity.The functions of pDCs have been implicated not only in antiviral innate immunity but also in immune tolerance,inflammation and tumor microenvironments.In this review,we will focus on TLR7/9 signaling and their regulation by pDC-specific receptors. | Musheng Bao Yong-Jun Liu | 2013 | Protein & Cell2013，4，1： | 9 |
| 3 | Famitinib in combination with concurrent chemoradiotherapy in patients with locoregionally advanced nasopharyngeal carcinoma: a phase 1, open-label, dose-escalation Study显示文摘Background:Famitinib is a tyrosine kinase inhibitor against multiple targets,including vascular endothelial growth factor receptor 2/3,platelet-derived growth factor receptor,and stem cell factor receptor(c-kit).Previous studies have demonstrated anti-tumour activities of famitinib against a wide variety of advanced-stage solid cancers.We aimed to determine the safety and efficacy of famitinib with concurrent chemoradiotherapy(CCRT)in patients with locoregionally advanced nasopharyngeal carcinoma(NPC).We also evaluated the feasibility of contrast-enhanced ultrasound(D-CEUS)as a predictor of early tumour response to famitinib and to correlate functional parameters with clinical efficacy.Methods:The trial was conducted in subjects with stage III or IVa-b NPC using a 3+3 design of escalating fami-tinib doses.Briefly,subjects received 2 weeks of famitinib monotherapy followed by 7 weeks of famitinib plus CCRT.D-CEUS of the neck lymph nodes was performed at day 0,8 and 15 after famitinib was administered before starting concurrent chemoradiotherapy.End points included safety,tolerability and anti-tumour activity.Results:Twenty patients were enrolled(six each for 12.5,16.5 and 20 mg and two for 25 mg).Two patients in the 25 mg cohort developed dose-limiting toxicities,including grade 4 thrombocytopenia and grade 3 hypertension.The most common grade 3/4 adverse events were leukopenia,neutropenia and radiation mucositis.D-CEUS tests showed that more than 60%of patients achieved a perfusion parameter response after 2 weeks taking famitinib alone,and the parameter response was associated with disease improvement.In the famitinib monotherapy stage,three patients(15%)showed partial responses.The complete response rate was 65%at the completion of treatment and 95%3 months after the treatment ended.After a median follow-up of 44 months,the 3-year progression-free survival(PFS)and distant metastasis-free survival were 70%and 75%,respectively.Subjects with a decrease of perfusion parameter response,such as peak intensity decreased at least 30%after 1 week of famitinib treatment,had higher 3-year PFS(90.9%vs.44.4%,95%CI 73.7%-100%vs.11.9%-76.9%,P<0.001)than those with an increase or a reduction of less than 30%.Conclusions:The recommended famitinib dose for phase II trial is 20 mg with CCRT for patients with local advanced NPC.D-CEUS is a reliable and early measure of efficacy for famitinib therapies.Further investigation is required to confirm the effects of famitinib plus chemoradiotherapy. | Qiuyan Chen Linquan Tang Na Liu Feng Han Ling Guo Shanshan Guo Jianwei Wang Huai Liu Yanfang Ye Lu Zhang Liting Liu Pan Wang Yingqin Li Qingmei He Xiaoqun Yang Qingnan Tang Yang Li YuJing Liang XueSong Sun Chuanmiao Xie Yunxian Mo Ying Guo Rui Sun Haoyuan Mo Kajia Cao Xiang Guo Musheng Zeng Haiqiang Mai Jun Ma | 2018 | Cancer Communications2018，38，1： | 6 |
| 4 | QUATERNION GENERALIZED SINGULAR VALUE DECOMPOSITION AND ITS APPLICATIONS显示文摘. This paper derives a theorem of generalized singular value decomposition of quaternion matrices(QGSVD),studies the solution of general quaternion matrix equation AXB-CYD=E,and obtains quaternionic Roth’s theorem.This paper also suggests sufficient and necessary conditions for the existence and uniqueness of solutions and explicit forms of the solutions of the equation. | Jiang Tongsong Liu Yonghui Wei Musheng | 2006 | Applied Mathematics(A Journal of Chinese Universities)2006，21，1： | 3 |
| 5 | In-cell infection: a novel pathway for Epstein-Barr virus infection mediated by cell-in-cell structures显示文摘 | Chao Ni Yuhui Chen Musheng Zeng Rongjuan Pei Yong Du Linquan Tang Mengyi Wang Yazhuo Hu Hanyu Zhu Meifang He Xiawei Wei Shan Wang Xiangkai Ning Manna Wang Jufang Wang Li Ma Xinwen Chen Qiang Sun Hong Tang Ying Wang Xiaoning Wang | 2015 | Cell Research2015，25，7： | 3 |
| 6 | A NUMERICALLY STABLE BLOCK MODIFIED GRAM-SCHMIDT ALGORITHM FOR SOLVING STIFF WEIGHTED LEAST SQUARES PROBLEMS显示文摘最近,魏在[18 ] 证明使不安那生硬加权的假逆和生硬加权的最少的广场问题是稳定的,如果几划船并且仅当原来、使不安的系数矩阵 A 和 A̅ 满足,评价保藏条件。根据这些条件,在这篇论文,我们证明一般来说,有列转动的平常的修改 Gram-Schmidt 不为解决生硬加权的最少的广场问题是数字地稳定的。我们然后建议行块与列转动修改了 Gram-Schmidt 算法,并且证明与适当地选择的忍耐,这个算法能正确地决定这些的数字等级划划分亚矩阵,和因素 R̅ 包含的计算 QR 是行马厩的小舍入错误。几个数字实验也被提供把平常的修改 Gram-Schmidt 算法的结果与列转动作比较,行块与列转动修改了 Gram-Schmidt 算法。 | Musheng Wei Qiaohua Liu | 2007 | Journal of Computational Mathematics2007，25，5： | 2 |
| 7 | Phospholipid Scramblase 1 regulates Toll-like receptor 9-mediated type I interferon production in plasmacytoid dendritic cells显示文摘像使用费的受体(TLR9 ) 9 在 plasmacytoid 的内涵体察觉到微生物引起的 DNA 树枝状的房间(pDCs ) 和扳机 MyD88 依赖的类型我干扰素(IFN ) 回答。更好在 pDCs 理解 TLR9 生物学,我们建立了酵母为交往 TLR9 蛋白质的鉴定的二混血儿的图书馆。这里,我们报导那 IFN 可诱导的蛋白质, phospholipid scramblase 1 (PLSCR1 ) ,在 pDCs 与 TLR9 交往。由在人的 pDC 的 siRNA 的 PLSCR1 表示击倒房间线导致了 IFN-α 的 60-70% 减小;回答列在后面 CpG-ODN (oligodeoxynucleotide ) 刺激。从生产的 PLSCR1 缺乏的老鼠的主要 pDCs 响应 CpG-ODN 从野类型的老鼠比 pDCs 降低类型 1 IFN 的数量,疱疹单一的病毒和流行性感冒 A 病毒。后面的 CpG -- 刺激,有在和 CpG 的早内涵体的 TLR9 的低得多的数量 -- 在从 PLSCR1 缺乏的老鼠的 pDCs 的 A。我们的学习证明 PLSCR1 是在 pDC 的类型起一个重要作用的交往 TLR9 蛋白质由调整 TLR9 trafficking 到 endosomal 分隔空间的 1 IFN 回答。 | Amjad H Talukder Musheng Bao Tae Whan Kim Valeria Facchinetti Shino Hanabuchi Laura Bover Tomasz Zal Yong-Jun Liu | 2012 | Cell Research2012，22，7： | 2 |
| 8 | On solutions of Matrix equation AXB + CYD = F 显示文摘 | Xu Guiping Wei Musheng Zheng Daosheng | 1998 | Linear Algebra Appl1998，279，： | 1 |
| 9 | On Solutions of Matrix Equation AXB + CYD = F显示文摘 | Wei Musheng Zheng Daosheng | 1998 | Linear Algebra Appl1998，279，： | 1 |
| 10 | On solutions of matrix equation AXB + CYD = F显示文摘 | Guiping Xu Musheng Wei Daosheng Zheng | 1998 | Linear Algebra Appl1998，279，： | 1 |
| 11 | Rank equalities related to the generalized inverse AT,S(2) and BT1,S1(2) of two matrices A and B显示文摘 | Liu Yonghui Wei Musheng | 2004 | Appl Math Comput2004，159，： | 1 |
| 12 | Concurrent Design for Process Quality, Statistical Tolerance, and SPC 显示文摘 | ZHANG Yu YANG Musheng ZHANG Yanxin | 2006 | Communications in Statistics - Theory and Methods2006，35，10： | 1 |
| 13 | A Coordinate SPC Model for Assuring Designated Fit Quality Via Quality -oriented Statistical Tolerancing显示文摘 | ZHANG Yu YANG Musheng | 2009 | Computers and Industrial Engineering2009，57，1： | 1 |
| 14 | DDX1, DDX21, and DHX36 Helicases Form a Complex with the Adaptor Molecule TRIF to Sense dsRNA in Dendritic Cells显示文摘 | Zhiqiang Zhang Taeil Kim Musheng Bao Valeria Facchinetti Sung Yun Jung Amir Ali Ghaffari Jun Qin Genhong Cheng Yong-Jun Liu | 2011 | Immunity2011，，6： | 1 |
| 15 | A Coordinate SPC Model for Assuring Designated Fit Quality via Quality-oriented Statistical Tolerancing显示文摘 | Zhang Yu Yang Musheng | | 0，，01： | 1 |
| 16 | Mixed-type reverse-order law of (AB)^(13)显示文摘 | Wang Minghui Wei Musheng Jia Zhijiang | 2009 | Linear Algebra and its Applications2009，430，： | 1 |
| 17 | Reverse order laws for least squares g-inverses and minimum norm g-inverses of products of two matrices 显示文摘 | Wei Musheng Guo Wenbin | 2002 | Linear Algebra and its Applications2002，342，： | 1 |
| 18 | On solutions of matrix equation AXB+CYD=-F 显示文摘 | Xu Guiping Wei Musheng Zheng Daosheng | 1998 | Linear Algebra and its Applications1998，279，123： | 1 |
| 19 | A human microsatellite DNA-mimieking oligodeoxynucleotide with CCT repeats nega tively regulates TLR7/9-mediated innate immune responses via selected TLR pathways 显示文摘 | Ran Sun Luguo Sun Musheng Bao | 2010 | Clinical immunology2010，134，3： | 1 |
| 20 | Iterative algorithms for solving the matrix equation AXB + CX^TD = E显示文摘 | WANG Minghui CHENG Xuehan WEI Musheng | 2007 | Appl Math Comput2007，187，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员