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| 1 | Simultaneous in-situ determination of U-Pb age and trace elements in zircon by LA-ICP-MS in 20 μm spot size显示文摘Simultaneous in-situ determination of U-Pb ages and 20 trace elements of three international zircon standards(91500,GJ1 and TEMORA 1) and one laboratory zircon standard(SK10-2) separated from Cenozoic fine-grained gabbro was carried out on quadrupole ICP-MS equipped with 193 nm excimer laser in 20 μm spot size. The weighted mean 206Pb/238U ages of 91500,GJ1 and TEMORA 1 are 1064.4±4.8 Ma(2σ ),603.2±2.4 Ma(2σ ) and 418.2±2.4 Ma(2σ ),respectively. The relative standard de-viations(RSDs) of 206Pb/238U ages(2σ ) are less than 2.2% for single measurements and 0.6% for weighted means. The obtained weighted mean 206Pb/238U ages of three standard zircons agree with the recommended values within 2σ error. The weighted mean 206Pb/238U age of SK10-2 is 31.42±0.25 Ma(2σ ) and the RSDs of 206Pb/238U ages(2σ ) are between 2.4% and 5.7% for single measurements and less than 0.8% for weighted mean. The obtained weighted mean 206Pb/238U age is in good agreement with the age obtained by Yuan(2004). Trace element concentrations of NIST612 and NIST614 obtained under the same LA-ICP-MS operating conditions agree with the recommended values within analytical error. The results indicate that it is possible to measure U-Pb age and trace elements simultaneously by LA-ICP-MS in a small spot size of 20 μm. | LIU XiaoMing GAO Shan DIWU ChunRong YUAN HongLin HU ZhaoChu | 2007 | Chinese Science Bulletin2007，52，9： | 107 |
| 2 | Determination of U-Pb age and rare earth element concentrations of zircons from Cenozoic intrusions in northeastern China by laser ablation ICP-MS显示文摘Using the in situ zircon U-Pb dating method of LA-ICPMS, we analyzed the 31 Ma old SHRIMP U-Pb age of the Yongsheng nepheline syenite from southern Jilin Province under different spot sizes. The obtained ages are comparable with that of SHRIMP in both accuracy and precision. The age is also identical to that of the Yinmawanshan gabbro from the Liaodong Peninsula within error. Both the Yongsheng nepheline syenite and the Yinmawanshan gabbro represent the youngest known exposed intrusions in northeastern and even eastern China. The results indicate the Eocene mantle-derived magmatic underplating, and the rapid crustal uplifting of this region since 30 Ma. The analyses also document extremely high LREE concentrations and relatively flat REE patterns for the zircons from the Yongsheng nepheline syenite, which represent a new type of zircon REE pattern. | YUAN Honglin WU Fuyuan GAO Shan LIU Xiaoming XU Ping SUN Deyou | 2003 | Chinese Science Bulletin2003，48，22： | 252 |
| 3 | U–Pb ages and Hf isotopes for detrital zircons from quartzite in the Paleoproterozoic Songshan Group on the southwestern margin of the North China Craton显示文摘In situ U-Pb dating and Lu-Hf isotopic analysis were carried out for detrital zircons from quartzite in the Paleoproterozoic Songshan Group on the southern margin of the North China Craton (NCC). The re- sults provide further constraints on the crustal formation and evolution history of NCC. Four 207Pb/206Pb age populations were obtained from 99 analyses, with clusters at ~3.40 Ga, 2.77―2.80 Ga, ~2.50 Ga and 2.34 Ga, respectively. The 3.40 Ga old zircons have similar Hf isotopic compositions to those from Ar- chean rocks in the Jidong and Anshan areas of NCC. However, crustal remnants older than 3.6 Ga have been identified in the southern margin of NCC, the South China Craton, the northwestern part of the Qinling Orogen and its adjacent area. Thus, it is not easy to trace the source rock from which the 3.40 Ga detrital zircons were derived. It can be inferred that the crustal remnants older than 3.40 Ga might have been widely distributed in the North China Craton. The 2.77―2.80 Ga zircons make up a relatively small proportion and have the highest εHf (t) values (up to 6.1±1.6), consistent with the Hf isotopic composition of the depleted mantle at 2.83 Ga. Their single-stage Hf model age of 2.83 Ga is close to their crystallized age, suggesting that their source rocks were extracted from the contemporaneous depleted mantle. The ~2.50 Ga zircon grains constitute about 85% of the total grain population and their Hf isotopic compositions indicate major growth of juvenile crust at ~2.50 Ga but minor reworking of ancient crust. The youngest zircon dated in this study gave an U-Pb age of 2337±23 Ma, which can be considered the maximum depositional age of the formation of the Songshan Group. | DIWU ChunRong SUN Yong YUAN HongLin WANG HongLiang ZHONG XingPing LIU XiaoMing | 2008 | Chinese Science Bulletin2008，53，18： | 54 |
| 4 | Geochemical and Pb-Sr-Nd isotopic compositions of Indosinian granitoids from the Bikou block,northwest of the Yangtze plate:Constraints on petrogenesis,nature of deep crust and geodynamics显示文摘This paper reports geochemical and Pb-Sr-Nd isotopic compositions of the Indosinian Yangba (215 Ma),Nanyili (225 Ma) and Mopi granitoids from the Bikou block of the northwestern margin of the Yangtze plate. These granitoids are enriched in Al (Al2O3:14.56%―16.48%) and Sr (352 μg/g―1047 μg/g),and depleted in Y (<16 μg/g) and HREE (e.g. Yb<1.61 μg/g),resulting in high Sr/Y (36.3―150) and (La/Yb)N (7.8―36.3) ratios and strongly fractionationed REE patterns. The Indosinian granotoids show initial Sr isotopic ratios (ISr) from 0.70419 to 70752,εNd(t) values from-3.1 to -8.5,and initial Pb isotopic ratios 206Pb/204Pb=17.891-18.250,207Pb/204Pb=15.494-15.575,and 208Pb/204Pb=37.788-38.335. Their geochemi-cal signatures indicate that the granitoids are adakitic. However,they are distinct from some adakites,generated by partial melting of subducted oceanic slab and/or underplated basaltic lower crust,be-cause they have high K (K2O: 1.49%―3.84%) and evolved Nd isotopic compositions,with older Nd iso-topic model ages (TDM=1.06―1.83 Ga). Geochemical and Sr-Nd isotopic compositions suggest that the magmas of the Insoninian adakitic rocks in the Bikou block were derived from partial melting of thick-ened basaltic lower crust. Combined with regional analyses,a lithospheric delamination model after collision between the North China and South China plates can account for the Indosinian adakitic magma generation. On the other hand,based on the Pb-Sr-Nd isotopic probing to the magma sources of the adakitic rocks,it is suggested that there is an unexposed continent-type basement under the exposed Bikou Group volcanic rocks. This can constrain on the Bikou Group volcanic rocks not to be MORB-or OIB-type. | ZHANG HongFei XIAO Long ZHANG Li YUAN HongLin JIN LanLan | 2007 | Science China Earth Sciences2007，50，7： | 38 |
| 5 | Changes of net primary productivity in China during recent 11 years detected using an ecological model driven by MODIS data显示文摘网主要生产率(NPP ) 是陆上的碳周期的一个重要部件。精确地在中国印射 NPP 的空间时间的变化为全球碳骑车是关键的学习。在这研究,基于过程的北方的生态系统生产率模拟器(BEPS ) 被采用从 2000 ~ 2010 为时期在中国的生态系统学习 NPP 的变化。BEPS 模型首先用在在不同区域测量的典型流动地点和森林 NPP 测量的粗野主要生产率(GPP ) 被验证。然后,它与叶区域索引( LAI )被驾驶从中等分辨率成像分光辐射函数( MODIS )反射和陆地盖子产品和气象学的数据的 inversed 在 753 个国家基本气象学的车站从观察插入内推从1月1日在每日的时间步和 500 m 的空间分辨率模仿 NPP , 2000 到2010年12月31日。确认证明 BEPS 能在中国的不同区域捕获基于塔的 GPP 的季节的变化和森林 NPP 的空间可变性。年度 NPP 的估计的国家总数从 2.63 变化了到 2.84Pg C 獥吗? | Yibo LIU Weimin JU Honglin HE Shaoqiang WANG Rui SUN Yuandong ZHANG | 2013 | Frontiers of Earth Science2013，7，1： | 30 |
| 6 | Altered trends in carbon uptake in China’s terrestrial ecosystems under the enhanced summer monsoon and warming hiatus显示文摘The carbon budgets in terrestrial ecosystems in China are strongly coupled with climate changes.Over the past decade,China has experienced dramatic climate changes characterized by enhanced summer monsoon and decelerated warming.However,the changes in the trends of terrestrial net ecosystem production(NEP)in China under climate changes are not well documented.Here,we used three ecosystem models to simulate the spatiotemporal variations in China's NEP during 1982–2010 and quantify the contribution of the strengthened summer monsoon and warming hiatus to the NEP variations in four distinct climatic regions of the country.Our results revealed a decadal-scale shift in NEP from a downtrend of–5.95 Tg C/yr^2(reduced sink)during 1982–2000 to an uptrend of 14.22 Tg C/yr^2(enhanced sink)during 2000–10.This shift was essentially induced by the strengthened summer monsoon,which stimulated carbon uptake,and the warming hiatus,which lessened the decrease in the NEP trend.Compared to the contribution of 56.3%by the climate effect,atmospheric CO2 concentration and nitrogen deposition had relatively small contributions(8.6 and 11.3%,respectively)to the shift.In conclusion,within the context of the global-warming hiatus,the strengthening of the summer monsoon is a critical climate factor that enhances carbon uptake in China due to the asymmetric response of photosynthesis and respiration.Our study not only revealed the shift in ecosystem carbon sequestration in China in recent decades,but also provides some insight for understanding ecosystem carbon dynamics in other monsoonal areas. | Honglin He Shaoqiang Wang Li Zhang Junbang Wang Xiaoli Ren Lei Zhou Shilong Piao Hao Yan Weimin Ju Fengxue Gu Shiyong Yu Yuanhe Yang Miaomiao Wang Zhongen Niu Rcmg Ge Huimin Yan Mei Huang Guoyi Zhou Yongfei Bai Zongqiang Xie Zhiyao Tang Bingfang Wu Leiming Zhang Nianpeng He Qiufeng Wang Guirui Yu | 2019 | National Science Review2019，6，3： | 24 |
| 7 | Strain-based design for buried pipelines subjected to landslides显示文摘Landslides are one of the key problems for stability analysis of pipelines in the western region of China where the geological conditions are extremely complicated. In order to offer a theoretical basis for the pipe-soil interaction, the general finite element program ABAQUS is used to analyze the distribution of pipe strain caused by landslide through which the pipeline passes. In this paper the Ramberg-Osgood constitutive equation is used to study the strain-based mechanical characteristics of pipelines. Different calculation schemas are designed by considering the change of spatial relationship between pipeline and landslide, and the change of D/t, diameter-thickness ratio of pipeline. The results indicate that the pipeline is primarily subjected to tension stress when the landslide crosses the pipeline perpendicularly, the pipe strain is a maximum along the central axis of the landslide, and reverse bending occurs on pipeline at both edges of the landslide. The pipeline is primarily subjected to friction force caused by the downward movement of the landslide, and the friction force is relatively small when the landslide is parallel to the pipeline. The pipe strain is in proportional to D/t, and this means decreasing D/t can help to improve security of pipelines subjected to the landslide. | Han Bing Wang Zhiyin Zhao Honglin Jing Hongyuan WuZhangzhong | 2012 | Petroleum Science2012，9，2： | 22 |
| 8 | Internal structure of Longmenshan fault zone at Hongkou outcrop,Sichuan,China,that caused the 2008 Wenchuan earthquake显示文摘This paper reports the internal structures of the Beichuan fault zone of Longmenshan fault system that caused the 2008 Wenchuan earthquake,at an outcrop in Hongkou,Sichuan province,China.Present work is a part of comprehensive project of Institute of Geology,China Earthquake Administration,trying to understand deformation processes in Longmenshan fault zones and eventually to reproduce Wenchuan earthquake by modeling based on measured mechanical and transport properties.Outcrop studies could be integrated with those performed on samples recovered from fault zone drilling,during the Wenchuan Earthquake Fault Scientific Drilling(WFSD) Project,to understand along-fault and depth variation of fault zone properties.The hanging wall side of the fault zone consists of weakly-foliated,clayey fault gouge of about 1 m in width and of several fault breccia zones of 30-40 m in total width.We could not find any pseudotachylite at this outcrop.Displacement during the Wenchuan earthquake is highly localized within the fault gouge layer along narrower slipping-zones of about 10 to 20 mm in width.This is an important constraint for analyzing thermal pressurization,an important dynamic weakening mechanism of faults.Overlapping patterns of striations on slickenside surface suggest that seismic slip at a given time occurred in even narrower zone of a few to several millimeters,so that localization of deformation must have occurred within a slipping zone during coseismic fault motion.Fault breccia zones are bounded by thin black gouge layers containing amorphous carbon.Fault gouge contains illite and chlorite minerals,but not smectite.Clayey fault gouge next to coseismic slipping zone also contains amorphous carbon and small amounts of graphite.The structural observations and mineralogical data obtained from outcrop exposures of the fault zone of the Wenchuan earthquake can be compared with those obtained from the WFSD-1 and WFSD-2 boreholes, which have been drilled very close to the Hongkou outcrop.The presence of carbon and graphite,observed next to the slipping-zone,may affect the mechanical properties of the fault and also provide useful information about coseismic chemical changes. | Tetsuhiro Togo Toshihiko Shimamoto Shengli Ma Xueze Wen Honglin He | 2011 | Earthquake Science2011，24，3： | 19 |
| 9 | Uniform Strike-Slip Rate along the Xianshuihe-Xiaojiang Fault System and Its Implications for Active Tectonics in Southeastern Tibet显示文摘Xiamshuihe-Xiaojiang 差错系统上的最近的研究建议 LateQuaternary 走向滑倒率沿着全部段断层带是近似一致的,关于 15+-2 mm/a。这个近似一致的罢工强烈滑动率支持顺时针方向,旋转东南的西藏的外壳当模特儿。由接近, arc-shapedXianshuihe-Xiaojiangx 的几何学在一个球形的地球上作为一个小圆的部分指责系统, 15+-2mm/a 罢工滑倒率对应于顺时针方向东南的西藏的块在的旋转( 5.2+-0.7 )在杆附近的 X10^-7deg/a 尖速度( 21 deg N , 88 deg E )相对向东北西藏的块,近似一致的罢工滑动率 Xianshuihe-Xiaojiangfault 系统也暗示 Longmenshan 戳地区不是活跃的,否则至少它的活动有后来是很弱的晚第四级。而且,沿着 theXianshuihe-Xiaojiang 差错系统的全部的偏移量建议相对东北西藏的块的东南的 TibetanBlock 的侧面的挤出是相对 theTarim 北方中国的大约 160 km 和 200-240 km 块。西藏的外壳的侧面的挤出的这数量应该基于集体平衡计算提供了在印度和欧亚大陆之间的大约 13-24% 集中。假设 slip 15+-2 mm/a 评价在整个 Xianshuihe-Xiaojiang 差错系统的全部历史是不变的, 11+-1.5 妈被需要让 Xianshuihe-Xiaojiang 差错系统达到全部的偏移量的 160 km。这暗示在 theXianshuihe-Xiaojiang 差错系统力量上指责的离开滑倒在 11+-1.5 妈开始。 | HE Honglin RAN Hongliu Yasutaka IKEDA | 2006 | Acta Geologica Sinica(English Edition)2006，80，3： | 18 |
| 10 | Contemporary crustal tectonic movement in the southern Sichuan-Yunnan block based on dense GPS observation data显示文摘We analyzed 360 permanent and campaign GPS data from 1999 to 2017 in the southern Sichuan-Yunan block, and obtained crustal horizontal deformation in this region.Then, we derived the strain rate using a multi-scale spherical wavelet method.Results reveal a complex pattern of tectonic movement in the southern Sichuan-Yunnan block.Compared to the stable Eurasian plate, the maximum rate of the horizontal deformation in the southern Sichuan-Yunnan block is approximately 22 mm/a.The Xiaojiang fault shows a significantly lower deformation—a left-lateral strike-slip movement of 9.5 mm/a.The Honghe fault clearly shows a complex segmental deformation from the north to south.The northern Honghe fault shows 4.3 mm/a right strike-slip with 6.7 mm/a extension; the southern Honghe fault shows 1.9 mm/a right strike-slip with 1.9 mm/a extension; the junction zone in the Honghe and Lijiang–Xiaojinhe faults shows an obvious clockwise-rotation deformation.The strain calculation results reveal that the maximum shear-strain rate in this region reaches 70 nstrain/a, concentrated around the Xiaojiang fault and at the junction of the Honghe and Lijiang–Xiaojinhe faults.We note that most of the earthquakes with magnitudes of 4 and above that occurred in this region were within the high shear strain-rate zones and the strain rate gradient boundary zone, which indicates that the magnitude of strain accumulation is closely related to the seismic activities.Comparison of the fast shear-wave polarization direction of the upper-crust with the upper-mantle anisotropy and the direction of the surface principal compressive strain rate obtained from the inversion of the GPS data reveals that the direction of the surface principal compressive strain is basically consistent with the fast shear-wave polarization direction of the upper crust anisotropy, but different from the polarization direction of the upper mantle.Our results support the hypothesis that the principal elements of the deformation mechanism in the southern Sichuan-Yunnan block are decoupling between the upper and lower crust and ductile flow in the lower crust. | HongLin Jin Yuan Gao XiaoNing Su GuangYu Fu | 2019 | Earth and Planetary Physics2019，3，1： | 18 |
| 11 | Identification of 3.5 Ga detrital zircons from Yangtze craton in south China and the implication for Archean crust evolution显示文摘在 Yichang 在 Sanxia 区域从 Liantuo 形成的 Sinian 沙岩和 Nantuo 形成的 tillites 几百由岩屑形成的锆石谷物标明日期的 LA-ICP-MS U-Pb 识别了 3319-3508 妈锆石谷物。他们的 207Pb/206 Pb 和 206Pb/238 U 年龄显示出优秀同意(concordia 度 99%100%) 。他们的 CL 图象展出比率在 0.46-0.76 以内的开发得好的摆动的 zoning 和 Th/U,暗示他们是形成了在期间的火的锆石中间早太古代。这些锆石是在 Yangtze craton 发现直到现在的最旧的。然而,有比在 Kongling 组的变形岩石中的 3.3 Ga 旧的年龄的由岩屑形成的锆石没被进一步的调查发现,它在 Yangtze craton 建议比高级变形 Kongling 地面旧的外壳的存在。 | LIU Xiaoming GAO Shan LING Wenli YUAN Honglin HU Zhaochu | 2006 | Progress in Natural Science:Materials International2006，16，6： | 17 |
| 12 | Complete chloroplast genome sequence of Magnolia grandiflora and comparative analysis with related species显示文摘Magnolia grandiflora is an important medicinal,ornamental and horticultural plant species.The chloroplast(cp) genome of M.grandiflora was sequenced using a 454 sequencing platform and the genome structure was compared with other related species.The complete cp genome of M.grandiflora was 159623 bp in length and contained a pair of inverted repeats(IR) of 26563 bp separated by large and small single copy(LSC,SSC) regions of 87757 and 18740 bp,respectively.A total of 129 genes were successfully annotated,18 of which included introns.The identity,number and GC content of M.grandiflora cp genes were similar to those of other Magnoliaceae species genomes.Analysis revealed 218 simple sequence repeat(SSR) loci,most composed of A or T,contributing to a bias in base composition.The types and abundances of repeat units in Magnoliaceae species were relatively conserved and these loci will be useful for developing M.grandiflora cp genome vectors.In addition,results indicated that the cp genome size in Magnoliaceae species and the position of the IR border were closely related to the length of the ycf1 gene.Phylogenetic analyses based on 66 shared genes from 30 species using maximum parsimony(MP) and maximum likelihood(ML) methods provided strong support for the phylogenetic position of Magnolia.The availability of the complete cp genome sequence of M.grandiflora provides valuable information for breeding of desirable varieties,cp genetic engineering,developing useful molecular markers and phylogenetic analyses in Magnoliaceae. | LI XiWen GAO HuanHuan WANG YiTao SONG JingYuan HENRY Robert WU HeZhen HU ZhiGang YAO Hui LUO HongMei LUO Kun PAN HongLin CHEN ShiLin | 2013 | Science China(Life Sciences)2013，56，2： | 17 |
| 13 | Effects of maize root exudates and organic acids on the desorption of phenanthrene from soils显示文摘The eects of maize root exudates and low-molecular-weight-organic anions (LMWOAs) on the desorption of phenanthrene from eight artificially contaminated soils were evaluated. A significant negative correlation was observed between the amounts of phenanthrene desorbed and the soil organic carbon (SOC) contents (P < 0.01), and the inuences of soil pH and clay content on phenanthrene desorption were insignificant (P > 0.1). Neither maize root exudates nor oxalate and citrate anions inuenced desorption of phenanthrene with the addition of NaN3. A faster phenanthrene desorption occurred without the addition of NaN3 in the presence of maize root exudates than oxalate or citrate due to the enhanced degradation by root exudates. Without the addition of NaN3, oxalate or citrate at dierent concentrations could inhibit phenanthrene desorption to dierent extents and the inhibiting eect by citrate was more significant than by oxalate. This study leads to the conclusion that maize root exudates can not enhance the desorption under abiotic condition with the addition of NaN3 and can promote the desorption of phenanthrene in soils without the addition of NaN3. | ZHU Yanhong, ZHANG Shuzhen, HUANG Honglin, WEN Bei State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. | 2009 | Journal of Environmental Sciences2009，21，7： | 14 |
| 14 | High precision in-situ Pb isotopic analysis of sulfide minerals by femtosecond laser ablation multi-collector inductively coupled plasma mass spectrometry显示文摘An in-situ microanalysis of Pb isotopic compositions in sulfide minerals is carried out by using femtosecond laser-ablation multi-collector inductively coupled plasma mass spectrometry(fs LA-MC-ICP-MS).High-temperature-activated carbon was used to filter Hg contained in the carrier gas,which reduced the Hg background signal by 48%and also lowered the detection limit of the analysis.Fractionation and mass discrimination effects existing in the ICP-MS analytical processes were corrected using an internal reference Tl in conjunction with an external reference NIST SRM 610.The proposed method was used to analyze the Pb isotopic compositions of chalcopyrite,pyrite,and sphalerite from the Dulong Sn-Zn-In polymetallic ore district.The results showed that in this ore district,the sulfide minerals and different grains of the same sulfide mineral show a large variation in Pb content up to 1000-fold.The studied pyrites show relatively higher Pb contents and homogeneous Pb isotopic compositions,whereas the sphalerites have low Pb contents but most variable Pb isotopic compositions.It is suggested that the large variation of Pb isotopic composition may reflect a late hydrothermal superimposition on the primary sulfide formation.In addition,radiogenic Pb accumulated by radioactive decay of trace amounts of U over time in the host minerals may also be one of the causes for the large variation range of Pb content and Pb isotopic composition of those low-Pb sphalerites.Chalcopyrite and sphalerite grains with Pb content greater than 10 ppm presented a consistent Pb isotopic distribution,whereas all the sulfide grains with Pb content greater than 100 ppm had consistent Pb isotopic composition within 2s measurement uncertainties.The in-situ analysis of Pb isotopic composition agreed well with the results obtained by conventional chemical methods within2s measurement uncertainties,indicating that the data obtained by fs LA-MC-ICP-MS are reliable.Additionally,this study indicates that the Pb isotopic composition could truthfully record the source of ore-forming minerals only for sulfide minerals with high Pb content.On the contrary,the Pb isotopic composition of low-Pb sulfide minerals may be affected by trace amounts of U in the host minerals that may lead to a highly radiogenic Pb isotope ratio.Alternatively,it is also possible that late fluid metasomatic overprinting may alter the Pb isotopic compositions. | YUAN HongLin YIN Cong LIU Xu CHEN KaiYun BAO ZhiAn ZONG ChunLei DAI MenNing LAI ShaoCong WANG Rong JIANG ShaoYong | 2015 | Science China Earth Sciences2015，58，10： | 14 |
| 15 | Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2显示文摘Emerging and re-emerging RNA viruses occasionally cause epidemics and pandemics worldwide,such as the on-going outbreak of the novel coronavirus SARS-CoV-2.Herein,we identified two potent inhibitors of human DHODH,S312 and S416,with favorable drug-likeness and pharmacokinetic profiles,which all showed broad-spectrum antiviral effects against various RNA viruses,including influenza A virus,Zika virus,Ebola virus,and particularly against SARS-CoV-2.Notably,S416 is reported to be the most potent inhibitor so far with an EC5o of 17 nmol/L and an SI value of 10,505.88 in infec-ted cells.Our results are the first to validate that DHODH is an attractive host target through high antiviral efficacy in vivo and low virus replication in DHODH knock-out cells.This work demonstrates that both S312/S416 and old drugs(Leflunomide/Teriflunomide)with dual actions of antiviral and immuno-regulation may have clinical potentials to cure SARS-CoV-2 or other RNA viruses circulating worldwide,no matter such viruses are mutated or not. | Rui Xiong Leike Zhang Shiliang Li Yuan Sun Minyi Ding Yong Wang Yongliang Zhao Yan Wu Weijuan Shang Xiaming Jiang Jiwei Shan Zihao Shen Yi Tong Liuxin Xu Yu Chen Yingle Liu Gang Zou Dimitri Lavillete Zhenjiang Zhao Rui Wang Lili Zhu Gengfu Xiao Ke Lan Honglin Li Ke Xu | 2020 | Protein & Cell2020，11，10： | 14 |
| 16 | Spatio-temporal variation of photosynthetically active radiation in China in recent 50 years显示文摘在中国上基于 weather/ecological 车站的长期的测量数据,计算并且生产每年平均、平均 seasonally 的光合地活跃的放射(同等) 的这份报纸从 1961 ~ 2007 的空间数据,用 climatological 计算和 spatialization 技术。在中国在上的每年平均、平均 seasonally 的同等空间数据的时间空间的变化特征最近 50 年与 Mann-Kendall 趋势分析方法和 GIS 被分析空间分析技术。结果显示出那:(1 ) 总体上,同等的空间分发越过中国复杂、不同类,与在中国的东方、南部的部分的更低的同等和在西方的部分的更高的同等。在中国上的吝啬的年度同等从 17.7 摩尔 m ? 2 d ? 1 ~ 39.5 摩尔 m ? 2 d ? 1。(2 ) 在中国上的每个象素的每年平均、平均 seasonally 的同等总体上被平均,平均数与变动进程显然珍视衰落,并且每年平均的同等的变化的率是 ? 0.138 摩尔 m ? 2 d ? 1/10a。在四个季节之中的变化振幅是不同的,与在里面的最大的落下夏天,和同等的下降速度在 1990 年代,速度在以后慢下来前是更快的。(3 ) 由每个象素的分析证明那同等显著地衰退(=0.05 ) 在中国的大多数部分。夏天和冬季在同等的 interannual 可变性起更重要的作用。诺思中国总是是在四个季节的一个减少的地区,当 Qinghai 西藏高原的西北转弯是在四个季节的一个增加的地区时。(4 ) 同等的 interannual 可变性的空间分布在不同时期之中变化。在某个区域的同等的 interannual 可变性不仅在四个季节之中,而且在不同时期之中是不同的。 | ZHU Xudong HE Honglin LIU Min YU Guirui SUN Xiaomin GAO Yanhua | 2010 | Journal of Geographical Sciences2010，20，6： | 12 |
| 17 | Metal Sealing Performance of Subsea X-tree Wellhead Connector Sealer显示文摘The metal sealing performance of subsea X-tree wellhead connectors is crucial for the safety and reliability of subsea X-trees. In order to establish the theoretical relation between metal sealing ring's contact stress and its structural parameters and working pressure, a mechanical analysis method for double-cone sealing of high pressure vessels is applied in analyzing the metal sealing ring under the condition of preload and operation. As a result, the formula of the unit sealing load for the metal sealing ring under operation with residual preload is shown in this paper, which ensures that the metal sealing ring has an excellent sealing effect and can prevent the metal sealing ring from yielding. Besides, while analyzing the sealing process of the metal sealing ring, the change rule of contact stress and working pressure is concluded here, putting forward that the structural parameters of the metal sealing ring are the major factors affecting the change rule. Finally, the analytical solution through theoretical analysis is compared with the simulation result through finite element analysis in a force feedback experiment, and both are consistent with each other, which fully verifies for the design and calculation theory on metal sealing ring's contact stress and its structural parameters and working pressure deduced in this paper. The proposed research will be treated as an applicable theory guiding the design of metal seal for subsea X-tree wellhead connectors. | ZHAO Honglin CHEN Rui LUO Xiaolan DUAN Menglan LU Yinghui FU Guowei TIAN Hongping YE Daohui | 2015 | Chinese Journal of Mechanical Engineering2015，28，3： | 9 |
| 18 | Tumor suppressor protein C53 antagonizes checkpoint kinases to promote cyclin-dependent kinase 1 activation显示文摘Cyclin 依赖的 kinase 1 (Cdk1 )/cyclin B1 建筑群是为有丝分裂的入口的驱动力,并且它的激活被 G2/M 检查点紧调整。我们原来报导了那新奇蛋白质 C53 (也作为 Cdk5rap3 和 LZAP 知道) 加强由 modulating 的 DNA 导致损坏的房间死亡 G2/M 检查点。更最近,王等。(2007 ) 发现 C53/LZAP 可以通过禁止 NF-魏 B 发信号作为肿瘤 suppressor 工作。我们这里作为 Cdk1 激活的一个新奇管理者报导 C53 蛋白质的鉴定。我们 C53 蛋白质原因发现那击倒推迟的 Cdk1 激活和有丝分裂的入口。在 DNA 损坏反应期间,检查点 kinase 的激活(Chk1 和 Chk2 ) 1 和 2 被 C53 overexpression 部分禁止。有趣地,我们发现 C53 与 Chk1 交往并且反对它的功能。而且, C53 蛋白质的部分 potently 在中心体,和指向中心体的 C53 是局部性的支持本地 Cdk1 激活。一起拿,我们的结果强烈建议 C53 是检查点反应的一个新奇否定管理者。由抵抗 Chk1, C53 在两不受搅乱的房间周期前进和 DNA 损坏反应支持 Cdk1 激活和有丝分裂的入口。 | Hai Jiang Jianchun Wu Chen He Wending Yang Honglin Li | 2009 | Cell Research2009，19，4： | 9 |
| 19 | Construction of an integrated map and location of a bruchid resistance gene in mung bean显示文摘Bruchid beetle(Callosobruchus chinensis) poses a serious threat to the production and storage of mung bean(Vigna radiata). Mapping bruchid resistance(Br) will provide an important basis for cloning the responsible gene(s) and elucidating its functional mechanism, and will also facilitate marker-assisted selection in mung bean breeding. Here, we report the construction of the genetic linkage groups of mung bean and mapping of the Br1 locus using an RIL population derived from a cross between Berken, a bruchid-susceptible line, and ACC41, a bruchid-resistant line. A total of 560 markers were mapped onto 11 linkage groups,with 38.0% of the markers showing distorted segregation. The lengths of the linkage groups ranged from 45.2 to 117.0 c M with a total coverage of 732.9 c M and an average interval of1.3 c M between loci. Br1 was located on LG9 between BM202(0.7 c M) and Vr2-627(1.7 c M).Based on 270 shared SSR markers, most of the linkage groups were assigned to specific chromosomes. These results should further accelerate the genetic study of this crop. | Lixia Wang Chuanshu Wu Min Zhong Dan Zhao Li Mei Honglin Chen Suhua Wang Chunji Liu Xuzhen Cheng | 2016 | The Crop Journal2016，4，5： | 9 |
| 20 | A Transgenic Study on Affecting Potato Tuber Yield by Expressing the Rice Sucrose Transporter Genes OsSUT5Z and OsSUT2M显示文摘在许多植物,蔗糖 transporters 为从来源和进口的两个蔗糖出口是必要的进水池,显示功能在吸收划分。为了调查蔗糖 transporters 是否能改进淀粉的收益,种,土豆植物(茄属 tuberosum L。cv。 | Aijun Sun Yan Dai Xinsheng Zhang Chunmin Li Kun Meng Honglin Xu Xiaoli Wei Guifang Xiao Pieter B.F, Ouwerkerk Mei Wang Zhen Zhu | 2011 | Journal of Integrative Plant Biology2011，53，7： | 9 |
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