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| 1 | Factors Affecting Phytoextraction: A Review显示文摘Hyperaccumulators 当在污染金属的土壤和这些成长时,在他们的射击集中踪迹金属和重金属踪迹装载金属的植物可以被收获这些地移开。探索这些 hyperaccumulators 的有益的角色清理环境的研究导致了 phytoextraction 的发展。phytoextraction 的成功为植物举起取决于植物种类的高生物资源和金属的 bioavailability。金属的 phytoavailability 被联系土壤的因素,并且由联系植物的因素影响,例如 pH,氧化还原作用潜力,阳离子交换能力,土壤类型,和土壤质地,例如根流出物和根根围过程(微生物) 。phytoextraction 的效率能被由遗传工程的申请包括土壤和庄稼管理提高金属忍耐,射击 translocation,累积,和隐遁的先进农学的惯例并且由螯的处理的申请改进提高金属 bioavailability。包括细菌和 mycorrhiza 的微生物的申请可以在商业地大的规模便于 phytoextraction 申请。 | Vimla SHEORAN Attar Singh SHEORAN Poonam POONIA | 2016 | Pedosphere2016，26，2： | 18 |
| 2 | Nexus of signaling and endocytosis in oncogenesis driven by non-small cell lung cancer-associated epidermal growth factor receptor mutants显示文摘Epidermal growth factor receptor(EGFR) controls a wide range of cellular processes, and aberrant EGFR signaling as a result of receptor overexpression and/or mutation occurs in many types of cancer. Tumor cells in non-small cell lung cancer(NSCLC) patients that harbor EGFR kinase domain mutations exhibit oncogene addiction to mutant EGFR, which confers high sensitivity to tyrosine kinase inhibitors(TKIs). As patients invariably develop resistance to TKIs, it is important to delineate the cell biological basis of mutant EGFR-induced cellular transformation since components of these pathways can serve as alternate therapeutic targets to preempt or overcome resistance. NSCLC-associated EGFR mutants are constitutively-active and induce ligandindependent transformation in nonmalignant cell lines. Emerging data suggest that a number of factors are critical for the mutant EGFR-dependent tumorigenicity, and bypassing the effects of TKIs on these pathways promotes drug resistance. For example, activation of downstream pathways such as Akt, Erk, STAT3 and Src is critical for mutant EGFR-mediated biological processes. It is now well-established that the potency and spatiotemporal features of cellular signaling by receptor tyrosine kinases such as EGFR, as well as the specific pathways activated, is determined by the nature of endocytic traffic pathways through which the active receptors traverse. Recent evidence indicates that NSCLCassociated mutant EGFRs exhibit altered endocytic trafficking and they exhibit reduced Cbl ubiquitin ligasemediated lysosomal downregulation. More recent work has shown that mutant EGFRs undergo ligand-independent traffic into the endocytic recycling compartment, a behavior that plays a key role in Src pathway activation and oncogenesis. These studies are beginning to delineate the close nexus between signaling and endocytic traffic of EGFR mutants as a key driver of oncogenicprocesses. Therefore, in this review, we will discuss the links between mutant EGFR signaling and endocytic properties, and introduce potential mechanisms by which altered endocytic properties of mutant EGFRs may alter signaling and vice versa as well as their implications for NSCLC therapy. | Byung Min Chung Eric Tom Neha Zutshi Timothy Alan Bielecki Vimla Band Hamid Band | 2014 | World Journal of Clinical Oncology2014，5，5： | 3 |
| 3 | The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells显示文摘 | Song Li-Bing Li Jun Liao Wen-Ting Feng Yan Yu Chun-Ping Hu Li-Juan Kong Qing-Li Xu Li-Hua Zhang Xing Liu Wan-Li Li Man-Zhi Zhang Ling Kang Tie-Bang Fu Li-Wu Huang Wen-Lin Xia Yun-Fei Tsao Sai Wah Li Mengfeng Band Vimla Band Hamid Shi | 2009 | Journal of Clinical Investigation2009，，12： | 2 |
| 4 | 谷类植物原生质体研究的重要进展显示文摘自1986年以来,已从所有重要的谷类植物,包括小麦、水稻、玉米和大麦,以及多种禾本科植物例如甘蔗的原生质体再生得到了完整的再生植株。此外,在一些实验室中已得到了谷类植物的体细胞杂种或胞质杂种以及一些带有引入的有用农艺性状的转基因植株。在过去的十年期间。 | Indra K.Vasil Vimla Vasil 黄健秋 | 1993 | 细胞生物学杂志1993，15，3： | 1 |
| 5 | Primary malignant melanoma in ovariam cystic teratoma显示文摘 | Vimla N kumar L | 2001 | Gynecol Oncol2001，82，2： | 1 |
| 6 | 人血管内皮抑素的基因克隆和表达载体构建及纯化显示文摘目的 克隆人血管内皮抑素基因(endostatin),纯化其表达蛋白并初步检测纯化蛋白的生物学活性。方法 用PCH技术从正常成人肝cDNA库扩增出人血管内皮抑素基因,将其克隆进pBluescript中测定其核苷酸序列。构建大肠杆菌分泌性表达载体pET-22b(+)-endostatin-6xHis,IPTG诱导表达,经Ni^(2+)-IDA Sepharose 6B亲和纯化该表达蛋白,并采用血管内皮细胞增殖抑制试验检测其活性。结果 经PCR扩增成功获得55lbp的人血管内皮抑素基因,测序正确,在大肠杆菌中表达后,该表达蛋白的表达量占菌体总蛋白的10%。SDS-PAGE和Western blot显示其分子最为21kd。经亲和纯化后的endostatin-6xHis纯度可达90%,得率为0.3mg/100ml,并且具有抑制血管内皮细胞增殖的活性,达到50%的抑制率需endostatin-6xHis浓度为600ng/ml。结论 endostatin基因克隆、表达和纯化的成功,为采用抗血管生成方法治疗裸鼠肿瘤模型和肿瘤病人的研究奠定了基础。 | 李彪 朱承谟 于金德 Vimla Band | 2003 | 上海第二医科大学学报2003，23，2： | 1 |
| 7 | lndispensahle roles of mammalian Chlfamily proteins as negative regulators of protein tyrosinc kinase signaling显示文摘 | Mayumi N Vimla B Harold B | 2011 | Communicative and Integrative Biology2011，4，2： | 1 |
| 8 | Accelerated production of transgenic wheat (Triticum aestivum L.) plants显示文摘 | Fredy Altpeter Vimla Vasil Vibha Srivastava Eva St?ger Indra K. Vasil | 1996 | Plant Cell Reports (-)1996，，1： | 1 |
| 9 | Primary malignant melanoma in ovarian eystic teratoma显示文摘 | Vimla N Kumar L Thulkar S | 2001 | Gyneeol Oncol2001，82，2： | 1 |
| 10 | A randomized controlled trial of prophylactic sublingual misoprostol versus intramuscular methyl-ergometrine versus intramuscular 15-methyl PGF2α in active management of third stage of labor显示文摘 | Arvind Vaid Vatsla Dadhwal Suneeta Mittal Deepika Deka Renu Misra Jai Bhagwan Sharma N. Vimla | 2009 | Archives of Gynecology and Obstetrics2009，，： | 1 |
| 11 | A Primer on Aspects of Cognition for Medical Informatics 显示文摘 | Vimla L | 2001 | Journal of the American Medical Informatics Association2001，8，4： | 1 |
| 12 | A Wnt-CKI?-Rap1 Pathway Regulates Gastrulation by Modulating SIPA1L1, a Rap GTPase Activating Protein显示文摘 | I-Chun Tsai Jeffrey D. Amack Zhong-Hua Gao Vimla Band H. Joseph Yost David M. Virshup | 2007 | Developmental Cell2007，，3： | 1 |
| 13 | Detecting adverse events for patient safety research:a review of current methodologies显示文摘 | Harvey JM Vimla LP David WB | 2003 | Journal of Biomedical Informatics2003，36，6： | 1 |
| 14 | Accelerated production of transgenic wheat(Triticum aestivum L)plants显示文摘 | Alpeter Fredy Vimla Vasil Vibha Srivastara | 1996 | Plant Cell Reports1996，16，： | 1 |
| 15 | Identification of downstream genetic pathways of Thxl in the second heart field显示文摘 | JUN L VIMLA S A SONJA N | 2008 | Dev Biol2008，316，： | 1 |
| 16 | Heuristic evaluation of paper-based Web pages: A simplified inspection usability methodology显示文摘 | Mureen Allen Leanne M. Currie Suzanne Bakken Vimla L. Patel James J. Cimino | 2005 | Journal of Biomedical Informatics2005，，4： | 1 |
| 17 | Transformation of wheat via particle bom- bardment显示文摘 | Indra K V Vimla V | 2006 | Methods Mol Biol2006，318，： | 1 |
| 18 | Primary malignant melanoma in ovarian cystic tecratoma 显示文摘 | Vimla N Kumar L | 2001 | Gynecol Oncol2001，82，2： | 1 |
| 19 | The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells显示文摘 | Song Li-Bing Li Jun Liao Wen-Ting Feng Yan Yu Chun-Ping Hu Li-Juan Kong Qing-Li Xu Li-Hua Zhang Xing Liu Wan-Li Li Man-Zhi Zhang Ling Kang Tie-Bang Fu Li-Wu Huang Wen-Lin Xia Yun-Fei Tsao Sai Wah Li Mengfeng Band Vimla Band Hamid Shi | 2009 | Journal of Clinical Investigation2009，，12： | 1 |
| 20 | Integration and expression of the high-molecular-weight glutenin subunit 1Ax1 gene into wheat显示文摘 | Fredy A Vimla V Vibha S | 1996 | Nature Biotechnology1996，14，： | 1 |
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