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| 1 | Acupuncture's Role in Solving the Opioid Epidemic: Evidence, Cost-Effectiveness, and Care Availability for Acupuncture as a Primary, Non-Pharmacologic Method for Pain Relief and Management-White Paper 2017显示文摘The United States(U.S.) is facing a national opioid epidemic, and medical systems are in need of nonpharmacologic strategies that can be employed to decrease the public's opioid dependence. Acupuncture has emerged as a powerful, evidence-based, safe, cost-effective, and available treatment modality suitable to meeting this need. Acupuncture has been shown to be effective for the management of numerous types of pain conditions, and mechanisms of action for acupuncture have been described and are understandable from biomedical, physiologic perspectives. Further, acupuncture's cost-effectiveness can dramatically decrease health care expenditures, both from the standpoint of treating acute pain and through avoiding addiction to opioids that requires costly care, destroys quality of life, and can lead to fatal overdose. Numerous federal regulatory agencies have advised or mandated that healthcare systems and providers offer non-pharmacologic treatment options for pain. Acupuncture stands out as the most evidence-based, immediately available choice to fulfil these calls. Acupuncture can safely, easily, and cost-effectively be incorporated into hospital settings as diverse as the emergency department, labor and delivery suites, andneonatal intensive care units to treat a variety of commonly seen pain conditions. Acupuncture is already being successful y and meaningfully utilized by the Veterans Administration and various branches of the U.S. Military, in some studies demonstrably decreasing the volume of opioids prescribed when included in care. | arthur yin fan david w.miller bonnie bolash matthew bauer john mcdonald sarah faggert hongjian he yong ming li amy matecki lindy camardella mel hopper koppelman jennifer a.m.stone lindsay meade john pang | 2017 | Journal of Integrative Medicine2017，15，6： | 29 |
| 2 | Activated carbon adsorption of quinolone antibiotics in water:Performance,mechanism,and modeling显示文摘The extensive use of antibiotics has led to their presence in the aquatic environment, and introduces potential impacts on human and ecological health. The capability of powdered activated carbon(PAC) to remove six frequently used quinolone(QN) antibiotics during water treatment was evaluated to improve drinking water safety. The kinetics of QN adsorption by PAC was best described by a pseudo second-order equation, and the adsorption capacity was well described by the Freundlich isotherm equation. Isotherms measured at different p H showed that hydrophobic interaction, electrostatic interaction,and π–π dispersion force were the main mechanisms for adsorption of QNs by PAC. A p H-dependent isotherm model based on the Freundlich equation was developed to predict the adsorption capacity of QNs by PAC at different p H values. This model had excellent prediction capabilities under different laboratory scenarios. Small relative standard derivations(RSDs), i.e., 0.59%–0.92% for ciprofloxacin and 0.09%–3.89% for enrofloxacin,were observed for equilibrium concentrations above the 0.3 mg/L level. The RSDs increased to 11.9% for ciprofloxacin and 32.1% for enrofloxacin at μg/L equilibrium levels, which is still acceptable. This model could be applied to predict the adsorption of other chemicals having different ionized forms. | Hao Fu Xuebing Li Jun Wang Pengfei Lin Chao Chen Xiaojian Zhang I.H.(Mel)Suffet | 2017 | Journal of Environmental Sciences2017，29，6： | 25 |
| 3 | Intercomparison of Humidity and Temperature Sensors:GTS1, Vaisala RS80, and CFH显示文摘GTS1 digital radiosonde, developed by the Shanghai Changwang Meteorological Science and Technology Company in 1998, is now widely used in operational radiosonde stations in China. A preliminary comparison of simultaneous humidity measurements by the GTS1 radiosonde, the Vaisala RS80 radiosonde, and the Cryogenic Frostpoint Hygrometer (CFH), launched at Kunming in August 2009, reveals a large dry bias produced by the GTS1 humidity sensor. The average relative dry bias is in the order of 10% below 500 hPa, increasing rapidly to 30% above 500 hPa, and up to 55% at 310 hPa. A much larger dry bias is observed in the daytime, and this daytime effect increases with altitude. The GTS1 radiosonde fails to respond to humidity changes in the upper troposphere, and sometimes even in the middle troposphere. The failure of GTS1 in the middle and upper troposphere will result in significant artificial humidity shifts in radiosonde climate records at stations in China where a transition from mechanical to digital radiosondes has occurred. A comparison of simultaneous temperature observations by the GTS1 radiosonde and the Vaisala RS80 radiosonde suggests that these two radiosondes provide highly reproducible temperature measurements in the troposphere, but produce opposite biases for daytime and nighttime measurements in the stratosphere. In the stratosphere, the GTS1 shows a warm bias (<0.5 K) in the daytime and a relatively large cool bias (-0.2 K to -1.6 K) at nighttime. | 卞建春 陈洪滨 Holger VMEL 段云俊 宣越健 吕达仁 | 2011 | Advances in Atmospheric Sciences2011，28，1： | 20 |
| 4 | 800kV气体绝缘金属封闭输电线路及竖井安装显示文摘气体绝缘金属封闭输电线路(GIL)因其传输容量大、可靠性高、电磁兼容性好等优点,正在广泛地应用于核电站、城市输电和大型水电站等场合。对于500kV及以上电压等级,1回GIL的输送容量相当于同电压等级的交链聚乙烯(XLPE)电缆两三回的输送容量。对拉西瓦水电站800kV GIL的结构、设计、制造及安装调试等特殊问题进行了介绍。特别对高海拔(2450m)、高落差(207m)场合(例如竖井中)安装GIL,给出了一些建议。对比发现,GIL与传统的电缆及全封闭组合电器(GIS)母线相比,在可靠性及经济性上有一定的优越性。 | 马仲鸣 李六零 Gary Bowman Mel Hopkins | 2008 | 中国电力2008，41，8： | 15 |
| 5 | Safety and success of precut biliary sphincterotomy: Is it linked to experience or expertise?显示文摘瞄准:决定成功的率和按规格裁切的复杂并发症胆汁的括约肌切开术(PBS ) 基于优先的经验并且到比较在 PBS 和标准内视镜的括约肌切开术(ES ) 之间的复杂并发症率。方法:回顾的评估有希望地在一个学术第三级的工作分派中心收集了非使随机化的数据。包括的学习没有 formal 在 PBS 训练的由单个 endoscopist 经历了 PBS 和 ES 的在一个八年的时期的所有病人。学习的主要结果措施是有到 ES 的复杂并发症的比较的 PBS 的成功和复杂并发症。结果:一个总数 2939 内视镜后退 cholangiopancreatographies (ERCP ) 在学习时期期间被执行,包括 818 (28%) ES 并且 150 (5%) PBS 过程。经由 PBS 的选择胆汁的管子在在 75% 病人的第一次尝试是成功的。管子被完成在一另外在一次随后的尝试(总数 87%) 的 13% 病人。从 PBS 的复杂并发症率比 ES 高是 45% ,但是没显著地不同[7%(10/50 ) 对 5%(38/818 ) , P = 0.29 ] 。任何一个从 PBS 的复杂并发症都不是严重的。向增加成功的一个重要趋势关于 endoscopist 存在 ?ˉs 在按规格裁切的第一次尝试(P = 0.0393,为趋势的 Cochran-Armitage 准确测试, Z =-1.7588) 。结论:尽管有在这种技术的特定的训练的缺乏, PBS 从另外的富有经验的中心与高成功率和类似于的复杂并发症率或不到报告被执行。这些结果建议内视镜的经验和也许天生的内视镜的技巧可以在这个过程的结果起一个重要作用。 | Lindsay S Robison Shyam Varadarajulu C Mel Wilcox | 2007 | World Journal of Gastroenterology2007，13，15： | 10 |
| 6 | Employability: A psycho-social construct, its dimensions, and applications显示文摘 | Mel Fugate Angelo J Kinicki Blake E Ashforth | 2003 | Journal of Vocational Behavior2003，，1： | 8 |
| 7 | Sphincter of Oddi dysfunction Type Ⅲ: New studies suggest new approaches are needed显示文摘Sphincter of Oddi dysfunction(SOD) has been classified into three types based upon the presence or absence of objective findings including liver test abnormalities and bile duct dilatation. Type Ⅲ is the most controversial and is classified as biliary type pain in the absence ofany these objective findings. Many prior studies have shown that the clinical response to endoscopic therapy is higher based upon the presence of these objective criteria. However, there has been variable correlation of the manometry findings to outcome after endoscopic therapy. Nevertheless, manometry and sphincterotomy has been recommended for Type Ⅲ patients given the overall response rate of 33%, although the reported response rates are highly variable. However, all of the prior data was non-blinded and non-randomized with variable follow-up. The evaluating predictors in SOD study- a prospective randomized blinded sham controlled one year outcome study showed no correlation between manometric findings and outcome after sphincterotomy. Furthermore, patients receiving sham therapy had a statistically significantly better outcome than those undergoing biliary or dual sphincterotomy. This study calls into question the whole concept of SOD Type Ⅲ and, based upon prior physiologic studies, one can suggest that SOD Type Ⅲ likely represents a right upper quadrant functional abdominal pain syndrome and should be treated as such. | C Mel Wilcox | 2015 | World Journal of Gastroenterology2015，21，19： | 6 |
| 8 | Equal Efficacy of Endoscopic and Surgical Cystogastrostomy for Pancreatic Pseudocyst Drainage in a Randomized Trial显示文摘 | Shyam Varadarajulu Ji Young Bang Bryce S. Sutton Jessica M. Trevino John D. Christein C. Mel Wilcox | 2013 | Gastroenterology2013，，： | 6 |
| 9 | Endoscopic closure of a gastrocolic fistula using the over-the-scope-clip-system显示文摘Gastrointestinal (GI) defects such as fistulas and leaks can be potentially closed endoscopically using hemo-clips and loops. However, hemoclips may not allow for closure of large defects and they do not exert enough tensile force to keep fibrotic defects larger than 5 mm approximated. Herein we present a case of successful endoscopic closure of a gastrocolic fistula in a severely malnourished patient with complex post-surgical upper GI anatomy. We strongly believe that this device is a major breakthrough for the management of various types of discontinuity defects or fistulas. In addition, we show the usefulness of placing a direct jejunostomy using the double balloon enteroscopy (DBE) technique during the same procedure. The concept of providing direct jejunal feedings while allowing for upper gas-trointestinal bowel rest to promote the healing of the minimally invasive endoscopic operation is novel. Thus, our case is unique and exemplifies the utility of mini-mally invasive endoscopic endoluminal surgery. | Klaus Mnkemüller Shajan Peter Basem Alkurdi Jayapal Ramesh Daniel Popa C Mel Wilcox | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，8： | 5 |
| 10 | Use of anesthesia on the rise in gastrointestinal endoscopy显示文摘Conscious sedation has been the standard of care for many years for gastrointestinal endoscopic procedures. As procedures have become more complex and lengthy, additional medications became essential for adequate sedation. Often time's deep sedation is required for procedures such as endoscopic retrograde cholangiography which necessitates higher doses of narcotics and benzodiazepines or even use of other medications such as ketamine. Given its pharmacologic properties, pro-pofol was rapidly adopted worldwide to gastrointestinal endoscopy for complex procedures and more recently to routine upper and lower endoscopy. Many studies have shown superiority for both the physician and patient compared to standard sedation. Nevertheless, its use remains highly controversial. A number of studies worldwide show that propofol can be given safely by endoscopists or nurses when well trained. Despite this wealth of data, at many centers its use has been pro-hibited unless administered by anesthesiology. In this commentary, we review the use of anesthesia support for endoscopy in the United States based on recent data and its implications for gastroenterologists world-wide. | Basil Al-Awabdy C Mel Wilcox | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，1： | 5 |
| 11 | New approaches for diagnosis of dry eye disease显示文摘We reviewed the literature for different diagnostic approaches for dry eye disease(DED) including the most recent advances, contradictions and promising diagnostic tools and technique. We performed a broad literature search for articles discussing different methods for diagnosis of DED including assessment of tear osmolarity, tear film stability, ocular biomarkers and others. Articles indexed in PubMed and google scholar were included. With the growing cosmetic industry, environmental pollution, and booming of digital screens, DED is becoming more prevalent. Its multifactorial etiology renders the diagnosis challenging and invites the emergence of new diagnostic tools and tests. Diagnostic tools can be classified, based on the parameter they measure, into tear film osmolarity, functional visual acuity, tear volume, tear turnover, tear film stability, tear film composition, ocular biomarkers and others. Although numerous methods exist, the most accurate diagnosis can be reached through combining the results of more than one test. Many reported tests have shown potential as diagnostic/screening tools, however, require more research to prove their diagnostic power, alone or in combination. Future research should focus on identifying and measuring parameters that are the most specific to DED diagnosis. | Abdelrahman MElhusseiny Ali AKhalil Reem HEl Sheikh Mohammad ABakr MohamedGaber Eissa Yasmine MEl Sayed | 2019 | International Journal of Ophthalmology(English edition)2019，12，10： | 5 |
| 12 | Multipurpose use of the ‘bear claw’ (over‐the‐scope‐clip system) to treat endoluminal gastrointestinal disorders显示文摘 | Klaus M?nkemüller Shajan Peter Jay Toshniwal Daniel Popa Marzena Zabielski Richard D. Stahl Jayapal Ramesh C. Mel Wilcox | 2014 | Digestive Endoscopy2014，，3： | 4 |
| 13 | Validation of Aura Microwave Limb Sounder water vapor and ozone profiles over the Tibetan Plateau and its adjacent region during boreal summer显示文摘We present validation studies of MLS V2.2 and V3.3 water vapor(WV) and ozone profiles over the Tibetan Plateau(Naqu and Lhasa) and its adjacent region(Tengchong) respectively by using the balloon-borne Cryogenic Frost point Hygrometer and Electrochemical Concentration Cell ozonesonde. Coincident in situ measurements were selected to compare the MLS V2.2 and V3.3 WV and ozone profiles for understanding the applicability of the two version MLS products over the region. MLS V2.2 and V3.3 WV profiles respectively show their differences within ?2.2±15.7%(n=74) and 0.3±14.9%(n=75) in the stratosphere at and above 82.5 h Pa. Accordingly, at 100 h Pa, the altitude approaching the tropopuase height, differences are within 9.8± 46.0%(n=18) and 23.0±45.8%(n=17), and they are within 21.5±90.6%(n=104) and 6.0±83.4%(n=99) in upper troposphere. The differences of MLS ozone are within ?11.7±16.3%(n=135, V2.2) and 15.6±24.2%(n=305, V3.3) at and above 82.5 h Pa. At 100 h Pa, they are within ?3.5±54.4%(n=27) and ?8.7±41.6%(n=38), and within 18.0±79.1%(n=47) and 34.2±76.6%(n=160) in the upper troposphere. The relative difference of MLS WV and ozone profile has significant oscillation and scatter at upper troposphere and lower stratosphere partly due to the stronger gradients of WV and ozone concentrations here as well the linear interpolation of sonde data for the intercomparison. At and below 70 h Pa, the relative differences of MLS ozone are significantly larger over Lhasa during the Tibetan Plateau 'ozone valley' season, which is also the Asian Summer Monsoon period. The MLS ozone differences over the three sites are similar in their vertical distributions during that period. A simple linear correlation analysis between MLS and sonde profiles indicates that the sensitivity of MLS profile products is related to concentrations at each pressure level. The MLS V3.3 product sensitivity is slightly improved for WV at and above 82.5 h Pa, whereas it is not obvious for ozone. The possible factors contributing to the differences of the MLS profile products of WV and ozone are discussed. | YAN XiaoLu ZHENG XiangDong ZHOU XiuJi Holger VMEL SONG JianYang LI Wei MA YongHong ZHANG Yong | 2015 | Science China Earth Sciences2015，58，4： | 4 |
| 14 | A review of chemical absorption of carbon dioxide for biogas upgrading显示文摘Significant attention has been given to biogas production, purification and upgrading as a renewable and clean fuel supplement. Biogas is a product of an anaerobic digestion process comprising methane, carbon dioxide,and trace amounts of other gases. Biogas purification removes trace gases in biogas for safe utilisation. Biogas upgrading produces methane-rich biogas by removing bulk carbon dioxide from the gas mixture. Several carbon dioxide removal techniques can be applied for biogas upgrading. However, chemical absorption of carbon dioxide for biogas upgrading is of special significance due to its operation at ambient or near ambient temperature and pressure, thus reducing energy consumption. This paper reviews the chemical absorption of carbon dioxide using amine scrubbing, caustic solvent scrubbing, and amino acid salt solution scrubbing. Each of these techniques for biogas upgrading is discussed. The paper concludes that an optimised implementation of the chemical absorption techniques for biogas upgrading requires further research. | Fouad R.H. Abdeen Maizirwan Mel Mohammed Saedi Jami Sany Izan Ihsan Ahmad Faris Ismail | 2016 | Chinese Journal of Chemical Engineering2016，24，6： | 3 |
| 15 | Differing profiles of people diagnosed with acute and chronic hepatitis B virus infection in British Columbia,Canada显示文摘AIM To describe the characteristics of people diagnosed with acute and chronic hepatitis B virus(HBV) infection in British Columbia(BC).METHODS We used data from the BC Hepatitis Testers Cohort(BCHTC),which includes all individuals tested for hepatitis C virus(HCV) or human immunodeficiency virus(HIV) or those diagnosed with HBV or active tuberculosis in BC since 1990.These data were integrated with prescription drug,medical visit,hospitalization and mortality data.HBV cases were classified as acute or chronic according to provincial guidelines.We compared characteristics of individuals by HBV infection group(acute,chronic and negative).Factors associated with acute or chronic HBV infection were assessed with multinomial logistic regression models in comparison to the HBV negative group.RESULTS46498 of the 1058056 eligible BC-HTC participants were diagnosed with HBV infection.4.3% of HBV positive individuals were diagnosed with acute HBV infections while 95.7% had chronic infections.Problematic alcohol use,injection drug use,and HIV or HCV co-infection were more common among individuals diagnosed with acute HBV compared to those with chronic infections and HBV negative individuals.In multivariable multinomial logistic regression models,we observed significant associations between acute or chronic HBV diagnosis and being male,age at HBV diagnosis or birth cohort,South and East Asian ethnicity,HCV or HIV infection,and injection drug use.The odds of acute HBV decreased with increasing age among people who inject drugs,while the opposite was true for chronic HBV.Persons with acute HBV were predominantly White(78%) while those with chronic HBV were mostly East Asian(60%).Relative to Whites,East Asians had 12 times greater odds of being diagnosed with chronic HBV infection.These odds increased with increasing socioeconomic deprivation.CONCLUSION Differences in the profiles of people diagnosed with acute and chronic HBV infection necessitate differentiated screening,prevention,care and treatment programs. | Mawuena Binka Zahid A Butt Stanley Wong Mei Chong Jane A Buxton Nuria Chapinal Amanda Yu Maria Alvarez Maryam Darvishian Jason Wong Gina McGowan Mikhail Torban Mark Gilbert Mark Tyndall Mel Krajden Naveed Z Janjua | 2018 | World Journal of Gastroenterology2018，24，11： | 3 |
| 16 | Bone marrow stromal cells as replacement cells for Parkinson’s disease: generation of an anatomical but not functional neuronal phenotype显示文摘 | Meghan G. Thomas Leah Stone Lauren Evill Syerna Ong Mel Ziman Livia Hool | 2011 | Translational Research2011，，2： | 2 |
| 17 | Two-Year Outcomes After Sirolimus-Eluting Stent Implantation显示文摘 | Giora Weisz Martin B. Leon David R. Holmes Dean J. Kereiakes Mel R. Clark Barry M. Cohen Stephen G. Ellis Patrick Coleman Carolyn Hill Chunxue Shi Donald E. Cutlip Richard E. Kuntz Jeffrey W. Moses | 2006 | Journal of the American College of Cardiology2006，，7： | 2 |
| 18 | 应用红外光谱结合化学计量学方法检测阿拉伯胶产地和蛋白质含量(英文)显示文摘研究利用傅里叶红外光谱结合化学计量学方法来实现对苏丹阿拉伯胶的产地和蛋白质含量的快速无损检测的可行性。采集自6个不同的产地,每个产地12个,总计72个阿拉伯胶样本,作为研究对象,运用线性判别分析(linear discriminant analysis,LDA)和反向区间偏最小二乘(backward interval partial least squares,Bi-PLS)法分别实现对苏丹阿拉伯胶的产地区分和蛋白质含量检测。结果表明,当主成分数为6时,LDA对样本的训练集(48个样本)和预测集(24个样本)的识别率都为100%。Bi-PLS法回归联合20个光谱子区间中的4个子区间得到最佳的蛋白质预测模型,其预测集相关系数为0.937 3,均方根误差为0.173%。因此,利用傅里叶红外光谱结合化学计量学方法可实现对苏丹阿拉伯胶的产地以及蛋白质的含量的快速无损检测。 | 邹小波 AlaaKamal Mohmmed KHAIRKHOGLY 石吉勇 Mel HOLMES | 2017 | 食品科学2017，38，20： | 2 |
| 19 | EUS versus surgical cyst-gastrostomy for management of pancreatic pseudocysts显示文摘 | Shyam Varadarajulu Tercio L. Lopes C. Mel Wilcox Ernesto R. Drelichman Meredith L. Kilgore John D. Christein | 2008 | Gastrointestinal Endoscopy2008，，4： | 2 |
| 20 | Multiple transluminal gateway technique for EUS-guided drainage of symptomatic walled-off pancreatic necrosis显示文摘 | Shyam Varadarajulu Milind A. Phadnis John D. Christein C. Mel Wilcox | 2011 | Gastrointestinal Endoscopy2011，，1： | 2 |
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