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| 1 | 肿瘤恶性转化与C/EBPβ和STAT3基因相关(英文)显示文摘The inference of transcriptional networks that regulate transitions into physiological or pathological cellular states remains a central challenge in systems biology. A mesenchymal phenotype is the hallmark of tumour aggressiveness in human malignant glioma,but the regulatory programs responsible for implementing the associated molecular signature are largely unknown. Here we show that reverse-engineering and an unbiased interrogation of a glioma-specific regulatory network reveal the transcriptional module that activates expression of mesenchymal genes in malignant glioma. Two transcription factors (C/EBPβ and STAT3) emerge as synergistic initiators and master regulators of mesenchymal transformation. Ectopic co-expression of C/EBPβ and STAT3 reprograms neural stem cells along the aberrant mesenchymal lineage,whereas elimination of the two factors in glioma cells leads to collapse of the mesenchymal signature and reduces tumour aggressiveness. In human glioma,expression of C/EBPβ and STAT3 correlates with mesenchymal differentiation and predicts poor clinical outcome. These results show that the activation of a small regulatory module is necessary and sufficient to initiate and maintain an aberrant phenotypic state in cancer cells. | Maria Stella Carro Wei Keat Lim Mariano Javier Alvarez Robert J. Bollo Evan Y. Snyder Erik P. Sulman Sandrine L. Anne Fiona Doetsch Howard Colman Anna Lasorella Ken Aldape Andrea Califano Antonio Iavarone | 2010 | 中华神经外科疾病研究杂志2010，9，1： | 16 |
| 2 | AMP-activated kinase in human spermatozoa: identification, intracellular localization, and key function in the reRulation of sperm motility显示文摘 | Violeta Calle-Guisado Ana Hurtado de Llera David Martin-Hidalgo Jose Mijares Maria C Gil Ignacio S Alvarez Maria J Bragado Luis J Garcia-Marin | 2017 | Asian Journal of Andrology2017，19，6： | 5 |
| 3 | Clinical-pathological and molecular characterization of long-term survivors with advanced non-small cell lung cancer显示文摘Objective:Long-term survivors(LS)of non-small cell lung cancer(NSCLC)without driver alterations,displaying an overall survival(OS)of more than 3 years,comprise around 10%of cases in several series treated with chemotherapy.There are classical prognosis factors for these cases[stage,Eastern Cooperative Oncology Group(ECOG),etc.],but more data are required in the literature.In this multi-center study,we focused on LS of advanced NSCLC with OS above 36 months to perform a clinical-pathological and molecular characterization.Methods:In the first step,we conducted a clinical-pathological characterization of the patients.Afterwards,we carried out a genetic analysis by comparing LS to a sample of short-term survivors(SS)(with an OS less than 9 months).We initially used whole-genome RNA-seq to identify differentiating profiles of LS and SS,and later confirmed these with reverse transcription-polymerase chain reaction(RT-PCR)for the rest of the samples.Results:A total of 94 patients were included,who were mainly men,former smokers,having adenocarcinoma(AC)-type NSCLC with an ECOG of 0-1.We obtained an initial differential transcriptome expression,displaying 5 over-and 33 under-expressed genes involved in different pathways:namely,the secretin receptor,surfactant protein,trefoil factor 1(T FF1),serpin,Ca-channels,and Tolllike receptor(TLRs)families.Finally,RT-PCR analysis of 40(20 LS/20 SS)samples confirmed that four genes(surfactant proteins and SFTP)were significantly down-regulated in SS compared to LS by using an analysis of covariance(ANCOVA)model:SFTPA1(P=0.023),SFTPA2(P=0.027),SFTPB{P=0.02),and SFT PC(P=0.047).Conclusions:We present a sequential genetic analysis of a sample of NSCLCLS with no driver alterations,obtaining a differential RNA-seq/RT-PCR profile showing an abnormal expression of SF genes. | Juan Moreno-Rubio Santiago Ponce Rosa Alvarez Maria Eugenia Olmedo Sandra Falagan Xabier Mielgo Fatima Navarro Patricia Cruz Luis Cabezon-Gutierrez Carlos Aguado Gonzalo Colmenarejo Marta Munoz-Fernandez de Leglaria Ana Belen Enguita Maria Cebollero Amparo Benito Isabel Alemany Carolina del Castillo Ricardo Ramos Ana Ramirez de Molina Enrique Casado Maria Sereno | 2020 | Cancer Biology & Medicine2020，17，2： | 4 |
| 4 | Differing profiles of people diagnosed with acute and chronic hepatitis B virus infection in British Columbia,Canada显示文摘AIM To describe the characteristics of people diagnosed with acute and chronic hepatitis B virus(HBV) infection in British Columbia(BC).METHODS We used data from the BC Hepatitis Testers Cohort(BCHTC),which includes all individuals tested for hepatitis C virus(HCV) or human immunodeficiency virus(HIV) or those diagnosed with HBV or active tuberculosis in BC since 1990.These data were integrated with prescription drug,medical visit,hospitalization and mortality data.HBV cases were classified as acute or chronic according to provincial guidelines.We compared characteristics of individuals by HBV infection group(acute,chronic and negative).Factors associated with acute or chronic HBV infection were assessed with multinomial logistic regression models in comparison to the HBV negative group.RESULTS46498 of the 1058056 eligible BC-HTC participants were diagnosed with HBV infection.4.3% of HBV positive individuals were diagnosed with acute HBV infections while 95.7% had chronic infections.Problematic alcohol use,injection drug use,and HIV or HCV co-infection were more common among individuals diagnosed with acute HBV compared to those with chronic infections and HBV negative individuals.In multivariable multinomial logistic regression models,we observed significant associations between acute or chronic HBV diagnosis and being male,age at HBV diagnosis or birth cohort,South and East Asian ethnicity,HCV or HIV infection,and injection drug use.The odds of acute HBV decreased with increasing age among people who inject drugs,while the opposite was true for chronic HBV.Persons with acute HBV were predominantly White(78%) while those with chronic HBV were mostly East Asian(60%).Relative to Whites,East Asians had 12 times greater odds of being diagnosed with chronic HBV infection.These odds increased with increasing socioeconomic deprivation.CONCLUSION Differences in the profiles of people diagnosed with acute and chronic HBV infection necessitate differentiated screening,prevention,care and treatment programs. | Mawuena Binka Zahid A Butt Stanley Wong Mei Chong Jane A Buxton Nuria Chapinal Amanda Yu Maria Alvarez Maryam Darvishian Jason Wong Gina McGowan Mikhail Torban Mark Gilbert Mark Tyndall Mel Krajden Naveed Z Janjua | 2018 | World Journal of Gastroenterology2018，24，11： | 3 |
| 5 | 3D additive manufactured composite scaffolds with antibiotic-loaded lamellar fillers for bone infection prevention and tissue regeneration显示文摘Bone infections following open bone fracture or implant surgery remain a challenge in the orthopedics field.In order to avoid high doses of systemic drug administration,optimized local antibiotic release from scaffolds is required.3D additive manufactured(AM)scaffolds made with biodegradable polymers are ideal to support bone healing in non-union scenarios and can be given antimicrobial properties by the incorporation of antibiotics.In this study,ciprofloxacin and gentamicin intercalated in the interlamellar spaces of magnesium aluminum layered double hydroxides(MgAl)andα-zirconium phosphates(ZrP),respectively,are dispersed within a thermoplastic polymer by melt compounding and subsequently processed via high temperature melt extrusion AM(~190◦C)into 3D scaffolds.The inorganic fillers enable a sustained antibiotics release through the polymer matrix,controlled by antibiotics counterions exchange or pH conditions.Importantly,both antibiotics retain their functionality after the manufacturing process at high temperatures,as verified by their activity against both Gram+and Gram-bacterial strains.Moreover,scaffolds loaded with filler-antibiotic do not impair human mesenchymal stromal cells osteogenic differentiation,allowing matrix mineralization and the expression of relevant osteogenic markers.Overall,these results suggest the possibility of fabricating dual functionality 3D scaffolds via high temperature melt extrusion for bone regeneration and infection prevention. | María C´amara-Torres Stacy Duarte Ravi Sinha Ainhoa Egizabal Noelia´Alvarez Maria Bastianini Michele Sisani Paolo Scopece Marco Scatto Alessandro Bonetto Antonio Marcomini Alberto Sanchez Alessandro Patelli Carlos Mota Lorenzo Moroni | 2021 | Bioactive Materials2021，6，4： | 2 |
| 6 | Long-term Clinical Course of Decompensated Alcoholic Cirrhosis: A Prospective Study of 165 Patients显示文摘 | Marco Antonio Alvarez Isabel Cirera Ricard Solà Ana Bargalló Rosa Maria Morillas Ramon Planas | 2011 | Journal of Clinical Gastroenterology2011，，10： | 1 |
| 7 | Determination of dimethylamine in groundwater by liquid chromatography and precolumn derivatization with 9-fluorenylmethylchloroformate显示文摘 | Margarita Rodriguez Lopez Maria Jose Gonzalez Alvarez Arturo J Miranda Ordieres | 1996 | J Chromatogr A1996，721，： | 1 |
| 8 | Community-level consequences of a plant invasion : Effects on three habitats in coastal California显示文摘 | Maria E Alvarez M E Cushman J H | 2002 | Ecological Applications2002，12，5： | 1 |
| 9 | The sticholysin family of pore-forming toxins induces the mixing of lipids in membrane domains显示文摘 | Uris Ros Michelle A. Edwards Raquel F. Epand Maria E. Lanio Shirley Schreier Christopher M. Yip Carlos Alvarez Richard M. Epand | 2013 | BBA - Biomembranes2013，，11： | 1 |
| 10 | The market ori- entation concept in the private nonprofit organisation domain显示文摘 | LUIS 1GNACIO ALVAREZ GONZALEZ Maria LETIC1A SANTOS VIJANDE RODOLFO VAZQUEZ CASIELLES | 2002 | lnternational Journal of Nonprofit and Voluntary Sector Marketing2002，，7： | 1 |
| 11 | Insulin resistance is associated with a higher risk of hepatocellular carcinoma in cirrhotic HIV/HCV-co-infected patients: Results from ANRS CO13 HEPAVIH显示文摘 | Dominique Salmon Firouzé Bani-Sadr Marc-Arthur Loko Hind Stitou Anne Gervais Jacques Durant Eric Rosenthal Yann Quertainmont Karl Barange Daniel Vittecoq Michka Shoai-Tehrani Muriel Alvarez Maria Winnock Jean Claude Trinchet Fran?ois Dabis Philippe Sogni | 2011 | Journal of Hepatology2011，，4： | 1 |
| 12 | Influence of deformation rate and degree of compression on textural parameters of potato and apple tissues in texture profile analysis 显示文摘 | Maria Dolores Alvarez | 2002 | Europe Food Research Technolo- gy2002，，215： | 1 |
| 13 | Influence of deformation rate and degree of compression on textural parameters of potato and apple tissues in texture profile analysis显示文摘 | Maria Dolores Alvarez | 2002 | Europe Food Research Technology2002，215，： | 1 |
| 14 | Absence of evidence for the participation of the macrophage cellular prion protein in infection with Brucella suis显示文摘 | Pascaline Fontes Maria Teresa Alvarez Martinez Antoine Gross | 2005 | Infec and Immun2005，73，10： | 1 |
| 15 | Efficacy of PPI, levofloxacin and amoxicillin in the eradication of Helicobacter pylori compared to conventional triple therapy at a Venezuelan hospital显示文摘 | Jacobo Dib Bethseidy Alvarez Liskie Mendez Maria E. Cruz | 2013 | Arab Journal of Gastroenterology2013，，3： | 1 |
| 16 | On Rigid 2-Step Nilpotent Lie Algebras显示文摘在这笔记,我们认为 2 步 nilpotent 是谎言代数学并且在尺寸 n 的 2 步 nilpotent 谎言代数学的变化 Nn2 为这个班的刚硬给一个标准。我们使用这个标准证明在 Nn2 的每僵硬谎言代数学是不能分解的,除了 h3 和 h3 h3。 | Maria Alejandra Alvarez | 2018 | Algebra Colloquium2018，25，2： | 1 |
| 17 | Simultaneous determination of lead,nickel,tin and copper in aluminium-base alloys using slurry sampling by electrical discharge and multielement ETAAS显示文摘 | Carrion Nereida Itriago Ana M Alvarez Maria A | 2003 | Talanta2003，61，5： | 1 |
| 18 | Simultaneous de- termination of arsenic, cadmium, copper, chromium, nickel, lead and thallium in total digested sediment samples and available fractions by electrothermal at- omization atomic absorption spectroscopy (ET AAS) 显示文摘 | Maria A Alvarez G6nesis Carrillo | 2012 | Talanta2012，97，： | 1 |
| 19 | Critical values reporting: Results of a Spanish laboratories survey显示文摘 | Maria Antonia Llopis Diaz Ruben Gomez Rioja Vir- tudes Alvarez Funes | 2010 | Revista del Laboratorio Clinico2010，3，4： | 1 |
| 20 | Influence of the particle diameter and density in the gas velocity in jet spouted beds显示文摘 | Maria J San José Sonia Alvarez | 2005 | Chemical Engineering and Processing2005，44，： | 1 |
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