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| 1 | Photocatalytic degradation of organic pollutants by MOFs based materials:A review显示文摘Metal-organic frameworks(MOFs)are currently popular porous materials with research and application value in various fields.Aiming at the application of MOFs in photocatalysis,this paper mainly reviews the main synthesis methods of MOFs and the latest research progress of MOFs-based photocatalysts to degrade organic pollutants in water,such as organic dyes,pharmaceuticals and personal care products,and other organic pollutants.The main characteristics of different synthesis methods of MOFs,the main design strategies of MOFs-based photocatalysts,and the excellent performance of photocatalytic degradation of organic pollutants are summarized.At the end of this paper,the practical application of MOFs,the current limitations of MOFs,the synthesis methods of MOFs,and the future development trend of MOFs photocatalysts are explained. | Tianliang Xia Yingchao Lin Weizun Li Meiting Ju | 2021 | Chinese Chemical Letters2021，32，10： | 8 |
| 2 | PI3K/Akt/mTOR signaling orchestrates the phenotypic transition and chemo-resistance of small cell lung cancer显示文摘Small cell lung cancer(SCLC)is a phenotypically heterogeneous disease with an extremely poor prognosis,which is mainly attributed to the rapid development of resistance to chemotherapy.However,the relation between the growth phenotypes and chemo-resistance of SCLC remains largely unclear.Through comprehensive bioinformatic analyses,we found that the heterogeneity of SCLC phenotype was significantly associated with different sensitivity to chemotherapy.Adherent or semiadherent SCLC cells were enriched with activation of the PI3K/Akt/mTOR pathway and were highly chemoresistant.Mechanistically,activation of the PI3K/Akt/mTOR pathway promotes the phenotypic transition from suspension to adhesion growth pattern and confers SCLC cells with chemo-resistance.Such chemo-resistance could be largely overcome by combining chemotherapy with PI3K/Akt/mTOR pathway inhibitors.Our findings support that the PI3K/Akt/mTOR pathway plays an important role in SCLC phenotype transition and chemo-resistance,which holds important clinical implications for improving SCLC treatment. | Xuefeng Li Cheng Li Chenchen Guo Qiqi Zhao Jiayu Cao Hsin-Yi Huang Meiting Yue Yun Xue Yujuan Jin Liang Hu Hongbin Ji | 2021 | Journal of Genetics and Genomics2021，48，7： | 5 |
| 3 | Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair显示文摘连接器 histone H1 在 DNA 损坏反应是更高的顺序染色质结构,而是它的参与的一个主人管理者,修理是不清楚的。这里,我们报导连接器 histone H1.2 是混乱毛细管扩张的一个必要管理者变异(ATM ) 激活。我们证明 H1.2 通过和 ATM 热重复领域和 MRE11-RAD50-NBS1 (MRN ) 的抑制的直接相互作用保护染色质免受异常 ATM 激活的伤害复杂依赖者的 ATM 招募。在 DNA 损坏之上, H1.2 通过它的 C 终点和进一步的 proteasomal 降级的 poly-ADP-ribosylation (PARylation ) 经历快速的 PARP1 依赖的染色质分离。由 PARylation 死了的变化妥协 ATM 激活和 DNA 损坏修理的 PARP1 弄空或 H1.2 的 H1.2 排水量的抑制,因此导致损害了房间幸存。一起拿,我们的调查结果建议连接器 histone H1.2 作为一个生理的障碍工作因为指向染色质的 ATM,和调停 PARylation 的活跃 H1.2 周转为柔韧的 ATM 激活和 DNA 损坏修理被要求。 | Zhiming Li Yinglu Li Ming Tang Bin Peng Xiaopeng Lu Qiaoyan Yang Qian Zhu Tianyun Hou Meiting Li Chaohua Liu Lina Wang Xingzhi Xu Ying Zhao Haiying Wang Yang Yang Wei-Guo Zhu | 2018 | Cell Research2018，28，7： | 3 |
| 4 | A Study on the Relationship Between Land Finance and Housing Price in Urbanization Process: An Empirical Analysis of 182 Cities in China Based on Threshold Panel Models显示文摘Scholars have a variety of theoretical explanations for housing price growth. However, few scholars have studied the internal influence mechanism among urbanization, land finance, and housing price. Based on the data of 182 prefecture-level cities from 2009 to 2016, this paper studies the influence of land finance on housing price under different urbanization rate levels. The study finds that with the increase of urbanization rate, the effect of land finance on housing price presents a 'U' shape.Specifically, an increase in land finance by 1% results in a corresponding increase in average housing price by 0.18%, with relatively low urbanization rate, 0.06% with medium level of urbanization rate,and 0.38% with high level of urbanization rate. | Meiting HU Jichang DONG Lijun YIN Chun MENG Xiuting LI | 2021 | Journal of Systems Science and Information2021，9，1： | 2 |
| 5 | Temperature and symmetry energy of neutron-rich fragments in the 1A GeV^(124,136)Xe+Pb reactions显示文摘In this work we study the symmetry-energy coefficient of neutron-rich nuclei,and the temperature dependence of nuclear symmetry energy at low temperatures.An isobaric method is used to extract the symmetry-energy coefficients of neutron-rich nucleus(asym) at zero temperature(T) and asym/T at nonzero temperature in the measured 1A GeV124,136Xe+Pb reactions.T of fragment is obtained from the ratio of its asym to asym/T.The results show that,for fragment with the same neutron-excess(I=N Z),the heavier the fragment is,the higher T it has,and T tends to saturate around 1 MeV for the large mass fragments.It is also shown that the more neutron-rich the isobar is,the higher temperature it has.The T2dependence of symmetry energy of finite nucleus at low temperatures is verified by the extracted results. | MA Chunwang QIAO Chunyuan WANG Shanshan LU Fangmei CHEN Li GUO Meiting | 2013 | Nuclear Science and Techniques2013，24，5： | 2 |
| 6 | Cellulose extraction from Zoysia japonica pretreated by alumina-doped MgO in AMIMCl显示文摘 | Le Liu Meiting Ju Weizun Li Yang Jiang | 2014 | Carbohydrate Polymers2014，，： | 1 |
| 7 | Ultra-thin metal-organic framework nanoribbons显示文摘Structure engineering of metal-organic frameworks(MOFs)at the nanometer scale is attracting increasing interest due to their unique properties and new functions that normally cannot be achieved in bulk MOF crystals.Here,we report the preparation of ultra-thin MOF nanoribbons(NRBs)by using metal-hydroxide nanostructures as the precursors.Importantly,this general method can be used to synthesize various kinds of ultra-thin MOF NRBs,such as MBDC(M=Co,Ni;BDC=1,4-benzenedicarboxylate),NiCoBDC,CoTCPP(TCPP=tetrakis(4-carboxyphenyl)porphyrin)and MIL-53(Al)NRBs.As a proof-of-concept application,the as-prepared ultra-thin Co BDC NRBs have been successfully used as a fluorescent sensing platform for DNA detection,which exhibited excellent sensitivity and selectivity.The present strategy might open an avenue to prepare MOF nanomaterials with new structures and unique properties for various promising applications. | Bingqing Wang Meiting Zhao Liuxiao Li Ying Huang Xiao Zhang Chong Guo Zhicheng Zhang Hongfei Cheng Wenxian Liu Jing Shang Jing Jin Xiaoming Sun Junfeng Liu Hua Zhang | 2020 | National Science Review2020，7，1： | 1 |
| 8 | EMERGY analysis for sustainability evaluation of the Baiyangdian wetland ecosystem in China显示文摘t This study presents a quantitative and ecological benefit evaluation of the Baiyangdian wetland in China between the years 2000 and 2006.Methods of EMERGY analysis were applied to illustrate the wetland ecosystem,to evaluate the economic and environmental inputs and consequent yields,and to assess the sustainability of the Baiyangdian wetland.The indicators for the integrated ecological and economic system,such as EMERGY yield ratio(EYR)(7.51),EMERGY investment ratio(EIR)(4.52),environmental loading ratio(ELR)(2.92),EMERGY exchange ratio(0.41),and EMERGY sustainable indicator(ESI)(2.57)were calculated,compared,analyzed,and discussed.The non-renewable investment in Baiyangdian was greater than renewable investment,leading to the unsustainable development of the system.High EYR indicated that the Baiyangdian integrated system had created huge profits for its people,while ELR and ESI revealed that human behavior has been a heavy burden on the environment,and countermeasures should be taken by the Chinese government to relieve and resolve these problems.Potential management methods were also proposed in this paper. | Weiqing MENG Cui HAO Hongyuan LI Meiting JU | 2010 | Frontiers of Environmental Science & Engineering2010，4，2： | 1 |
| 9 | Headspace Solid-Phase Micro-Extraction Gas Chromatography/Mass Spectrometry(HS-SPME-GC/MS)-Based Untargeted Metabolomics Analysis for Comparing the Volatile Components from 12 Panax Herbal Medicines显示文摘Quality control of ginseng currently is mainly based on ginsenoside analysis,but rarely focuses on the volatile organic components.In the current work,an untargeted metabolomics approach,by headspace solid-phase micro-extraction gas chromatography/mass spectrometry(HS-SPME-GC/MS),was elaborated and further employed to holistically compare the compositional difference of the volatile components simultaneously from 12 Panax herbal medicines,which included P.ginseng(PG),P.quinquefolius(PQ),P.notoginseng(PN),red ginseng(PGR),P.ginseng leaf(PGL),P.quinquefolius leaf(PQL),P.notoginseng leaf(PNL),P.ginseng flower(PGF),P.quinquefolius flower(PQF),P.notoginseng flower(PNF),P.japonicus(PJ),and P.japonicus var.major(PJvm).Chromatographic separation was performed on an HP-5MS elastic quartz capillary column using helium as the carrier gas,enabling good resolution within 1 h.We were able to characterize totally 259 volatile compounds,including 82 terpenes(T),46 alcohols(Alc),29 ketones(K),25 aldehydes(Ald),21 esters(E),and the others.By analyzing 90 batches of ginseng samples based on the untargeted metabolomics workflows,236 differential ions were unveiled,and accordingly 36 differential volatile components were discovered.It is the first report that simultaneously compares the compositional difference of volatile components among 12 Panax herbal medicines,and useful information is provided for the quality control of ginseng aside from the well-known ginsenosides. | Simiao Wang Xiaohang Li Meiting Jiang Xinlong Wu Yuying Zhao Meiyu Liu Xiaoyan Xu Huimin Wang Hongda Wang Heshui Yu Wenzhi Yang | 2022 | Phyton-International Journal of Experimental Botany2022，91，7： | 1 |
| 10 | Combining metal-organic frameworks(MOFs)and covalentorganic frameworks(COFs):Emerging opportunities for new materials and applications显示文摘In the past decades,metal-organic frameworks(MOFs)and covalent organic frameworks(COFs)basically enjoy the coordination chemistry and covalent chemistry,respectively,and such uniqueness has become the major obstacle hampering their further scope diversity and application multi-functionalization.Inspired from the principle of organic retrosynthesis,combining coordination bond and covalent bond together offers additional opportunities for constructing novel MOFs,COFs and MOF@COF hybrids as well as confer on them superior performances in versatile application fields.In this review,we firstly classify and summarize the recently reported synthesis strategies based on the integration of metal-ligand coordination and dynamic covalent bonds.Then,the application performances of as-constructed MOFs,COFs as well as MOF@COF hybrids are discussed and highlighted in the fields of adsorption,separation,catalysis,biosensing,energy storage and so on.Last,our personal insights of the remaining challenges and further prospects are also provided,in order to trigger much more inspirations and endeavors for this hot research field. | Zhixi Li Jun Guo Yue Wan Yutian Qin Meiting Zhao | 2022 | Nano Research2022，15，4： | 1 |
| 11 | Size engineering of 2D MOF nanosheets for enhanced photodynamic antimicrobial therapy显示文摘Although porphyrin-based metal-organic frameworks(MOFs)have been widely explored as photosensitizers for photodynamic therapy,how the size will affect the light-induced catalytic activity for generation of reactive oxygen species(ROS)still remain unclear.Herein,we first report the size-controlled synthesis of two-dimensional(2D)porphyrin-based PCN-134 MOF nanosheets by a two-step solvothermal method to explore the size effect on its PDT performance,thus yielding enhanced photodynamic antimicrobial therapy.By simply controlling the reaction temperature in the synthesis process,the bulk PCN-134 crystal,large PCN-134(L-PCN-134)nanosheets with a lateral size of 2–3μm and thickness of 33.2–37.5 nm and small PCN-134 nanosheets(S-PCN-134)with a lateral size of 160–180 nm and thickness of 9.1–9.7 nm were successfully prepared.Interestingly,the S-PCN-134 nanosheets exhibit much higher photodynamic activity for ROS generation than that of the bulk 3D PCN-134 crystal and L-PCN-134 nanosheets under a660 nm laser irradiation,suggesting that the photodynamic activity of PCN-134 MOF increases when the size reduces.Therefore,the S-PCN-134 nanosheets show much enhanced performance when used as a photosensitizer for photodynamic antimicrobial activity and wound healing. | Baoli Xue Xiwen Geng Haohao Cui Huiying Chen Zhikang Wu Hong Chen Hai Li Zhan Zhou Meiting Zhao Chaoliang Tan Jingguo Li | 2023 | Chinese Chemical Letters2023，34，9： | 0 |
| 12 | Double-cycle weighted imputation method for wastewater treatment process data with multiple missing patterns显示文摘Due to sensor malfunctions and communication faults,multiple missing patterns frequently happen in wastewater treatment process(WWTP).Nevertheless,the existing missing data imputation works cannot stand multiple missing patterns because they have not sufficiently utilized of data information.In this article,a double-cycle weighted imputation(DCWI)method is proposed to deal with multiple missing patterns by maximizing the utilization of the available information in variables and instances.The proposed DCWI is comprised of two components:a double-cycle-based imputation sorting and a weighted K nearest neighbor-based imputation estimator.First,the double-cycle mechanism,associated with missing variable sorting and missing instance sorting,is applied to direct the missing values imputation.Second,the weighted K nearest neighbor-based imputation estimator is used to acquire the global similar instances and capture the volatility in the local region.The estimator preserves the original data characteristics as much as possible and enhances the imputation accuracy.Finally,experimental results on simulated and real WWTP datasets with non-stationarity and nonlinearity demonstrate that the proposed DCWI produces more accurate imputation results than comparison methods under different missing patterns and missing ratios. | HAN HongGui SUN MeiTing WU XiaoLong LI FangYu | 2022 | Science China(Technological Sciences)2022，65，12： | 0 |
| 13 | Temperature Gradient Analyses of a Tubular Solid Oxide Fuel Cell Fueled by Methanol显示文摘Thermal management in solid oxide fuel cells(SOFC)is a critical issue due to non-uniform electrochemical reactions and convective fl ows within the cells.Therefore,a 2D mathematical model is established herein to investigate the thermal responses of a tubular methanol-fueled SOFC.Results show that unlike the low-temperature condition of 873 K,where the peak temperature gradient occurs at the cell center,it appears near the fuel inlet at 1073 K because of the rapid temperature rise induced by the elevated current density.Despite the large heat convection capacity,excessive air could not eff ectively eliminate the harmful temperature gradient caused by the large current density.Thus,optimal control of the current density by properly selecting the operating potential could generate a local thermal neutral state.Interestingly,the maximum axial temperature gradient could be reduced by about 18%at 973 K and 20%at 1073 K when the air with a 5 K higher temperature is supplied.Additionally,despite the higher electrochemical performance observed,the cell with a counter-fl ow arrange-ment featured by a larger hot area and higher maximum temperature gradients is not preferable for a ceramic SOFC system considering thermal durability.Overall,this study could provide insightful thermal information for the operating condition selection,structure design,and stability assessment of realistic SOFCs combined with their internal reforming process. | Qidong Xu Meiting Guo Lingchao Xia Zheng Li Qijiao He Dongqi Zhao Keqing Zheng Meng Ni | 2023 | Transactions of Tianjin University2023，29，1： | 0 |
| 14 | Differential pricing and production strategies for heterogeneous products under cannibalization and promotional effects显示文摘This study examines the optimal pricing and production strategy of a closed-loop supply chain consisting of a manufacturer, a recycler, and consumers. Considering the cannibalization and promotion effects of remanufactured products on new and secondhand products, we constructed Stackelberg game models under different scenarios. We analyze the impact of the changes in the two effects on the optimal prices and production strategies of the manufacturer and recycler, as well as their countermeasures. We find that (i) how the cannibalization and promotional effects influence the manufacturer and the recycler's pricing and production strategies differ under different scenarios;(ii) when the two effects exceed a threshold, the manufacturer abandons new or remanufactured products, and the recycler prefers to stop production on its new products or continue to remanufacture products;and (iii) the two effects always reduce the profits of the manufacturer and increase the profits of the recycler. | Aijun Liu Meiting Jing Jie Miao Zengxian Li Yun Yang | 2022 | Journal of Management Science and Engineering2022，7，4： | 0 |
| 15 | Circulation of Development Factors Promoted by Innovation of Land Management Under Background of Rural Vitalization:A Case Study of Tengtou Village in Zhejiang Province,China显示文摘Land is the space carrier for the existence and flow of other development factors.Activating rural land and promoting the circulation of other development factors through land management innovation is necessary to realize rural vitalization.This paper identifies the connotation of factor flow in the rural vitalization context,the action mechanism of land management innovation to boost the flow of development factors,the issues and obstacles restricting factor circulation,and the realization mechanism of the flow of development factors in rural vitalization.Based on the analytic paradigm constructed in the paper,the successful practice of promoting the flow of development factors through innovative land management in a model village is examined.The results show that:1)the unreasonable systems characterized by the land use system in rural areas are the main obstacles causing circulation issues in development factors.It is essential to engage in comprehensive reform to break down these long-lasting obstacles to the smooth flow of development factors.2)The land should play a leading role in the circulation of development factors in the background of rural vitalization;the main purpose of land management innovation is to activate the land factor,thereby promoting the circulation of other factors.3)The activated land factor will act as a‘trigger’to promote capital and technology in rural settings and use capital and technology to attract the inflow of talents and the return of migrant workers,whereby the population factor will act as a‘catalyst’for the cultivation of rural culture,bringing about the integration of various development factors.4)The innovation of land use and management,increased funding,and new technologies have brought multiple talents to Tengtou Village.The high-frequency mutual feedback between the village’s own and the external development factors resulted in its successful integration of industrial development. | WEI Pengjun LIU Yongqiang YAN Jinlong LI Meiting ZHANG Yingnan | 2023 | Chinese Geographical Science2023，33，5： | 0 |
| 16 | The ionome and proteome landscape of aging in laying hens and relation to egg white quality显示文摘The ionome is essential for maintaining body function and health status by participating in diverse key biological processes.Nevertheless, the distribution and utilization of ionome among different organs and how aging impacts the ionome leading to a decline in egg white quality remain unknown. Thus, we used inductively coupled plasma mass spectrometry(ICP-MS) to analyze 35 elements and their isotopic contents in eight organs of laying hens at 35, 72, and 100 weeks. Moreover, the magnum proteome, amino acids in egg white, and egg white quality were analyzed in laying hens at three different ages using 4D proteomics techniques, an amino acid analyzer, and an egg quality analyzer. Across the organs, we identified varying distribution patterns among macroelements(Mg24, Ca43/44, K39, and P31), transition metals(Zn64/66, Cu63/65, Fe56/57, and Mn55), and toxic elements(Pb208, Ba137, and Sr86). We observed an organ-specific aging pattern characterized by the accumulation of toxic elements(Pb208, Ba137, and Sr86) and calcification in the small intestine. Additionally, a decrease in the utilization of essential trace elements selenium(Se78/82) and manganese(Mn55) was noted in the oviduct. By analyzing ionome in tandem with egg quality, egg white amino acids, and proteome, we unveiled that the reduction of selenium and manganese concentrations in the magnum during the aging process affected amino acid metabolism, particularly tryptophan metabolism, thereby inhibiting the amino acid synthesis in the magnum. Furthermore, it accelerated the senescence of magnum cells through necroptosis activation, leading to a decline in the albumen secretion function of the magnum and subsequently reducing egg white quality.Overall, this study provides insights into the evolution of 35 elements and their isotopes across 8 organs of laying hens with age.It also reveals the elemental composition, interactions, and utilization patterns of these organs, as well as their correlation with egg white quality. The present study highlights the significance of ionome and offers a comprehensive perspective on the selection of ionome for regulating the aging of laying hens. | Guang Li Yuqing Feng Jian Cui Qihang Hou Tanfang Li Meiting Jia Zhengtian lv Qiuyu Jiang Ying Wang Ming Zhang Lin Wang Zengpeng Lv Junyou Li Yuming Guo Bingkun Zhang | 2023 | Science China(Life Sciences)2023，66，9： | 0 |
| 17 | MiR-430 Can Affect the Mesoderm Formation and Metamorphosis of Paralichthys olivaceus by Targeting lefty Gene显示文摘MiR-430 is a non-coding small RNA that participates in early embryonic development by acting on the Nodal signaling pathway.Its functions in Paralichthys olivaceus(P.olivaceus),however,remain unclear.In this study,through biological information technology,we hypothesized lefty was the target gene of miR-430.Lefty is a divergent member of the transforming growth factor-β(TGF-β)superfamily,and is involved in regulating left-right patterning as an antagonist of the Nodal signaling pathway.To study the relationship between miR-430 and lefty gene,miR-430 and fluorescent expression vector were transfected into embryo cells.Our results showed that miR-430 has important effects on early embryonic development.It can inhibit the expressions of lefty and other genes related to Nodal signaling pathway.Additionally,the expression of miR-430 was involved in the metamorphosis of P.olivaceus.This study clarifies the function of miR-430 in P.olivaceus,which will be helpful for further research on the interactions between miR-430 and the Nodal signaling pathway. | LI Rui WANG Zhenwei SUN Minmin PENG Meiting QI Jie WANG Zhigang | 2020 | Journal of Ocean University of China2020，19，2： | 0 |
| 18 | Comparison of point detection and area detection for point-scanning structured illumination microscopy显示文摘Structured illumination microscopy(SIM)is suitable for biological samples because of its relatively low-peak illumination intensity requirement and high imaging speed.The system resolution is affected by two typical detection modes:Point detection and area detection.However,a systematic analysis of the imaging performance of the different detection modes of the system has rarely been conducted.In this study,we compared laser point scanning point detection(PS-PD)and point scanning area detection(PS-AD)imaging in nonconfocal microscopy through theoretical analysis and simulated imaging.The results revealed that the imaging resolutions of PSPD and PS-AD depend on excitation and emission point spread functions(PSFs),respectively.Especially,we combined the second harmonic generation(SHG)of point detection(P-SHG)and area detection(A-SHG)with SIM to realize a nonlinear SIM-imaging technique that improves the imaging resolution.Moreover,we analytically and experimentally compared the nonlinear SIM performance of P-SHG with that of A-SHG. | Wenshuai Wu Jiajie Chen Meiting Wang Lei Wang Xiaomin Zheng Jia Li Junle Qu Bruce Zhi Gao Yonghong Shao | 2023 | Journal of Innovative Optical Health Sciences2023，16，4： | 0 |
| 19 | Transgenerational analysis of H3K4me3 and H3K27me3 by ChIP-Seq links epigenetic inheritance to metabolism显示文摘Histone methylation is a kind of important epigenetic modification which occurs on the lysine residue or arginine residue of histone tails(Zhang and Reinberg,2001).It takes part in multiple biological processes,including gene expression,genomic stability,stem cell maturity,genetic imprinting,mitosis and development(Fischle et al.,2005).Abnormal histone methylation pattern | Ke An Fengxia Du Hao Meng Guochao Li Minjie Zhang Zongzhi Liu Zitong Zhao Zilong Zhang Di Yu Dong Wang Caiyun Yang Wencui Ma Lin Yuan Meiting Zhou Lili Duan Li Jin Hui Li Yan Zhang Jianzhong Su Jie Qiao Yingli Sun | 2018 | Journal of Genetics and Genomics2018，45，3： | 0 |
| 20 | Modified R-CODOX-M/IVAC chemotherapy regimens in Chinese patients with untreated sporadic Burkitt lymphoma显示文摘Objective:To characterize modified R-CODOX-M/IVAC-based chemotherapy to lower the severe adverse events in Chinese adult patients with sporadic Burkitt lymphoma.Methods:We enrolled a retrospective cohort including 123 adult patients with untreated sporadic Burkitt lymphoma from August 2008 to September 2019 at Sun Yat-sen University Cancer Center.We studied a dose-modified and long-course R-CODOX-M/IVAC regimen utilizing a low dose of 1.0 g/m2/cycle cyclophosphamide,2 g/m2/cycle methotrexate,4,500 mg/m2/cycle ifosfamide,and 4.0 g/m2/cycle cytarabine.Forty-nine patients with low risk disease underwent 4–6 cycles of dose-modified R-CODOX-M-based chemotherapy.Seventy-four patients with high risk disease underwent 6–8 cycles of dose-modified alternating R-CODOX-M/IVAC regimens.Results:The objective remission was 87.0%.The event-free survival rate and overall survival at 3 years were 81.2%and 92.1%,respectively.Major grade 3–4 adverse events included leukopenia(91.9%),anemia(58.5%),thrombocytopenia(73.2%),and febrile neutropenia(48.8%).A total of 26.0%and 37.4%of patients received red blood cell and platelet transfusions,respectively.We observed 4 cases(3.3%)of septic shock after chemotherapy.Two treatment-related deaths occurred from severe infection.Conclusions:The modified R-CODOX-M/IVAC chemotherapy regimen was effective for sporadic Burkitt lymphoma in the Chinese population,with a lower toxicity than standard regimens. | Meiting Chen Zhao Wang Xiaojie Fang Yuyi Yao Quanguang Ren Zegeng Chen Ying Tian Fei Pan Xiaoqian Li Zhiming Li Qingqing Cai He Huang Tongyu Lin | 2021 | Cancer Biology & Medicine2021，18，3： | 0 |
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