|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Current pattern of Chinese dialysis units: a cohort study in a representative sample of units显示文摘 | ZHOU Qiu-gen JIANG Jian-ping WU Sheng-jie TIAN Jian-wei CHEN Jiang-hua YU Xue-qing CHEN Ping-yan MEI Chang-lin XIONG Fei SHI Wei ZHOU Wei LIU Xu-sheng SUN Shi-ren XIE Di LIU Jun XU Xin HOU Fan-fan | 2012 | Chinese Medical Journal2012，，19： | 69 |
| 2 | An Interdisciplinary Nutrition Support Team Improves Clinical and Hospitalized Outcomes of Esophageal Cancer Patients with Concurrent Chemoradiotherapy显示文摘 | Ming-Hua Cong Shu-Luan Li Guo-Wei Cheng Jin-Ying Liu Chen-Xin Song Ying-Bing Deng Wei-Hu Shang Di Yang Xue-Hui Liu Wei-Wei Liu Shi-Yan Lu Lei Yu | 2015 | Chinese Medical Journal2015，，22： | 41 |
| 3 | The Galectin-9/Tim-3 pathway is involved in the regulation of NK cell function at the maternal-fetal interface in early pregnancy显示文摘蜕膜的生来的杀手(dNK ) 房间活跃地对感染作为本地保护者参予母亲胎儿的有免疫力的忍耐和行为的建立和维护。然而, dNK 房间怎么在怀孕期间维持在忍耐和反感染免疫者回答之间的有免疫力的平衡,仍然保持未知。这里,我们证明禁止的分子 T 房间免疫球蛋白领域和粘蛋白包含域的 molecule-3 (Tim-3 ) 在超过 60 % 上被表示;dNK 房间。Tim-3 + dNK 房间显示更高的 interleukin (IL )-4 和更低的肿瘤坏死因素(TNF )-α并且 perforin 生产。人的 trophoblast 房间能经由 galectin-9 (Gal-9 ) 和在 Gal-9 和 Tim-3 之间的相互作用的分泌物导致外部 NK 房间的转变进象 dNK 一样显型。另外, trophoblasts 禁止导致的 lipopolysaccharide (LPS ) 由 dNK 房间的支持 inflammatory cytokine 和 perforin 生产,它能被抵销抗体的 Tim-3 稀释。有趣地, Tim-3-expressing dNK 房间的一个减少的百分比在人的流产和鼠科的流产容易的模型被观察。而且, T 助手(Th )2 类型 cytokines 被减少, Th1 类型 cytokines 从人和老鼠流产在 Tim-3 + 然而并非 Tim-3 − dNK 房间被增加。因此,我们的结果建议 Gal-9/Tim-3 信号为 dNK 房间功能的规定是重要的,它为正常怀孕的维护是有益的。 | Yan-Hong Li Wen-Hui Zhou Yu Tao Song-Cun Wang Yun-Lan Jiang Di Zhang Hai-Lan Piao Qiang Fu Da-Jin Li Mei-Rong Du | 2016 | Cellular & Molecular Immunology2016，13，1： | 40 |
| 4 | Environmental connections of novel avian-origin H7N9 influenza virus infection and virus adaptation to the human显示文摘A novel H7N9 influenza A virus has been discovered as the causative identity of the emerging acute respiratory infection cases in Shanghai,China.This virus has also been identified in cases of infection in the neighboring area Hangzhou City in Zhejiang Province.In this study,epidemiologic,clinical,and virological data from three patients in Hangzhou who were confirmed to be infected by the novel H7N9 influenza A virus were collected and analyzed.Human respiratory specimens and chicken feces from a contacted free market were tested for influenza virus by real-time reverse transcription PCR(RT-PCR) and sequencing.The clinical features of the three cases were similar featured with high fever and severe respiratory symptoms;however,only one of the patients died.A certain degree of diversity was observed among the three Hangzhou viruses sequenced from human samples compared with other reported H7N9 influenza A viruses.The sequences of the novel avian-origin H7N9 influenza viruses from Hangzhou City contained important amino acid substitutions related to human adaptation.One of the Hangzhou viruses had gained a novel amino acid substitution(Q226I) in the receptor binding region of hemagglutinin.More importantly,the virus sequenced from the chicken feces had a 627E substitution in the PB2 protein instead of the mammalian-adapted 627K substitution that was found in the PB2 proteins from the Hangzhou viruses from the three patients.Therefore,the newly-emerging H7N9 virus might be under adaptation pressure that will help it 'jump' from avian to human hosts.The significance of these substitutions needs further exploration,with both laboratory experiments and extensive field surveillance. | LI Jun YU XinFen PU XiaoYing XIE Li SUN YongXiang XIAO HaiXia WANG FenJuan DIN Hua WU Ying LIU Di ZHAO GuoQiu LIU Jun PAN JingCao | 2013 | Science China(Life Sciences)2013，56，6： | 32 |
| 5 | Application of GC/MS-based metabonomic profiling in studying the lipid-regulating effects of Ginkgo biloba extract on diet-induced hyperlipidemia in rats显示文摘 | Qi ZHANG Guang-ji WANG Ji-ye A Di WU Ling-ling ZHU Bo MA Yu DU | 2009 | Acta Pharmacologica Sinica2009，30，12： | 28 |
| 6 | Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment显示文摘 | Pu Li Jing-Xuan Shan Xue-Hua Chen Di Zhang Li-Ping Su Xiu-Ying Huang Bei-Qin Yu Qiao-Ming Zhi Cheng-Long Li Ya-Qing Wang Sara Tomei Qu Cai Jun Ji Jian-Fang Li Lotfi Chouchane Ying-Yan Yu Fang-Zhen Sun Zhi-Heng Xu Bing-Ya Liu Zheng-Gang Zhu | 2015 | Cell Research2015，25，5： | 24 |
| 7 | Systematic review and meta-analysis of laparoscopy-assisted and open total gastrectomy for gastric cancer显示文摘AIM:To evaluate the safety and efficacy of laparoscopy-assisted total gastrectomy(LATG)and open total gastrectomy(OTG)for gastric cancer.METHODS:A comprehensive search of PubMed,Cochrane Library,Web of Science and BIOSIS Previews was performed to identify studies that compared LATG and OTG.The following factors were checked:operating time,blood loss,harvested lymph nodes,flatus time,hospital stay,mortality and morbidity.Data synthesis and statistical analysis were carried out using RevMan 5.1 software.RESULTS:Nine studies with 1221 participants were included(436 LATG and 785 OTG).Compared to OTG,LATG involved a longer operating time[weighted mean difference(WMD)=57.68 min,95%CI:30.48-84.88;P<0.001];less blood loss[standard mean difference(SMD)=-1.71;95%CI:-2.48--0.49;P<0.001];earlier time to flatus(WMD=-0.76 d;95%CI:-1.22--0.30;P<0.001);shorter hospital stay(WMD=-2.67d;95%CI:-3.96--1.38,P<0.001);and a decrease in medical complications(RR=0.41,95%CI:0.19-0.90,P=0.03).The number of harvested lymph nodes,mortality,surgical complications,cancer recurrence rate and long-term survival rate of patients undergoing LATG were similar to those in patients undergoing OTG.CONCLUSION:Despite a longer operation,LATG can be performed safely in experienced surgical centers with a shorter hospital stay and fewer complications than open surgery. | Ke Chen Xiao-Wu Xu Ren-Chao Zhang Yu Pan Di Wu Yi-Ping Mou | 2013 | World Journal of Gastroenterology2013，19，32： | 23 |
| 8 | Cell–cell contact with proinflammatory macrophages enhances the immunotherapeutic effect of mesenchymal stem cells in two abortion models显示文摘Mesenchymal stem cells(MSCs),which are pluripotent cells with immunomodulatory properties,have been considered good candidates for the therapy of several immune disorders,such as inflammatory bowel diseases,concanavalin A-induced liver injury,and graft-versus-host disease.The embryo is a natural allograft to the maternal immune system.A successful pregnancy depends on the timely extinction of the inflammatory response induced by embryo implantation,followed by the switch to a tolerant immune microenvironment in both the uterus and the system.Excessive infiltration of immune cells and serious inflammatory responses are triggers for embryo rejection,which results in miscarriage.Here,we demonstrated that adoptive transfer of MSCs could prevent fetal loss in a lipopolysaccharide(LPS)-induced abortion model and immune response-mediated spontaneous abortion model.The immunosuppressive MSCs alleviated excessive inflammation by inhibiting CD4+T cell proliferation and promoting the decidual macrophage switch to M2 in a tumor necrosis factor-stimulated gene-6(TSG-6)-dependent manner.Cell-tocell contact with proinflammatory macrophages increased the TSG-6 production by the MSCs,thereby enhancing the suppressive regulation of T cells and macrophages.Moreover,proinflammatory macrophages in contact with the MSCs upregulated the expression of CD200 on the stem cells and facilitated the reprogramming of macrophages towards an anti-inflammatory skew through the interaction of CD200 with CD200R on proinflammatory macrophages.Therefore,the results demonstrate that a TSG-6-mediated paracrine effect,reinforced by cell-to-cell contact between MSCs and proinflammatory macrophages,is involved in the mechanism of MSC-mediated abortion relief through the induction of immune tolerance.Our study also indicates the potential application of MSCs in clinical recurrent miscarriages. | Yanhong Li Di Zhang Ling Xu Lin Dong Ji Zheng Yikong Lin Jiefang Huang Yanyun Zhang Yu Tao Xingxing Zang Dajin Li Meirong Du | 2019 | Cellular & Molecular Immunology2019，16，12： | 23 |
| 9 | The Role of Fibrocyte in the Pathogenesis of Silicosis显示文摘Exposure to free silica induces silicosis and myofibroblasts are regarded as primary effector cells.Fibrocytes can differentiate into myofibroblast.Therefore,the present study was designed to investigate whether | LI Juan YAO Wu HOU Jian Yong ZHANG Lin BAO Lei CHEN Hui Ting WANG Di YUE Zhong Zheng LI Yi Ping ZHANG Miao YU Xing Hao ZHANG Jian Hui QU Ya Qian HAO Chang Fu | 2018 | Biomedical and Environmental Sciences2018，31，4： | 20 |
| 10 | Seasonal variations and size distributions of water-soluble ions in atmospheric aerosols in Beijing, 2012显示文摘The characteristics of water-soluble ions in airborne particulate matter in Beijing were investigated using ion chromatography. The results showed that the total concentrations of ions were 83.7 ± 48.9 μg/m3 in spring, 54.0 ± 17.0 μg/m3 in summer, 54.1 ± 42.9 μg/m3 in autumn, and 88.8 ± 47.7 μg/m3 in winter, respectively. Furthermore, out of all the ions, NO3-,SO42-and NH4+accounted for 81.2% in spring, 78.5% in summer, 74.6% in autumn, and 76.3%in winter. Mg2+and Ca2+were mainly associated with coarse particles, with a peak that ranged from 5.8 to 9.0 μm. Na+, NH4+and Cl-had a multi-mode distribution with peaks that ranged from 0.43 to 1.1 μm and 4.7 to 9.0 μm. K+, NO3-, and SO42-were mainly associated with fine particles, with a peak that ranged from 0.65 to 2.1 μm. The concentrations of Na+, K+,Mg2+, Ca2+, NH4+, Cl-, NO3-and SO42-were 2.69, 2.32, 1.01, 4.84, 16.9, 11.8, 42.0, and 44.1 μg/m3 in particulate matter(PM) on foggy days, respectively, which were 1.4 to 7.3 times higher than those on clear days. The concentrations of these ions were 2.40, 1.66, 0.92, 4.95, 17.5,7.00, 32.6, and 34.7 μg/m3 in PM on hazy days, respectively, which were 1.2–5.7 times higher than those on clear days. | Yongjie Yang Rui Zhou Jianjun Wu Yue Yu Zhiqiang Ma Lejian Zhang Yi'an Di | 2015 | Journal of Environmental Sciences2015，27，8： | 19 |
| 11 | Totally laparoscopic gastrectomy for gastric cancer: A systematic review and meta-analysis of outcomes compared with open surgery显示文摘AIM:To systematically review the surgical outcomes of totally laparoscopic gastrectomy(TLG)vs open gastrectomy(OG)for gastric cancer.METHODS:A systematic search of PubMed,Embase,Cochrane Library,and Web of Science was conducted.All original studies comparing TLG with OG were included for critical appraisal.Data synthesis and statistical analysis were carried out using RevMan 5.1 software.RESULTS:One RCT and 13 observational studies involving 1532 patients were included(721 TLG and811 OG).TLG was associated with longer operation time[weighted mean difference(WMD)=58.04min,95%CI:37.77-78.32,P<0.001],less blood loss[WMD=-167.57 min,95%CI:-208.79-(-126.34),P<0.001],shorter hospital stay[WMD=-3.75 d,95%CI:-4.88-(-2.63),P<0.001]and fewer postoperative complications(RR=0.71,95%CI:0.58-0.86,P<0.001).The number of harvested lymph nodes,surgical margin,mortality and cancer recurrence rate were similar between the two groups.CONCLUSION:TLG may be a technically safe,feasible and favorable approach in terms of better cosmesis,less blood loss and faster recovery compared with OG. | Ke Chen Yu Pan Jia-Qin Cai Xiao-Wu Xu Di Wu Yi-Ping Mou | 2014 | World Journal of Gastroenterology2014，20，42： | 19 |
| 12 | Effects of Al_2O_3 Nano-additive on Performance of Micro-arc Oxidation Coatings Formed on AZ91D Mg Alloy显示文摘Ceramic coatings were prepared on AZ91 D Mg alloy by micro-arc oxidation(MAO) in aluminate electrolytes,with Al_2O_3 nano-additive suspending at different concentrations.Effects of nano-additive concentration on the structure,phase composition,hardness and anti-corrosion property of the MAO coatings were analyzed by scanning electron microscopy,X-ray diffraction,micro-hardness test and electrochemical method,respectively.The results revealed that Al_2O_3 nano-particles were mostly incorporated into ceramic coating chemically,transferred into MgAl_2O_4,rather than being trapped mechanically during MAO process.With the increase of Al_2O_3 concentration,the voltage-time response,content of MgAl_2O_4,hardness and anti-corrosion property increased.However,when the concentration varied from 10 g/L to 15 g/L,these behaviors and properties changed only a little.This result indicated that,after the concentration of Al_2O_3 nano-additive reaching 10 g/L,the incorporation of Al_2O_3 nano-particles turned into a saturation state,due to the complex process during MAO treatment.Therefore,10 g/L might be a proper concentration for MAO coating to incorporate Al_2O_3 nano-particles. | Yan Wang Dongbo Wei Jie Yu Shichun Di | 2014 | Journal of Materials Science & Technology2014，30，10： | 18 |
| 13 | 冠状动脉内影像学临床应用专家共识(第一部分):对冠状动脉介入治疗的指导与优化显示文摘欧洲心血管介入协会(EAPCI)专家组系统总结了血管内超声(IVUS)和光学相干断层成像(OCT)这两种血管内影像学检查临床应用指征的现有证据,提供了关于IVUS和OCT指导经皮冠状动脉介入治疗(PCI)的应用价值,并明确了最可能从腔内影像学指导的介入治疗中获得临床收益的患者或病变类型,同时详细论述了PCI前如何使用IVUS或OCT优化支架尺寸(支架长度和直径)和手术策略的选择。此外,专家推荐对支架失败(支架内再狭窄或支架内血栓形成)的患者应常规进行冠状动脉内影像学检查,并首选OCT。最后,重点论述了IVUS和OCT在指导PCI和评估支架失败两个方面的优势和局限性,并对未来需要深入研究的领域进行了展望。 | Lorenz Raber Gary S Mintz Konstantinos C Koskinas Thomas W Johnson Niels R Holm Yoshinubo Onuma Maria D Radu Michael Joner Bo Yu Haibo Jia Nicolas Meneveau Jose M.de la Torre Hemandez Javier Escaned Jonathan Hill Francesco Prati Antonio Colombo Carlo di Mario Evelyn Regar Davide Capodanno William Wijns Robert A Byme Giulio Guagliumi | 2019 | 中华心血管病杂志2019，47，1： | 17 |
| 14 | Role of tumor microenvironment in triple-negative breast cancer and its prognostic significance显示文摘Breast cancer has been shown to live in the tumor microenvironment, which consists of not only breast cancer cells themselves but also a significant amount of pathophysiologically altered surrounding stroma and cells. Diverse components of the breast cancer microenvironment, such as suppressive immune cells, re-programmed fibroblast cells, altered extracellular matrix(ECM) and certain soluble factors, synergistically impede an effective anti-tumor response and promote breast cancer progression and metastasis. Among these components, stromal cells in the breast cancer microenvironment are characterized by molecular alterations and aberrant signaling pathways,whereas the ECM features biochemical and biomechanical changes. However, triple-negative breast cancer(TNBC), the most aggressive subtype of this disease that lacks effective therapies available for other subtypes, is considered to feature a unique microenvironment distinct from that of other subtypes, especially compared to Luminal A subtype. Because these changes are now considered to significantly impact breast cancer development and progression, these unique alterations may serve as promising prognostic factors of clinical outcome or potential therapeutic targets for the treatment of TNBC. In this review, we focus on the composition of the TNBC microenvironment, concomitant distinct biological alteration, specific interplay between various cell types and TNBC cells, and the prognostic implications of these findings. | Tianjian Yu Genhong Di | 2017 | Chinese Journal of Cancer Research2017，29，3： | 17 |
| 15 | Modeling,Control,and Protection of Modular Multilevel Converter-based Multi-terminal HVDC Systems:A Review显示文摘Multi-terminal direct current(MTDC)grids provide the possibility of meshed interconnections between regional power systems and various renewable energy resources to boost supply reliability and economy.The modular multilevel converter(MMC)has become the basic building block for MTDC and DC grids due to its salient features,i.e.,modularity and scalability.Therefore,the MMC-based MTDC systems should be pervasively embedded into the present power system to improve system performance.However,several technical challenges hamper their practical applications and deployment,including modeling,control,and protection of the MMC-MTDC grids.This paper presents a comprehensive investigation and reference in modeling,control,and protection of the MMC-MTDC grids.A general overview of state-of-the-art modeling techniques of the MMC along with their performance in simulation analysis for MTDC applications is provided.A review of control strategies of the MMC-MTDC grids which provide AC system support is presented.State-of-the art protection techniques of the MMCMTDC systems are also investigated.Finally,the associated research challenges and trends are highlighted. | Lei Zhang Yuntao Zou Jicheng Yu Jiangchao Qin Vijay Vittal George G.Karady Di Shi Zhiwei Wang | 2017 | CSEE Journal of Power and Energy Systems2017，3，4： | 17 |
| 16 | Biological properties of neural progenitor cells isolated from the hippocampus of adult cynomolgus monkeys显示文摘Background The existence of neurogenesis in the hippocampus of adult nonhuman primates has been confirmed in recent years, however, the biological properties of adult neural stem cells or neural progenitor cells (NPCs) from this region remain to be extensively explored. The present work was to investigate on the expansion of NSCs/NPCs from the hippocampus of adult cynomolgus monkeys and the examination of their characteristics in vitro. Methods NPCs isolated from the hippocampus of adult cynomolgus monkeys were expanded in vitro in serum-free media containing growth factors, and were then allowed to differentiate by removing mitotic factors. The expansion capacity of NPCs and their differentiation potential were assayed by immunohistochemical and immunocytochemical analysis. Results During primary culture, NPCs underwent cell division, proliferation and aggregation to form neurospheres that were growing in suspension. Without mitotic stimulation, most neurospheres adhered to the culture dish and started to differentiate. Eventually, nearly 12% of the differentiated cells expressed neuron specific marker-βIII-tubulin (Tuj1) and 84% expressed astrocyte specific marker-fibrillary acidic protein (GFAP). In addition, the expression of a neural stem cell marker, nestin, was found both in NPCs and in the subgranular zone of adult monkey hippocampus, where NPCs were originally derived. Conclusions NPCs from the hippocampus of adult cynomolgus monkeys can be expanded to some extent in vitro and are capable of differentiating into neurons and astrocytes. Further experiments to promote the in vitro proliferation capacity of NPCs will be required before adult NPCs can be used as a useful cell model for studying adult neurogenesis and cell replacement therapy using adult stem cells. | YUE Feng CHEN Biao WU Di DONG Kai ZENG Si-en ZHANG Yu | 2006 | Chinese Medical Journal2006，，2： | 16 |
| 17 | Stability of QTL Across Environments and QTL-by-Environment Interactions for Plant and Ear Height in Maize显示文摘Better understanding of genotype-by-environment interaction(GEI)is expected to provide a solid foundation for genetic improvement of crop productivity especially under drought-prone environments.To elucidate the genetic basis of the plant and ear height,2 F2:3 populations were derived from the crosses of Qi 319 × Huangzaosi(Q/H)and Ye 478 × Huangzaosi(Y/H)with 230 and 235 families,respectively,and their parents were evaluated under 3 diverse environments in Henan,Beijing,and Xinjiang,China during the year of 2007 and 2008,and all the lines were also evaluated under water stress environment.The mapping results showed that a total of 21 and 12 QTLs were identified for plant height in the Q/H and Y/H population,respectively,and 24 and 13 QTLs for ear height,respectively.About 56 and 73% of the QTLs for 2 traits did not present significant QTL-by-environment interaction(QEI)in the normal joint analyses for Q/H and Y/H population,respectively,and about 73% of the QTLs detected did not show significant QEI according to joint analyses for stress condition in Q/H.Most of the detected major QTLs exhibited high stability across different environments.Besides,several major QTLs were detected with large and consistent effect under normal condition(Chr.6 and 7 in Q/H;Chr.1,3 and 9 in Y/H),or across 2 water regimes(Chr.1,8 and 10 for in Q/H).There were several constitutive QTLs(3 for Q/H and 1 for Y/H)with no or minor QTL-by-environment for the 2 populations.Finally,we found several genomic regions(Chr.1,10,etc.)to be co-located across the populations,which could provide useful reference for genetic improvement of these traits in maize breeding programs.Comparative genomic analysis revealed that 3 genes/genetic segments associated with plant height in rice were orthologous to these 3 identified genomic regions carrying the major QTLs for plant and ear height on Chr.1,6,and 8,respectively. | ZHANG Yan LI Yong-xiang WANG Wang LIU Zhi-zhai LIU Cheng PENG Bo TAN Wei-wei WANG Di SHI Yun-su SUN Bao-cheng SONG Yan-chun WANG Tian-yu LI Yu | 2010 | Agricultural Sciences in China2010，9，10： | 16 |
| 18 | Size-resolved aerosol water-soluble ions at a regional background station of Beijing, Tianjin, and Hebei, North China显示文摘The characteristics of water-soluble ions in size-resolved particulate matter were investigated usingion chromatography at Shangdianzi,a regional background station of Beijing,Tianjin,and Hebei.Seasonal total concentrations of ions(Na^+,Mg^(2+),K^+,Ca^(2+),NH_4^+,Cl^-,SO_4^(2-) and NO_3^-) were75.5±52.9 μg/m^3 in spring,26.5±12.3μg/m^3 in summer,22.7±20.4μg/m^3 in autumn,and31.1±23.9 μg/m^3 in winter,respectively.The secondary ions(NO_3^-,SO_4^(2-) and NH_4^+),mainly associated with fine particles,accounted for 84.2%in spring,82.1%in summer,81.5%in autumn and 76.3%in winter of all ions.Strong correlations were found between NH_4^+ and SO_4^(2-)(r=0.95,p<0.01) as well as NH_4^+ and NO_3^-(r=0.90,p<0.01) in fine particles;while in coarse particles,correlations between Mg^(2+) and NO_3^-(r=0.80,p<0.01),and Ca^(2+) and NO_3^-(r=0.85,p<0.01) were found.The concentrations of Na^+,K^+,Mg^(2+),Ca^(2+),NH_4^+,Cl^-,NO_3^-,and SO_4^(2-) were 2.02,0.81,0.36,1.65,9.58,4.01,18.9,and 18.4 μg/m^3 in particulate matter from southeast-derived air masses,which were typically 1.58-3.37 times higher than in northwest trajectories.Thus,concentrations of water-soluble ions at this background station were heavily influenced by regional transport of serious pollution derived from biomass burning,coal combustion,industrial and vehicle exhaust emissions from Beijing,Tianjin,and Hebei. | Yongjie Yang Rui Zhou Yue Yu Yan Yan Yan Liu Yi'an Di Dan Wu Weiqi Zhang | 2017 | Journal of Environmental Sciences2017，29，5： | 16 |
| 19 | Multiple checkpoints keep follicular helper T cells under control to prevent autoimmunity显示文摘Follicular helper T(Tfh)cells select mutated B cells in germinal centres,which can then differentiate into long-lived high affinity memory B cells and plasma cells.Tfh cells are regulated by a unique molecular programme orchestrated by the transcriptional repressor Bcl6.This transcription factor turns down expression of multiple genes,including transcriptional regulators of other T helper lineages and a vast amount of microRNAs.This enables Tfh cells to express a suite of chemokine receptors,stimulatory ligands and cytokines that enable migration into B-cell follicles,and provision of effective help to B cells.Not surprisingly,dysregulation of this powerful helper subset can lead to a range of autoantibody-mediated diseases;indeed,aberrant accumulation of Tfh cells has been linked with systemic lupus erythematosus,Sjogren’s disease and autoimmune arthritis.Here we dissect multiple checkpoints that operate throughout Tfh cell development and maturation to maintain immunological tolerance while mounting robust and long-lasting antibody responses. | Di Yu Carola G Vinuesa | 2010 | Cellular & Molecular Immunology2010，7，3： | 16 |
| 20 | Molecular Epidemiological Characteristics of Streptococcus pyogenes Strains Involved in an Outbreak of Scarlet Fever in China,2011显示文摘Objective To investigate molecular characterization of streptococcus pyogenes isolates involved in an outbreak of scarlet fever in China in 2011.Methods Seventy-four Streptococcal pyogenes involved in an outbreak of scarlet fever were isolated from pediatric patients in the areas with high incidence in China from May to August of 2011.Emm genotyping,pulsed-field gel electrophoresis (PFGE),superantigen (SAg) genes and antimicrobial susceptibility profiling were analyzed for these isolates.Results A total of 4 different emm types were identified.Emm12 was the most prevalent type which contained four predominating PFGE patterns corresponding to four different virulence and superantigen profiles.Emm12 (79.7%) and emml (14.9%) accounted for approximately 94%of all the isolates.The speA gene was all negative in emm12 isolates and positive in emml isolates.All strains were resistant to erythromycin,and 89.4%of them were resistant to erythromycin,tracycline,and clindamycin simultaneously.Conclusion Several highly diversified clones with a high macrolide resistance rate comprise a predominant proportion of circulating strains,though no new emm type was found in this outbreak.The data provide a baseline for further surveillance of scarlet fever,which may contribute to the explanation of the outbreak and development of a GAS vaccine in China. | YOU Yuan Hai SONG Yan Yan YAN Xiao Mei WANG Hai Bin ZHANG Meng Han TAO Xiao Xia Li Lei Lei ZHANG Yu Xin JIANG Xi Hong ZHANG Bing Hua ZHOU Hao XIAO Di JIN Lian Mei FENG Zi Jian LUO Feng Ji ZHANG Jian Zhong | 2013 | Biomedical and Environmental Sciences2013，26，11： | 15 |
您所在的机构暂未开通此部分的功能，请联系管理员