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| 1 | PROPER CONDITIONS OF MESHING FOR Hy-Vo SILENT CHAIN AND SPROCKET显示文摘Hy-Vo 沉默的链和链轮齿的合适的协调为与更多的效率和更少的噪音认识到沉默的链的传播是重要的。与切的链轮齿和转动在 Hy-Vo 沉默的链的主题 shing 理论的学习上基于与壁炉内部的一锅架用机器制造链轮齿的原则,为 Hy-Vo 沉默的链和链轮齿协调的合适的条件与考虑的 Hy-Vo 沉默的链的可变沥青特征被提出,并且连接牙齿压力角度的价值对链轮齿牙齿压力角度的价值不相等的条件上的合适的协调设计方法被学习。实验证明这个新设计方法是可行的。另外,沥青,链轮齿牙齿压力角度和链轮齿补遗圆的 fillet 半径的设计被学习。为指导切 Hy-Vo 沉默的链链轮齿的壁炉内部的一锅架的设计关键的 Itis。 | MENG Fanzhong LI Chun CHENG Yabing | 2007 | Chinese Journal of Mechanical Engineering2007，20，4： | 16 |
| 2 | A Chromosome-Level Genome Assembly of Garlic (Allium sativum) Provides Insights into Genome Evolution and Allicin Biosynthesis显示文摘Garlic,an economically important vegetable,spice,and medicinal crop,produces highly enlarged bulbs and unique organosulfur compounds.Here,we report a chromosome-level genome assembly for garlic,with a total size of approximately 16.24 Gb,as well as the annotation of 57561 predicted protein-coding genes,making garlic the first Allium species with a sequenced genome.Analysis of this garlic genome assembly reveals a recent burst of transposable elements,explaining the substantial expansion of the garlic genome.We examined the evolution of certain genes associated with the biosynthesis of allicin and inulin neoseries-type fructans,and provided new insights into the biosynthesis of these two compounds.Furthermore,a large-scale transcriptome was produced to characterize the expression patterns of garlic genes in different tissues and at various growth stages of enlarged bulbs.The reference genome and large-scale transcriptome data generated in this study provide valuable new resources for research on garlic biology and breeding. | Xiudong Sun Siyuan Zhu Ningyang Li Yi Cheng Jing Zhao Xuguang Qiao Li Lu Shiqi Liu Yanzhou Wang Chan Liu Benping Li Wu Guo Shuang Gao Zemao Yang Fu Li Zheng Zeng Qing Tang Yupeng Pan Mengjiao Guan Jian Zhao Xiaomi ng Lu Huanwe n Meng Zhenlin Han Chun she ng Gao Wenkai Jiang Xing Zhao Shilin Tian Jianguang Su Zhihui Cheng Touming Liu | 2020 | Molecular Plant2020，13，9： | 14 |
| 3 | A 12-year cohort study on the efficacy of plasmaderived hepatitis B vaccine in rural newborns显示文摘AIM To understand the anti-HBs persistenceand the long-term preventive efficacy in ruralnewborns after vaccination with plasma-derivedhepatitis B vaccine.METHODS In the time of expanded program onimmunization(EPI),the newborns werevaccinated with 10μg×3 doses of hepatitis Bvaccine and 762 newborns who were HBsAgnegative after primary immunization wereselected for cohort observation from 1986 to1998.Their serum samples were detectedqualitatively and quantitatively for hepatitis Binfecting markers,including HBsAg,anti-HBsand anti-HBc by SPRIA Kits.The annual HBsAgpositive conversion rate was counted by life-table method.RESULTS①The anti-HBs positive rate was94.44% for the babies born to HBsAg negativemothers and 84.21% for those born to HBsAgpositive mothers in the 1st year afterimmunization,and dropped to 51.31% and52.50% in the 12th year respectively.GMT valuewas dropped from 31.62 to 3.13 and 23.99 to 3.65in the 2nd to the 12th year respectively.Therewas a marked drop in GMT at the 3rd to the 5thyear,and in anti-HBs positive rate at the 9th tothe 10th year.②In the period of 12 yearsobservation,the person-year HBsAg positive conversion rates were 0.12%(5/4150.0)innewborns born to HBsAg negative mothers and0.20%(1/508.0)in those born to HBsAgpositive mothers,and none of the HBsAgpositive converted children became HBsAgchronic carriers.Compared with the baselinebefore immunization,the protective rates were97.19% and 95.32% respectively.CONCLUSION The protective efficacy ofplasma-derived hepatitis B vaccine persisted atleast 12 years,and a booster dose seems notnecessary within at least 12 years after theprimary three-doses immunization to newbornsborn to HBsAg negative mothers. | Hong Bin Liu Zong Da Meng Jing Chen Ma Chang Quan Han Ying Lin Zhang Zhan Chun Xing Yu Wei Zhang Yu Zhong Liu Hui Lin Cao | 2000 | World Journal of Gastroenterology2000，6，3： | 11 |
| 4 | Boundedness of Some Maximal Commutators in Hardy-type Spaces with Non-doubling Measures显示文摘让μ是满足一些仅仅生长条件的 R^d 上的一项非否定的氡措施。在这个假设下面,在一些强壮类型的空格的围住的海角为是 Calderon-Zygmund 操作符和 RBMO 产生的平常的最大的整流器的变体的最大的 Calderon-Zygmund 操作符和最大的整流器的一个类被建立(μ)函数,在强壮类型的空格是一些的地方,拨出潜水艇空格,与考虑 RBMO 联系了(μ)函数,强壮的空格 H^1 ( Tolsa 的μ)。 | Guo En HU Yan MENG Da Chun YANG | 2007 | Acta Mathematica Sinica,English Series2007，23，6： | 8 |
| 5 | Cardioprotective Effects of Qishen Granule(芪参颗粒)on Sarcoplasmic Reticulum Ca^2+ Handling in Heart Failure Rats显示文摘Objective:To assess the effects of Qishen Granule(芪参颗粒, QSG) on sarcoplasmic reticulum(SR) Ca^(2+) handling in heart failure(HF) model of rats and to explore the underlying molecular mechanisms. Methods:HF rat models were induced by left anterior descending coronary artery ligation surgery and high-fat diet feeding. Rats were randomly divided into sham(n=10), model(n=10), QSG(n=12, 2.2 g/kg daily) and metoprolol groups(n=12, 10.5 mg/kg daily). The therapeutic effects of QSG were evaluated by echocardiography and blood lipid testing. Intracellular Ca^(2+) concentration and sarco-endoplasmic reticulum ATPase 2a(SERCA2a) activity were detected by specific assay kits. Expressions of the critical regulators in SR Ca^(2+) handling were evaluated by Western blot and real-time quantitative polymerase chain reaction. Results:HF model of rats developed ventricular remodeling accompanied with calcium overload and defective Ca^(2+) releaseuptake cycling in cardiomyocytes. Treatment with QSG improved contractive function, attenuated ventricular remodeling and reduced the basal intracellular Ca^(2+) level. QSG prevented defective Ca^(2+) leak by attenuating hyperphosphorylation of ryanodine receptor 2, inhibiting expression of protein kinase A and up-regulating transcriptional expression of protein phosphatase 1. QSG also restored Ca^(2+) uptake by up-regulating expression and activity of SERCA2 a and promoting phosphorylation of phospholamban. Conclusion:QSG restored SR Ca^(2+)cycling in HF rats and served as an ideal alternative drug for treating HF. | LU Ling-hui LI Chun WANG Qi-yan ZHANG Qian ZHANG Yi MENG Hui WANG Yong WANG Wei | 2017 | Chinese Journal of Integrative Medicine2017，23，7： | 7 |
| 6 | FED:a web tool for foreign element detection of genome-edited organism显示文摘Dear Editor,Genome editing,especially the newly developed CRISPR technology,is now widely implemented for diverse medical and agricultural applications(Puchta,2018).However,for genome editing,the DNA cassettes encoding the editing components are usually assembled and delivered into the cells of organisms(Cong et al.,2013). | Qing Liu Xiaozhen Jiao Xiangbing Meng Chun Wang Cao Xu Zhixi Tian Chuanxiao Xie Genying Li Jiayang Li Hong Yu Kejian Wang | 2021 | Science China(Life Sciences)2021，64，1： | 6 |
| 7 | Inhibition of ethanol-induced toxicity by tanshinone ⅡA in PC12 cells显示文摘瞄准:为了在 neurotoxicity 上观察 tanshinone IIA (谭伊伊亚) 的效果,在 PC12 房间并且到由乙醇导致了探索它的保护的角色。方法:PC12 房间幸存被 MTT 试金测量。种类(ROS ) 和 lactate 脱氢酶(LDH ) 释放的反应的氧的形成被 2',7'-dichlorofluorescin (DCF ) 检测荧光和 calorimetric 分别地。房间 apoptosis 的百分比被流动血细胞计数监视。p53 的表示被免疫荧光和流动血细胞计数检测。结果:乙醇显著地损害了由 MTT 试金示威了的 PC12 房间的幸存。乙醇也导致了重要 ROS 形成并且增加了 LDH 版本。与在培养基的谭伊伊亚一起的孵化前显著地颠倒了这些变化。乙醇引起了房间 apoptosis 并且起来 p53 的规定蛋白质。导致乙醇的毒性上的谭伊伊亚的 anti-apoptosis 效果被伴随由下面 pro-apoptotic p53 的规定蛋白质表示。结论:谭伊伊亚能保护神经原免受 apoptosis 的伤害并且可能为乙醇导致的神经病学的混乱用作潜在的治疗学的药。 | Xian-fang MENG Xiao-jing ZOU Bin PENG Jing SHI Xin-min GUAN Chun ZHANG | 2006 | Acta Pharmacologica Sinica2006，27，6： | 5 |
| 8 | The Changes in the Awareness of Cervical Cancer Prevention and the Acceptability of HPV Vaccines among Women after Their Introduction in China显示文摘Cervical cancer is a form of malignant tumor that seriously threatens women’s health. In China,according to the cancer statistics, 98,900 new cervical cancer cases and 30,500 deaths due to cervical cancer were estimated to have occurred in2015, and the incidence and mortality rates still exhibited an upward trend[1]. | MA Quan Fu GUO Yu Lin YAN Bin FAN Chun Li XU Meng DAI Xuan WANG Ying ZOU Miao WANG Chao Nan WU Xu Feng | 2019 | Biomedical and Environmental Sciences2019，32，11： | 5 |
| 9 | Photochemical properties and source of pollutants during continuous pollution episodes in Beijing, October, 2011显示文摘Beijing sufered from serious air pollution in October, 2011 with the occurrence of three continuous episodes. Here we analyze the pollution status of particulate matter, the relationship between the gaseous pollutants, physical and chemical properties of single particles, and the profile of watersoluble ions in PM2.5during the three episodes. Regional and photochemically aged air masses, which were characterized as having high values of O3and SO2, were hypothesized to have played a dominant role in the first episode. After mixing local air masses with freshly-emitted primary pollutants, the concentration of NOx continued to increase and the size of SO4 2, NO3 and NH4 +in the particle population continued to become smaller. The amount of elemental carbon-rich and organic carbonrich particles in the scaled single particles(0.2–2 μm) and water-soluble K+in PM2.5also increased in the episodes. All the available information suggests that the biomass or fuel burning sources in or around Beijing may have had a huge impact on the last two episodes. | Jian Gao Yuechong Zhang Meng Zhang Jingqiao Zhang Shulan Wang Jun Tao Han Wang Datong Luo Fahe Chai Chun Ren | 2014 | Journal of Environmental Sciences2014，26，1： | 4 |
| 10 | ScCas9 recognizes NNG protospacer adjacent motif in genome editing of rice显示文摘The CRISPR/Cas(clustered regularly in terspaced short palindromic repeats/CRISPR-associated protein)system has been widely used in genome editing,epigenetic modification,and other applications,because it is a precise,inexpensive,powerful and easy-to?use editing tool(Zhang et al.,2019).However,the scope of genome editing is limited by a short protospacer adjacent motif(PAM)specific sequence flanking the target site.Streptococcus pyogenes Cas9(5^Cas9),the most widely used Cas,strongly recognizes NGG PAM and partially recognizes NAG PAM in rice and is restricted to target the sites with these motifs(Anders et al.,2014;Meng et al.,2018). | Yibo Xu Xiangbing Meng Junjie Wang Baoxiang Qin Kejian Wang Jiayang Li Chun Wang Hong Yu | 2020 | Science China(Life Sciences)2020，63，3： | 4 |
| 11 | High-throughput microfabrication of axially tunable helices显示文摘Helical structures exhibit novel optical and mechanical properties and are commonly used in different fields such as metamaterials and microfluidics. A few methods exist for fabricating helical microstructures, but none of them has the throughput or flexibility required for patterning a large surface area with tunable pitch. In this paper, we report a method for fabricating helical structures with adjustable forms over large areas based on multiphoton polymerization(MPP) using single-exposure, three dimensionally structured, self-accelerating, axially tunable light fields. The light fields are generated as a superposition of high-order Bessel modes and have a closed-form expression relating the design of the phase mask to the rotation rate of the beam. The method is used to fabricate helices with different pitches and handedness in the material SU-8. Compared to point-by-point scanning, the method reported here can be used to reduce fabrication time by two orders of magnitude, paving the way for adopting MPP in many industrial applications. | He Cheng Pooria Golvari Chun Xia Mingman Sun Meng Zhang Stephen M.Kuebler Xiaoming Yu | 2022 | Photonics Research2022，10，2： | 4 |
| 12 | Polymorphism in the upstream regulatory region of human papilloma virus type 16 from the cervical cancer biopsies in Xinjiang Uygur women显示文摘To investigate the mutations in the upstream regulatory region (URR) of human papillomavirus type 16 (HPV-16) from the cervical cancer biopsies in Xinjiang Uygur women and its relationship to the high incidence of cervical cancer in the southern Xinjiang, the tissue DNA was extracted from the cervical cancer biopsies, and the URR segment of HPV-16 DNA was amplified, sequenced and analyzed. Thereafter, the polymorphism of URR in HPV-16 was then analyzed. It was demonstrated that the positive rate detected for the presence of URR in HPV-16 was 89.47% (17/19). Compared with the previously published sequence in URR of prototype HPV-16, some mutations were detected in the sequence of URR. The mutations in 17 URR fragments of HPV-16 could be divided into 11 patterns (XJU-1 to XJU-11) at nucleic acid level, in which each of XJU-1 and XJU-4 accounted for 23.53% (4/17), and other patterns of mutation accounted for 5.88% (1/17) . In comparison with the URR of prototype HPV-16, the DNA identity of these patterns was 98.50%-99.68% . In these 17 URR fragments, two point mutations occurred at position 7192 (G to T) and position 7520 (G to A) and they appeared to be constant in Xinjiang area. These two mutations were ubiquitous in the Asia-American type and conferred strong infection activity and carcinogenicity of this virus. In addition, the mutations at position 7729 (A to C), position 7843 (A to G) and position 7792 (C to T) could enhance its transcription activity considerably. It is concluded that some mutations occur in URR gene of HPV-16 in the cervical cancer biopsies taken from Uygur women in Xinjiang area, suggesting that certain relationship exists among the mutations in URR of HPV-16, the phylogeny of HPV-16 and the high incidence of cervical cancer in southern part of Xinjiang area. | MENG YU ZHENG HAI MA YAN PIN WANG XI DAN RE FU CHUN ZHANG | 2006 | Journal of Microbiology and Immunology2006，4，3： | 4 |
| 13 | Separation and enrichment of trace ractopamine in biological samples by uniformly-sized molecularly imprinted polymers显示文摘In order to prepare a high capacity packing material for solid-phase extraction with specific recognition ability of trace ractopamine in biological samples, uniformly-sized, molecularly imprinted polymers (MIPs) were prepared by a multi-step swelling and polymerization method using methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker, and toluene as a porogen respectively. Scanning electron microscope and specific surface area were employed to identify the characteristics of MIPs. Ultraviolet spectroscopy, Fourier transform infrared spectroscopy, Scatchard analysis and kinetic study were performed to interpret the specific recognition ability and the binding process of MIPs. The results showed that, compared with other reports, MIPs synthetized in this study showed high adsorption capacity besides specific recognition ability. The adsorption capacity of MIPs was 0.063 mmol/g at 1 mmol/L ractopamine concentration with the distribution coefficient 1.70. The resulting MIPs could be used as solid-phase extraction materials for separation and enrichment of trace ractopamine in biological samples. | Ya Li Qiang Fu Meng Liu Yuan-Yuan Jiao Wei Du Chong Yu Jing Liu Chun Chang Jian Lu | 2012 | Journal of Pharmaceutical Analysis2012，2，6： | 4 |
| 14 | Expanding the scope of genome editing with SpG and SpRY variants in rice显示文摘Dear Editor,The clustered regularly interspaced short palindromic repeats/CRISPR-associated nuclease 9(CRISPR/Cas9)system,since it was excavated,has been rapidly developed and sparked a revolution in the genome editing field.In principle,CRISPR/Cas9 system relies on the recognition of specific loci on the genome,which is titled the protospacer adjacent motif(PAM).However,the canonical Streptococcus pyogenes Cas9(SpCas9)nuclease only recognizes NGG or NAG PAMs,rendering an inherent obstacle in amplifying the application of CRISPR/Cas9 technology. | Jun Ren Xiangbing Meng Fengyue Hu Qing Liu Yuexuan Cao Huiying Li Changjie Yan Jiayang Li Kejian Wang Hong Yu Chun Wang | 2021 | Science China(Life Sciences)2021，64，10： | 4 |
| 15 | Fracture of two three-dimensional parallel internal cracks in brittle solid under ultrasonic fracturing显示文摘Similar to hydraulic fracturing(HF), the coalescence and fracture of cracks are induced within a rock under the action of an ultrasonic field, known as ultrasonic fracturing(UF). Investigating UF is important in both hard rock drilling and oil and gas recovery. A three-dimensional internal laser-engraved crack(3D-ILC) method was introduced to prefabricate two parallel internal cracks within the samples without any damage to the surface. The samples were subjected to UF. The mechanism of UF was elucidated by analyzing the characteristics of fracture surfaces. The crack propagation path under different ultrasonic parameters was obtained by numerical simulation based on the Paris fatigue model and compared to the experimental results of UF. The results show that the 3D-ILC method is a powerful tool for UF research.Under the action of an ultrasonic field, the fracture surface shows the characteristics of beach marks and contains powder locally, indicating that the UF mechanism includes high-cycle fatigue fracture, shear and friction, and temperature load. The two internal cracks become close under UF. The numerical result obtained by the Paris fatigue model also shows the attraction of the two cracks, consistent with the test results. The 3D-ILC method provides a new tool for the experimental study of UF. Compared to the conventional numerical methods based on the analysis of stress-strain and plastic zone, numerical simulation can be a good alternative method to obtain the crack path under UF. | Haijun Wang Hanzhang Li Lei Tang Xuhua Ren Qingxiang Meng Chun Zhu | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，3： | 4 |
| 16 | A novel approach for synthesis of 3-amino-5-aryl-2,5-dihydropyridazines using onium salt as soluble support显示文摘在这个工作,它被介绍任务的应用象对 3-amino-5-aryl-2,5-dihydropyridazines 的合成的可溶的支持咸的特定的 onium。这可溶的支持具有宽适用性并且没有它的限制,溶液阶段化学把稳固的阶段合成的优点与那些相结合。在一个简单的洗步骤以后,产品从支持被劈开并且在好收益获得了。 | Meng Gao Cui Fen Lu Gui Chun Yang Zu Xing Chen | 2011 | Chinese Chemical Letters2011，22，7： | 4 |
| 17 | Evaluation of Multidrug Resistant Loop-mediated Isothermal Amplification Assay for Detecting the Drug Resistance of Mycobacterium tuberculosis显示文摘Objective To evaluate multidrug resistant loop-mediated isothermal amplification(MDR-LAMP)assay for the early diagnosis of multidrug-resistant tuberculosis and to compare the mutation patterns associated with the rpoB,katG,and inhA genes at the Chinese Center for Disease Control and Prevention.Methods MDR-LAMP assay was evaluated using 100 Mycobacterium tuberculosis(Mtb)isolates obtained from the National Reference Laboratory for Tuberculosis in China.Phenotypic resistance to isoniazid and rifampicin and whole-genome sequencing served as reference standards.Results The sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)of MDR-LAMP were 85.5%,93.6%,96.7%,and 74.4%for the detection of resistance to isoniazid and rifampicin,respectively,and 80.5%,92.3%,98.6%,and 41.4%for the detection of Mtb cultured from smear-positive sputum samples,respectively.When DNA sequencing was used as the reference standard,the sensitivity,specificity,PPV,and NPV of MDR-LAMP were 93.1%,92.3%,97.2%,and 82.8%for the detection of katG and inhA gene mutations,respectively,and 89.1%,88.9%,93.4%,and 81.1%for the detection of rpoB gene mutation,respectively.Conclusion MDR-LAMP is a rapid and accessible assay for the laboratory identification of rifampicin and isoniazid resistance of Mtb isolates. | LIU Chun Fa SONG Yi Meng HE Ping LIU Dong Xin HE Wen Cong LI Yan Ming ZHAO Yan Lin | 2021 | Biomedical and Environmental Sciences2021，34，8： | 3 |
| 18 | Preparation of Chromium-iron Metal Powder from Chromium Slag by Reduction Roasting and Magnetic Separation显示文摘Chromium slag(CS)has become one of the most hazardous solid waste containing chromium and iron.Based on its characteristics,the technology of reduction roasting and magnetic separation was employed to treat CS.The major impurity element of CS is magnesium and it exists in magnesium ferrite phase,which is hard to recover iron in the absence of additives.During reduction roasting,additives(Al2O3and CaF2)could destroy the structure of magnesium ferrite and improve the iron grade and recovery.The final product,i.e.chromium-iron powder,contains 72.54% Fe and 13.56% Cr,with the iron recovery of 80.34% and chromium recovery of 80.70%. | Hong-ming LONG Qing-min MENG Ping WANG Tie-jun CHUN Yong-lin YAO | 2015 | Journal of Iron and Steel Research(International)2015，22，9： | 3 |
| 19 | Improving the efficiency of prime editing with epegRNAs and high-temperature treatment in rice显示文摘Dear Editor,Prime editing(PE)systems are important genome-editing tools developed for mediating arbitrary small DNA insertions,deletions and all 12 base-to-base conversions using a CRISPR-nCas9 fusion of an engineered M-MLV and PE guide RNAs(peg RNAs)(Anzalone et al.,2019). | Jinpeng Zou Xiangbing Meng Qing Liu Meiqi Shang Kejian Wang Jiayang Li Hong Yu Chun Wang | 2022 | Science China(Life Sciences)2022，65，11： | 3 |
| 20 | Protocol of Jidong Women Health Cohort Study: Rationale, Design, and Baseline Characteristics显示文摘Objective The Jidong Women Health Cohort Study is a prospective cohort study on female-specific characteristics and risks of chronic diseases in Chinese women and focuses on the potential association between menopause and risks of cardiovascular disease(CVD). Methods The study includes 4,179 female participants with an age of older than 18 years from Caofeidian district, Tangshan city, northern China. Baseline information on female-specific characteristics and potential cardiovascular risk factors was collected and all the participants underwent a physical examination with blood samples collected in 2013. To establish a better risk assessment tool of female CVD, updated information from questionnaire investigation, physical examinations and occurrence of outcome events will be collected through a longitudinal follow-up annually up to the year 2024. Results At baseline, Mean age of the participants was 42.3 ± 12.8 years. Reproduction occurred in 2,948 participants(70.5%), menopausal transition in 173(4.3%), and postmenopause in 1,058(25.3%). The incidence of arterial hypertension, dyslipidemia, and diabetes showed significant difference across different groups stratified by Stage of Reproductive Aging Workshop(STRAW) system(P < 0.05). Conclusion The Jidong Women Health Cohort Study will contribute to the scientific evidence on association between female-specific characteristics and cardiovascular risks, and will also be helpful to provide a new path for early detection and prevention of CVD. | QIU Meng Si WANG Xian Wei YAO Yan GE Si Qi LIU Hua Min DAI Ying Chun ZHOU Yong | 2019 | Biomedical and Environmental Sciences2019，32，2： | 3 |
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