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| 1 | Diagnostic value of elevated serum carbohydrate antigen 199 level in acute cholangitis secondary to choledocholithiasis显示文摘AIM To investigate the diagnostic value of abnormal serum carbohydrate antigen 199(CA199) level in acute cholangitis secondary to choledocholithiasis.METHODS In this retrospective cohort study, the clinical data of 727 patients with choledocholithiasis admitted to the Third Affiliated Hospital of Zunyi Medical College from June 2011 to June 2017 were collected. Among these patients, 258 patients had secondary acute cholangitis and served as observation group, and the remaining 569 choledocholithiasis patients served as the control group. Serum liver function indexes and tumor markers were detected in both groups, and the receiver operating characteristic(ROC) curves were constructed for markers showing statistical significances. The cutoff value, sensitivity, and specificity of each marker were calculated according to the ROC curves. RESULTS The results of liver function tests showed no significant differences between the two groups(P > 0.05). Tumor markers including serum CA125, CA153, carcinoembryonic antigen, and alpha fetoprotein levels were also not significantly different(P > 0.05); however, the serum CA199 level was significantly higher in the observation group than in the control group(P < 0.05). The ROC curve analysis showed that the area under the curve was 0.885(95%CI: 0.841-0.929) for CA199, and the cutoff value of 52.5 kU/L had the highest diagnostic accuracy, with a sensitivity of 86.8% and a specificity of 81.6%.CONCLUSION Abnormally elevated serum CA199 level has an important value in the diagnosis of acute cholangitis secondary to choledocholithiasis. It may be a specific inflammatory marker for acute cholangitis. | Yong Mei Li Chen Ci-Jun Peng Jun Wang Peng-Fei Zeng Guo-Xing Wang Wen-Ping Li Yan-Qing Luo Chao Du Kai Liu Kun Xiong Kai Leng Chun-Lin Feng Ji-Hu Jia | 2018 | World Journal of Clinical Cases2018，6，11： | 11 |
| 2 | Combination of serum gamma-glutamyltransferase and alkaline phosphatase in predicting the diagnosis of asymptomatic choledocholithiasis secondary to cholecystolithiasis显示文摘BACKGROUND Gamma-glutamyltransferase(GGT) is one of the most important laboratory tests for the evaluation of liver damage. Through a long-term clinical observation of patients with secondary asymptomatic choledocholithiasis, we found that most patients had abnormal GGT serum levels.AIM To investigate the combination of serum GGT and alkaline phosphatase(ALP) in predicting the diagnosis of asymptomatic choledocholithiasis secondary to cholecystolithiasis.METHODS In this retrospective cohort study, the clinical data of 829 patients with cholecystolithiasis admitted to the Third Affiliated Hospital of Zunyi Medical College from August 2014 to August 2017 were collected. Among these patients,151 patients had secondary asymptomatic choledocholithiasis and served as the observation group, and the remaining 678 cholecystolithiasis patients served as the control group. Serum liver function indexes were detected in both groups,and the receiver operating characteristic(commonly known as ROC) curves were constructed for markers showing statistical significances. The cutoff value,sensitivity, and specificity of each marker were calculated according to the ROC curves.RESULTS The overall incidence of asymptomatic choledocholithiasis secondary to cholecystolithiasis was 18.2%. The results of liver function indexes including serum aspartate aminotransferase, alanine aminotransferase, direct bilirubin and total bilirubin levels showed no significant differences between the two groups(P> 0.05). However, the serum GGT and ALP levels were significantly higher in the observation group than in the control group(P < 0.05). The ROC curve analysis showed that the area under the curve was 0.881(95%CI: 0.830-0.932), 0.647(95%CI: 0.583-0.711) and 0.923(0.892-0.953) for GGT, ALP, and GGT + ALP,respectively. The corresponding cut-off values of GGT and ALP were 95.5 U/L and 151.5 U/L, sensitivity were 90.8% and 65.1%, and specificity were 83.6% and59.8%, respectively. The sensitivity and specificity of GGT + ALP were 93.5% and85.1%, respectively.CONCLUSION An abnormally elevated serum GGT level has an important value in the diagnosis of asymptomatic choledocholithiasis secondary to cholecystolithiasis.The combination of serum GGT and ALP has better diagnostic performance. As a convenient, rapid and inexpensive test, it should be applied in secondary asymptomatic choledocholithiasis routine screening. | Yong Mei Li Chen Peng-Fei Zeng Ci-Jun Peng Jun Wang Wen-Ping Li Chao Du Kun Xiong Kai Leng Chun-Lin Feng Ji-Hu Jia | 2019 | World Journal of Clinical Cases2019，7，2： | 8 |
| 3 | Selective Synthesis of Hexagonal Ag Nanoplates in a Solution-Phase Chemical Reduction Process显示文摘Two-dimensional(2-D)Ag nanoplates have surface plasmon resonances which can be tuned from the visible to the near-IR by varying the size and morphology of the nanoplates.Due to their anisotropic structures and different surface energy distributions,Ag nanoplates-especially triangular ones-are kinetically stable and can transform into other nanostructures.Taking advantage of the synergetic effects of HNO_(3)and Cl-in the reduction solution,uniform Ag hexagonal nanoplates(HNPs)have been captured during the transformation of Ag triangular nanoplates(TNPs).The dimensions of the Ag HNPs can be controlled by changing the concentrations of reagents in the reaction or/and reduction solutions.Resonance absorption spectra of the obtained Ag HNPs indicated that their in-plane resonance peaks could be tuned from the visible to the near-IR region,showing their potential applications in medical diagnosis. | Mingzhu Liu Mei Leng Chao Yu Xin Wang Cheng Wang | 2010 | Nano Research2010，3，12： | 5 |
| 4 | Synthesis of N-methylene phosphonic chitosan(NMPCS)and its potential as gene carder显示文摘N-Methylene phosphoulc chitosan (NMPCS),an amphiphilic macromolecule with powerful chelating ability of Ca^(2+) ions,was synthesized and characterized.The physicochemical properties of NMPCS and the interactions between NMPCS and plasmid DNA were investigated by FTIR,^(13)C NMR,X-ray,agarose gel electrophorcsis retardation assay,atomic force microscopy (AFM) and circular dichroism (CD).The results suggest that at charge ratio 2:1 or above,DNA could be completely entrapped and spherical complexes with mean size of 80-210 nm were formed.Taking HeLa as host cell,luciferase expression mediated by NMPCS improved about 100 times compared to the expression mediated by chitosan. | Dun Wan Zhu Jin Gen Bo Hai Ling Zhang Wen Guang Liu Xi Gang Leng Cun Xian Song Yu Ji Yin Li Ping Song Lan Xia Liu Lin Mei Xiu Lan Li Yang Zhang Kang De Yao | 2007 | Chinese Chemical Letters2007，18，11： | 3 |
| 5 | G-protein Coupled Receptor 34 Knockdown Impairs the Proliferation and Migration of HGC-27 Gastric Cancer Cells In Vitro显示文摘 | Zhong-Tian Jin Kun Li Mei Li Zhi-Gang Ren Fu-Shun Wang Ji-Ye Zhu Xi-Sheng Leng Wei-Dong Yu | 2015 | Chinese Medical Journal2015，，4： | 2 |
| 6 | Experimental study on permanent deformation characteristics of coarse-grained soil under repeated dynamic loading显示文摘Practical assessment of subgrade settlement induced by train operation requires developing suitable models capable of describing permanent deformation characteristics of subgrade filling under repeated dynamic loading.In this paper,repeated load triaxial tests were performed on coarse-grained soil(CGS),and the axial permanent strain of CGS under different confining pressures and dynamic stress amplitudes was analysed.Permanent deformation behaviors of CGS were categorized based on the variation trend of permanent strain rate with accumulated permanent strain and the shakedown theory.A prediction model of permanent deformation considering stress state and number of load cycles was established,and the ranges of parameters for different types of dynamic behaviors were also divided.The results indicated that the variational trend of permanent strain rate with accumulated permanent strain can be used as a basis for classifying dynamic behaviors of CGS.The stress state(confining pressure and dynamic stress amplitude)has significant effects on the permanent strain rate.The accumulative characteristics of permanent deformation of CGS with the number of load cycles can be described by a power function,and the model parameters can reflect the influence of confining pressure and dynamic stress amplitude.The study’s results could help deepen understanding of the permanent deformation characteristics of CGS. | Huihao Mei Sajjad Satvati Wuming Leng | 2021 | Railway Engineering Science2021，29，1： | 2 |
| 7 | Risk factors for liver disease among adults of Mexican descent in the United States and Mexico显示文摘AIM To compare the prevalence of chronic liver disease(CLD) risk factors in a representative sample of MexicanAmericans born in the United States(US) or Mexico, to a sample of adults in Mexico.METHODS Data for Mexican-Americans in the US were obtained from the 1999-2014 National Health and Nutrition Examination Survey(NHANES), which includes persons of Mexican origin living in the US(n = 4274). The NHANES sample was restricted to Mexican-American participants who were 20 years and older, born in the US or Mexico, not pregnant or breastfeeding, and with medical insurance.The data in Mexico were obtained from the 2004-2013 Health Worker Cohort Study in Cuernavaca, Mexico(n =9485). The following known risk factors for liver disease/cancer were evaluated: elevated aminotransferase levels(elevated alanine aminotransferase was defined as > 40 IU/L for males and females; elevated aspartate aminotransferase was defined as > 40 IU/L for males and females), infection with hepatitis B or hepatitis C,metabolic syndrome, high total cholesterol, diabetes,obesity, abdominal obesity, and heavy alcohol use. The main independent variables for this study classified individuals by country of residence(i.e., Mexico vs the US) and place of birth(i.e., US-born vs Mexico-born).Regression analyses were used to investigate CLD risk factors.RESULTS After adjusting for socio-demographic characteristics,Mexican-American males were more likely to be obese,diabetic, heavy/binge drinkers or have abdominal obesity than males in Mexico. The adjusted multivariate results for females also indicate that Mexican-American females were significantly more likely to be obese, diabetic, be heavy/binge drinkers or have abdominal obesity than Mexican females. The prevalence ratios and prevalence differences mirror the multivariate analysis findings for the aforementioned risk factors, showing a greater risk among US-born as compared to Mexico-born MexicanAmericans. CONCLUSION In this study, Mexican-Americans in the US had more risk factors for CLD than their counterparts in Mexico.These findings can be used to design and implement more effective health promotion policies and programs to address the specific factors that put Mexicans at higher risk of developing CLD in both countries. | Yvonne N Flores Zuo-Feng Zhang Roshan Bastani Mei Leng Catherine M Crespi Paula Ramírez-Palacios Heather Stevens Jorge Salmerón | 2018 | World Journal of Gastroenterology2018，24，37： | 1 |
| 8 | Cloning and functional analysis of 9-cis-epoxycarotenoid dioxygenase (NCED) genes encoding a key enzyme during abscisic acid biosynthesis from peach and grape fruits显示文摘 | Zhang Mei Leng Ping Zhang Guanglian Li Xiangxin | | 0，，： | 1 |
| 9 | PDK1 Signaling Toward PLK1–MYC Activation Confers Oncogenic Transformation, Tumor-Initiating Cell Activation, and Resistance to mTOR-Targeted Therapy显示文摘 | Jing Tan Zhimei Li Puay Leng Lee Peiyong Guan Mei Yee Aau Shuet Theng Lee Min Feng Cheryl Zihui Lim Eric Yong Jing Lee Zhen Ning Wee Yaw Chyn Lim R.K. Murthy Karuturi Qiang Yu | 2013 | Cancer Discovery2013，，10： | 1 |
| 10 | The role of ABA in triggering ethylene biosynthesis and ripening of tomato fruit显示文摘 | Zhang Mei Yuan Bing Leng Ping | | 0，，06： | 1 |
| 11 | Cloning and functional analysis of 9- cis -epoxycarotenoid dioxygenase (NCED) genes encoding a key enzyme during abscisic acid biosynthesis from peach and grape fruits显示文摘 | Mei Zhang Ping Leng Guanglian Zhang Xiangxin Li | 2009 | Journal of Plant Physiology2009，，12： | 1 |
| 12 | Polyhedral50-facet Cu2〇 microcrystals partially enclosed by{311} high-index planes: synthesis and enhanced catalyticCO oxidation activity 显示文摘 | LENG Mei LIU Mingzhu ZHANG Yibo | 2010 | Journal of the AmericanChemical Society2010，132，17： | 1 |
| 13 | 显示文摘 | Guo L H Huang Mei Leng Yang | 2001 | Key Engineering Materials2001，187，： | 1 |
| 14 | Hydrogen sulfide: Regulatory role on blood pressure in hyperhomocysteinemia显示文摘 | Sagiraju Sowmya Yada Swathi Ai Ling Yeo Mei Leng Shoon Philip Keith Moore Madhav Bhatia | 2010 | Vascular Pharmacology2010，，3： | 1 |
| 15 | Alanine aminotransferase is an inadequate surrogate marker for detecting lamivudine resistance显示文摘AIM: To investigate the accuracy of serum alanine aminotransferase (ALT) in diagnosing lamivudine resistance and factors that contributed to abnormal serum ALT.METHODS: This was a retrospective study of chronic hepatitis B patients on lamivudine therapy who were followed for 3-mo with liver function tests and hepatitis B virus (HBV) DNA measurement. Lamivudine resistance was defined as HBV DNA ≥ 1 log from nadir on at least 2 occasions, confirmed by genotyping. Serum ALT levels in patients with lamivudine resistance were compared to serum ALT levels in those without lamivudine resistance. RESULTS: There were 111 patients with and 117 without lamivudine resistance. The area under the receiver operating characteristic of serum ALT to diagnose lamivudine resistance was 0.645 ± 0.037. Serum ALT > 42.5 U/L gave the best diagnostic accuracy with sensitivity = 61%, specificity = 60%, positive predictive value = 60%, negative predictive value = 61%, positive likelihood ratio = 1.53 and negative likelihood ratio = 0.65 for predicting lamivudine resistance, missing 39% of resistant patients. Using other serum ALT cutoffs, diagnostic accuracy was lower. By multivariate analysis, baseline abnormal serum ALT was associated with abnormal ALT during resistance (OR = 5.98, P = 0.003), and males were associated with serum ALT flares during resistance (OR = 8.9, P = 0.016). CONCLUSION: Serum ALT is inadequate for diagnosing lamivudine resistance and has implications where viral resistance testing is suboptimal and for reimbursement of rescue therapy. | Lee Guan Lim Myat Oo Aung Bee Leng Seet Cindy Tan Yock Young Dan Yin Mei Lee Dede Selamat Sutedja Mark Fernandes Guan Huei Lee Evelyn Koay Seng Gee Lim | 2010 | World Journal of Gastroenterology2010，16，37： | 1 |
| 16 | On clock synchronization algorithms for wireless sensor networks under unknown delay显示文摘 | Leng Mei and Wu Yik-chung | 2010 | IEEE Transactions on Vehicular Technology2010，59，1： | 1 |
| 17 | Structure and composition comparison of bone mineral and apatite layers formed in vitro 显示文摘 | Guo L H Mei Huang Yang Leng | 2001 | Key Engineering Materials2001，19，2195： | 1 |
| 18 | Competitive Business Intelli- gence in Singapore 显示文摘 | Chow Hou Wee Mei Leng Leow | 1994 | Journal of strategic Marketing1994，，2： | 1 |
| 19 | Overexpression of the Arabidopsis thaliana MinD1 gene alters chloroplast size and number in transgenic tobacco plants显示文摘 | Randy Dinkins Srinivasa M. Reddy Mei Leng Glenn B. Collins | 2001 | Planta2001，，2： | 1 |
| 20 | Spectroscopic/Microscopic Elucid显示文摘The Arundo donax is a typical fast-growing species from the family Gramineae,which is widely cultivated in China.With a huge yield of A.donax in China,this plant offers great potential for biofuels production.The different types of organization of cell and the tissue in the A.donax could influence the efficiency of enzymatic hydrolysis.In this study,A.donax was subjected to 0.5%(w/w)sulfuric acid(H2SO4)for pretreatment at 140℃for 10 min,20 min,40 min,and 60 min,respectively.The changes in microstructure,chemical composition,topochemical properties were comprehensively analyzed.Using a series of spectroscopic and microscopic techniques including Fourier transform infrared spectroscopy(FT-IR),X-Ray diffraction(XRD),polarized light microscopy(PLM),and confocal Raman microscopy(CRM)to obtain the correlative structural and chemical information.Analysis results of chemical composition,FT-IR spectra and XRD indicated that with increasing reaction time,more hemicellulose and lignin would be removed.Correspondingly,there was an obvious increase of the cellulose relative crystallinity via extending reaction time.Results of the PLM observations showed that the birefringence gradually dimmed due to the diminishing of the cellulose component.Furthermore,the CRM mapping images showed the lignin component in compound middle lamellar(CML)was difficult to remove relatively as compared with that in secondary walls.These results indicated that the combination of spectroscopic and microscopic elucidation could give an insightful understanding of chemical changes in cellular level during pretreatment. | Bingwei CHEN Xinzhou WANG Weiqi LENG Yu’na KAN Changtong MEI Shengcheng ZHAI | 2019 | Journal of Bioresources and Bioproducts2019，4，3： | 0 |
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