|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Kaposiform Hemangioendothelioma: A Study of 33 Cases Emphasizing Its Pathologic, Immunophenotypic, and Biologic Uniqueness From Juvenile Hemangioma显示文摘 | Lisa L Lyons Paula E North Fernand Mac-Moune Lai Mark H Stoler Andrew L Folpe Sharon W Weiss | 2004 | The American Journal of Surgical Pathology2004，，5： | 1 |
| 2 | Alanine aminotransferase is an inadequate surrogate marker for detecting lamivudine resistance显示文摘AIM: To investigate the accuracy of serum alanine aminotransferase (ALT) in diagnosing lamivudine resistance and factors that contributed to abnormal serum ALT.METHODS: This was a retrospective study of chronic hepatitis B patients on lamivudine therapy who were followed for 3-mo with liver function tests and hepatitis B virus (HBV) DNA measurement. Lamivudine resistance was defined as HBV DNA ≥ 1 log from nadir on at least 2 occasions, confirmed by genotyping. Serum ALT levels in patients with lamivudine resistance were compared to serum ALT levels in those without lamivudine resistance. RESULTS: There were 111 patients with and 117 without lamivudine resistance. The area under the receiver operating characteristic of serum ALT to diagnose lamivudine resistance was 0.645 ± 0.037. Serum ALT > 42.5 U/L gave the best diagnostic accuracy with sensitivity = 61%, specificity = 60%, positive predictive value = 60%, negative predictive value = 61%, positive likelihood ratio = 1.53 and negative likelihood ratio = 0.65 for predicting lamivudine resistance, missing 39% of resistant patients. Using other serum ALT cutoffs, diagnostic accuracy was lower. By multivariate analysis, baseline abnormal serum ALT was associated with abnormal ALT during resistance (OR = 5.98, P = 0.003), and males were associated with serum ALT flares during resistance (OR = 8.9, P = 0.016). CONCLUSION: Serum ALT is inadequate for diagnosing lamivudine resistance and has implications where viral resistance testing is suboptimal and for reimbursement of rescue therapy. | Lee Guan Lim Myat Oo Aung Bee Leng Seet Cindy Tan Yock Young Dan Yin Mei Lee Dede Selamat Sutedja Mark Fernandes Guan Huei Lee Evelyn Koay Seng Gee Lim | 2010 | World Journal of Gastroenterology2010，16，37： | 1 |
| 3 | Remodeling of the plasma for sperm-egg recognition: proteins membrane in preparation roles of acrosomal显示文摘有卵的细胞外的矩阵的精子的相互作用,带 pellucida (ZP ) 是在男、女的配偶子之间的联合的第一个步骤。这个过程的分子的机制被学习过去的六十年了,结果获得了有趣、糊涂。在这篇文章,我们描述我们的最近的工作,它从以前的研究尝试问题的二根线到地址。首先,因为有众多的 ZP,有约束力的蛋白质由各种各样的研究人员报导了,这些蛋白质怎么在 sperm-ZP 一起行动相互作用吗?第二,很多 acrosomal 蛋白质为什么有 ZP 亲密关系?他们主要涉及起始的 sperm-ZP 绑定或相当在抛锚的 acrosome 反应 / 反应精子到 ZP 吗?我们的研究揭示那很多 ZP 有约束力的蛋白质和女伴,从前面的精子头血浆膜提取了,作为高分子的重量(HMW ) 共存建筑群,和那在使能够的精子的这些建筑群有优先的能力绑在 ZP。Zonadhesin (ZAN ) ,与 ZP 亲密关系作为 acrosomal 蛋白质知道,是在 HMW 建筑群的这些蛋白质之一。Immunoprecipitation 显示 ZAN 与另外的 acrosomal 蛋白质, proacrosin/acrosin 和 sp32 (ACRBP ) 交往,在 HMW 建筑群也在场。精子上的 ZAN 和 proacrosin/acrosin 的 Immunodetection 进一步显示到精子头的两蛋白质交通在精子 acrosomal 矩阵仍然是未经触动的 capacitation 期间出现,并且因此,他们多半涉及起始的 sperm-ZP 绑定步。 | Nongnuj Tanphaichitr Kessiri Kongmanas Hathairat Kruevaisayawan Arpornrad Saewu Clarissa Sugeng Jason Fernandes Puneet Souda Jonathan B Angel Kym F Faull R John Aitken Julian Whitelegge Daniel Hardy Trish Berger Mark Baker | 2015 | Asian Journal of Andrology2015，17，4： | 0 |
| 4 | 美国西部重要害虫摩门螽斯病原真菌的研究(英文)显示文摘The Mormon cricket (MC),Anabrus simplex (Orthoptera:Tettigoniidae),has a long and negative history with agriculture in the western states of the USA where MC often migrates in large groups and causes significant damage to forage plants and cultivated crops.In this review, virulence to MC of isolates of the insect-pathogenic fungus Metarhizium anisopliae varieties acridum and anisopliae were compared in an effort to identify isolates with promise for use as MC biological control agents.All of the isolates tested induced 100% or nearly 100% mortality by six days post application of the fungal conidia.Searches for new Metarhizium isolates with high heat and UV-B tolerance included isolation fungi from field-caught MC and grasshopper after they died in the laboratory and culturing fungi from soil samples collected from numerous western USA sites.The survey was preceded by development of a dodine based selective medium that,at 0.002% active ingredient,permitted growth of M.anisopliae var.acridum,but inhibited most contaminating fungi.The M.anisopliae var.acridum isolates examined to date have much higher tolerance to heat and UV-B irradiation than M.anisopliae var.anisopliae isolates,and this may be critical to successful field applications.The variety acridum has not yet been found in the USA,so our search for such isolates continues.Several new M.anisopliae var.anisopliae and Beauveria spp.were found,and the Metarhizium isolates are being characterized as to stress tolerance and virulence to insects.Characterization includes comparisons of new and pre-existing Metarhizium isolates by amplified fragment-length polymorphism (AFLP) analysis.Finally, experiments on MC developmental biology were conducted to gather data needed to develop a degree day model and to establish laboratory colonies of MC. | 唐诺德.罗伯茨 Drauzio E N Rangel Chad A Keyser Helen G Bignayan Seth J Dettenmaier Everton K K Fernandes Mark P Miller Edward W Evans | 2007 | 安徽农业大学学报2007，34，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员