|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Immunosuppression for in vivo research: state-of-the-at protocols and experimental approaches显示文摘几乎,用非自体同源的房间,织物或机关移植的每试验性的治疗策略在临床的翻译前在小、大的动物模型被测试。因为这些策略在大多数情况中要求免疫力的抑制,抑制免疫力的协议是在移植实验的一个关键元素。然而,没有详细知识,标准抑制免疫力的协议经常在特别试验性的背景以内并且在选择模型种类关于他们的功效被使用。如此的协议的优化对到人的病人的试验性的结果的翻译恰当,因此,保证推进调查。这评论与种类特定的药 metabolization 和副作用的考虑关于抑制免疫力的药类以及他们的剂量和应用程序政体总结当前的知识。它也总结新奇 immunomodulatory 策略的当代的知识,例如间充质的干细胞或抗体的使用。因此,这评论被打算用作一个最先进的概要让研究人员精制应用试验性的免疫力的抑制和 immunomodulation 策略提高现出症状之前的潜的移植研究的预兆的价值。 | Rita Diehl Fabienne Ferrara Claudia Müller Antje Y Dreyer Damian D McLeod Stephan Fricke Johannes Boltze | 2017 | Cellular & Molecular Immunology2017，14，2： | 5 |
| 2 | STAT3-Driven Upregulation of TLR2 Promotes Gastric Tumorigenesis Independent of Tumor Inflammation显示文摘 | Hazel Tye Catherine L. Kennedy Meri Najdovska Louise McLeod William McCormack Norman Hughes Anouk Dev William Sievert Chia Huey Ooi Tomo-o Ishikawa Hiroko Oshima Prithi S. Bhathal Andrew E. Parker Masanobu Oshima Patrick Tan Brendan J. Jenkins | 2012 | Cancer Cell2012，，4： | 3 |
| 3 | Ischemic penumbra in retina endures: vascular neuropathology is reconciled显示文摘A physiological state of'normoxia'obtains when tissue oxygen tension(pO2)is sufficient to drive mitochondrial respiration throughout a volume of cells.Between 30–40%of the available oxygen is normally extracted from hemoglobin as it passes through neural tissue,implying a balance between oxygen de- | David McLeod | 2016 | Neural Regeneration Research2016，11，5： | 3 |
| 4 | Dark mode plasmonic optical microcavity biochemical sensor显示文摘Whispering gallery mode(WGM) microtoroid optical resonators have been effectively used to sense low concentrations of biomolecules down to the single molecule limit. Optical WGM biochemical sensors such as the microtoroid operate by tracking changes in resonant frequency as particles enter the evanescent near field of the resonator.Previously, gold nanoparticles have been coupled to WGM resonators to increase the magnitude of resonance shifts via plasmonic enhancement of the electric field. However, this approach results in increased scattering from the WGM, which degrades its quality(Q) factor, making it less sensitive to extremely small frequency shifts caused by small molecules or protein conformational changes. Here, we show using simulation that precisely positioned trimer gold nanostructures generate dark modes that suppress radiation loss and can achieve high (> 10~6) Q with an electric-field intensity enhancement of 4300, which far exceeds that of a single rod(~2500 times). Through an overall evaluation of a combined enhancement factor, which includes the Q factor of the system, the sensitivity of the trimer system was improved 105× versus 84× for a single rod. Further simulations demonstrate that unlike a single rod system, the trimer is robust to orientation changes and has increased capture area. We also conduct stability tests to show that small positioning errors do not greatly impact the result. | CHENG LI LEI CHEN EUAN MCLEOD JUDITH SU | 2019 | Photonics Research2019，7，8： | 3 |
| 5 | Diagnostic Accuracy of MRI for Assessment of T Category, Lymph Node Metastases, and Circumferential Resection Margin Involvement in Patients with Rectal Cancer: A Systematic Review and Meta-analysis显示文摘 | Eisar Al-Sukhni Laurent Milot Mark Fruitman Joseph Beyene J. Victor Selina Schmocker Gina Brown Robin McLeod Erin Kennedy | 2012 | Annals of Surgical Oncology2012，，7： | 3 |
| 6 | Defining Surgical Quality in Gastric Cancer: A RAND/UCLA Appropriateness Study显示文摘 | Savtaj Brar Calvin Law Robin McLeod Lucy Helyer Carol Swallow Lawrence Paszat Rajini Seevaratnam Roberta Cardoso Matthew Dixon Alyson Mahar Laercio G. Lourenco Lavanya Yohanathan Alina Bocicariu Tanios Bekaii-Saab Ian Chau Neal Church Daniel Coit Christop | 2013 | Journal of the American College of Surgeons2013，，2： | 3 |
| 7 | Roles of autophagy in lymphocytes: reflections and directions显示文摘最近的研究揭示了那 autophagy,基本细胞内部的进程,在淋巴细胞开发和功能起许多不同作用。Autophagy 调整天真的 T 淋巴细胞动态平衡,明确地由调整 mitochondrial 质量和周转,并且为成熟 T 房间的增长是必要的。Autophagy 也在淋巴细胞充当一条细胞的死亡小径,在延长 cytokine 退却之上并且在尖锐抗原受体刺激期间如果不正确地调整了。在 HIV 感染期间,而且, autophagy 的 hyperinduction 在 uninfected CD4+ T 房间导致巨大的 T 房间死亡,并且被禁止 autophagic 救开始。在 thymic 的 autophagy 组成地高级上皮的房间为最佳的处理和内长的抗原的表示是必要的,并且为开发 thymocytes 的合适的积极、否定的选择要求。Autophagy 也支持早 B 房间祖先的 B 淋巴细胞,以及发展的幸存。在 B 房间, autophagy 是一条其他的死亡小径,当当 costimulation 不在时的抗原受体刺激导致有势力 autophagic 死亡。因此, autophagy 在淋巴细胞起一个复杂作用并且在他们的 lifespan 期间被调整保证一个健康免疫系统。 | Ian X McLeod Youwen He | 2010 | Cellular & Molecular Immunology2010，7，2： | 2 |
| 8 | Pigment gallstone pathogenesis: Slime production by biliary bacteria is more important than beta-glucuronidase production显示文摘 | Lygia Stewart M.D. Rosio Ponce Adair L. Oesterk J. McLeod Griffiss M.D. Lawrence W. Way M.D | 2000 | Journal of Gastrointestinal Surgery2000，，5： | 2 |
| 9 | Arthropod prey of imported fire ants (Hymenoptera: Formicidae) in Mississippi sweetpotato fields显示文摘红进口的火蚂蚁, Solenopsis invicta (Buren ) ,通常被认为害虫。他们也被看作了在各种各样的 agroecosystems 的另外的昆虫害虫上喂的有益的食肉动物。这研究在密西西比在一块 sweetpotato 地里记录火蚂蚁的 foraging 习惯。与一个 sweetpotato 领域在殖民地外面连接的火蚂蚁 foraging 小道被暴露, foraging 蚂蚁向殖民地的方向从这个领域移动与固体一起是镇定的他们正在带的食物粒子。食物材料在起源作为节肢动物或植物被分类。节肢动物粒子被识别到订单。火蚂蚁 foragers 比植物材料带了更多的节肢动物。翘目和 Homoptera 是最丰富的组 preyed 在之上。这些昆虫订单包含 sweetpotato 的各种各样的经济地重要的害虫。另外的主要昆虫组包括了订单半翅类,双翅目并且 Collembola。foraged 材料的数量在季节变化了。sweetpotato 根的损坏都不能被归因开除蚂蚁喂。进口的火蚂蚁 foraging 可以在 sweetpotato 地里减少昆虫害虫的数字。 | Tahir Rashid Jian Chen James T. Vogt Paul J. McLeod | 2013 | Insect Science2013，20，4： | 2 |
| 10 | PNPLA 3 rs738409 I748M is associated with steatohepatitis in 434 non‐obese subjects with hepatitis C显示文摘 | S. Petta E. Vanni E. Bugianesi C. Rosso D. Cabibi C. Cammà V. Di Marco M. Eslam S. Grimaudo F. S. Macaluso D. McLeod R. M. Pipitone M. L. Abate A. Smedile J. George A. Craxì | 2015 | Aliment Pharmacol Ther2015，，10： | 2 |
| 11 | Exome Resequencing Identifies Potential Tumor‐Suppressor Genes that Predispose to Colorectal Cancer显示文摘 | Christopher G. Smith Marc Naven Rebecca Harris James Colley Hannah West Ning Li Yuan Liu Richard Adams Timothy S. Maughan Laura Nichols Richard Kaplan Michael J. Wagner Howard L. McLeod Jeremy P. Cheadle | 2013 | Human Mutation2013，，7： | 2 |
| 12 | Apolipoprotein B100 quality control and the regulation of hepatic very low density lipoprotein secretion显示文摘Apolipoprotein B (apoB ) 是很低的密度脂蛋白(VLDL ) 的主要蛋白质部件并且为这些 triglyceride (TG ) 的集会和分泌物是必要的富有的粒子。从肝的后面的版本, VLDL 在血浆被变换成低密度脂蛋白(LDL ) 并且增加了 VLDL 的生产能因此在心血管的疾病起一个有害作用。增加的证据帮助了为 dyslipidemias 的处理作为一个目标建立 VLDL 汇编。多重因素涉及合拢 apoB 蛋白质和一个分泌物能干的 VLDL 粒子的形成。没有通过的 VLDL 汇编能在 hepatocyte 开始质量控制机制为降级的那目标 apoB。ApoB 是底层因为 endoplasmic 蜂窝胃由 ubiquitin proteasome 系统并且为 autophagy 联系了降级(ERAD ) 。有效指向和 apoB 的处理是调制 VLDL 分泌物的一个调整过程并且 TG 划分。新兴的证据建议那重要重叠在这些 degradative 小径之间存在。例如,到 autophagy 和展开的蛋白质反应(UPR ) 的饭后的激活的 apoB 的调停胰岛素的指向可以采用一样的细胞的机械和规章的暗示。在为 apoB 的质量控制机制的变化影响肝的生理学和病理状态,包括胰岛素抵抗和脂肪肝。发信号的胰岛素,类脂化合物新陈代谢和肝的 UPR 可以影响 VLDL 生产,特别地在饭后的状态期间。在我们总结我们 VLDL 的当前的理解的这评论,汇编, apoB 降级,质量控制机制和这些的角色在肝生理学并且处于病理学的状态处理。 | Eric Fisher Elizabeth Lake Roger S McLeod | 2014 | The Journal of Biomedical Research2014，28，3： | 2 |
| 13 | Evidence-Based Guidelines for Prevention of Perioperative Hypothermia显示文摘 | Shawn S. Forbes Cagla Eskicioglu Avery B. Nathens Darlene S. Fenech Claude Laflamme Richard F. McLean Robin S. McLeod | 2009 | Journal of the American College of Surgeons2009，，4： | 2 |
| 14 | Farmer Participatory Evaluation of Nursery Bed Treatments for the Control of Root-Knot Nematodes [Meloidogynejavanica (Treub) Chitwood and Meloidogyne incognita (Kofoid and White) Chitwood] in Smallholder Farms in Kenya显示文摘 | D. K. Karanja S. R. Gowen B. Ndung u R. O. Musebe S. Simons A McLeod B. R. Kerry P. K. Karanja B. Pembroke | 2011 | Journal of Agricultural Science and Technology(A)2011，1，5： | 2 |
| 15 | The effect of food on the oral bioavailability and the pharmacodynamic actions of the insulinotropic agent nateglinide in healthy subjects显示文摘 | Karara AH Dunning BE McLeod JF | 1999 | J Clin Pharmacol1999，39，： | 2 |
| 16 | Lateral Internal Sphincterotomy is Superior to Topical Nitroglycerin for Healing Chronic Anal Fissure and does not Compromise Long-Term Fecal Continence: Six-Year Follow-Up of a Multicenter, Randomized, Controlled Trial显示文摘 | Carl J. Brown M.D. Daniel Dubreuil M.D. Laura Santoro B.Sc. Maria Liu B.Sc. Brenda I. O'Connor B.ScN. Robin S. McLeod M.D | 2007 | Diseases of the Colon & Rectum2007，，4： | 2 |
| 17 | Biliary stenting versus bypass surgery for the palliation of malignant distal bile duct obstruction:a meta-analysis显示文摘 | Taylor MC McLeod RS Langer B | 2000 | Liver Transpl2000，6，3： | 1 |
| 18 | Pharmacogenomics:Unlocking the human genome for better drug therapy显示文摘 | McLeod HL Evans WE | 2001 | Ann Rev Pharmacol Toxicol2001，41，1： | 1 |
| 19 | Obesity in pregnancy 显示文摘 | Davies GA Maxwell C McLeod L | 2010 | J Obstet Gynaecol Can2010，32，2： | 1 |
| 20 | Developmentof resistance to picking wound entrybotrytis cinereastorage rots in kiwifruit显示文摘 | Poole P R Mcleod L C | 1994 | New Zealand Journal of Crop and Horticultural Science1994，22，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员