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| 1 | Outcomes of severe sepsis and septic shock patients after stratifi cation by initial lactate value显示文摘BACKGROUND: In the setting of severe sepsis and septic shock, mortality increases when lactate levels are ≥ 4 mmol/L. However, the consequences of lower lactate levels in this population are not well understood. The study aimed to determine the in-hospital mortality associated with severe sepsis and septic shock when initial lactate levels are < 4 mmol/L.METHODS: This is a retrospective cohort study of septic patients admitted over a 40-month period. Totally 338 patients were divided into three groups based on initial lactate values. Group 1 had lactate levels < 2 mmol/L; group 2: 2–4 mmol/L; and group 3: ≥ 4 mmol/L. The primary outcome was in-hospital mortality.RESULTS: There were 111 patients in group 1, 96 patients in group 2, and 131 in group 3. The mortality rates were 21.6%, 35.4%, and 51.9% respectively. Univariate analysis revealed the mortality differences to be statistically significant. Multivariate logistic regression demonstrated higher odds of death with higher lactate tier group, however the findings did not reach statistical significance.CONCLUSION: This study found that only assignment to group 3, initial lactic acid level of ≥ 4 mmol/L, was independently associated with increased mortality after correcting for underlying severity of illness and organ dysfunction. However, rising lactate levels in the other two groups were associated with increased severity of illness and were inversely proportional to prognosis. | Kimberly A. Chambers Adam Y. Park Rosa C. Banuelos Bryan F. Darge Bindu H. Akkanti Annamaria Macaluso Manoj Thangam Pratik B. Doshi | 2018 | World Journal of Emergency Medicine2018，9，2： | 26 |
| 2 | Genetic background in nonalcoholic fatty liver disease: A comprehensive review显示文摘In the Western world, nonalcoholic fatty liver disease(NAFLD) is considered as one of the most significant liver diseases of the twenty-first century. Its development is certainly driven by environmental factors, but it is also regulated by genetic background. The role of heritability has been widely demonstratedby several epidemiological, familial, and twin studies and case series, and likely reflects the wide interindividual and inter-ethnic genetic variability in systemic metabolism and wound healing response processes. Consistent with this idea, genome-wide association studies have clearly identified Patatin-like phosholipase domain-containing 3 gene variant I148 M as a major player in the development and progression of NAFLD. More recently, the transmembrane 6 superfamily member 2 E167 K variant emerged as a relevant contributor in both NAFLD pathogenesis and cardiovascular outcomes. Furthermore, numerous casecontrol studies have been performed to elucidate the potential role of candidate genes in the pathogenesis and progression of fatty liver, although findings are sometimes contradictory. Accordingly, we performed a comprehensive literature search and review on the role of genetics in NAFLD. We emphasize the strengths and weaknesses of the available literature and outline the putative role of each genetic variant in influencing susceptibility and/or progression of the disease. | Fabio Salvatore Macaluso Marcello Maida Salvatore Petta | 2015 | World Journal of Gastroenterology2015，21，39： | 14 |
| 3 | 中国妇女低剂量口服避孕药使用者中脑卒中发病情况的前瞻性研究显示文摘目的 了解目前我国广泛应用的国产低剂量复方口服避孕药 (COC)与脑卒中发病危险性的关系 ,以期降低COC的不良反应。方法 应用前瞻性队列研究的方法 ,于 1997年 7月至 2 0 0 0年6月在江苏太仓市和如东县 2 5个乡镇随访比较 44 40 8名使用甾体激素避孕药 (HC)和 75 2 30名使用IUD妇女的脑卒中发病率。结果 (1)HC队列出血型脑卒中的调整后发病率为 34 74/ 10万 ,是IUD队列的 2 72倍 (P <0 0 1) ;HC队列 45岁以下妇女出血型脑卒中的发病率明显高于IUD队列 ;停用HC 10年以上者出血型脑卒中发病危险度为 2 17(1 16 ,4 0 6 ) ,仍显著高于IUD使用者。 (2 )国产低剂量COC当前使用者中出血型脑卒中发病危险性为非使用者 3 6 0倍 (1 73,7 5 3) ,停用 5年以内发病危险度达 3 0 9(1 2 6 ,7 5 7) ,但停用 5年以后发病危险度明显下降。 (3)在国产COC当前使用者中未发现梗塞型脑卒中发病率明显升高现象。 (4 )在国产低剂量COC使用者中 ,高血压可能是出血型脑卒中最重要的危险性因素。结论 使用国产低剂量COC的妇女出血型脑卒中发病危险性明显升高 ,其对出血型脑卒中发病的影响可持续到停用以后 。 | 李瑛 高尔生 刘云嵘 罗琳 王心如 王海燕 吴玉璘 周利锋 孙志明 张立英 吴世仲 Jason Shia Maurizio Macaluso Brian McCarthy | 2002 | 中华医学杂志2002，82，15： | 12 |
| 4 | 男、女用避孕套临床可接受性的比较显示文摘目的:比较男、女用避孕套的临床可接受性。方法:以40名健康育龄期妇女自愿者为研究对象,采用交叉设计,每人使用男女用避孕套各5个,每使用完一种后填写评价性调查表;使用完两种后,填写总结性调查表,对两种避孕套进行比较。结果:在避孕套的取出/取下、性生活中阴茎的插入、以及性生活中是否感觉不舒服(疼痛、烧灼感)等方面,对两种避孕套的评价基本相同。男用避孕套的主要优点是易学、易用,而女用避孕套可使性生活更有兴趣和感到更安全。总的说来,女性对使用两种避孕套的态度没有明显差异,而男性则比较喜欢使用男用避孕套。结论:通过适当的推广和改进,在我国会有一定比例的育龄妇女接受并使用女用避孕套。 | 姜宝法 郭秀英 付萍 徐晓菲 Maurizio Macaluso | 2004 | 生殖与避孕2004，24，2： | 7 |
| 5 | 女用安全套预防性传播疾病的效果评价显示文摘目的 评价女用安全套防止非意愿性妊娠和性传播疾病的效果。方法 以 40名健康育龄妇女志愿者为研究对象 ,每人使用 5个女用安全套 ,每次使用前、后各采集阴道分泌物标本 ,记录安全套出现机械性问题的情况 ,采用化学发光免疫测定法检测标本浸泡液中前列腺特异性抗原 (PSA)浓度。结果 186个安全套中有 18 2 7%至少出现 1次机械性问题 ;自我报告有机械性问题者的后拭子PSA平均浓度为 (3 3 3 5± 3 5 56)ng/ml,无机械性问题者的后拭子PSA平均浓度为 (14 97± 16 96)ng/ml,二者有显著性差异 (t =8 942 ,P <0 0 0 1) ;有机械性问题与PSA阳性密切相关 (r =0 77,P <0 0 0 1)。结论 尽管使用屏障性避孕工具可以有效地防止性病 /艾滋病的传播 ,但根本的预防方法还是洁身自好 。 | 姜宝法 郭秀英 付萍 徐晓菲 Maurizio Macaluso | 2004 | 中国公共卫生2004，20，1： | 4 |
| 6 | 炔诺酮口服避孕药与妇女出血型脑卒中的关系显示文摘目的:明确目前我国不同配方的国产低剂量复方口服避孕药(Combined oral contraceptives,COC)与出血型脑卒中的关系,以降低COC严重不良反应的发生,提高妇女的生殖健康水平。方法:前瞻观察1997年7月~2000年6月江苏省太仓和如东两县的25个乡镇使用COC妇女和同期使用宫内节育器妇女。结果:①与从未使用者相比,当前国产含炔诺酮的低剂量COC使用者出血型脑卒中发病率明显升高,但未发现梗塞型脑卒中发病率升高;②含炔诺酮的低剂量COC停用5年内仍然存在较高的出血型脑卒中发病危险性(RR=3.55,1.43~8.85),但停用5年以上者出血型脑卒中发病危险性明显降低(RR=1.27,0.59~2.74);③复方炔诺酮片与出血型脑卒中的关系明确,但不能排除其他配方的国产避孕药对出血型脑卒中的影响;④低剂量COC使用者中高血压仍然是出血型脑卒中最重要的危险性因素。结论:国产低剂量复方炔诺酮与出血型脑卒中有关,其对出血型脑卒中发病危险性的影响可持续到停用以后,但该作用可逆。应加强对其它国产COC严重不良反应的监测和研究,对COC使用者进行血压筛查和医学监护。 | 李瑛 高尔生 刘云嵘 罗琳 王心如 王海燕 吴玉璘 周利锋 孙志明 张立英 吴世仲 Jason Shia Maurizio Macaluso Brian McCarthy | 2003 | 中国计划生育学杂志2003，11，6： | 3 |
| 7 | Senescence and p130/Rb12: a new beginning to the end显示文摘 | Francesco P Fiorentinot Catherine E Symonds Marcella Macaluso Antonio Giordano | 2009 | Cell Research2009，19，9： | 3 |
| 8 | clinical course and prognostic factors of hepatorenal syndrome:a retrospective single-center cohort study显示文摘AIM: To investigate clinical and biochemical features of hepatorenal syndrome(HRS), to assess short and long- term survival evaluating potential predictors of early mortality. METHODS: Sixty-two patients with liver cirrhosis and renal failure, defined as a serum creatinine value > 1.5 mg/dL on at least two measurements within 48 h, admitted to our tertiary referral Unit from 2001 to 201, were retrospectively reviewed. Among them, 33 patients(53.2%) fulfilled the revised criteria of the International Ascites Club for the diagnosis of HRS. Twenty-eight patients were treated with combinations of terlipressin and albumin, two with dopamine and al- bumin, and three with albumin alone. No patients were suitable for liver transplantation. Complete response was defined as normalization of creatinine levels to less than 1.5 mg/dL, partial response as a decrease of at least 50% but not to less than 1.5 mg/dL, no response as no reduction in creatinine or a decrease of less 50% compared to pre-treatment values. All of the patients were followed up for at least 1 year until January 2013. RESULTS: HRS type 1 was diagnosed in 15 patients(45.5%). Hepatitis C virus infection was the primary etiology(69.6%), followed by alcohol(15.2%), and cryptogenesis(15.2%). Complete response to therapy was obtained in only 3 cases(9.1%) and partial re- sponse in 7 patients(21.2%). Median survival was 30 d(range: 10-274) without significant differences be- tween type 1 and type 2 HRS. By univariate analysis, Child-Pugh class C(P = 0.009), presence of hepatocel- lular carcinoma(P = 0.04), low serum sodium(P = 0.02), high bilirubin values(P = 0.009) and high Model for End-stage Liver Disease(MELD) score(P = 0.03) were predictive factors of 30-d mortality. By multivari- ate analysis, only serum sodium < 132 mEq/L(OR = 31.39; P = 0.02) and MELD score > 27(OR = 18.72; P = 0.01) were independently associated with a survival of less than one month. CONCLUSION: HRS still has a poor prognosis, even when vasoactive drug therapies are extensively used. | Anna Licata Marcello Maida Ambra Bonaccorso Fabio Salvatore Macaluso Maria Cappello Antonio Craxì Piero Luigi Almasio | 2013 | World Journal of Hepatology2013，5，12： | 2 |
| 9 | Effectiveness of very low-volume preparation for colonoscopy:A prospective, multicenter observational study显示文摘BACKGROUND The effectiveness of colonoscopy strictly depends on adequate bowel cleansing.Recently,a 1 L polyethylene glycol plus ascorbate(PEG-ASC)solution(Plenvu;Norgine,Harefield,United Kingdom)has been introduced on the evidence of three phase-3 randomized controlled trials,but it had never been tested in the real-life.AIM To assess the effectiveness and tolerability of the 1 L preparation compared to 4 L and 2 L-PEG solutions in a real-life setting.METHODS All patients undergoing a screening or diagnostic colonoscopy after a 4,2 or 1 L PEG preparation,were consecutively enrolled in 5 Italian centers from September 2018 to February 2019.The primary endpoints of the study were the assessment of bowel cleansing success and high-quality cleansing of the right colon.The secondary endpoints were the evaluation of tolerability,adherence and safety of the different bowel preparations.Bowel cleansing was assessed through the Boston Bowel Preparation Scale.Adherence was defined as consumption of at least 75%of each dose,while tolerability was evaluated through a semiquantitative scale.Safety was systematically monitored through adverse events reporting.RESULTS Overall,1289 met the inclusion criteria and were enrolled in the study.Of these,490 patients performed a 4 L-PEG preparation(Selgesse^■),566 a 2 L-PEG cleansing(Moviprep^■or Clensia^■)and 233 a 1 L-PEG preparation(Plenvu^■).Bowel cleansing by Boston Bowel Preparation Scale was 6.5±1.5 overall and 6.3±1.5,6.2±1.5,7.3±1.5(P<0.001)in the subgroups of 4 L,2 L and 1 L-PEG preparation,respectively.Cleansing success was achieved in 72.4%,74.1%and 90.1%(P<0.001),while a high-quality cleansing of the right colon in 15.9%,12.0%and 41.4%(P<0.001)for 4 L,2 L and 1 L-PEG preparation groups,respectively.The 1 L preparation was the most tolerated compared to the 2 and 4 L-PEG solutions in the absence of serious adverse events within any of the three groups.Multiple regression models confirmed 1 L PEG-ASC preparation as an independent predictor of overall cleansing success,high-quality cleansing of the right colon and of tolerability.CONCLUSION This study supports the effectiveness and tolerability of 1 L PEG-ASC,also showing it is an independent predictor of overall cleansing success,high-quality cleansing of the right colon and of tolerability. | Marcello Maida Emanuele Sinagra Gaetano Cristian Morreale Sandro Sferrazza Giuseppe Scalisi Dario Schillaci Marco Ventimiglia Fabio Salvatore Macaluso Giovanni Vettori Giuseppe Conoscenti Concetta Di Bartolo Serena Garufi Domenico Catarella Michele Manganaro Clara Maria Virgilio Salvatore Camilleri | 2020 | World Journal of Gastroenterology2020，26，16： | 2 |
| 10 | PNPLA 3 rs738409 I748M is associated with steatohepatitis in 434 non‐obese subjects with hepatitis C显示文摘 | S. Petta E. Vanni E. Bugianesi C. Rosso D. Cabibi C. Cammà V. Di Marco M. Eslam S. Grimaudo F. S. Macaluso D. McLeod R. M. Pipitone M. L. Abate A. Smedile J. George A. Craxì | 2015 | Aliment Pharmacol Ther2015，，10： | 2 |
| 11 | Dexmedetomidine Infusion During Laparoscopic Bariatric Surgery: The Effect on Recovery Outcome Variables显示文摘 | Burcu Tufanogullari Paul F. White Mariana P. Peixoto Daniel Kianpour Thomas Lacour James Griffin Gary Skrivanek Amy Macaluso Mary Shah David A. Provost | 2008 | Anesthesia & Analgesia2008，，6： | 2 |
| 12 | Condom effectiveness for prevention of trachoma infection显示文摘 | Warner L Macaluso M Newman D | 2006 | Sexually transmitted infections2006，82，3： | 1 |
| 13 | Revival of the in- trauterine device: increased insertions among US women with employer-sponsored insurance, 2002-2008 显示文摘 | Xin Xu Maurizio Macaluso Lijing Ouyang | 2012 | Contraception2012，85，2： | 1 |
| 14 | A higher degree of methylation of the HPV 16 E6 gene is associated with a lower likelihood of being diagnosed with eervieal intraepithelial neoplasia 显示文摘 | Piyathilake C J Macaluso M Alvarez RD | 2011 | Cancer2011，117，5： | 1 |
| 15 | Sleep bruxism as a motor disorder显示文摘 | De Laat A Macaluso GM | | 0，，2： | 1 |
| 16 | CoOx catalysts supported on alumina and alumina-baria: Influence of the support on the cobalt species and their activity in NO reduction by C3 H6 in lean conditions显示文摘 | Liotta L F PantaIeo G Macaluso A | 2003 | Sol-Gel Sci Technol2003，28，： | 1 |
| 17 | High binaural coherence determines successful sound localization and increased activity in posterior auditory areas显示文摘 | U Zimmer E Macaluso | 2005 | Neuron2005，47，： | 1 |
| 18 | Osteoeytes and WNT: the rnechanieal control of bone formation 显示文摘 | Galli C Passeri C Macaluso GM | 2010 | Journal of dental research2010，89，4： | 1 |
| 19 | Effects of redox treatments on the structural composition of a ceria-zirconia oxide for application in the three-way catalysis显示文摘 | liotta L F Macaluso A longo A | 2003 | Applied Catalysis A2003，240，12： | 1 |
| 20 | Protective association of MTHFR polymorphism on cervical intraepithelial neoplasia is modified by riboflavin status显示文摘 | Piyathi|ake C J Azrad M Macaluso M | 2007 | Nutrition2007，23，3： | 1 |
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