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| 1 | Prognostic value of serum microRNA-122 in hepatocellular carcinoma is dependent on coexisting clinical and laboratory factors显示文摘BACKGROUND There is ongoing search for new noninvasive biomarkers to improve management of patients with hepatocellular carcinoma(HCC).Studies,mostly from the Asian-Pacific region,demonstrated differential expression of liverspecific microRNA-122(miR-122)in tissue as well as in sera of patients with hepatitis B virus-and hepatitis C virus-induced HCC.AIM To evaluate prognostic value of miR-122 in patients with HCC in a European population and determine potential factors related to alteration of miR-122 in sera.METHODS Patients with confirmed HCC(n=91)were included in the study over a two-year period.Patients were characterized according to Child-Pugh score,Barcelona clinic liver cancer(BCLC)staging system,etiology of liver disease,laboratory parameters and overall survival.MiR-122 was measured in sera using TaqMan assay normalized to spiked-in cel-miR-39.RESULTS Serum miR-122 quantity was independent of the Child-Pugh score,the BCLC stage or the underlying etiology.Significant positive correlation was found between miR-122 and alanine aminotransferase(P<0.0001),aspartate aminotransferase(P=0.0001),alpha-fetoprotein(AFP)(P=0.0034)and hemoglobin concentration(P=0.076).Negative correlation was observed between miR-122 level and creatinine concentration(P=0.0028).AFP,Child-Pugh score and BCLC staging system were associated with survival differences.In overall cohort low miR-122 in sera was only associated with a trend for a better overall survival without reaching statistical significance.Subgroup analysis revealed that low miR-122 was significantly associated with better prognosis in patients with advanced cirrhosis(Child-Pugh class B/C),advanced tumor stage(BCLC B/C/D)and normal AFP(<7 ng/mL).CONCLUSION Our results strongly support the value of miR-122 as potential biomarker of liver injury and probably prognosis.Nevertheless,the value of miR-122 in prediction of prognosis of HCC patients was limited to certain patients’subgroups.Since circulating miR-122 may be influenced by impaired renal function,AFP and hemoglobin concentration,those factors need to be considered while interpreting miR-122 level. | Martin Franck Kerstin Schütte Peter Malfertheiner Alexander Link | 2020 | World Journal of Gastroenterology2020，26，1： | 3 |
| 2 | Induction of apoptosis by curcumin: mediation by glutathione S -transferase P1-1 inhibition显示文摘 | Annelyse Duvoix Franck Morceau Sylvie Delhalle Martine Schmitz Micha?l Schnekenburger Marie-Madeleine Galteau Mario Dicato Marc Diederich | 2003 | Biochemical Pharmacology2003，，8： | 2 |
| 3 | Circulating miR-21-5p level has limited prognostic value in patients with hepatocellular carcinoma and is influenced by renal function显示文摘BACKGROUND MicroRNAs(miRNAs)have been suggested as biomarkers for malignant diseases including hepatocellular carcinoma(HCC).Specifically,hsa-miR-21-5p(miR-21)is among the most frequently deregulated miRNA in cancer.The diagnostic and prognostic value of miR-21 has been demonstrated in HCC tissue,mostly in the Asian population.Although the impact of various factors has been recently reported for circulating hsa-miR-122-5p(miR-122),at present only limited knowledge is available for miR-21.AIM To evaluate the value of miR-21 for the assessment of prognosis in HCC patients and to delineate the influence of clinical and preanalytical factors on miR-21 level in sera.METHODS Patients with confirmed HCC from our European cohort with predominantly alcohol-associated liver damage were included in the study.All subjects were characterized according to their clinical and laboratory work-up and overall survival data were obtained.Quantitative real-time polymerase chain reaction was performed for miR-21 and spiked-in cel-miR-39-3p.The results were compared to previously reported miR-122 data.RESULTS Survival of HCC patients was comparable between patients with low and high serum miR-21 concentration.No association was observed between miR-21 level in sera and Child-Pugh score,Barcelona Clinic Liver Cancer staging system,or etiology of HCC/liver disease.Age,gender,or pretreatment had no association with miR-21 level.A positive correlation was observed between miR-21 and aspartate aminotransferase(r=0.2854,P=0.0061),serum miR-122(r=0.2624,P=0.0120),and the International Normalized Ratio(r=0.2065,P=0.0496).Negative correlation of miR-21 with serum creatinine(r=-0.2215,P=0.0348)suggests renal function as a potential influencing factor in miR-21 biogenesis in blood.CONCLUSION The results from this work do not support clinically relevant prognostic value of circulating miR-21 in HCC patients in real-life settings.Following systematic evaluation,we identified renal function and aspartate aminotransferase as potential factors that may affect miR-21 concentration in blood.This knowledge should be considered in future miRNA-based biomarker studies not only for HCC but also for other diseases. | Martin Franck Cosima Thon Kerstin Schutte Peter Malfertheiner Alexander Link | 2020 | World Journal of Hepatology2020，12，11： | 2 |
| 4 | Idel Sense: An Optiaml Access Method for High Throughput and Fairness in Rate Di- verse Wireless LANs显示文摘 | Martin H Franck R Romaric G | 2005 | Proceedings of the 2005 Conference Applications Technologies Architectures and Protocols for Computer Co mmunications(SIGCOMM) 20052005，35，4： | 1 |
| 5 | Transforming growth factor-beta signal transduction in angiogenesis and vascular disorders显示文摘 | Philippe B Martine D Franck L | 2005 | Chest2005，128，6： | 1 |
| 6 | Sedation and analgesia in German intensive care units:howis it done in reality Results of a patient-based survey of analgesia and sedation显示文摘 | Martin J Franck M Fischer M | 2006 | Intensive Care M ed2006，32，： | 1 |
| 7 | Practice of sedation and analgesi- a in German intensive care units: results of a national survey显示文摘 | Martin J Parsch A Franck M | 2005 | Crit Care2005，9，2： | 1 |
| 8 | Shimmed matching pulses: Simultaneous control of RF and static gradients for inhomogeneity correction显示文摘 | Franck J M Demas V Martin R W | 2009 | J Chem Phys2009，131，23： | 1 |
| 9 | Usefulness of quantitative polymerase chain reaction in amniotic fluid as early prognostic marker of fetal infection with Toxoplasma gondii显示文摘 | Stéphane Romand Muriel Chosson Jacqueline Franck Martine Wallon Fran?ois Kieffer Karine Kaiser Henri Dumon Fran?ois Peyron Philippe Thulliez Stéphane Picot | 2004 | American Journal of Obstetrics and Gynecology2004，，3： | 1 |
| 10 | Tr- ansforming Growth Factor- Signal Transduction in Angio genesis and Vascular Disorders显示文摘 | Philippe Bertolino Martine Deckers Franck Lebrin | 2005 | Chest2005，6，128： | 1 |
| 11 | Iron isotope composition of the suspended matter along depth and lateral profiles in the Amazon River and its tributaries显示文摘 | Giana Márcia dos Santos Pinheiro Franck Poitrasson Francis Sondag Lucieth Cruz Vieira Márcio Martins Pimentel | 2013 | Journal of South American Earth Sciences2013，，： | 1 |
| 12 | Transforming growth factor-beta signal transduction in angiogenesis and vascular disorders 显示文摘 | Philippe B Martine D Franck L | 2005 | Chest2005，128，6： | 1 |
| 13 | Impact of STAT3 Phosphorylation on the Clinical Effectiveness of Anti-EGFR–Based Therapy in Patients With Metastatic Colorectal Cancer显示文摘 | Erion Dobi Franck Monnien Stefano Kim Arben Ivanaj Thiery N’Guyen Martin Demarchi Olivier Adotevi Antoine Thierry-Vuillemin Marie Jary Bernadette Kantelip Xavier Pivot Yann Godet Severine Valmary Degano Christophe Borg | 2012 | Clinical Colorectal Cancer2012，，： | 1 |
| 14 | Practice of sedation and analgesia in German intensive care units:results of a nat ional survey显示文摘 | MARTIN J PARSCH A FRANCK M | 2005 | Crit Care2005，9，2： | 1 |
| 15 | Sedation and analgesia in Ger- man intensive care units: how is it done in reality? Results of a patient -based survey of analgesia and sedation 显示文摘 | Martin J Franck M Fischer M | 2006 | Intensive Care Med2006，32，8： | 1 |
| 16 | 6- Versus 24-Month Dual Antiplatelet Therapy After Implantation of Drug-Eluting Stents in Patients Nonresistant to Aspirin显示文摘 | Martine Gilard Paul Barragan Arif A.L. Noryani Hussam A. Noor Talib Majwal Thomas Hovasse Philippe Castellant Michel Schneeberger Luc Maillard Erwan Bressolette Jaroslaw Wojcik Nicolas Delarche Didier Blanchard Bernard Jouve Olivier Ormezzano Franck Pagan | 2014 | Journal of the American College of Cardiology2014，，： | 1 |
| 17 | Top soil radioactivity assessment in a high natural radiation background area: The case of Vinaninkarena,Antsirabe-Madagascar显示文摘 | NAIVO R MARTIN R FRANCK T | 2008 | Appl Radiat Isotop2008，66，： | 1 |
| 18 | Practice of sedation and analgesia in German intensive care units :results of a national survey 显示文摘 | Conti G Axel Parseh Martin Franck | 2005 | Grit Care2005，9，2： | 1 |
| 19 | Morphogenesis of Oil Palm Fruit (Elaeis guineensis Jacq.) in Mesocarp and Endocarp Development显示文摘 | Hermine Bille Ngalle Joseph Martin Bell Georges Franck Ngando Ebongue Lambert Nyobe Felix Chancelin Ngangnou Godswill Ntsefong Ntsomboh | 2013 | Journal of Life Sciences2013，7，2： | 1 |
| 20 | Top soil radioactivity assessment in a high natural radiation background area: the case of Vinaninkarena, Antsirabe-Madagascar 显示文摘 | NAIVO RABESIRANANA MARTIN RASOLONIRINA FRANCK TERI- NA | 2008 | Applied Radiation and Isotopes2008，66，： | 1 |
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