|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | FOLFIRI regimen in metastatic pancreatic adenocarcinoma resistant to gemcitabine and platinum-salts显示文摘AIM: To evaluate the efficacy and safety of the FOLFIRI regimen in patients with metastatic pancreatic adenocarcinoma (PAC) after the failure of gemcitabine and platinum salts. METHODS: All consecutive patients with histologically confirmed, metastatic PAC and World Health Organiza-tion performance status (PS) ≤ 2 received FOLFIRI-1 [irinotecan 180 mg/m2 on day 1 and leucovorin 400 mg/m2 followed by 5-fluorouracil (5-FU) 400 mg/m2 bolus, then 5-FU 2400 mg/m2 as a 46-h infusion, biweekly] or FOLFIRI-3 (irinotecan 100 mg/m2 on day 1 and leucovorin 400 mg/m2, then 5-FU 2400 mg/m2 as a 46-h infusion and irinotecan 100 mg/m2 repeated on day 3, biweekly) after failure of gemcitabine and platinum-based chemotherapies as a systematic policy in two institutions between January 2005 and May 2010. Tumor response, time to progression (TTP), overall survival rate (OS) and grade 3-4 toxicities were retrospectively studied. Subgroup analyses were performed to search for prognostic factors. RESULTS: Sixty-three patients (52.4% male, median age 59 years) were analyzed. Among them, 42.9% were PS 0, 38.1% were PS 1 and 19.0% were PS 2. Fifty one patients (81.0%) had liver metastases. Before the FOLFIRI regimen, patients had received 1 line (n = 19), 2 lines (n = 39) or 3 lines (n = 5) of chemotherapy. Median TTP obtained with the line before FOLFIRI was 3.9 mo (95% CI: 3.4-5.3 mo). A total of 480 cycles was completed (median: 6 cycles, range: 1-51 cycles). The main reason for discontinuing FOLFIRI was tumor progression (90.3%). Tumor control was achieved in 25 patients (39.7%) (partial response: n = 5, stable disease: n = 20) with FOLFIRI. Median TTP was 3.0 mo (95% CI: 2.1-3.9 mo) and median OS was 6.6 mo (95% CI: 5.3-8.1 mo). Dose adaptation was required in 36 patients (57.1%). Fifteen patients (23.8%) had grade 3-4 toxicities, mainly hematological (n = 11) or digestive (n = 4). Febrile neutropenia occurred in 3 patients. There was no toxic death. PS 2 was significantly associated with poor TTP [hazard ratio (HR): 16.036, P < 0.0001] and OS (HR: 4.003, P = 0.004). CONCLUSION: The FOLFIRI regimen had an acceptable toxicity and an interesting efficacy in our study, limited to patients in good condition (PS 0-1). | Cindy Neuzillet Olivia Hentic Benot Rousseau Vinciane Rebours Léla Bengrine-Lefèvre Franck Bonnetain Philippe Lévy Eric Raymond Philippe Ruszniewski Christophe Louvet Pascal Hammel | 2012 | World Journal of Gastroenterology2012，18，33： | 3 |
| 2 | Toxoplasmosis among pregnant women:High seroprevalence and risk factors in Kinshasa,Democratic Republic of Congo显示文摘Objective:To determine the seroprevalence of toxoplasmosis in pregnant women,as well as the proportion of acutely infected and risk factors in the Democratic Republic of Congo.Methods:Thirty maternities in Kinshasa were randomly selected and women attending antenatal consultation were invited to participate.They were interviewed with a structured questionnaire about known risk factors(age,meat consumption,contact with soil,and presence of cat)and a venous blood sample was taken.Sera were analysed for total immunoglobulins(Ig)by VIDAS Toxo Competition using Enzyme Linked Fluorescent Assay.IgM was determined by VIDIA Toxo IgM and IgG avidity by VIDAS Toxo IgG avidity.Results:A total of 781 women were included.Median age was 28 years old(IQR:8.S).And 627women(80.3%;95%CI:77.5-83.1)were found to be positive to total Ig and 17 out of 387(4.4%;95%CI:2.3-6.4)were positive to IgM.IgC avidity was low for 2(11.8%)women,intermediate for 2(11.8%)and high for 13 women(76.4%).There was no statistically significant association between Toxoplasma gondii infection and any risk factors assessed.Conclusion:In Kinshasa,toxoplasmosis endemicity is highly prevalent.One woman out of twenty five had a recent toxoplasmosis infection and 20%were not protected against primoinfection,indicating a need for measures to prevent and control toxoplasmosis during pregnancy. | Doudou Yobi Renaud Piarroux Coralie L'Ollivier Jacqueline Franck Hypolite Situakibanza Hypolite Muhindo Patrick Mitashi Raquel Andreia Inocencio da Luz Marc Van Sprundel Marleen Boelaert Jean-Pierre Van Geertruyden Pascal Lutumba | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，1： | 2 |
| 3 | Induction of apoptosis by curcumin: mediation by glutathione S -transferase P1-1 inhibition显示文摘 | Annelyse Duvoix Franck Morceau Sylvie Delhalle Martine Schmitz Micha?l Schnekenburger Marie-Madeleine Galteau Mario Dicato Marc Diederich | 2003 | Biochemical Pharmacology2003，，8： | 2 |
| 4 | Synthesis and growth inhibitory properties of glucosamine-derived glycerolipids 显示文摘 | YANG G L FRANCK R W BITTMAN R | 2001 | Organic Lett2001，3，2： | 1 |
| 5 | Molecular analysis and chromosomal mapping of amplified genes isolated from a transformedmouse 3T3 cell line显示文摘 | CAHILLY SNYDER L YANG FENG T FRANCKE U | 1987 | Somat Cell Mol Genet1987，13，3： | 1 |
| 6 | Chromosomal mapping of genes involved in growth control 显示文摘 | Francke U Yang - Feng T L Brissenden J E | 1986 | Cold Spring Harbor Symposia on Quantitative Biology1986，51，1： | 1 |
| 7 | Parent involvement in children's pain care:Views of parents and nurses显示文摘 | Simons J Franck L Roberson E | 2001 | J Adv Nurs2001，36，4： | 1 |
| 8 | The TSG101 tumor susceptibility gene is located in chromosome 11 band p15 and is mutated in human breast cancer显示文摘 | Li L Li X Francke U | 1997 | Cell1997，88，1： | 1 |
| 9 | Orthodenticle and empty spiracles genes are expressed in a segmental pattern in chelicerates显示文摘 | SIMONNET Franck CL RIER Marie-Louise QUéINNEC Eric | 2006 | Dev Genes2006，216，： | 1 |
| 10 | Reticulocyte hemoglobin measurement--comparison of two methods in the diagnosis of iron-restricted erythropoiesis显示文摘 | Thomas L Franck S Messinger M | 2005 | Clin Chem Lab Med2005，43，11： | 1 |
| 11 | Risk factors for inadequate emergence after anesthesia:emergence delirium and hypoactive emergence显示文摘 | Radtke FM Franck M Hagemann L | | 0，，06： | 1 |
| 12 | A Comparison of Pain Measures in Newborn Infants after Cardiac Surgery显示文摘 | Franck L S Ridout D Howard R | | 0，，08： | 1 |
| 13 | Polynomial chaos repre- sentation for identification of mechanical characteristics ofinstrumented structures 显示文摘 | Franck S Humberto Y Francesca L | 2011 | Computer-Aided Civil and Infras- tructure Engineering2011，26，3： | 1 |
| 14 | A New Set of Quality Indicators for Palliative Care:Process and Results of the Development Trajectory显示文摘 | CLAESSEN S J FRANCKE A L BELARBI H E | 2011 | J Pain Symptom Manage2011，42，2： | 1 |
| 15 | Molecular confirmation of a fourth lineage in honeybees from the Near East 显示文摘 | Franck P Garnery L Solignac M | 2000 | Apidologie2000，31，2： | 1 |
| 16 | Evalua- tion of communication training programs in nursing care:A review of the literature显示文摘 | Kruijver I P M Kerkstra A Francke A L | 2000 | Patient Edu Couns2000，39，1： | 1 |
| 17 | The origin of west European subspecies of honeybees ( Apis mellifera) : new insights from microsatellite and mitochondrial data 显示文摘 | Franck P Garnery L Solignac M | 1998 | Evolution1998，52，4： | 1 |
| 18 | Cytokinin modulates catalase activity and coumarin accumulation in in vitro cultures of Tobacco显示文摘 | Petit-Paly G Franck T Brisson L | 1999 | Journal of Plant Physiology1999，155，1： | 1 |
| 19 | Risk factors for inadequate emergence after anesthesia:emergemce delirium and hypoaelive emergence显示文摘 | Radtke F M Franck M Hagemann L | | 0，，06： | 1 |
| 20 | Molecular cConfirmation of aA fFourth 1Lineage in hHoney bBees from the Near East显示文摘 | Franck P Garnery L Solignac M | 2000 | Apidologie2000，31，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员